LOCUS       NM_001044245            6134 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus ArfGAP with SH3 domain, ankyrin repeat and PH
            domain 1 (Asap1), mRNA.
ACCESSION   NM_001044245 XM_001066206 XM_001066263 XM_039079172 XM_235296
VERSION     NM_001044245.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6134)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6134)
  AUTHORS   Jain,S., Yoon,S.Y., Zhu,L., Brodbeck,J., Dai,J., Walker,D. and
            Huang,Y.
  TITLE     Arf4 determines dentate gyrus-mediated pattern separation by
            regulating dendritic spine development
  JOURNAL   PLoS One 7 (9), e46340 (2012)
   PUBMED   23050017
REFERENCE   3  (bases 1 to 6134)
  AUTHORS   Shiba,Y. and Randazzo,P.A.
  TITLE     GEFH1 binds ASAP1 and regulates podosome formation
  JOURNAL   Biochem Biophys Res Commun 406 (4), 574-579 (2011)
   PUBMED   21352810
REFERENCE   4  (bases 1 to 6134)
  AUTHORS   Muller,T., Stein,U., Poletti,A., Garzia,L., Rothley,M.,
            Plaumann,D., Thiele,W., Bauer,M., Galasso,A., Schlag,P.,
            Pankratz,M., Zollo,M. and Sleeman,J.P.
  TITLE     ASAP1 promotes tumor cell motility and invasiveness, stimulates
            metastasis formation in vivo, and correlates with poor survival in
            colorectal cancer patients
  JOURNAL   Oncogene 29 (16), 2393-2403 (2010)
   PUBMED   20154719
  REMARK    GeneRIF: ASAP1 can contribute to the dissemination of a variety of
            tumor types and represent a potential target for cancer therapy.
REFERENCE   5  (bases 1 to 6134)
  AUTHORS   Kim,J., Lee,J.E., Heynen-Genel,S., Suyama,E., Ono,K., Lee,K.,
            Ideker,T., Aza-Blanc,P. and Gleeson,J.G.
  TITLE     Functional genomic screen for modulators of ciliogenesis and cilium
            length
  JOURNAL   Nature 464 (7291), 1048-1051 (2010)
   PUBMED   20393563
REFERENCE   6  (bases 1 to 6134)
  AUTHORS   Bharti,S., Inoue,H., Bharti,K., Hirsch,D.S., Nie,Z., Yoon,H.Y.,
            Artym,V., Yamada,K.M., Mueller,S.C., Barr,V.A. and Randazzo,P.A.
  TITLE     Src-dependent phosphorylation of ASAP1 regulates podosomes
  JOURNAL   Mol Cell Biol 27 (23), 8271-8283 (2007)
   PUBMED   17893324
REFERENCE   7  (bases 1 to 6134)
  AUTHORS   Nie,Z., Hirsch,D.S., Luo,R., Jian,X., Stauffer,S., Cremesti,A.,
            Andrade,J., Lebowitz,J., Marino,M., Ahvazi,B., Hinshaw,J.E. and
            Randazzo,P.A.
  TITLE     A BAR domain in the N terminus of the Arf GAP ASAP1 affects
            membrane structure and trafficking of epidermal growth factor
            receptor
  JOURNAL   Curr Biol 16 (2), 130-139 (2006)
   PUBMED   16431365
REFERENCE   8  (bases 1 to 6134)
  AUTHORS   Kruljac-Letunic,A., Moelleken,J., Kallin,A., Wieland,F. and
            Blaukat,A.
  TITLE     The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation
            and inhibition of the Arf-GTPase-activating protein ASAP1
  JOURNAL   J Biol Chem 278 (32), 29560-29570 (2003)
   PUBMED   12771146
REFERENCE   9  (bases 1 to 6134)
  AUTHORS   Kam,J.L., Miura,K., Jackson,T.R., Gruschus,J., Roller,P.,
            Stauffer,S., Clark,J., Aneja,R. and Randazzo,P.A.
  TITLE     Phosphoinositide-dependent activation of the ADP-ribosylation
            factor GTPase-activating protein ASAP1. Evidence for the pleckstrin
            homology domain functioning as an allosteric site
  JOURNAL   J Biol Chem 275 (13), 9653-9663 (2000)
   PUBMED   10734117
REFERENCE   10 (bases 1 to 6134)
  AUTHORS   Brown,M.T., Andrade,J., Radhakrishna,H., Donaldson,J.G.,
            Cooper,J.A. and Randazzo,P.A.
  TITLE     ASAP1, a phospholipid-dependent arf GTPase-activating protein that
            associates with and is phosphorylated by Src
  JOURNAL   Mol Cell Biol 18 (12), 7038-7051 (1998)
   PUBMED   9819391
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Oct 12, 2022 this sequence version replaced
            XM_039079172.1, NM_001044245.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: DQ238622.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA5760383,
                                    SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                JAXUCZ010000007.1  97981863-97981950   c
            89-167              JAXUCZ010000007.1  97947521-97947599   c
            168-294             JAXUCZ010000007.1  97909898-97910024   c
            295-367             JAXUCZ010000007.1  97808914-97808986   c
            368-513             JAXUCZ010000007.1  97784570-97784715   c
            514-588             JAXUCZ010000007.1  97762763-97762837   c
            589-638             JAXUCZ010000007.1  97762161-97762210   c
            639-768             JAXUCZ010000007.1  97757167-97757296   c
            769-854             JAXUCZ010000007.1  97755929-97756014   c
            855-930             JAXUCZ010000007.1  97750627-97750702   c
            931-1053            JAXUCZ010000007.1  97749360-97749482   c
            1054-1154           JAXUCZ010000007.1  97742366-97742466   c
            1155-1224           JAXUCZ010000007.1  97739195-97739264   c
            1225-1312           JAXUCZ010000007.1  97726467-97726554   c
            1313-1361           JAXUCZ010000007.1  97724289-97724337   c
            1362-1525           JAXUCZ010000007.1  97718832-97718995   c
            1526-1659           JAXUCZ010000007.1  97717903-97718036   c
            1660-1751           JAXUCZ010000007.1  97716060-97716151   c
            1752-1938           JAXUCZ010000007.1  97712857-97713043   c
            1939-2024           JAXUCZ010000007.1  97712453-97712538   c
            2025-2140           JAXUCZ010000007.1  97712003-97712118   c
            2141-2208           JAXUCZ010000007.1  97711813-97711880   c
            2209-2316           JAXUCZ010000007.1  97709929-97710036   c
            2317-2545           JAXUCZ010000007.1  97707867-97708095   c
            2546-2716           JAXUCZ010000007.1  97698518-97698688   c
            2717-2786           JAXUCZ010000007.1  97689785-97689854   c
            2787-2845           JAXUCZ010000007.1  97687055-97687113   c
            2846-3345           JAXUCZ010000007.1  97681843-97682342   c
            3346-3468           JAXUCZ010000007.1  97680141-97680263   c
            3469-6134           JAXUCZ010000007.1  97675354-97678019   c
FEATURES             Location/Qualifiers
     source          1..6134
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..6134
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /note="ArfGAP with SH3 domain, ankyrin repeat and PH
                     domain 1"
                     /db_xref="GeneID:314961"
                     /db_xref="RGD:1307379"
     exon            1..88
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            89..167
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..3543
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /note="PIP2-dependent ARF1 GAP; ARF GTPase-activating
                     protein 1; differentiation-enhancing factor 1; development
                     and differentiation-enhancing factor 1; ADP-ribosylation
                     factor-directed GTPase-activating protein 1; 130 kDa
                     phosphatidylinositol 4,5-biphosphate-dependent ARF1
                     GTPase-activating protein; 130 kDa phosphatidylinositol
                     4,5-bisphosphate-dependent ARF1 GTPase-activating protein;
                     development and differentiation enhancing"
                     /codon_start=1
                     /product="arf-GAP with SH3 domain, ANK repeat and PH
                     domain-containing protein 1"
                     /protein_id="NP_001037710.2"
                     /db_xref="GeneID:314961"
                     /db_xref="RGD:1307379"
                     /translation="MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTS
                     SFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKF
                     GSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKG
                     DLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQM
                     CEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIK
                     QTQDEEKKQLTALRDLIKSSLQLDPKEVGGLYVPSRANSDSQSRQGGYSMHQLQGNKE
                     YGSEKKGFLLKKSDGIRKVWQRRKCAVKNGILTISHATSNRQPAKLNLLTCQVKPNAE
                     DKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSTGENSLEDLT
                     KAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLEL
                     DKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSR
                     KTCASSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTA
                     DQTSLHLVDFLVQNCGNLDKQTSVGNTVLHYCSMYGKPECLKLLLRSKPTVDIVNQNG
                     ETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQDEMDESDDDLDDKPSPI
                     KKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDLPTSP
                     TSEAPPLPPRNAGKGPTGPPSTLPLGTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSP
                     LPHGPPNKGAIPWGNDVGPSSSSKTANKFEGLSQQASTSSAKTALGPRVLPKLPQKVA
                     LRKTETSHHLSLDRANIPPETFQKSSQLSELPQKPPLGDLPPKPMELAPKPQIGELPP
                     KPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQASDLSAKVQPPS
                     EVTQRSHTGDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVK
                     TIYDCQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD"
     exon            168..294
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            295..367
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            368..513
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            514..588
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..638
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..768
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            769..854
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            855..930
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1053
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1154
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1224
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1312
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1361
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1525
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1659
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1751
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1938
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2024
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2140
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2208
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2316
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2545
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2716
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2786
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..2845
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..3345
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3346..3468
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3469..6134
                     /gene="Asap1"
                     /gene_synonym="Ddef1; DEF-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccttcctgc gccgcgctcg gctcccgcgc ctcgcccggc ctcgccgcgc ccgtgatgga
       61 ataatgccca gcggcccgcc cggtcccggt cattttcgga tgtgagacat gagatcttca
      121 gcctcccggc tctccagttt ttcctcaaga gattcactat ggaatcggat gccggaccag
      181 atctccgtgt ccgagttcat cgccgagacc accgaggact acaactcgcc caccacgtcc
      241 agcttcacca cgcggctgca caactgcagg aacaccgtca cgctgctgga ggaggctcta
      301 gaccaagata gaacagccct ccagaaagtg aagaaatctg tgaaagcaat atataattct
      361 ggtcaagatc atgtacaaaa tgaggaaaac tatgcacaag ttctggataa gtttggaagt
      421 aattttttaa gcagagacaa ccctgacctt ggcactgctt ttgtcaagtt ttctacactt
      481 acaaaggaac tgtccacgct gctgaaaaat ctgctccagg gtctgagcca caatgtgatc
      541 ttcaccttgg attccttgtt aaaaggagac ctgaaggggg tcaaaggaga tctcaagaag
      601 ccatttgaca aagcctggaa agattatgag acgaagttta caaaaatcga gaaggagaaa
      661 agagagcacg caaaacagca cgggatgatc cgaacagaga taacaggagc tgagattgca
      721 gaagaaatgg aaaaggaacg gcggcttttt cagctccaga tgtgtgaata tctcattaaa
      781 gttaatgaaa tcaagaccaa aaagggtgtg gacctgctgc agaacctcat aaagtattat
      841 catgcacaat gcaatttctt tcaggatggc ttgaaaacag ctgataaact gaaacagtac
      901 attgaaaagc tggctgctga cttatataat ataaagcaaa cccaagatga agaaaagaaa
      961 cagttaactg cactccgaga cctaataaaa tcctctctgc agcttgatcc gaaagaagta
     1021 ggtggtttat atgttcccag cagggctaac agtgactctc agagccggca aggtggctac
     1081 agtatgcatc agctccaggg caacaaggag tatggcagtg aaaagaaggg ctttctgctg
     1141 aagaagagtg acgggatccg gaaagtgtgg caaagaagga agtgtgctgt caagaatggg
     1201 atactgacca tttcacatgc aacttccaac aggcagcctg ctaagttaaa cctcctcacc
     1261 tgccaggtga aaccgaatgc tgaggacaag aagtcttttg acctgatatc acataatcga
     1321 acatatcact ttcaggcaga agacgagcag gactatgtag cgtggatatc agtactgacg
     1381 aatagcaaag aagaggccct aaccatggcc ttccgtggtg agcagagcac aggggagaat
     1441 agcctggagg atctgaccaa agccatcatt gaggatgtac agcgactccc tgggaatgac
     1501 atctgctgtg actgtggctc atcagaaccc acatggcttt ccaccaactt gggtattttg
     1561 acctgtatag aatgttccgg aatccatagg gaaatggggg ttcatatttc tcgcattcag
     1621 tctttggaac tagacaaatt aggaacttct gaactcttgc tggccaagaa tgtaggaaac
     1681 aatagtttta atgatattat ggaagcaaat ttacccagcc cttcaccaaa gcccacccct
     1741 tcaagtgata tgactgtacg gaaagagtac atcactgcaa agtatgttga ccaccggttc
     1801 tccaggaaga cctgtgcctc ttcctcagca aagctgaatg aattgcttga ggccatcaag
     1861 tccagggact tacttgcact aatccaagtc tatgcagagg gagtggagtt aatggagcca
     1921 ctgctagaac ctgggcagga gcttggggag acagctcttc accttgctgt caggaccgca
     1981 gaccagacgt ctctccatct ggtggatttc cttgtccaaa actgtgggaa cctggataag
     2041 cagacgtccg tggggaatac ggtgttgcac tattgcagca tgtacggcaa gcccgagtgt
     2101 ctgaagctgc tgcttaggag caagcccaca gtggacattg ttaaccaaaa tggagaaact
     2161 gccttggata tagcaaagag actcaaagct acgcagtgcg aagatctgct ttcccaagct
     2221 aagtctggga agttcaaccc gcatgtccat gtagagtacg agtggaatct tcgacaggac
     2281 gagatggatg agagcgatga cgacctggat gacaaaccaa gccccatcaa aaaggagcgc
     2341 tcacccagac cacagagctt ctgccactca tccagcatct caccacagga caagctggca
     2401 ctgccagggt tcagcactcc acgggacaaa cagcggctct cctacggagc cttcaccaac
     2461 cagatcttcg tctctacgag cacagatttg cccacatcac ccaccagtga ggctccccct
     2521 ttaccgccta ggaatgccgg gaaaggtcca actggcccac cttcaacact ccctctaggc
     2581 acccagacct ctagtggcag ctccacccta tccaagaaga ggcctcctcc cccaccacca
     2641 ggacacaaga gaaccctgtc tgaccctccc agcccactac ctcatgggcc cccaaacaaa
     2701 ggcgcaattc cttggggtaa cgatgtgggc ccatcatctt caagtaaaac agcaaacaag
     2761 tttgagggac tatctcagca agcaagcacc agttctgcta agactgccct tggcccgaga
     2821 gtgcttccta aactacctca gaaagtggca ctaaggaaga cagagaccag ccatcatctt
     2881 tccctcgaca gagctaacat cccacctgag acttttcaga aatcatcaca gttgtcggag
     2941 ttaccccaaa agccaccact tggagacctg cccccaaagc ctatggaact ggcccccaag
     3001 ccccaaattg gagagttgcc gcctaagcct ggagagctgc cccctaagcc ccaattaggt
     3061 gacctgcccc ccaagccaca gctctcagac ttacctccca agccacagat gaaggacctt
     3121 ccccccaagc cacagctggg ggacctgctg gcaaagtctc aggctagcga tttgtcggcc
     3181 aaggtgcagc caccctcaga ggtcacacag aggtcacaca ctggggatct gtctccaaat
     3241 gtgcagtcca gagatgccat ccagaagcaa gcatctgagg actccaacga cctcacaccc
     3301 acgctgccag agacacccgt accactgccc agaaaaatca atacggggaa aaataaagtg
     3361 aggcgtgtga agaccattta tgactgccag gcagacaatg acgatgagct cacatttatt
     3421 gagggtgaag tgatcattgt cactggggaa gaggaccagg agtggtggat tgggcatatc
     3481 gaaggacagc ctgaaaggaa gggtgtcttt ccagtgtcct ttgttcacat cctgtctgac
     3541 tagcaaaaag cagaaccttc tgtccgtcca cacccttcat gccagaccgc tgcctccatg
     3601 taatcctgtg tacaacatgt atatagctgc tgttacagac caagaactca tggaagggcc
     3661 actcaggagg ggaatatagt atgtattgta aatatcctgt ggccttctgc cttcaccagt
     3721 attagggtaa cctcgggacc tggtgcgcct tactggtttg ccaaagccat ccttggcatc
     3781 tagcacttac atctctctgt gctgttttat gagcaaacaa aaaccaggag tataggaact
     3841 gctggctttg caggtgaaga gtctccagca gctgtcaaag ggtgcagaac tgacttctaa
     3901 caatgcagta ttctcagtgg cgttactgaa catgcaacat tagcagaggt gggttctgtg
     3961 ctccgggtgg aacgttaggt tagccccctg gccagccagc ctgtagttat ctgtgtacac
     4021 agtttacagc tacaaaaacc tactttggta tttattacag aaaagtgttc agttaattgt
     4081 gttattcctt cagcaaatat tcactgacac aaaatcctct gcagcatttt acagcatatg
     4141 cagcctcgtg caagtttaga tgagtggatt tgtacatctt atggcgagtg gccacccctg
     4201 agatattacc tcattatgca gaagtaacat atccttcatg actattttga caaaagctta
     4261 aaaccacatc tgatggaagt ccaactttca ggaaccaagg actgccagaa aatatctgcc
     4321 tctacgttat gcatgcatct agacgcttac ctgaattctg ccttttataa aggaacaaac
     4381 agtatgaaga agtgaactgt acatttttaa acttgattgc cattaaagca gaagttacaa
     4441 ggttgcaaca atacttgttt ctggtcactc atttggcctt ttccagagtg tttgcacatg
     4501 gtgttgacac agcaccccca atggtgttga aaagcatcta aggggtcagt ttgacatagt
     4561 tttcttcatt ttgttcttga ttaaaccctt actatacaag ttggaaaact ataaagttgg
     4621 tcttcccgtt ttctcctgca gaatccaggt gctgacacca cacgttgctt ttcctccccc
     4681 ctctcctctt ccttaactcc aatgctagag tactctcctt accctcagct tacccagtgg
     4741 acacatgccc ttcaggtcag tgtataaccg agttgtggga tgctgctatg aatcgcactg
     4801 tgatgaagcc ctctgcaagc catctctgtc tgtccgattg tcttctgtct gtctctggtt
     4861 tgttgtcgct tgtgtttttc tttgttatga ttcttttccc tcagcccatt cagcccattg
     4921 cgtttccgtc tttggcctca gagtgagttt ggggaaagga tgcctagctg tgttgcccct
     4981 ggctccagga ctgctgtgac tctgaggtgt gctgtcatgc catgctccat ttgcttaagt
     5041 tcatcttgag cacagcacag aagacaaata ctcttaagca gacaacctca caatgaatta
     5101 aaaacactga tttcacagaa gcacagttcc catgaagcct gtgggaagag ccctctcata
     5161 gccacagtgc ttagtaaata ctaactcagt tctgcctacg tggttgcagt gagatctctg
     5221 aatagccacc caagaaataa accttgcagg acaaacctgc aaaatactct atcatctatt
     5281 actgggaact gatcttgaac aattgcttcc atagtctctg ggcacctgtg catccaccgc
     5341 accaaaccag gagcaaaggt gcctgccagc atgctggtgt gtggccagca gcacctgaca
     5401 gccatgtttt agaggccata atggtttcag gaatgtggtg attgcccaat gtgccatttt
     5461 gttcacacat tcttaagagc cgttaaagtt gcgttgtggg ggtctcagct gtcttctgct
     5521 gatttgaaca taagctgttt ttaaacaaac aagctccttg tctaaaatga tgaagagtcg
     5581 ttactctgtt ctgctgcagg gactcacaaa tgtgtgttca tacctttctt ttctggtttc
     5641 cgtttgtttc ccatcaggaa tttgagttct ctctactccg ttgtactgtg ggacatagga
     5701 aaactaggta gacattcctt tggtgatctt gttaaattta aatctgacct tgttctggga
     5761 cggggtaagc cactatctag ttttggacat gacataatat ttcgaaggta tgcaacctta
     5821 agaaagaaag atcaaatcca ttccttttcc cccctagaag ggaaaagtta tgtctgcaaa
     5881 cagtgtgtct tgttttcctg ttggacagcc attgttattt atttttttat tgcctactac
     5941 ctggacgtgg aatataggag cccagtcatg cctgccacta gttaaatccc acattcgtac
     6001 ccgagagtta ccatggagca tcagtacact ttttatttca catgtatttg atgtgagttt
     6061 ctcagtactg tatgtgttaa tttctacttt tttaatattt aagattgctt ttaaataaac
     6121 atattctcag ttga
//
