LOCUS       NP_001124485             973 aa            linear   ROD 31-MAR-2024
DEFINITION  splicing regulator ARVCF [Rattus norvegicus].
ACCESSION   NP_001124485
VERSION     NP_001124485.1
DBSOURCE    REFSEQ: accession NM_001131013.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 973)
  AUTHORS   Kausalya,P.J., Phua,D.C. and Hunziker,W.
  TITLE     Association of ARVCF with zonula occludens (ZO)-1 and ZO-2: binding
            to PDZ-domain proteins and cell-cell adhesion regulate plasma
            membrane and nuclear localization of ARVCF
  JOURNAL   Mol Biol Cell 15 (12), 5503-5515 (2004)
   PUBMED   15456900
REFERENCE   2  (residues 1 to 973)
  AUTHORS   Laura,R.P., Witt,A.S., Held,H.A., Gerstner,R., Deshayes,K.,
            Koehler,M.F., Kosik,K.S., Sidhu,S.S. and Lasky,L.A.
  TITLE     The Erbin PDZ domain binds with high affinity and specificity to
            the carboxyl termini of delta-catenin and ARVCF
  JOURNAL   J Biol Chem 277 (15), 12906-12914 (2002)
   PUBMED   11821434
REFERENCE   3  (residues 1 to 973)
  AUTHORS   Waibler,Z., Schafer,A. and Starzinski-Powitz,A.
  TITLE     mARVCF cellular localisation and binding to cadherins is influenced
            by the cellular context but not by alternative splicing
  JOURNAL   J Cell Sci 114 (Pt 21), 3873-3884 (2001)
   PUBMED   11719554
REFERENCE   4  (residues 1 to 973)
  AUTHORS   Kaufmann,U., Zuppinger,C., Waibler,Z., Rudiger,M., Urbich,C.,
            Martin,B., Jockusch,B.M., Eppenberger,H. and Starzinski-Powitz,A.
  TITLE     The armadillo repeat region targets ARVCF to cadherin-based
            cellular junctions
  JOURNAL   J Cell Sci 113 (Pt 22), 4121-4135 (2000)
   PUBMED   11058098
REFERENCE   5  (residues 1 to 973)
  AUTHORS   Sirotkin,H., O'Donnell,H., DasGupta,R., Halford,S., St Jore,B.,
            Puech,A., Parimoo,S., Morrow,B., Skoultchi,A., Weissman,S.M.,
            Scambler,P. and Kucherlapati,R.
  TITLE     Identification of a new human catenin gene family member (ARVCF)
            from the region deleted in velo-cardio-facial syndrome
  JOURNAL   Genomics 41 (1), 75-83 (1997)
   PUBMED   9126485
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1 and BC168253.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168253.1, SRR26643287.27433.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..973
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     Protein         1..973
                     /product="splicing regulator ARVCF"
                     /note="armadillo repeat protein deleted in
                     velo-cardio-facial syndrome; armadillo repeat gene deleted
                     in velo-cardio-facial syndrome; armadillo repeat protein
                     deleted in velo-cardio-facial syndrome homolog"
                     /calculated_mol_wt=105356
     Region          95..123
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (B4F7F3.1)"
     Site            103
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O00192; propagated from
                     UniProtKB/Swiss-Prot (B4F7F3.1)"
     Site            105
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O00192; propagated from
                     UniProtKB/Swiss-Prot (B4F7F3.1)"
     Site            171
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:P98203; propagated from
                     UniProtKB/Swiss-Prot (B4F7F3.1)"
     Region          233..254
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (B4F7F3.1)"
     Region          267..331
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (B4F7F3.1)"
     Site            268
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P98203; propagated from
                     UniProtKB/Swiss-Prot (B4F7F3.1)"
     Site            333
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P98203; propagated from
                     UniProtKB/Swiss-Prot (B4F7F3.1)"
     Site            336
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P98203; propagated from
                     UniProtKB/Swiss-Prot (B4F7F3.1)"
     Site            344
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00192; propagated from
                     UniProtKB/Swiss-Prot (B4F7F3.1)"
     Site            346
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00192; propagated from
                     UniProtKB/Swiss-Prot (B4F7F3.1)"
     Region          349..388
                     /region_name="ARM 1.
                     /evidence=ECO:0000250|UniProtKB:P98203"
                     /note="propagated from UniProtKB/Swiss-Prot (B4F7F3.1)"
     Region          361..386
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Site            order(377,381,385,419,423,427,462,467,471)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          390..429
                     /region_name="Arm"
                     /note="Armadillo/beta-catenin-like repeat; pfam00514"
                     /db_xref="CDD:425727"
     Region          391..430
                     /region_name="ARM 2.
                     /evidence=ECO:0000250|UniProtKB:P98203"
                     /note="propagated from UniProtKB/Swiss-Prot (B4F7F3.1)"
     Region          394..430
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          433..474
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          434..468
                     /region_name="ARM 3.
                     /evidence=ECO:0000250|UniProtKB:P98203"
                     /note="propagated from UniProtKB/Swiss-Prot (B4F7F3.1)"
     Region          437..472
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          469..509
                     /region_name="ARM 4.
                     /evidence=ECO:0000250|UniProtKB:P98203"
                     /note="propagated from UniProtKB/Swiss-Prot (B4F7F3.1)"
     Region          479..530
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          527..566
                     /region_name="ARM 5.
                     /evidence=ECO:0000250|UniProtKB:P98203"
                     /note="propagated from UniProtKB/Swiss-Prot (B4F7F3.1)"
     Region          576..623
                     /region_name="ARM 6.
                     /evidence=ECO:0000250|UniProtKB:P98203"
                     /note="propagated from UniProtKB/Swiss-Prot (B4F7F3.1)"
     Region          593..623
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (B4F7F3.1)"
     Site            607
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00192; propagated from
                     UniProtKB/Swiss-Prot (B4F7F3.1)"
     Region          608..624
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (B4F7F3.1)"
     Site            637
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P98203; propagated from
                     UniProtKB/Swiss-Prot (B4F7F3.1)"
     Region          641..681
                     /region_name="ARM 7.
                     /evidence=ECO:0000250|UniProtKB:P98203"
                     /note="propagated from UniProtKB/Swiss-Prot (B4F7F3.1)"
     Region          651..687
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          651..687
                     /region_name="Arm"
                     /note="Armadillo/beta-catenin-like repeat; pfam00514"
                     /db_xref="CDD:425727"
     Region          694..733
                     /region_name="ARM 8.
                     /evidence=ECO:0000250|UniProtKB:P98203"
                     /note="propagated from UniProtKB/Swiss-Prot (B4F7F3.1)"
     Region          697..732
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          697..731
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          734..776
                     /region_name="ARM 9.
                     /evidence=ECO:0000250|UniProtKB:P98203"
                     /note="propagated from UniProtKB/Swiss-Prot (B4F7F3.1)"
     Region          738..783
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          771..955
                     /region_name="Required for interaction with RNA-binding
                     proteins DDX5, HNRNPH2 and SRSF1 and with mRNAs.
                     /evidence=ECO:0000250|UniProtKB:O00192"
                     /note="propagated from UniProtKB/Swiss-Prot (B4F7F3.1)"
     Region          789..821
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          844..926
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (B4F7F3.1)"
     Site            865
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00192; propagated from
                     UniProtKB/Swiss-Prot (B4F7F3.1)"
     Site            866
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O00192; propagated from
                     UniProtKB/Swiss-Prot (B4F7F3.1)"
     CDS             1..973
                     /gene="Arvcf"
                     /coded_by="NM_001131013.2:298..3219"
                     /db_xref="GeneID:303798"
                     /db_xref="RGD:1306655"
ORIGIN      
        1 medcnvhsaa silasvkeqe arferltral eqerrhvalq leraqqpgms sggmvgsgqp
       61 lpmawqqlvl qeqspgsqas latmpeapev leetvtveed pgtptshvsi vtsedgttrr
      121 tetkvtktvk tvttrtvrqv plgpdglpll dggpplgsfa dgpldrhyvl rgggpaatls
      181 raylssgggf pdgpeprdip sygslsrglg vrpprtgllg pgpgdgcftl pgrreafpmg
      241 sesgppsgrs lpehfqaepy gleddtrsla addeggpdle pdystatrrr peygrglrar
      301 aledtaddtg elveerppfp aataplaqpe rgslgsldrv vrrspsvdst rkeprwrdpe
      361 lpevlamlrh pvdpvkanaa aylqhlcfen egikrrvrql rglpllvall dhpraevrrr
      421 acgalrnlsy grdadnkaai rdcggvpalv rllraardne vrelvtgtlw nlssyeplkm
      481 viidhglqtl thevivphsg werepnedsk prdaewttvf kntsgclrnv ssdgaearrr
      541 lreceglvda llhalqsavg rkdtdnksve ncvcimrnls yhvhkevpga dryqevepgi
      601 pgsaatsqrr rkddascfgg kkakgkkdae adrnfdtldl pkrteaakgf ellyqpevvr
      661 lylslltesr nfntleaaag alqnlsagnw mwatyiratv rkerglpvlv ellqsetdkv
      721 vravaialrn lsldqrnkdl igsyamtelv rnvrnaqapa hpsahleedt vvavlntihe
      781 ivsdsldnar sllqargvpa lvalvassqs vreakaashv lqtvwsykel rgalqrdgwt
      841 kahfqsasta kgpkgtpnsg gfddstlplv dknldgekst trdvipmdtl gpdgystvdr
      901 rerrtlgsds igdssekell kgpgpavcss dhmevigrgp sgtdpvlgpg appfcvglak
      961 plvylalpss lls
//
