LOCUS       NM_001100174            2861 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus aristaless related homeobox (Arx), mRNA.
ACCESSION   NM_001100174 XM_001064618 XM_228590
VERSION     NM_001100174.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2861)
  AUTHORS   Navik,U., Rawat,K. and Tikoo,K.
  TITLE     L-Methionine prevents beta-cell damage by modulating the expression
            of Arx, MafA and regulation of FOXO1 in type 1 diabetic rats
  JOURNAL   Acta Histochem 124 (1), 151820 (2022)
   PUBMED   34871948
  REMARK    GeneRIF: L-Methionine prevents beta-cell damage by modulating the
            expression of Arx, MafA and regulation of FOXO1 in type 1 diabetic
            rats.
REFERENCE   2  (bases 1 to 2861)
  AUTHORS   Curie,A., Nazir,T., Brun,A., Paulignan,Y., Reboul,A., Delange,K.,
            Cheylus,A., Bertrand,S., Rochefort,F., Bussy,G., Marignier,S.,
            Lacombe,D., Chiron,C., Cossee,M., Leheup,B., Philippe,C.,
            Laugel,V., De Saint Martin,A., Sacco,S., Poirier,K., Bienvenu,T.,
            Souville,I., Gilbert-Dussardier,B., Bieth,E., Kauffmann,D.,
            Briot,P., de Freminville,B., Prieur,F., Till,M., Rooryck-Thambo,C.,
            Mortemousque,I., Bobillier-Chaumont,I., Toutain,A., Touraine,R.,
            Sanlaville,D., Chelly,J., Freeman,S., Kong,J., Hadjikhani,N.,
            Gollub,R.L., Roy,A. and des Portes,V.
  TITLE     The c.429_452 duplication of the ARX gene: a unique
            developmental-model of limb kinetic apraxia
  JOURNAL   Orphanet J Rare Dis 9, 25 (2014)
   PUBMED   24528893
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2861)
  AUTHORS   Poeta,L., Fusco,F., Drongitis,D., Shoubridge,C., Manganelli,G.,
            Filosa,S., Paciolla,M., Courtney,M., Collombat,P., Lioi,M.B.,
            Gecz,J., Ursini,M.V. and Miano,M.G.
  TITLE     A regulatory path associated with X-linked intellectual disability
            and epilepsy links KDM5C to the polyalanine expansions in ARX
  JOURNAL   Am J Hum Genet 92 (1), 114-125 (2013)
   PUBMED   23246292
REFERENCE   4  (bases 1 to 2861)
  AUTHORS   Du,A., McCracken,K.W., Walp,E.R., Terry,N.A., Klein,T.J., Han,A.,
            Wells,J.M. and May,C.L.
  TITLE     Arx is required for normal enteroendocrine cell development in mice
            and humans
  JOURNAL   Dev Biol 365 (1), 175-188 (2012)
   PUBMED   22387004
REFERENCE   5  (bases 1 to 2861)
  AUTHORS   Quille,M.L., Carat,S., Quemener-Redon,S., Hirchaud,E., Baron,D.,
            Benech,C., Guihot,J., Placet,M., Mignen,O., Ferec,C., Houlgatte,R.
            and Friocourt,G.
  TITLE     High-throughput analysis of promoter occupancy reveals new targets
            for Arx, a gene mutated in mental retardation and
            interneuronopathies
  JOURNAL   PLoS One 6 (9), e25181 (2011)
   PUBMED   21966449
REFERENCE   6  (bases 1 to 2861)
  AUTHORS   Yoshihara,S., Omichi,K., Yanazawa,M., Kitamura,K. and Yoshihara,Y.
  TITLE     Arx homeobox gene is essential for development of mouse olfactory
            system
  JOURNAL   Development 132 (4), 751-762 (2005)
   PUBMED   15677725
REFERENCE   7  (bases 1 to 2861)
  AUTHORS   Poirier,K., Van Esch,H., Friocourt,G., Saillour,Y., Bahi,N.,
            Backer,S., Souil,E., Castelnau-Ptakhine,L., Beldjord,C.,
            Francis,F., Bienvenu,T. and Chelly,J.
  TITLE     Neuroanatomical distribution of ARX in brain and its localisation
            in GABAergic neurons
  JOURNAL   Brain Res Mol Brain Res 122 (1), 35-46 (2004)
   PUBMED   14992814
REFERENCE   8  (bases 1 to 2861)
  AUTHORS   Kitamura,K., Yanazawa,M., Sugiyama,N., Miura,H., Iizuka-Kogo,A.,
            Kusaka,M., Omichi,K., Suzuki,R., Kato-Fukui,Y., Kamiirisa,K.,
            Matsuo,M., Kamijo,S., Kasahara,M., Yoshioka,H., Ogata,T.,
            Fukuda,T., Kondo,I., Kato,M., Dobyns,W.B., Yokoyama,M. and
            Morohashi,K.
  TITLE     Mutation of ARX causes abnormal development of forebrain and testes
            in mice and X-linked lissencephaly with abnormal genitalia in
            humans
  JOURNAL   Nat Genet 32 (3), 359-369 (2002)
   PUBMED   12379852
REFERENCE   9  (bases 1 to 2861)
  AUTHORS   Scheffer,I.E., Wallace,R.H., Phillips,F.L., Hewson,P., Reardon,K.,
            Parasivam,G., Stromme,P., Berkovic,S.F., Gecz,J. and Mulley,J.C.
  TITLE     X-linked myoclonic epilepsy with spasticity and intellectual
            disability: mutation in the homeobox gene ARX
  JOURNAL   Neurology 59 (3), 348-356 (2002)
   PUBMED   12177367
REFERENCE   10 (bases 1 to 2861)
  AUTHORS   Bienvenu,T., Poirier,K., Friocourt,G., Bahi,N., Beaumont,D.,
            Fauchereau,F., Ben Jeema,L., Zemni,R., Vinet,M.C., Francis,F.,
            Couvert,P., Gomot,M., Moraine,C., van Bokhoven,H., Kalscheuer,V.,
            Frints,S., Gecz,J., Ohzaki,K., Chaabouni,H., Fryns,J.P.,
            Desportes,V., Beldjord,C. and Chelly,J.
  TITLE     ARX, a novel Prd-class-homeobox gene highly expressed in the
            telencephalon, is mutated in X-linked mental retardation
  JOURNAL   Hum Mol Genet 11 (8), 981-991 (2002)
   PUBMED   11971879
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EF638804.1.
            
            On or before Jul 29, 2007 this sequence version replaced
            XM_228590.4, XM_001064618.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF638804.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2861
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..2861
                     /gene="Arx"
                     /gene_synonym="RGD1562672"
                     /note="aristaless related homeobox"
                     /db_xref="GeneID:317268"
                     /db_xref="RGD:1562672"
     exon            1..392
                     /gene="Arx"
                     /gene_synonym="RGD1562672"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1897
                     /gene="Arx"
                     /gene_synonym="RGD1562672"
                     /codon_start=1
                     /product="homeobox protein ARX"
                     /protein_id="NP_001093644.1"
                     /db_xref="GeneID:317268"
                     /db_xref="RGD:1562672"
                     /translation="MSNQYQEEGCSERPECKSKSPTLLSSYCIDSILGRRSPCKMRLL
                     GAAQSLPAPLASRTDQEKAMQGSPKGSSAPFEAELHLPPKLRRLYGPGGGRLLQGAAA
                     AAAAAAAAAAAAATATGTAGPRGEVPPPPPPAARPGERQDSAGAVAAAAAAAWDTLKI
                     SQAPQVSISRSKSYRENGAPFVPPPPALDELGGPGGVAHPEERLSAASGPGSAPAAGG
                     GTGTEEDEEELLEDEEDEDEEEELLEDDEEELLEDDARALLKEPRRCSVATTGTVAAA
                     AAAAAAAAAVATEGGELSPKEELLLHPEDAEGKDGEDSVCLSAGSDSEEGLLKRKQRR
                     YRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREK
                     AGAQTHPPGLPFPGPLSATHPLSPYLDASPFPPHHPALDSAWTAAAAAAAAAFPSLPP
                     PPGSASLPPSGAPLGLSTFLGAAVFRHPAFISPAFGRLFSTMAPLTSASTAAALLRQP
                     TPAVEGAVASGALADPATAAADRRASSIAALRLKAKEHAAQLTQLNILPGTSTGKEVC
                     "
     exon            393..1281
                     /gene="Arx"
                     /gene_synonym="RGD1562672"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1327
                     /gene="Arx"
                     /gene_synonym="RGD1562672"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1656
                     /gene="Arx"
                     /gene_synonym="RGD1562672"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..2851
                     /gene="Arx"
                     /gene_synonym="RGD1562672"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgagcgcgg agaggacgag ctccggctga ggtcagagtg ggagcccgca tccgaggggg
       61 gcagaaagga acaaagatcg cagtaatacc tgttataatc agcaatctaa cccatcccca
      121 acacacactc tttcacccta ccggccagga gaggcaggca gaggtccact ctgagcccaa
      181 ggaaaaagct ccaaccatga gcaatcagta ccaggaagag ggctgctctg agaggcccga
      241 gtgcaagagt aaatcgccaa ctttgctctc ctcctactgc atcgacagca tcctgggccg
      301 gagaagcccg tgcaaaatga ggcttctggg agccgcgcag agcttgcctg ccccgctggc
      361 cagccgtact gaccaagaaa aagccatgca aggctccccc aagggcagca gcgccccgtt
      421 cgaggctgag ctgcacctgc cacccaagct gcggcgcctg tacggcccgg gcgggggccg
      481 cctcctccag ggcgcagcag cggcggcagc ggcggcggcc gcggcggcgg cggcggcagc
      541 cacggccact ggcaccgcag gtccccgtgg agaggttcct ccaccgccac cgccagcagc
      601 acggccaggg gagcgtcagg acagcgcggg ggccgtggcc gccgccgccg ccgctgcctg
      661 ggacacgctc aaaattagcc aggcaccgca ggtgagcatc agccgcagca agtcgtaccg
      721 cgagaacggg gcgcccttcg tgccaccgcc gcccgccctg gacgagctgg gtggtccggg
      781 gggcgtcgcg cacccagagg agcgcctcag cgcggccagc ggacccggca gtgccccggc
      841 ggcgggtggt ggcacgggca ccgaggagga cgaggaggag ctgttggagg atgaggaaga
      901 tgaagatgag gaagaggagc tgctggagga cgacgaggag gagctgctgg aagacgatgc
      961 ccgcgcgcta ctcaaggagc cccggcgctg ctctgtggcc accactggca cggtggccgc
     1021 cgccgccgcc gccgccgctg ccgccgccgc cgtggccacc gagggcgggg agctgtcgcc
     1081 caaggaagag ctgttgctgc acccggagga cgccgagggc aaggatggtg aggacagcgt
     1141 gtgcctgtcc gccggcagcg actccgagga ggggctcctg aagcgcaaac agaggcgtta
     1201 ccgcaccacg ttcaccagtt accagctgga ggaactggag cgggctttcc agaagacaca
     1261 ctaccctgac gtcttcacca gggaggagct ggccatgagg ctggacctga ctgaggcccg
     1321 agtccaggtg tggttccaga accgcagggc caagtggcgc aagcgggaga aggctggcgc
     1381 gcagacccac cccccggggc tgccctttcc cgggccactc tcggctaccc accctctcag
     1441 cccctacctg gacgccagcc cctttccccc gcatcaccca gcgcttgact cggcctggac
     1501 cgccgccgct gcagcggctg cagctgcctt cccgagccta cctccgcccc cgggctctgc
     1561 tagcctgccg cccagcgggg cgccgctggg cctgagcact ttcctgggag cagccgtgtt
     1621 ccggcacccg gccttcatca gcccagcatt tggcaggctc ttttccacta tggcccccct
     1681 gaccagcgcg tcgaccgcgg ctgcgctcct gagacagccc acacccgcag tggagggcgc
     1741 agtggcctcg ggcgcgctgg ccgatcccgc caccgctgcg gcagacagac gcgcatcgag
     1801 catagcggcg ctgaggctca aggctaagga gcacgccgcg cagctcacgc agctcaacat
     1861 cctcccgggc accagcacgg ggaaggaggt gtgctaaagg ctgccctccg cccttgcgcc
     1921 cctagggcgc gccccgaaag gtcacctcac tcagcaccac tcaagaccaa atggaaacag
     1981 aggaccagct cactcccaag acggcaaaga cagagcgcag ccgccttcgc agcagcctgg
     2041 accctggacg cggacaaggc agctcttggc gctaaaggac gtggcacctc ttccgttggc
     2101 tgtccatttg cccttgtccc tgtccctacc cctgccactg ccaacgtcac tccaactcaa
     2161 atgtccacgc tcccgttttt atcttactga aaacaagcgg gagggtttct ccccaatatg
     2221 cctagtattg aagttttaaa aattaaaagc ccaaccttct cttcctccgg ataccccact
     2281 tagcttttct tttgaatagc attttggcgc tctaagttga tttaagcgcg gcccggctag
     2341 acagacacca gggccaggga agcgaatacg aatctgtaag atagctaaca gtgcacttaa
     2401 aggaaagggg cgtctcgttc ttgttctctt ctttatcata caccaaccaa ggtttttata
     2461 tcaaaccaaa gggaaatact ctgctagaat atggactgtt gaagtcacca aactgtgatt
     2521 attgattctg tacataccat tgttattaaa aaaaaaagaa cagagctttg tatatttgaa
     2581 atgttataac gcaattgcac tcagcgtggt atggtaaaag tttgtcctcc tgtagattct
     2641 tactgtgttg tagatatggt agggttccta gacaaatatt tatgtactca agccctttat
     2701 ttaacttatt aactgtagag gcttcggaaa ccttcaagat aaaggcaatg gtacagtact
     2761 tttgtgtaat gtgtaattgt tatcactttt ccttgctatc tagtggagaa gtgtcacgct
     2821 caaaataaaa aaaaatatat gtttaacaaa aaaaaaaaaa a
//
