LOCUS       NM_053407               2436 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Rattus norvegicus N-acylsphingosine amidohydrolase 1 (Asah1), mRNA.
ACCESSION   NM_053407
VERSION     NM_053407.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2436)
  AUTHORS   Thaysen-Andersen,M., Venkatakrishnan,V., Loke,I., Laurini,C.,
            Diestel,S., Parker,B.L. and Packer,N.H.
  TITLE     Human neutrophils secrete bioactive paucimannosidic proteins from
            azurophilic granules into pathogen-infected sputum
  JOURNAL   J Biol Chem 290 (14), 8789-8802 (2015)
   PUBMED   25645918
REFERENCE   2  (bases 1 to 2436)
  AUTHORS   Gulbins,E., Palmada,M., Reichel,M., Luth,A., Bohmer,C., Amato,D.,
            Muller,C.P., Tischbirek,C.H., Groemer,T.W., Tabatabai,G.,
            Becker,K.A., Tripal,P., Staedtler,S., Ackermann,T.F., van
            Brederode,J., Alzheimer,C., Weller,M., Lang,U.E., Kleuser,B.,
            Grassme,H. and Kornhuber,J.
  TITLE     Acid sphingomyelinase-ceramide system mediates effects of
            antidepressant drugs
  JOURNAL   Nat Med 19 (7), 934-938 (2013)
   PUBMED   23770692
REFERENCE   3  (bases 1 to 2436)
  AUTHORS   Lucki,N.C., Li,D., Bandyopadhyay,S., Wang,E., Merrill,A.H. and
            Sewer,M.B.
  TITLE     Acid ceramidase (ASAH1) represses steroidogenic factor 1-dependent
            gene transcription in H295R human adrenocortical cells by binding
            to the receptor
  JOURNAL   Mol Cell Biol 32 (21), 4419-4431 (2012)
   PUBMED   22927646
REFERENCE   4  (bases 1 to 2436)
  AUTHORS   Lucki,N.C., Bandyopadhyay,S., Wang,E., Merrill,A.H. and Sewer,M.B.
  TITLE     Acid ceramidase (ASAH1) is a global regulator of steroidogenic
            capacity and adrenocortical gene expression
  JOURNAL   Mol Endocrinol 26 (2), 228-243 (2012)
   PUBMED   22261821
REFERENCE   5  (bases 1 to 2436)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 2436)
  AUTHORS   Strelow,A., Bernardo,K., Adam-Klages,S., Linke,T., Sandhoff,K.,
            Kronke,M. and Adam,D.
  TITLE     Overexpression of acid ceramidase protects from tumor necrosis
            factor-induced cell death
  JOURNAL   J Exp Med 192 (5), 601-612 (2000)
   PUBMED   10974027
REFERENCE   7  (bases 1 to 2436)
  AUTHORS   Li,C.M., Park,J.H., He,X., Levy,B., Chen,F., Arai,K., Adler,D.A.,
            Disteche,C.M., Koch,J., Sandhoff,K. and Schuchman,E.H.
  TITLE     The human acid ceramidase gene (ASAH): structure, chromosomal
            location, mutation analysis, and expression
  JOURNAL   Genomics 62 (2), 223-231 (1999)
   PUBMED   10610716
REFERENCE   8  (bases 1 to 2436)
  AUTHORS   Li,C.M., Hong,S.B., Kopal,G., He,X., Linke,T., Hou,W.S., Koch,J.,
            Gatt,S., Sandhoff,K. and Schuchman,E.H.
  TITLE     Cloning and characterization of the full-length cDNA and genomic
            sequences encoding murine acid ceramidase
  JOURNAL   Genomics 50 (2), 267-274 (1998)
   PUBMED   9653654
REFERENCE   9  (bases 1 to 2436)
  AUTHORS   Longo,C.A., Tyler,D. and Mallampalli,R.K.
  TITLE     Sphingomyelin metabolism is developmentally regulated in rat lung
  JOURNAL   Am J Respir Cell Mol Biol 16 (5), 605-612 (1997)
   PUBMED   9160843
REFERENCE   10 (bases 1 to 2436)
  AUTHORS   Bernardo,K., Hurwitz,R., Zenk,T., Desnick,R.J., Ferlinz,K.,
            Schuchman,E.H. and Sandhoff,K.
  TITLE     Purification, characterization, and biosynthesis of human acid
            ceramidase
  JOURNAL   J Biol Chem 270 (19), 11098-11102 (1995)
   PUBMED   7744740
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061540.1.
            
            On Aug 31, 2012 this sequence version replaced NM_053407.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061540.1, AF214647.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2436              BC061540.1         4-2439
FEATURES             Location/Qualifiers
     source          1..2436
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..2436
                     /gene="Asah1"
                     /gene_synonym="Asah"
                     /note="N-acylsphingosine amidohydrolase 1"
                     /db_xref="GeneID:84431"
                     /db_xref="RGD:621568"
     exon            1..109
                     /gene="Asah1"
                     /gene_synonym="Asah"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1219
                     /gene="Asah1"
                     /gene_synonym="Asah"
                     /EC_number="3.5.1.23"
                     /note="acid ceramidase; AC; acylsphingosine deacylase;
                     ACDase; acid CDase; N-acylsphingosine amidohydrolase (acid
                     ceramidase) 1; N-acylethanolamine hydrolase ASAH1"
                     /codon_start=1
                     /product="acid ceramidase precursor"
                     /protein_id="NP_445859.2"
                     /db_xref="GeneID:84431"
                     /db_xref="RGD:621568"
                     /translation="MLGRSLLTWVLAAAVTCAQAQQVPPWTEDCRKSTYPPSGPTYRG
                     PVPWYTINLDLPPYKRWHELLAHKAPVLRTLVNSISNLVNAFVPSGKIMQMVDEKLPG
                     LIGSIPGPFGEEMRGIADVTGIPLGEIISFNIFYELFTMCTSIITEDGKGHLLHGRNM
                     DFGIFLGWNINNNTWVVTEELKPLTVNLDFQRNNKTVFKATSFAGYVGMLTGFKPGLL
                     SLTLNERFSLNGGYLGILEWMFGKKNAQWVGFITRSVLENSTSYEEAKNILTKTKITA
                     PAYFILGGNQSGEGCVITRERKESLDVYELDPKHGRWYVVQTNYDRWKNTLFLDDRRT
                     PAKKCLNHTTQKNLSFATIYDVLSTKPVLNKLTVFTTLIDVTKDQFESHLRDCPDPCI
                     GW"
     exon            110..156
                     /gene="Asah1"
                     /gene_synonym="Asah"
                     /inference="alignment:Splign:2.1.0"
     exon            157..247
                     /gene="Asah1"
                     /gene_synonym="Asah"
                     /inference="alignment:Splign:2.1.0"
     exon            248..334
                     /gene="Asah1"
                     /gene_synonym="Asah"
                     /inference="alignment:Splign:2.1.0"
     exon            335..413
                     /gene="Asah1"
                     /gene_synonym="Asah"
                     /inference="alignment:Splign:2.1.0"
     exon            414..488
                     /gene="Asah1"
                     /gene_synonym="Asah"
                     /inference="alignment:Splign:2.1.0"
     exon            489..534
                     /gene="Asah1"
                     /gene_synonym="Asah"
                     /inference="alignment:Splign:2.1.0"
     exon            535..679
                     /gene="Asah1"
                     /gene_synonym="Asah"
                     /inference="alignment:Splign:2.1.0"
     exon            680..734
                     /gene="Asah1"
                     /gene_synonym="Asah"
                     /inference="alignment:Splign:2.1.0"
     exon            735..816
                     /gene="Asah1"
                     /gene_synonym="Asah"
                     /inference="alignment:Splign:2.1.0"
     exon            817..948
                     /gene="Asah1"
                     /gene_synonym="Asah"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1072
                     /gene="Asah1"
                     /gene_synonym="Asah"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1129
                     /gene="Asah1"
                     /gene_synonym="Asah"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..2263
                     /gene="Asah1"
                     /gene_synonym="Asah"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtccctc gtagcgccgc ttgcagctgg gaagatgctg ggccgtagtc tcctcacctg
       61 ggtcctggcc gcggctgtca cctgcgccca ggcacagcaa gtgccaccgt ggacagaaga
      121 ttgcagaaaa tcaacttatc ctccttctgg accaacctat agaggaccag ttccgtggta
      181 caccataaat cttgatttac caccctacaa gagatggcat gaattattgg ctcacaaggc
      241 acctgtgttg agaactttag tgaattccat ctcgaattta gtgaatgcat ttgtgccaag
      301 tggaaaaata atgcagatgg tggatgaaaa gttgcctggt ctgattggca gcattcctgg
      361 cccttttgga gaggaaatga gggggattgc agatgttact gggattcctc taggagagat
      421 tatttcattc aacattttct atgaactgtt caccatgtgt acatcgatca taactgaaga
      481 tggaaaaggt catttactac atggaagaaa catggatttt ggaatatttc ttgggtggaa
      541 cattaacaac aacacttggg tggtgacaga agaattaaag cctttaacag tgaatttgga
      601 cttccagagg aacaataaga ctgtgttcaa ggctacaagt ttcgctggat acgtgggcat
      661 gttgacagga ttcaaaccag gactgttaag tcttacactg aatgaacgtt tcagtttaaa
      721 tggtggttat ctgggtatcc tagaatggat gtttggaaag aaaaatgccc aatgggtagg
      781 gtttatcact agatcagttc tggaaaatag cacaagttat gaagaagcca agaatatatt
      841 gaccaagacc aagataacgg ccccagcata ttttatcctg ggaggcaacc agtctggaga
      901 aggttgtgtg attacacgag aaagaaaaga gtctttagac gtctatgaac ttgatcctaa
      961 gcatggcaga tggtacgtgg tacaaaccaa ttatgaccgg tggaaaaaca ccttgtttct
     1021 tgatgaccgc agaacacctg cgaagaagtg tctaaatcac acgacacaga agaatctgtc
     1081 atttgctacc atctatgatg ttctatcaac aaaacctgtc ctcaacaagc tgactgtatt
     1141 cacaaccttg atagatgtca ccaaagatca atttgaaagc caccttcgag attgcccaga
     1201 cccttgtata ggctggtgag cacacatcag ccagcataca ggacagacat actcagacct
     1261 gaagatgtgt tctccagcat gcctggtctc cttccatagg ctaagactca aggcctcttg
     1321 tctttagtca tgattgtcct catgtttctg ttgtttacag atgttttgtt gtttgtttgg
     1381 tttgatcacc atcatcactt ccacttatag gtaaatcctt taagggacgc catgtagata
     1441 gaaattgcca gttcatttca cttcgacact gaggaagtgg taacctgacc tctatggaac
     1501 ccatcaaggt tctctgatgg tgtttaatcc agtgccctgt gtgattaatg taaaagtcat
     1561 tcaccttttc ttttttaatc tacatattta tgtttttctg tacaccagta gctttctttt
     1621 ttcctggttc tctcttagaa ccaccatgtc attcaccttt gctgttagtg acagcagtgc
     1681 agtatcacta tgcttggctg gagttcctca gatggatatt tgacacatat tttaatgggc
     1741 aatcaataga cctctgactc tggaaatggt attttggagg agtataaaat aaccattata
     1801 aaagcagtat ttttttttta aagaataagt gttctctttt tcctaattat tttgcctgcc
     1861 agtaacactt caaaaacttg agttcaagaa cttagcacaa actcattatt ttaaattctt
     1921 tttttctttt cttttctttt tttcggagct ggggaccaaa cccagggcct tgcgcttgct
     1981 aggcaagtgc gctaccactg agctaaatcc ccaacccgtt aaattcttat atgtataatc
     2041 aatttaatgt tttttccttc taatcatatt tttttagatt ttcatacaat atagtattaa
     2101 caatattttt cagaaatcaa tgtatttatg aaaacttcga acagaacttg ttatcttcct
     2161 aattttcaca attgacagtg aaatgtattt tgtggcagac tgtacccatt tagttttgga
     2221 cagtctcagt tgtgtcatga tgctcaataa acagtcactg tcaaaaaaaa aaaaaaaaaa
     2281 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2341 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2401 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
