LOCUS       NM_001047885            2331 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus arylsulfatase L (Arsl), mRNA.
ACCESSION   NM_001047885 XM_001068222 XM_006232280 XM_227066
VERSION     NM_001047885.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2331)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   2  (bases 1 to 2331)
  AUTHORS   Sardiello,M., Annunziata,I., Roma,G. and Ballabio,A.
  TITLE     Sulfatases and sulfatase modifying factors: an exclusive and
            promiscuous relationship
  JOURNAL   Hum Mol Genet 14 (21), 3203-3217 (2005)
   PUBMED   16174644
REFERENCE   3  (bases 1 to 2331)
  AUTHORS   Parenti,G., Buttitta,P., Meroni,G., Franco,B., Bernard,L.,
            Rizzolo,M.G., Brunetti-Pierri,N., Ballabio,A. and Andria,G.
  TITLE     X-linked recessive chondrodysplasia punctata due to a new point
            mutation of the ARSE gene
  JOURNAL   Am J Med Genet 73 (2), 139-143 (1997)
   PUBMED   9409863
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Oct 5, 2022 this sequence version replaced
            XM_006232280.3, NM_001047885.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.7847.1,
                                           SRR26643292.8548.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               JAXUCZ010000002.1  120966992-120967159
            169-205             JAXUCZ010000002.1  120967614-120967650
            206-358             JAXUCZ010000002.1  120968593-120968745
            359-480             JAXUCZ010000002.1  120969126-120969247
            481-603             JAXUCZ010000002.1  120969775-120969897
            604-1042            JAXUCZ010000002.1  120970208-120970646
            1043-1179           JAXUCZ010000002.1  120971538-120971674
            1180-1314           JAXUCZ010000002.1  120972335-120972469
            1315-1477           JAXUCZ010000002.1  120973313-120973475
            1478-1599           JAXUCZ010000002.1  120973967-120974088
            1600-2331           JAXUCZ010000002.1  120974284-120975015
FEATURES             Location/Qualifiers
     source          1..2331
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q25"
     gene            1..2331
                     /gene="Arsl"
                     /gene_synonym="Arse"
                     /note="arylsulfatase L"
                     /db_xref="GeneID:310326"
                     /db_xref="RGD:1304917"
     exon            1..168
                     /gene="Arsl"
                     /gene_synonym="Arse"
                     /inference="alignment:Splign:2.1.0"
     exon            169..205
                     /gene="Arsl"
                     /gene_synonym="Arse"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..2018
                     /gene="Arsl"
                     /gene_synonym="Arse"
                     /EC_number="3.1.6.1"
                     /note="arylsulfatase E (chondrodysplasia punctata 1)"
                     /codon_start=1
                     /product="arylsulfatase L precursor"
                     /protein_id="NP_001041350.1"
                     /db_xref="GeneID:310326"
                     /db_xref="RGD:1304917"
                     /translation="MAPPHRTCSSPATLLCIVLLGLQYVDALRSPPPRPNFLIIMADD
                     LGIGDLGCYGNTSIRTPNIDRLAEDGVRLTQYLAAESVCTPSRAAFLTGRYPIRSGMT
                     SGNGHRVLQWAAGAGGLPPKEITFARILQGQGYVTGLVGKWHLGLSCRTVSDLCHHPL
                     NHGFHHFLGLPLGMMGDCAGAEPSEKRAGLERRLRGAGRALAAVAVAIAALAWGRGRG
                     LAPACWAPWAAIALGAVAAIFEAGSYVVGGAVARYDCFLMRNATVTQQPLQLDHVTPL
                     LLREAKDFLRRHRHAPFLLFLSLLHTHTPLVTSPEFRGRSAHGRYGDNVEEMDWVVGQ
                     ILEVLEHEGLTDSTLVHFTSDNGAWLEAQAGGEQLGGSNGVFRGGKGMGGWEGGIRVP
                     GVFRWPGVLPRGRVLDQPVSLMDVFPTVVRLGGGVLPSDREIDGRDLLPLLRGETWHS
                     AHEVLLHYCEVFLHAVRWVQRDSGQVWKAHFVTPTFDPLGSGSCSGAGGAAAVCPCVG
                     KVEEHDPPLLFELTSDPGEVRPLRAPAKMSEAPNLTAAITSEAVTAAMATAARVRQEY
                     DMLRPTAGHVPQQMGSLYNLWLPWLQPCCGHFPACACDLEGGSRK"
     exon            206..358
                     /gene="Arsl"
                     /gene_synonym="Arse"
                     /inference="alignment:Splign:2.1.0"
     exon            359..480
                     /gene="Arsl"
                     /gene_synonym="Arse"
                     /inference="alignment:Splign:2.1.0"
     exon            481..603
                     /gene="Arsl"
                     /gene_synonym="Arse"
                     /inference="alignment:Splign:2.1.0"
     exon            604..1042
                     /gene="Arsl"
                     /gene_synonym="Arse"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1179
                     /gene="Arsl"
                     /gene_synonym="Arse"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1314
                     /gene="Arsl"
                     /gene_synonym="Arse"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1477
                     /gene="Arsl"
                     /gene_synonym="Arse"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1599
                     /gene="Arsl"
                     /gene_synonym="Arse"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..2331
                     /gene="Arsl"
                     /gene_synonym="Arse"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acactccgcc ccggcccgcc ccgccgcccg gatccagaac cgaccggaca gacgggttcc
       61 cgcgcccgct tgctccgggc cccgcccctg ccatagacag ggtgaccgag gagcacgaaa
      121 cggagcagct gcgacaggcc ggaacccgat tgacttcttg aggacgcgga aaccaatgca
      181 tcatggctcc gccccatcgc acctgttcca gtcctgcaac cctactgtgc attgtcctcc
      241 tgggcctgca gtatgtggat gccctgcgct cgcccccgcc ccgccccaac ttcctgatca
      301 tcatggctga cgaccttggc attggagacc taggctgtta tggcaacacc agcatcagga
      361 ccccaaacat tgaccgcctg gcggaggatg gagtgcgcct cacacagtac ctggcagcag
      421 agtcggtgtg cacgcccagt agggccgcat tcctcactgg gcgctaccct atccgctcag
      481 ggatgacttc tggcaacgga caccgagtgc tgcagtgggc agcaggcgca ggcggccttc
      541 ctccaaagga gatcaccttt gctcgcatcc tgcaggggca gggctatgtc acagggctcg
      601 tggggaagtg gcacctgggc ctgagctgcc gcactgtctc cgacctctgc caccacccgc
      661 tgaaccacgg cttccaccac ttcctggggc tgccgctcgg catgatggga gactgtgcgg
      721 gggcggagcc ttctgagaag cgggcagggc tggagcggcg ccttcgaggg gcggggcggg
      781 ccctggcagc agtggccgtt gccattgcag cactggcctg ggggcggggc cggggactgg
      841 caccggcctg ctgggctcct tgggcagcta ttgccctggg tgcagtggcg gccatctttg
      901 aagcagggtc gtatgtggta ggtggggctg tggcgcgcta tgactgcttc ctcatgcgca
      961 acgccaccgt cacccagcag cccctgcagc tcgaccatgt cacacctctg ctgctccgcg
     1021 aggccaagga cttcctgcga aggcatcgcc atgccccctt cctgctgttc ctgtccctgc
     1081 tgcacacgca cactcccctt gtgacatcgc ctgaattccg aggtcggagc gctcatgggc
     1141 gctatggcga caatgtggag gagatggact gggtagtggg ccagatactg gaggtgctgg
     1201 agcacgaggg cctgacggac agcacacttg tccatttcac atctgacaac ggcgcctggc
     1261 ttgaagccca ggctgggggc gagcagctcg gcggctccaa cggggtcttc cggggtggca
     1321 agggcatggg cggctgggag ggcggcatcc gcgtgccagg agtgttccgc tggccgggcg
     1381 tgctgcctcg ggggcgtgtc ctcgaccagc ctgtgagcct catggatgtc ttccccaccg
     1441 ttgtgcggct ggggggcggg gtgttgccct cagacaggga gattgatggg cgcgacctgt
     1501 tgcccctgct gcgaggggag acctggcact ccgcccacga ggtcctgctg cactactgtg
     1561 aggtcttcct gcacgcagtc cgctgggtac agcgtgacag tggccaggtg tggaaggccc
     1621 acttcgtaac gccgaccttc gatcccttgg ggtcggggtc gtgcagtggg gcagggggcg
     1681 ccgcagccgt gtgcccatgc gtgggcaagg tcgaggagca cgaccctccg ctgctcttcg
     1741 agctgacctc ggaccctggc gaggtgcggc ccctccgcgc acccgccaag atgtcggagg
     1801 cgccgaactt gacggcggcc ataacgtcag aggcagtgac ggcagccatg gcaacggcgg
     1861 cgcgcgtgag gcaggagtat gacatgctgc gccccaccgc cggccatgta ccccagcaga
     1921 tggggtcgct ctacaacctg tggctgcctt ggctgcagcc gtgctgtggc cacttccctg
     1981 cctgtgcttg cgacttggaa ggcgggagcc ggaagtgatc ttggtggtgc cggaagtgac
     2041 ggtggcgcat gggggtggga cttcctgtga gacaggaagt actggtggct ttggggacag
     2101 agagggaggc ctgctgagtg gggttccatg gaggaacagg aagtaaggaa gaggaaatca
     2161 gaagtccctg ggagtggtgt gtgtgtgtgt ggggtggggg gtggtatgta cctttataat
     2221 agttaaagta ggggttcaca acctccctaa tgctgcagcc ttttaacata gtttctcatg
     2281 taacagtcct caaccataaa atgattttca ctgctatttc agcactgtaa a
//
