LOCUS       NP_001102686             465 aa            linear   ROD 23-MAR-2023
DEFINITION  ankyrin repeat and SOCS box protein 10 [Rattus norvegicus].
ACCESSION   NP_001102686 XP_001057256 XP_575325
VERSION     NP_001102686.1
DBSOURCE    REFSEQ: accession NM_001109216.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 465)
  AUTHORS   Pasutto F, Keller KE, Weisschuh N, Sticht H, Samples JR, Yang YF,
            Zenkel M, Schlotzer-Schrehardt U, Mardin CY, Frezzotti P, Edmunds
            B, Kramer PL, Gramer E, Reis A, Acott TS and Wirtz MK.
  TITLE     Variants in ASB10 are associated with open-angle glaucoma
  JOURNAL   Hum Mol Genet 21 (6), 1336-1349 (2012)
   PUBMED   22156576
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168867.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_575325.2, XP_001057256.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168867.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     Protein         1..465
                     /product="ankyrin repeat and SOCS box protein 10"
                     /note="ankyrin repeat and SOCS box-containing protein 10"
                     /calculated_mol_wt=51066
     Region          <112..312
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          116..143
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          146..176
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(147,151..152,155..157,159..160,164,167,176,178,180,
                     184..185,187..188,190,192..193,197,200,210,212,214,
                     218..219,222..224,226..227,231,234,243)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          178..210
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          212..243
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          245..289
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          291..322
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          296..>359
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:463710"
     Region          419..458
                     /region_name="SOCS"
                     /note="SOCS (suppressors of cytokine signaling) box. The
                     SOCS box is found in the C-terminal region of CIS/SOCS
                     family proteins (in combination with a SH2 domain), ASBs
                     (ankyrin repeat-containing proteins with a SOCS box), SSBs
                     (SPRY domain-containing proteins...; cd03587"
                     /db_xref="CDD:239641"
     Site            order(419..424,430,440,446)
                     /site_type="active"
                     /note="elongin B/C interaction [active]"
                     /db_xref="CDD:239641"
     CDS             1..465
                     /gene="Asb10"
                     /gene_synonym="RGD1562922"
                     /coded_by="NM_001109216.2:92..1489"
                     /db_xref="GeneID:499972"
                     /db_xref="RGD:1562922"
ORIGIN      
        1 mswspeecrd qgepqgnrys lcarlvekpd rapeenpepg lgpiivrkas gpalafwqav
       61 lvgdvgsvsq ilsdsstgla pdstfdtsdp erwrdyrfni ralrlwsltf eeelttplhv
      121 aasrghtevl qlllrrrakp dsapggrtal heacaaghaa cvhvllvaga dpntpdqdgk
      181 rplhlcrgpg ilecvelllk fgaqvdgrse deeetplhva arlghvelad lllrwgacph
      241 vrnsegwtpl ltacdarcqs pvdaeatanr cfqlcsllls vgadadaanq dkqrplhlac
      301 rhghsavvql llscgvsana mdygghtplh callgpttal ahspehivrd llnygavrvw
      361 pgalpkvldr wcmsprtiev lmntyrvvql peeakglvpp eilqkhcgfy sslfalvkqp
      421 rslqhlcrwa lrthlegrlp halprlplpp rmlrylqldf edlly
//
