LOCUS       NM_198735               1183 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ADP-ribosyltransferase 2b (Art2b), mRNA.
ACCESSION   NM_198735 XM_215014
VERSION     NM_198735.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1183)
  AUTHORS   Morrison,A.R., Moss,J., Stevens,L.A., Evans,J.E., Farrell,C.,
            Merithew,E., Lambright,D.G., Greiner,D.L., Mordes,J.P.,
            Rossini,A.A. and Bortell,R.
  TITLE     ART2, a T cell surface mono-ADP-ribosyltransferase, generates
            extracellular poly(ADP-ribose)
  JOURNAL   J Biol Chem 281 (44), 33363-33372 (2006)
   PUBMED   16931513
  REMARK    GeneRIF: capability of polymerizing ADP-ribose may not be unique to
            poly(ADP-ribose) polymerases and that poly(ADP-ribosylation), an
            established nuclear activity, may occur extracellularly and
            modulate cell function
REFERENCE   2  (bases 1 to 1183)
  AUTHORS   Stevens,L.A., Bourgeois,C., Bortell,R. and Moss,J.
  TITLE     Regulatory role of arginine 204 in the catalytic activity of rat
            alloantigens ART2a and ART2b
  JOURNAL   J Biol Chem 278 (22), 19591-19596 (2003)
   PUBMED   12649291
REFERENCE   3  (bases 1 to 1183)
  AUTHORS   Mueller-Dieckmann,C., Ritter,H., Haag,F., Koch-Nolte,F. and
            Schulz,G.E.
  TITLE     Structure of the ecto-ADP-ribosyl transferase ART2.2 from rat
  JOURNAL   J Mol Biol 322 (4), 687-696 (2002)
   PUBMED   12270706
  REMARK    GeneRIF: Structure of the ecto-ADP-ribosyl transferase ART2.2 from
            rat.
REFERENCE   4  (bases 1 to 1183)
  AUTHORS   Rothenburg,S., Eiben,M., Koch-Nolte,F. and Haag,F.
  TITLE     Independent integration of rodent identifier (ID) elements into
            orthologous sites of some RT6 alleles of Rattus norvegicus and
            Rattus rattus
  JOURNAL   J Mol Evol 55 (3), 251-259 (2002)
   PUBMED   12187378
  REMARK    GeneRIF: Our data indicate that the RT6 alleles diverged about 1
            myr ago and that the ID element integrated into the RT6a locus soon
            after this.
REFERENCE   5  (bases 1 to 1183)
  AUTHORS   Mueller-Dieckmann,C., Scheuermann,T., Wursthorn,K., Schroder,J.,
            Haag,F., Schulz,G.E. and Koch-Nolte,F.
  TITLE     Expression, purification, crystallization and preliminary X-ray
            analysis of rat ecto-ADP-ribosyltransferase 2 (ART2.2)
  JOURNAL   Acta Crystallogr D Biol Crystallogr 58 (Pt 7), 1211-1213 (2002)
   PUBMED   12077446
  REMARK    GeneRIF: Expression, purification, crystallization and X-ray
            analysis
REFERENCE   6  (bases 1 to 1183)
  AUTHORS   Maehama,T., Hoshino,S. and Katada,T.
  TITLE     Increase in ADP-ribosyltransferase activity of rat T lymphocyte
            alloantigen RT6.1 by a single amino acid mutation
  JOURNAL   FEBS Lett 388 (2-3), 189-191 (1996)
   PUBMED   8690084
REFERENCE   7  (bases 1 to 1183)
  AUTHORS   Takada,T., Iida,K. and Moss,J.
  TITLE     Expression of NAD glycohydrolase activity by rat mammary
            adenocarcinoma cells transformed with rat T cell alloantigen RT6.2
  JOURNAL   J Biol Chem 269 (13), 9420-9423 (1994)
   PUBMED   8144525
REFERENCE   8  (bases 1 to 1183)
  AUTHORS   Haag,F., Koch,F. and Thiele,H.G.
  TITLE     Nucleotide and deduced amino acid sequence of the rat T-cell
            alloantigen RT6.1
  JOURNAL   Nucleic Acids Res 18 (4), 1047 (1990)
   PUBMED   2129547
REFERENCE   9  (bases 1 to 1183)
  AUTHORS   Koch,F., Haag,F., Kashan,A. and Thiele,H.G.
  TITLE     Primary structure of rat RT6.2, a nonglycosylated
            phosphatidylinositol-linked surface marker of postthymic T cells
  JOURNAL   Proc Natl Acad Sci U S A 87 (3), 964-967 (1990)
   PUBMED   2300588
REFERENCE   10 (bases 1 to 1183)
  AUTHORS   Kashan,A., Buck,F., Haag,F., Koch,F. and Thiele,H.G.
  TITLE     A single-step purification procedure and partial amino acid
            sequence analysis of picomole amounts of the rat T cell alloantigen
            RT6.2
  JOURNAL   Immunol Lett 23 (2), 133-137 (1989)
   PUBMED   2632369
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_198735.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099070.1, M85193.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                JAXUCZ010000001.1  165371885-165371958 c
            75-768              JAXUCZ010000001.1  165370724-165371417 c
            769-1183            JAXUCZ010000001.1  165368639-165369053 c
FEATURES             Location/Qualifiers
     source          1..1183
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1183
                     /gene="Art2b"
                     /gene_synonym="Ag-F; Art2; Art2a; ARTC2; Ly-2; LY2; PtaA;
                     Rt6; RT6.1; RT6.2"
                     /note="ADP-ribosyltransferase 2b"
                     /db_xref="GeneID:293152"
                     /db_xref="RGD:3521"
     exon            1..74
                     /gene="Art2b"
                     /gene_synonym="Ag-F; Art2; Art2a; ARTC2; Ly-2; LY2; PtaA;
                     Rt6; RT6.1; RT6.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..851
                     /gene="Art2b"
                     /gene_synonym="Ag-F; Art2; Art2a; ARTC2; Ly-2; LY2; PtaA;
                     Rt6; RT6.1; RT6.2"
                     /EC_number="2.4.2.31"
                     /EC_number="3.2.2.5"
                     /note="ADP-ribosyltransferase 2a; T-cell
                     ecto-ADP-ribosyltransferase 1; T-cell
                     ecto-ADP-ribosyltransferase 2; T cell differentiation
                     marker RT6.1; alloantigen Rt6.1; alloantigen Rt6.2; T-cell
                     surface protein Rt6.1; T-cell surface protein Rt6.2;
                     T-cell mono(ADP-ribosyl)transferase 1; T-cell
                     mono(ADP-ribosyl)transferase 2; T-cell NAD(P)(+)--arginine
                     ADP-ribosyltransferase 1; T-cell NAD(P)(+)--arginine
                     ADP-ribosyltransferase 2; mono(ADP-ribosyl)transferase 2A;
                     mono(ADP-ribosyl)transferase 2B; NAD(+) glycohydrolase;
                     cell surface alloantigen 6; Cell surface alloantigen
                     peripheral T-cell antigen; ADP-ribosyltransferase C2 and
                     C3 toxin-like 2"
                     /codon_start=1
                     /product="T-cell ecto-ADP-ribosyltransferase 2 precursor"
                     /protein_id="NP_942030.1"
                     /db_xref="GeneID:293152"
                     /db_xref="RGD:3521"
                     /translation="MPSNICKFFLTWWLIQQVTGLTGPLMLDTAPNAFDDQYEGCVNK
                     MEEKAPLLLQEDFNMNAKLKVAWEEAKKRWNNIKPSRSYPKGFNDFHGTALVAYTGSI
                     AVDFNRAVREFKENPGQFHYKAFHYYLTRALQLLSNGDCHSVYRGTKTRFHYTGAGSV
                     RFGQFTSSSLSKKVAQSQEFFSDHGTLFIIKTCLGVYIKEFSFRPDQEEVLIPGYEVY
                     QKVRTQGYNEIFLDSPKRKKSNYNCLYSSAGARESCVSLFLVVLPSLLVQLLCLAEP"
     exon            75..768
                     /gene="Art2b"
                     /gene_synonym="Ag-F; Art2; Art2a; ARTC2; Ly-2; LY2; PtaA;
                     Rt6; RT6.1; RT6.2"
                     /inference="alignment:Splign:2.1.0"
     exon            769..1183
                     /gene="Art2b"
                     /gene_synonym="Ag-F; Art2; Art2a; ARTC2; Ly-2; LY2; PtaA;
                     Rt6; RT6.1; RT6.2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttttttttt tttgaacttg acgatgccat caaatatttg caagttcttc ctaacttggt
       61 ggttaattca gcaggtgact gggctgacag ggcctttgat gctagacacg gctcccaatg
      121 catttgatga ccagtatgag ggctgtgtca acaaaatgga ggaaaaggca cccctgcttt
      181 tacaggaaga ctttaatatg aatgcgaaat taaaagttgc gtgggaagag gcaaagaaac
      241 gatggaacaa cataaaacct agtaggagtt atcccaaagg tttcaatgat ttccatggaa
      301 cggctttagt tgcctacact gggagtatcg ctgtagattt taacagagct gttagggaat
      361 tcaaggaaaa tcctggtcaa ttccactaca aggccttcca ttactactta acaagagctc
      421 ttcagctttt gagtaacggg gattgtcatt cagtctaccg aggcactaag accaggtttc
      481 actatactgg agctggctcc gtgcgattcg ggcagttcac gtcttcatct ttatctaaga
      541 aagtagctca atctcaagag tttttcagtg atcatgggac gctgttcatc atcaaaacct
      601 gcttgggggt ttatatcaaa gaattctctt tccgtcctga ccaagaggag gtgttaattc
      661 caggctatga ggtatatcag aaagtcagga cacaaggcta caacgaaatt ttcctggact
      721 ccccgaagag gaagaagagc aactacaatt gcttatacag cagcgcagga gccagagaga
      781 gctgtgtatc cctgttcctt gtggttctcc ccagtcttct ggtccagctg ctttgtcttg
      841 ctgagccgta gccctctcct gtctgcagtt tgtgggtctg agtgttaaag ggaggccaag
      901 gagcaagcac tcaattggtt gtctaagatc tgtggtggag gggagggtcg gatcctatca
      961 gggaaagtct gctctagcat gcacgacttc tgtaagcatc caaggatctg actgggtcag
     1021 ccattaaaat ttacacctaa acttcaacta tactaccttt ttacagtttg ctacgatcga
     1081 aaaaagcagt gtttgtctac tccgtcagca ataagagatt tacatacagt atgcattttg
     1141 tgataaattt tgcaatctca ggaaataaaa atttataatc gtg
//
