LOCUS       NM_001024318            1509 bp    mRNA    linear   ROD 17-JUL-2023
DEFINITION  Rattus norvegicus ankyrin repeat and SOCS box-containing 4 (Asb4),
            mRNA.
ACCESSION   NM_001024318 XM_575371
VERSION     NM_001024318.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1509)
  AUTHORS   Li JY, Chai B, Zhang W, Wu X, Zhang C, Fritze D, Xia Z, Patterson C
            and Mulholland MW.
  TITLE     Ankyrin repeat and SOCS box containing protein 4 (Asb-4)
            colocalizes with insulin receptor substrate 4 (IRS4) in the
            hypothalamic neurons and mediates IRS4 degradation
  JOURNAL   BMC Neurosci 12, 95 (2011)
   PUBMED   21955513
  REMARK    GeneRIF: The interaction of Asb-4 with IRS4 in cell lines mediates
            the degradation of IRS4 and decreases insulin signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1509)
  AUTHORS   Ferguson JE 3rd, Wu Y, Smith K, Charles P, Powers K, Wang H and
            Patterson C.
  TITLE     ASB4 is a hydroxylation substrate of FIH and promotes vascular
            differentiation via an oxygen-dependent mechanism
  JOURNAL   Mol Cell Biol 27 (18), 6407-6419 (2007)
   PUBMED   17636018
REFERENCE   3  (bases 1 to 1509)
  AUTHORS   Li JY, Kuick R, Thompson RC, Misek DE, Lai YM, Liu YQ, Chai BX,
            Hanash SM and Gantz I.
  TITLE     Arcuate nucleus transcriptome profiling identifies ankyrin repeat
            and suppressor of cytokine signalling box-containing protein 4 as a
            gene regulated by fasting in central nervous system feeding
            circuits
  JOURNAL   J Neuroendocrinol 17 (6), 394-404 (2005)
   PUBMED   15929745
  REMARK    GeneRIF: Based on its differential expression, neuroanatomical
            distribution and colocalisation, we hypothesise that rat Asb-4 is a
            gene involved in energy homeostasis.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY577765.1.
            
            On May 27, 2005 this sequence version replaced XM_575371.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY577765.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1509
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q21"
     gene            1..1509
                     /gene="Asb4"
                     /gene_synonym="Asb-4"
                     /note="ankyrin repeat and SOCS box-containing 4"
                     /db_xref="GeneID:500017"
                     /db_xref="RGD:1563114"
     exon            1..199
                     /gene="Asb4"
                     /gene_synonym="Asb-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1293
                     /gene="Asb4"
                     /gene_synonym="Asb-4"
                     /note="ankyrin repeat and SOCS box-containing protein 4"
                     /codon_start=1
                     /product="ankyrin repeat and SOCS box protein 4"
                     /protein_id="NP_001019489.1"
                     /db_xref="GeneID:500017"
                     /db_xref="RGD:1563114"
                     /translation="MDGITASMSRAGAAKLVKKEFLEALKTNDFEKLKAILIERQIDV
                     DTVFEVEDENMILASYKQGYWLPSYKLKSSWATGLHLSVLLGHVECLMVLLDHNATIN
                     CRPNGKTPLHVACEIANLECVKILCDRGAKLNCYSLSGHTALHFCTTPSSIVCAKQLV
                     SRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVENGAIVDSMNAHMETPLAIATYW
                     ALRFKEQEYSREHHLICRMLLDNNAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGA
                     EANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPPQFHKVIQACHSC
                     PKAIEVVVNAYEHIRWNIKWRRAIPDDDLEKHWDFYHSLFKVCCNTPRTLMHLSRCAI
                     RKALHNRCHKAIPMLSLPLSLKKYLLLEPEGIIY"
     exon            200..499
                     /gene="Asb4"
                     /gene_synonym="Asb-4"
                     /inference="alignment:Splign:2.1.0"
     exon            500..990
                     /gene="Asb4"
                     /gene_synonym="Asb-4"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1104
                     /gene="Asb4"
                     /gene_synonym="Asb-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1509
                     /gene="Asb4"
                     /gene_synonym="Asb-4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggctcgga ggatggacgg catcactgcc tctatgagca gagctggggc tgccaagtta
       61 gttaagaaag agttcctgga ggctctaaaa acaaatgact tcgaaaagct gaaggctatt
      121 ttaatcgaaa ggcaaataga tgtggacaca gtgtttgaag tggaagatga gaacatgatt
      181 ttggcatcat acaaacaagg ctattggctg cccagttata agctgaagtc ttcctgggca
      241 acaggcctgc acctctcagt tttgctcggt cacgtggagt gcctgatggt actgctggac
      301 cacaatgcga ccatcaactg tcggcccaac gggaagaccc ctctgcacgt ggcttgtgag
      361 atagctaacc tcgaatgcgt gaagattctc tgtgaccgtg gcgcaaagct caactgctac
      421 tccctcagcg gccacactgc tttgcacttc tgtaccacac ccagctccat cgtctgtgcc
      481 aagcagttgg tgtcgagagg tgcaaacgtg aacatgaaaa ccaacaacca ggatgaggag
      541 acacccctgc acacggcggc ccacttcggc ctctctgagc tggtggcctt ctatgtggag
      601 aacggggcca tcgtggatag catgaacgcc cacatggaga ccccactggc catcgccacc
      661 tactgggccc tgcgcttcaa ggagcaggag tacagcaggg aacaccacct catctgccgt
      721 atgcttctag acaacaacgc tgaggtcaac gctcgggatg acgacttcaa gtcccctctg
      781 cacaaggctg cctggaattg cgaccacgtg ctcatgcaca tgatgctgga ggcgggtgcg
      841 gaggccaacc tcatggatat caatggctgt gcagccatcc agtacgtgct gaaggtcacc
      901 tccgtgcgtc ctgctgcgca gcccgagatc tgctaccagc tgctgctgaa tcacggggct
      961 gcgcgcatct accccccaca gttccacaag gtgatccagg cttgccactc ttgtcccaag
     1021 gcaattgaag ttgtggtcaa tgcctacgag cacatcagat ggaacataaa gtggaggaga
     1081 gccattcctg atgacgacct ggagaaacac tgggatttct accactctct cttcaaggtg
     1141 tgctgtaaca ctcccaggac cctcatgcac ctgtcaagat gtgccattcg aaaagcgtta
     1201 cacaacagat gccacaaagc aattcctatg ctgtccctcc cactgtcatt gaagaagtac
     1261 ttgcttttgg agccagaggg aatcatttat taagtcttag gagacaacag ttcccaaccc
     1321 tagatttcta agtggactca ctgggtagac gcagtttgca tggataaaac ggtacttggg
     1381 ttggttatca cactttaggg atttcaaaat gctttacatt caccaagcca ttaatcctag
     1441 agtagcatgc tgagggaaaa taagccggta aagttaaaga attttgagac aatggccaca
     1501 tttagaagg
//
