LOCUS       NM_053397               1357 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus artemin (Artn), mRNA.
ACCESSION   NM_053397 XM_342891
VERSION     NM_053397.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1357)
  AUTHORS   Nencini,S., Ringuet,M., Kim,D.H., Greenhill,C. and Ivanusic,J.J.
  TITLE     GDNF, Neurturin, and Artemin Activate and Sensitize Bone Afferent
            Neurons and Contribute to Inflammatory Bone Pain
  JOURNAL   J Neurosci 38 (21), 4899-4911 (2018)
   PUBMED   29712778
  REMARK    GeneRIF: We have shown evidence of a role for GDNF, neurturin, and
            artemin in the activation and sensitization of bone afferent
            neurons, and that sequestering these ligands reduces pain behavior
            in a model of inflammatory bone pain
REFERENCE   2  (bases 1 to 1357)
  AUTHORS   Shang,H., Wang,Y., Chao,X., Sun,G., Bai,X., Xu,L., Han,Y., Li,J.,
            Wang,H. and Fan,Z.
  TITLE     Artemin transiently increases iNOS expression in primary cultured
            trigeminal ganglion neurons
  JOURNAL   Neurosci Lett 660, 34-38 (2017)
   PUBMED   28899786
  REMARK    GeneRIF: Results indicate a previously unknown role of artemin in
            regulating inducible form of nitric oxide synthase (iNOS)
            expression in primary cultured TGNs, and regulation of iNOS might
            be involved in the mechanism through which artemin participates in
            the trigeminal pain pathway.
REFERENCE   3  (bases 1 to 1357)
  AUTHORS   Wong,L.E., Gibson,M.E., Arnold,H.M., Pepinsky,B. and Frank,E.
  TITLE     Artemin promotes functional long-distance axonal regeneration to
            the brainstem after dorsal root crush
  JOURNAL   Proc Natl Acad Sci U S A 112 (19), 6170-6175 (2015)
   PUBMED   25918373
  REMARK    GeneRIF: artemin has a role in robust regeneration of large,
            myelinated sensory axons to the brainstem and in promoting
            functional reinnervation of the cuneate nucleus
REFERENCE   4  (bases 1 to 1357)
  AUTHORS   Ikeda-Miyagawa,Y., Kobayashi,K., Yamanaka,H., Okubo,M., Wang,S.,
            Dai,Y., Yagi,H., Hirose,M. and Noguchi,K.
  TITLE     Peripherally increased artemin is a key regulator of TRPA1/V1
            expression in primary afferent neurons
  JOURNAL   Mol Pain 11, 8 (2015)
   PUBMED   25889103
  REMARK    GeneRIF: indicate the important roles of peripherally-derived
            artemin on the regulation of TRPV1/A1 in DRG neurons in
            pathological conditions such as inflammatory and neuropathic pain
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1357)
  AUTHORS   Albers,K.M., Zhang,X.L., Diges,C.M., Schwartz,E.S., Yang,C.I.,
            Davis,B.M. and Gold,M.S.
  TITLE     Artemin growth factor increases nicotinic cholinergic receptor
            subunit expression and activity in nociceptive sensory neurons
  JOURNAL   Mol Pain 10, 31 (2014)
   PUBMED   24886596
  REMARK    GeneRIF: This study suggest that Artn regulates the expression and
            composition of nAChRs in GFRalpha3 nociceptors and that these
            changes contribute to the thermal hypersensitivity that develops in
            response to Artn injection and perhaps to inflammation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1357)
  AUTHORS   Zihlmann,K.B., Ducray,A.D., Schaller,B., Huber,A.W., Krebs,S.H.,
            Andres,R.H., Seiler,R.W., Meyer,M. and Widmer,H.R.
  TITLE     The GDNF family members neurturin, artemin and persephin promote
            the morphological differentiation of cultured ventral mesencephalic
            dopaminergic neurons
  JOURNAL   Brain Res Bull 68 (1-2), 42-53 (2005)
   PUBMED   16325003
  REMARK    GeneRIF: ARTN acts as potent neurotrophic factor that may play an
            important role in the structural development and plasticity of
            ventral mesencephalic dopaminergic neurons
REFERENCE   7  (bases 1 to 1357)
  AUTHORS   Bolon,B., Jing,S., Asuncion,F., Scully,S., Pisegna,M., Van,G.Y.,
            Hu,Z., Yu,Y.B., Min,H., Wild,K., Rosenfeld,R.D., Tarpley,J.,
            Carnahan,J., Duryea,D., Hill,D., Kaufman,S., Yan,X.Q., Juan,T.,
            Christensen,K., McCabe,J. and Simonet,W.S.
  TITLE     The candidate neuroprotective agent artemin induces autonomic
            neural dysplasia without preventing peripheral nerve dysfunction
  JOURNAL   Toxicol Pathol 32 (3), 275-294 (2004)
   PUBMED   15204970
REFERENCE   8  (bases 1 to 1357)
  AUTHORS   Honma,Y., Araki,T., Gianino,S., Bruce,A., Heuckeroth,R., Johnson,E.
            and Milbrandt,J.
  TITLE     Artemin is a vascular-derived neurotropic factor for developing
            sympathetic neurons
  JOURNAL   Neuron 35 (2), 267-282 (2002)
   PUBMED   12160745
REFERENCE   9  (bases 1 to 1357)
  AUTHORS   Stover,T., Gong,T.L., Cho,Y., Altschuler,R.A. and Lomax,M.I.
  TITLE     Expression of the GDNF family members and their receptors in the
            mature rat cochlea
  JOURNAL   Brain Res Mol Brain Res 76 (1), 25-35 (2000)
   PUBMED   10719212
REFERENCE   10 (bases 1 to 1357)
  AUTHORS   Baloh,R.H., Tansey,M.G., Lampe,P.A., Fahrner,T.J., Enomoto,H.,
            Simburger,K.S., Leitner,M.L., Araki,T., Johnson,E.M. Jr. and
            Milbrandt,J.
  TITLE     Artemin, a novel member of the GDNF ligand family, supports
            peripheral and central neurons and signals through the
            GFRalpha3-RET receptor complex
  JOURNAL   Neuron 21 (6), 1291-1302 (1998)
   PUBMED   9883723
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079078.1.
            
            On Apr 19, 2005 this sequence version replaced XM_342891.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079078.1, CK476025.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN16093042
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1357
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1357
                     /gene="Artn"
                     /note="artemin"
                     /db_xref="GeneID:362572"
                     /db_xref="RGD:621427"
     exon            1..41
                     /gene="Artn"
                     /inference="alignment:Splign:2.1.0"
     exon            42..190
                     /gene="Artn"
                     /inference="alignment:Splign:2.1.0"
     exon            191..317
                     /gene="Artn"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..932
                     /gene="Artn"
                     /codon_start=1
                     /product="artemin precursor"
                     /protein_id="NP_445849.1"
                     /db_xref="GeneID:362572"
                     /db_xref="RGD:621427"
                     /translation="MELGLGEPTALSHCLRPRWQPALWPTLAALALLSSVTEASLDPM
                     SRSPASRDVPSPVLAPPTDYLPGGHTAHLCSERALRPPPQSPQPAPPPPGPALQSPPA
                     ALRGARAARAGTRSSRARATDARGCRLRSQLVPVSALGLGHSSDELIRFRFCSGSCRR
                     ARSPHDLSLASLLDAGALRSPPGSRPISQPCCRPTRYEAVSFMDVNSTWRTVDHLSAT
                     ACGCLG"
     exon            318..456
                     /gene="Artn"
                     /inference="alignment:Splign:2.1.0"
     exon            457..1331
                     /gene="Artn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagccctcgc tacgactggg gcttggagcc ctgcacccga gggcacagac cggctgccaa
       61 ggccccactt ttaactaaaa gaggcgctgc caggtgcaca attctgggca tgatccattt
      121 gagcttcggg ggaaagccca gcactggtcc cagggaaggt gcctagaagg acacggagcg
      181 gacccctttg ctgcctcaag aagagggtgg ggaaacagat ccacgaaggc tgatgggagc
      241 tcctggagtt gaaagcgatg gaactgggac ttggagagcc tactgcattg tcccactgcc
      301 tccggcctag gtggcaacca gccttgtggc caaccctagc tgctctagcc ctgctgagca
      361 gcgtcacaga agcttccctg gacccaatgt cccgcagccc cgcctctcgc gatgttccct
      421 cgccggtcct ggcgccccca acagactacc tacctggggg acacaccgca catctgtgca
      481 gcgaaagagc cctgcgacca ccgccgcagt ctcctcagcc cgcaccccca ccacccggtc
      541 ccgcgctcca gtctcctccc gctgcgctcc gcggggcacg cgcggcgcgt gcaggaaccc
      601 ggagcagccg cgcacgggct acagatgcgc gcggctgccg cctgcgctca cagctggtgc
      661 cggtgagcgc tctcggcctg ggccacagct ccgacgagct gatacgtttc cgcttctgca
      721 gcggttcgtg ccgccgagca cgctccccgc acgatctcag cctggccagc ctgctggacg
      781 ccggggccct gcggtcgcct cccgggtccc ggccgatcag ccagccctgt tgccggccca
      841 ctcgctatga ggccgtctcc ttcatggacg tgaacagcac ctggagaacc gtggaccatc
      901 tctccgccac cgcctgcggc tgtctgggct gaggatgatc ttcaagcttt tgcacactgg
      961 acccatatgt cgccctacct ggaacagccc cacggggcct cactagctag gagcctcaac
     1021 tcaacaggaa gtggaagctg cagagctcag gcctcaggcc gatgagggac agacagagcc
     1081 tggaaagatg accgaaccac tgaccaacag tcccaaggtg ttcatggatc ccagctctac
     1141 agacagcaga aacctcagct aaagagaact cctctgggtg aatccagaaa tggccctagg
     1201 acctcgggag tgcattttga ggagatatat tgtagtcgcg ttgctggacc agcctgtgct
     1261 gaaaccagcc ttgtgttcac ttgtggaagc cgaagcccta tttattattt ctaaattatt
     1321 tatttacttt gaaaaaaaaa aaaaaaaaaa aaaaaaa
//
