LOCUS       NP_001102334             525 aa            linear   ROD 23-MAR-2023
DEFINITION  ankyrin repeat and SOCS box protein 3 [Rattus norvegicus].
ACCESSION   NP_001102334 XP_344278
VERSION     NP_001102334.1
DBSOURCE    REFSEQ: accession NM_001108864.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473996.1.
            
            On Oct 4, 2007 this sequence version replaced XP_344278.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     Protein         1..525
                     /product="ankyrin repeat and SOCS box protein 3"
                     /note="ankyrin repeat and SOCS box-containing protein 3"
                     /calculated_mol_wt=58053
     Region          23..303
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          42..76
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          78..109
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          146..176
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(147,151..152,155..157,159..160,164,167,176,178,180,
                     184..185,188..190,192..193,197,200,209,211,213,217..218,
                     221..223,225..226,230,233)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          178..209
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          211..240
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          245..279
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          281..309
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          314..346
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          458..508
                     /region_name="SOCS_ASB3"
                     /note="SOCS (suppressors of cytokine signaling) box of
                     ASB3-like proteins. ASB family members have a C-terminal
                     SOCS box and an N-terminal ankyrin-related sequence. ABS3
                     has been shown to be negative regulator of TNF-R2-mediated
                     cellular responses to TNF-alpha...; cd03722"
                     /db_xref="CDD:239692"
     Site            order(459..464,470,483,489,494)
                     /site_type="other"
                     /note="putative elongin B/C interaction [polypeptide
                     binding]"
                     /db_xref="CDD:239692"
     CDS             1..525
                     /gene="Asb3"
                     /coded_by="NM_001108864.1:179..1756"
                     /db_xref="GeneID:364227"
                     /db_xref="RGD:1308462"
ORIGIN      
        1 mdfteaysdt cstvglaare gnvkilrkll kkgrsvdvad nrgwmpihea ayhnaveclq
       61 mlihtdssen yiktktfegf calhlavsqg hwkvtqille agadpntttl eettplflav
      121 esgqidvlkl llqhganvng shsmcgwnsl hqasfqgnae aiklllkqga drecqddfgi
      181 tplfvaaqyg kleslsilis sganvncqal dkatplfiaa qeghtkcvel llsngadpdl
      241 ycnednwqlp ihaaaqmghr ktldlliplt nracdsgpdk vspvysavfg greecletll
      301 qngyspdaqm clvfgfsspl cmalqkdcef sgvvnillky gaqlnelhla yclkyekfsm
      361 fccflkkgcl vvpwnhtsef vsyavkaqtk ykawlphlll agfdplillc ssswvdsvsd
      421 diliftlefs nwkrlppave kmlsvranss falqqhmasv pslthlcrle irsslkaehl
      481 hsdifihqlp lprslqsyll yeevlrmngi lepatnhdge ireat
//
