LOCUS       NP_001178842             290 aa            linear   ROD 28-OCT-2024
DEFINITION  ankyrin repeat and SOCS box protein 9 [Rattus norvegicus].
ACCESSION   NP_001178842 XP_017457609 XP_346302
VERSION     NP_001178842.1
DBSOURCE    REFSEQ: accession NM_001191913.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 290)
  AUTHORS   Debrincat,M.A., Zhang,J.G., Willson,T.A., Silke,J., Connolly,L.M.,
            Simpson,R.J., Alexander,W.S., Nicola,N.A., Kile,B.T. and
            Hilton,D.J.
  TITLE     Ankyrin repeat and suppressors of cytokine signaling box protein
            asb-9 targets creatine kinase B for degradation
  JOURNAL   J Biol Chem 282 (7), 4728-4737 (2007)
   PUBMED   17148442
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On or before Oct 26, 2024 this sequence version replaced
            XP_017457609.1, XP_346302.3.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1511277.1,
                                           SRR26360181.1878084.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..290
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq14"
     Protein         1..290
                     /product="ankyrin repeat and SOCS box protein 9"
                     /note="ankyrin repeat and SOCS box-containing protein 9"
                     /calculated_mol_wt=31321
     Site            order(31,33,37..38,41..43,45..46,50,53,62,64,66,70..71,
                     74..76,78..79,83,86,95,97,99,103..104,107..109,111..112,
                     116,119)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          31..62
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          32..234
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          64..95
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          97..127
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          132..160
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(135..136,139..141,143..144,148,151,160,162,164,
                     168..169,172..174,176..177,181,184,192,194,196,200..201,
                     204..206,208..209,213,216,225)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          162..192
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          194..225
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          249..290
                     /region_name="SOCS"
                     /note="SOCS (suppressors of cytokine signaling) box. The
                     SOCS box is found in the C-terminal region of CIS/SOCS
                     family proteins (in combination with a SH2 domain), ASBs
                     (ankyrin repeat-containing proteins with a SOCS box), SSBs
                     (SPRY domain-containing proteins...; cl02533"
                     /db_xref="CDD:470605"
     Site            order(250..255,261,271,277)
                     /site_type="active"
                     /note="elongin B/C interaction [active]"
                     /db_xref="CDD:239641"
     CDS             1..290
                     /gene="Asb9"
                     /gene_synonym="RGD1560537"
                     /coded_by="NM_001191913.2:168..1040"
                     /db_xref="GeneID:367785"
                     /db_xref="RGD:1560537"
ORIGIN      
        1 mdgeqggrsd kpggsphlrf lsnplmgdvv sdwsplhdaa ihgrlltlrn lisqgwpvni
       61 itadhvsplh eaclrghlsc atvlishgaq vngmtidwrt plfnacvsgs qdcvnlllqh
      121 gaaphpesdl aspiheaakr ghakciesla ahganidyni shlgtplyva cknqqvdcak
      181 kllesgasvn qgkgsdsplh vvarmssgel vhllmdfgan aqtknadgkr pvdlvplesp
      241 vieiflqreg plslmqlcrl rirkcfgirq hhkitglllp edlkrfllhl
//
