LOCUS       NP_001041346             573 aa            linear   ROD 01-MAY-2025
DEFINITION  arylsulfatase I precursor [Rattus norvegicus].
ACCESSION   NP_001041346 XP_001061902 XP_225899
VERSION     NP_001041346.1
DBSOURCE    REFSEQ: accession NM_001047881.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 573)
  AUTHORS   Sardiello,M., Annunziata,I., Roma,G. and Ballabio,A.
  TITLE     Sulfatases and sulfatase modifying factors: an exclusive and
            promiscuous relationship
  JOURNAL   Hum Mol Genet 14 (21), 3203-3217 (2005)
   PUBMED   16174644
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On or before Sep 8, 2006 this sequence version replaced
            XP_225899.4, XP_001061902.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.62934.1, BN000739.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..573
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     Protein         1..573
                     /product="arylsulfatase I precursor"
                     /note="ASI; arylsulfatase i"
                     /calculated_mol_wt=61888
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2554
     mat_peptide     24..573
                     /product="Arylsulfatase I. /id=PRO_0000356285"
                     /note="propagated from UniProtKB/Swiss-Prot (Q32KJ8.1)"
                     /calculated_mol_wt=61888
     Region          48..478
                     /region_name="4-S"
                     /note="N-acetylgalactosamine 4-sulfatase, also called
                     arylsulftase B; cd16029"
                     /db_xref="CDD:293753"
     Site            order(55..56,93,147,149,239,297..298)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:293753"
     Site            order(55..56,93,147,149,239,298)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:293753"
     Site            276
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q32KJ8.1)"
     Site            288
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q32KJ8.1)"
     Site            466
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q32KJ8.1)"
     Site            496
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q32KJ8.1)"
     Region          506..550
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q32KJ8.1)"
     CDS             1..573
                     /gene="Arsi"
                     /gene_synonym="RGD1310242"
                     /coded_by="NM_001047881.2:257..1978"
                     /db_xref="GeneID:307404"
                     /db_xref="RGD:1310242"
ORIGIN      
        1 mhalsgfslv sllslgylsw dwakpglvad gpaeaedqps aappqpphii filtddqgyh
       61 dvgyhgsdie tptldrlaae gvklenyyiq pictpsrsql ltgryqihtg lqhsiirprq
      121 pnclpldqvt lpqklqeagy sthmvgkwhl gfyrkeclpt rrgfdtflgs ltgnvdyyty
      181 dncdgpgvcg fdlhegesva wglsgqystm lyaqrashil ashspqkplf lyvafqavht
      241 plqspreyly ryrtmgnvar rkyaamvtcm deavrnitwa lkrygfynns viifssdngg
      301 qtfsggsnwp lrgrkgtywe ggvrglgfvh spllkkkrrt sralvhitdw yptlvglagg
      361 ttsaadgldg ydvwpaiseg rasprteilh nidplynhar hgsleggfgi wntavqaair
      421 vgewklltgd pgygdwippq tlasfpgsww nlermasirq avwlfnisad pyeredladq
      481 rpdvvrtlla rladynrtai pvrypaanpr ahpdfnggaw gpwasdedee eedeeeegra
      541 rsfprgrrkk kckicklrsf frklntrlms hri
//
