LOCUS       NM_001007632            1508 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus activating signal cointegrator 1 complex subunit
            1 (Ascc1), mRNA.
ACCESSION   NM_001007632 XM_215419
VERSION     NM_001007632.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1508)
  AUTHORS   Knierim E, Hirata H, Wolf NI, Morales-Gonzalez S, Schottmann G,
            Tanaka Y, Rudnik-Schoneborn S, Orgeur M, Zerres K, Vogt S, van
            Riesen A, Gill E, Seifert F, Zwirner A, Kirschner J, Goebel HH,
            Hubner C, Stricker S, Meierhofer D, Stenzel W and Schuelke M.
  TITLE     Mutations in Subunits of the Activating Signal Cointegrator 1
            Complex Are Associated with Prenatal Spinal Muscular Atrophy and
            Congenital Bone Fractures
  JOURNAL   Am J Hum Genet 98 (3), 473-489 (2016)
   PUBMED   26924529
REFERENCE   2  (bases 1 to 1508)
  AUTHORS   Hall JM and McDonnell DP.
  TITLE     Coregulators in nuclear estrogen receptor action: from concept to
            therapeutic targeting
  JOURNAL   Mol Interv 5 (6), 343-357 (2005)
   PUBMED   16394250
  REMARK    Review article
REFERENCE   3  (bases 1 to 1508)
  AUTHORS   Jung DJ, Sung HS, Goo YW, Lee HM, Park OK, Jung SY, Lim J, Kim HJ,
            Lee SK, Kim TS, Lee JW and Lee YC.
  TITLE     Novel transcription coactivator complex containing activating
            signal cointegrator 1
  JOURNAL   Mol Cell Biol 22 (14), 5203-5211 (2002)
   PUBMED   12077347
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK357599.1, BP504504.1 and CB742862.1.
            
            On May 2, 2007 this sequence version replaced NM_001007632.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-688               CK357599.1         1-688
            689-1086            BP504504.1         180-577
            1087-1508           CB742862.1         17-438              c
FEATURES             Location/Qualifiers
     source          1..1508
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..1508
                     /gene="Ascc1"
                     /gene_synonym="Asc-1; CGI-18"
                     /note="activating signal cointegrator 1 complex subunit 1"
                     /db_xref="GeneID:294512"
                     /db_xref="RGD:1359255"
     exon            1..66
                     /gene="Ascc1"
                     /gene_synonym="Asc-1; CGI-18"
                     /inference="alignment:Splign:2.1.0"
     exon            67..183
                     /gene="Ascc1"
                     /gene_synonym="Asc-1; CGI-18"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1145
                     /gene="Ascc1"
                     /gene_synonym="Asc-1; CGI-18"
                     /codon_start=1
                     /product="activating signal cointegrator 1 complex subunit
                     1"
                     /protein_id="NP_001007633.1"
                     /db_xref="GeneID:294512"
                     /db_xref="RGD:1359255"
                     /translation="MDVLRPQLVTFDGRNYRKNPVQEKQPQHEEEEDFYQDSMEYSDE
                     PCGAYEVEQTPHGFRATVSAPSLLYKHIVGKRGDTKKKIEVETKTSINIPKLGHEGEI
                     VITGHHRNGVVSARTRIDVLLDTFRRRQPFTHFLSFFLNEVEVQERFLEFQAEVLKKC
                     SKDRGVDSTIFQNPKKLHLTIGMLVLLSEQEIQQTCEILQRCKEEFINDISGGKPLEV
                     EMAGIEYMNDDPAMVDVLYAKVHMKDGSNRLQELVDRVLERFQSMGLVMKEWTSVKLH
                     ATVMNTLLRKDPNAEGRYNLYTADGKYIFKERESFDGRNILKTFENFYFGSLKLNSIH
                     ISQRFTVDSFGNYASCGHVDFS"
     exon            184..283
                     /gene="Ascc1"
                     /gene_synonym="Asc-1; CGI-18"
                     /inference="alignment:Splign:2.1.0"
     exon            284..381
                     /gene="Ascc1"
                     /gene_synonym="Asc-1; CGI-18"
                     /inference="alignment:Splign:2.1.0"
     exon            382..560
                     /gene="Ascc1"
                     /gene_synonym="Asc-1; CGI-18"
                     /inference="alignment:Splign:2.1.0"
     exon            561..697
                     /gene="Ascc1"
                     /gene_synonym="Asc-1; CGI-18"
                     /inference="alignment:Splign:2.1.0"
     exon            698..817
                     /gene="Ascc1"
                     /gene_synonym="Asc-1; CGI-18"
                     /inference="alignment:Splign:2.1.0"
     exon            818..942
                     /gene="Ascc1"
                     /gene_synonym="Asc-1; CGI-18"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1028
                     /gene="Ascc1"
                     /gene_synonym="Asc-1; CGI-18"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1150
                     /gene="Ascc1"
                     /gene_synonym="Asc-1; CGI-18"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1486
                     /gene="Ascc1"
                     /gene_synonym="Asc-1; CGI-18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgtctgca tacgcccggc gcgggagagc ctccagggtt tctttccacc cagttagtcc
       61 tggcagaagg tgtcatggat gttctgcgcc cacagcttgt aacattcgat ggtcggaatt
      121 atagaaagaa tcctgtccag gaaaagcagc cccaacatga agaggaggag gatttctatc
      181 aagactccat ggagtactcg gatgagccct gcggtgccta tgaggtggag cagacccctc
      241 atggattccg ggccaccgtc agtgccccta gcctgctcta caagcacata gttggaaaga
      301 gaggcgatac caagaagaaa atagaagtgg agactaaaac atctattaac attcctaaac
      361 tcggccatga gggagaaatc gtgatcactg gtcatcatcg aaatggtgta gtttccgcgc
      421 gaactcggat cgatgtcctc ctggacacgt tcaggaggag gcagcctttc actcacttcc
      481 tctccttctt cctcaatgaa gttgaagtcc aggaacggtt tctggagttc caggcggaag
      541 tactgaagaa gtgttccaag gatcgtgggg ttgacagcac catttttcag aatcccaaaa
      601 agcttcacct aactattggc atgttggtac tcctaagtga acaagagatc cagcagacct
      661 gtgagatcct gcagcgctgt aaggaggaat tcattaatga catttccgga ggcaaacccc
      721 tggaagtaga gatggcaggg atcgaataca tgaatgacga ccctgctatg gtggatgttc
      781 tttatgccaa agtccacatg aaagacggct ccaacaggct gcaggaacta gttgatcgag
      841 tgctggaacg ctttcagtca atggggctcg tcatgaagga gtggaccagt gtgaaactgc
      901 acgccaccgt catgaacaca ctcctcagga aagaccccaa tgctgaaggc aggtacaacc
      961 tctacacagc agatggcaag tatatcttca aggaaagaga atcttttgat ggccggaaca
     1021 ttttaaagac atttgagaac ttctactttg gttccctgaa gctgaattct attcacatct
     1081 cccagaggtt cacggtggac agcttcggaa actatgcttc ctgcggacat gttgacttct
     1141 cctgacatgg gagagcatcg gagaacaggg actgactgag gcgttggcca tcgggagcct
     1201 ggcagcacca cagcagcagg cccttccttc aggctccagt tgactgacga ggaggacgct
     1261 ccagcctgtg ctcctccctc ctggctctca tcctccccct catccttggc ttctttttcc
     1321 tcattcctca tcctccagcc ctcctttctg tgaagcctgt ccctgaactc tgtggtgcat
     1381 catggtgctg tggagaggtg gtgcttctct gtgagatggc acagcacagg ccgtctgcaa
     1441 ataaatgagc ttcccaggcc gctgtgccgt gccctgggaa cggtgaaaaa aaaaaaaaaa
     1501 aaaaaaaa
//
