LOCUS       NM_080890               1631 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus arsenite methyltransferase (As3mt), mRNA.
ACCESSION   NM_080890
VERSION     NM_080890.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1631)
  AUTHORS   Zhang,H., Ge,Y., He,P., Chen,X., Carina,A., Qiu,Y., Aga,D.S. and
            Ren,X.
  TITLE     Interactive Effects of N6AMT1 and As3MT in Arsenic Biomethylation
  JOURNAL   Toxicol Sci 146 (2), 354-362 (2015)
   PUBMED   25997655
REFERENCE   2  (bases 1 to 1631)
  AUTHORS   Li,J., Waters,S.B., Drobna,Z., Devesa,V., Styblo,M. and Thomas,D.J.
  TITLE     Arsenic (+3 oxidation state) methyltransferase and the inorganic
            arsenic methylation phenotype
  JOURNAL   Toxicol Appl Pharmacol 204 (2), 164-169 (2005)
   PUBMED   15808521
  REMARK    GeneRIF: In rat AS3MT, Cys156 located in a well-defined cavity
            structure may be situated to participate in the binding of
            substrates which contain A(III).
REFERENCE   3  (bases 1 to 1631)
  AUTHORS   Waters,S.B., Devesa,V., Fricke,M.W., Creed,J.T., Styblo,M. and
            Thomas,D.J.
  TITLE     Glutathione modulates recombinant rat arsenic (+3 oxidation state)
            methyltransferase-catalyzed formation of trimethylarsine oxide and
            trimethylarsine
  JOURNAL   Chem Res Toxicol 17 (12), 1621-1629 (2004)
   PUBMED   15606138
  REMARK    GeneRIF: Enzyme catalyzing the conversion of inorganic arsenic to
            volatile arsenicals.
REFERENCE   4  (bases 1 to 1631)
  AUTHORS   Thomas,D.J., Waters,S.B. and Styblo,M.
  TITLE     Elucidating the pathway for arsenic methylation
  JOURNAL   Toxicol Appl Pharmacol 198 (3), 319-326 (2004)
   PUBMED   15276411
REFERENCE   5  (bases 1 to 1631)
  AUTHORS   Lin,S., Shi,Q., Nix,F.B., Styblo,M., Beck,M.A., Herbin-Davis,K.M.,
            Hall,L.L., Simeonsson,J.B. and Thomas,D.J.
  TITLE     A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from
            rat liver cytosol
  JOURNAL   J Biol Chem 277 (13), 10795-10803 (2002)
   PUBMED   11790780
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jul 29, 2021 this sequence version replaced NM_080890.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF393243.1, SRR26643285.6380.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000001.1  255537511-255537573
            64-104              JAXUCZ010000001.1  255537783-255537823
            105-232             JAXUCZ010000001.1  255538108-255538235
            233-383             JAXUCZ010000001.1  255538976-255539126
            384-520             JAXUCZ010000001.1  255539576-255539712
            521-590             JAXUCZ010000001.1  255541713-255541782
            591-672             JAXUCZ010000001.1  255544629-255544710
            673-804             JAXUCZ010000001.1  255548538-255548669
            805-947             JAXUCZ010000001.1  255548961-255549103
            948-1064            JAXUCZ010000001.1  255555125-255555241
            1065-1631           JAXUCZ010000001.1  255568679-255569245
FEATURES             Location/Qualifiers
     source          1..1631
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1631
                     /gene="As3mt"
                     /gene_synonym="Cyt19"
                     /note="arsenite methyltransferase"
                     /db_xref="GeneID:140925"
                     /db_xref="RGD:621325"
     exon            1..63
                     /gene="As3mt"
                     /gene_synonym="Cyt19"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1172
                     /gene="As3mt"
                     /gene_synonym="Cyt19"
                     /EC_number="2.1.1.137"
                     /note="S-adenosylmethionine:arsenic (III)
                     methyltransferase; methylarsonite methyltransferase;
                     S-adenosyl-L-methionine:arsenic(III) methyltransferase;
                     methyltransferase Cyt19; arsenic (+3 oxidation state)
                     methyltransferase"
                     /codon_start=1
                     /product="arsenite methyltransferase"
                     /protein_id="NP_543166.2"
                     /db_xref="GeneID:140925"
                     /db_xref="RGD:621325"
                     /translation="MAAPRDAEIHKDVQNYYGNVLKTSADLQTNACVTPAKGVPEYIR
                     KSLQNVHEEVTSRYYGCGLVVPEHLENCRILDLGSGSGRDCYVLSQLVGQKGHITGID
                     MTKVQVEVAKAYLEYHTEKFGFQTPNVTFLHGQIEMLAEAGIQKESYDIVISNCVINL
                     VPDKQKVLREVYQVLKYGGELYFSDVYASLEVSEDIKSHKVLWGECLGGALYWKDLAV
                     IAKKIGFCPPRLVTANIITVGNKELERVLGDCRFVSATFRLFKLPKTEPAGRCQVVYN
                     GGIMGHEKELIFDANFTFKEGEAVEVDEETAAILRNSRFAHDFLFTPVEASLLAPQTK
                     VIIRDPFKLAEESDKMKPRCAPEGTGGCCGKRKSC"
     exon            64..104
                     /gene="As3mt"
                     /gene_synonym="Cyt19"
                     /inference="alignment:Splign:2.1.0"
     exon            105..232
                     /gene="As3mt"
                     /gene_synonym="Cyt19"
                     /inference="alignment:Splign:2.1.0"
     exon            233..383
                     /gene="As3mt"
                     /gene_synonym="Cyt19"
                     /inference="alignment:Splign:2.1.0"
     exon            384..520
                     /gene="As3mt"
                     /gene_synonym="Cyt19"
                     /inference="alignment:Splign:2.1.0"
     exon            521..590
                     /gene="As3mt"
                     /gene_synonym="Cyt19"
                     /inference="alignment:Splign:2.1.0"
     exon            591..672
                     /gene="As3mt"
                     /gene_synonym="Cyt19"
                     /inference="alignment:Splign:2.1.0"
     exon            673..804
                     /gene="As3mt"
                     /gene_synonym="Cyt19"
                     /inference="alignment:Splign:2.1.0"
     exon            805..947
                     /gene="As3mt"
                     /gene_synonym="Cyt19"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1064
                     /gene="As3mt"
                     /gene_synonym="Cyt19"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1631
                     /gene="As3mt"
                     /gene_synonym="Cyt19"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgaccttc tccggagccg gctagaggga atccctggtt ctggaagtgg agatcgtgag
       61 tcatggctgc tccccgagac gcagagatcc acaaggacgt tcagaactac tatgggaatg
      121 tactgaagac atctgcagac ctccagacta atgcttgtgt caccccagcc aagggggtcc
      181 ctgagtacat ccggaaaagt ctgcagaatg tacatgaaga agttacttcc aggtattatg
      241 gctgcggtct ggtggtgcct gagcatctgg aaaactgccg gattttggat ctgggcagtg
      301 ggagtggcag agattgctat gtgcttagcc agctggtcgg ccagaaggga cacatcaccg
      361 ggatagacat gactaaggtc caggtggaag tggctaaggc ctatcttgag taccacacgg
      421 aaaagttcgg tttccagaca cccaatgtga cttttcttca cggccaaatt gagatgttgg
      481 cagaggccgg gatccagaag gagagctatg atatcgttat atccaattgt gtgatcaacc
      541 ttgttcccga caaacaaaaa gtccttcggg aggtctacca agtcctgaag tacggcgggg
      601 agctctattt cagtgacgtc tatgctagcc ttgaagtgtc agaagacatc aagtcacaca
      661 aggttttatg gggggaatgc ctgggtggcg ctctgtactg gaaggacctc gccgtcattg
      721 ccaaaaagat tgggttctgc cctccacgtt tggtcactgc caatattatt acggttggaa
      781 acaaggaact agaaagggtt cttggtgact gtcgcttcgt gtctgccaca tttcgcctct
      841 tcaaactccc taagacagag ccagccggaa gatgccaagt tgtttacaat ggaggaatca
      901 tggggcacga aaaggaacta attttcgatg caaattttac attcaaggaa ggtgaagctg
      961 ttgaagtgga tgaggagacg gcagccatct tgaggaactc tcggtttgct cacgattttc
     1021 tcttcacacc tgttgaggcc tccctgttgg ctccccaaac aaaggttata atcagagatc
     1081 cattcaagct tgcagaggaa tctgacaaga tgaagccgag atgtgcacca gaaggcactg
     1141 gaggctgctg tggcaaaagg aaaagctgct agacctaggg ccagcgtaga gcccaccgag
     1201 catgaggggg tggctaaagg gcagtcacaa agtcttctga gcctgctctt caccagagca
     1261 cagactatgg gaagatggca aagccactgc taagaaaaag tgatttttag agggtgttaa
     1321 tttaaggttc acagcaaact ttttctattt cactatttca gagttctggc gccacctagt
     1381 ggtcagaagt agaacttgta cgtctaaggt ttacaaatat cttccttctg gcctaccaca
     1441 ggacacctct gggtttttct ctgtggttat tcaggaagca cagtacttac tgaatttatg
     1501 ctgactatga caaaaggttg ccaactcaaa tttggtagga gtactcttta ggtcgctgtc
     1561 ttcaaacttt tttccctgta aatgaatgaa aatgaaaaca aatgaaaaat aaatttgact
     1621 tcatcctgat a
//
