LOCUS       NM_033443               1862 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus arylsulfatase B (Arsb), mRNA.
ACCESSION   NM_033443 XM_345140
VERSION     NM_033443.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1862)
  AUTHORS   Palmer,K., Fairfield,H., Borgeia,S., Curtain,M., Hassan,M.G.,
            Dionne,L., Yong Karst,S., Coombs,H., Bronson,R.T., Reinholdt,L.G.,
            Bergstrom,D.E., Donahue,L.R., Cox,T.C. and Murray,S.A.
  TITLE     Discovery and characterization of spontaneous mouse models of
            craniofacial dysmorphology
  JOURNAL   Dev Biol 415 (2), 216-227 (2016)
   PUBMED   26234751
REFERENCE   2  (bases 1 to 1862)
  AUTHORS   Zhang,X., Bhattacharyya,S., Kusumo,H., Goodlett,C.R., Tobacman,J.K.
            and Guizzetti,M.
  TITLE     Arylsulfatase B modulates neurite outgrowth via astrocyte
            chondroitin-4-sulfate: dysregulation by ethanol
  JOURNAL   Glia 62 (2), 259-271 (2014)
   PUBMED   24311516
REFERENCE   3  (bases 1 to 1862)
  AUTHORS   Eliyahu,E., Wolfson,T., Ge,Y., Jepsen,K.J., Schuchman,E.H. and
            Simonaro,C.M.
  TITLE     Anti-TNF-alpha therapy enhances the effects of enzyme replacement
            therapy in rats with mucopolysaccharidosis type VI
  JOURNAL   PLoS One 6 (8), e22447 (2011)
   PUBMED   21887218
REFERENCE   4  (bases 1 to 1862)
  AUTHORS   Mitsunaga-Nakatsubo,K., Kusunoki,S., Kawakami,H., Akasaka,K. and
            Akimoto,Y.
  TITLE     Cell-surface arylsulfatase A and B on sinusoidal endothelial cells,
            hepatocytes, and Kupffer cells in mammalian livers
  JOURNAL   Med Mol Morphol 42 (2), 63-69 (2009)
   PUBMED   19536613
REFERENCE   5  (bases 1 to 1862)
  AUTHORS   Bhattacharyya,S. and Tobacman,J.K.
  TITLE     Arylsulfatase B regulates colonic epithelial cell migration by
            effects on MMP9 expression and RhoA activation
  JOURNAL   Clin Exp Metastasis 26 (6), 535-545 (2009)
   PUBMED   19306108
REFERENCE   6  (bases 1 to 1862)
  AUTHORS   Jin,W.D., Jackson,C.E., Desnick,R.J. and Schuchman,E.H.
  TITLE     Mucopolysaccharidosis type VI: identification of three mutations in
            the arylsulfatase B gene of patients with the severe and mild
            phenotypes provides molecular evidence for genetic heterogeneity
  JOURNAL   Am J Hum Genet 50 (4), 795-800 (1992)
   PUBMED   1550123
REFERENCE   7  (bases 1 to 1862)
  AUTHORS   Vinay,S.D. and Sood,P.P.
  TITLE     Inability of thiol compounds to restore CNS arylsulfatases
            inhibited by methyl mercury
  JOURNAL   Pharmacol Toxicol 69 (1), 71-74 (1991)
   PUBMED   1682910
REFERENCE   8  (bases 1 to 1862)
  AUTHORS   van der Pal,R.H., Klein,W., van Golde,L.M. and Lopes-Cardozo,M.
  TITLE     Developmental profiles of arylsulfatases A and B in rat cerebral
            cortex and spinal cord
  JOURNAL   Biochim Biophys Acta 1081 (3), 315-320 (1991)
   PUBMED   1671824
REFERENCE   9  (bases 1 to 1862)
  AUTHORS   Zachariah,E. and Moudgal,N.R.
  TITLE     Enzymic changes in the cervix of the rat and hamster during the
            oestrous cycle and the effect of steroids
  JOURNAL   J Endocrinol 72 (2), 153-161 (1977)
   PUBMED   15040
REFERENCE   10 (bases 1 to 1862)
  AUTHORS   Sanghavi,P. and Koenig,H.
  TITLE     Autophagy-related changes of arylsulphatases A and B in rat liver
            lysosomes
  JOURNAL   Biochem J 155 (3), 725-728 (1976)
   PUBMED   8037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK482953.1, D49434.1, CF113828.1 and AI071950.1.
            
            On Oct 23, 2005 this sequence version replaced XM_345140.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D49434.1, BC168241.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-496               CK482953.1         1-496
            497-889             D49434.1           239-631
            890-1102            CF113828.1         58-270
            1103-1728           D49434.1           845-1470
            1729-1862           AI071950.1         18-151              c
FEATURES             Location/Qualifiers
     source          1..1862
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..1862
                     /gene="Arsb"
                     /note="arylsulfatase B"
                     /db_xref="GeneID:25227"
                     /db_xref="RGD:2158"
     exon            1..392
                     /gene="Arsb"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1682
                     /gene="Arsb"
                     /EC_number="3.1.6.12"
                     /note="ASB; G4S; N-acetylgalactosamine-4-sulfatase;
                     Arylsulfatase B (MPS VI)"
                     /codon_start=1
                     /product="arylsulfatase B precursor"
                     /protein_id="NP_254278.1"
                     /db_xref="GeneID:25227"
                     /db_xref="RGD:2158"
                     /translation="MGELSGCTGGSRAGGPGPRLPLLLLLLLWPARASDAAPPPHVVF
                     VLADDLGWNDLGFHGSVIRTPHLDALAAGGVVLDNYYVQPLCTPSRSQLLTGRYQIHM
                     GLQHYLIMTCQPNCVPLDEKLLPQLLKDAGYATHMVGKWHLGMYRKECLPTRRGFDTY
                     FGYLLGSEDYYTHEACAPIECLNGTRCALDLRDGEEPAKEYTDIYSTNIFTKRATTLI
                     ANHPPEKPLFLYLAFQSVHDPLQVPEEYMEPYDFIQDKHRRIYAGMVSLLDEAVGNVT
                     KALKSRGLWNNTVLIFSTDNGGQTRSGGNNWPLRGRKGTLWEGGIRGAGFVASPLLKQ
                     KGVKSRELMHITDWLPTLVNLAGGSTHGTKPLDGFDVWETISEGSPSPRVELLLNIDP
                     DFFDGLPCPGKNTTPEKNDSFPLEHSAFNTSIHAGIRYKNWKLLTGYPGCGYWFPPPS
                     QSNISEVPSVDSPTKTLWLFDINRDPEERHDVSREHPHIVQNLLSRLQYYHEHSVPSY
                     FPPLDPRCDPKGTGVWSPWM"
     exon            393..579
                     /gene="Arsb"
                     /inference="alignment:Splign:2.1.0"
     exon            580..770
                     /gene="Arsb"
                     /inference="alignment:Splign:2.1.0"
     exon            771..978
                     /gene="Arsb"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1222
                     /gene="Arsb"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1293
                     /gene="Arsb"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1416
                     /gene="Arsb"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1862
                     /gene="Arsb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctaggtga atgtagtctt gcagggggtg cccgggcgct cagttcccga ttctgccggg
       61 ggcgcgggca gctcaggctc ctcaggctgc taaggatggg cgagctgagc ggatgcaccg
      121 gcgggagccg agctggaggt ccggggccgc ggctgccact gttgctgctg ctgctgctgt
      181 ggcccgcccg ggcctccgac gccgccccgc cgccccatgt ggtcttcgtg ctggcggacg
      241 acctgggctg gaacgacttg ggtttccacg gctcggtcat ccgcacgccg cacctggatg
      301 cgctggcggc cggcggcgtg gtcctggaca actactacgt gcagccgctg tgcacgccct
      361 cgcggagcca gctgctcacc ggccgctatc agatccatat gggcttacag cattacctca
      421 tcatgacctg tcagcccaac tgtgttccgc tagacgaaaa actcctgccc cagcttttaa
      481 aggacgcagg ctatgctacg catatggtcg gaaaatggca cctgggaatg taccggaagg
      541 aatgcctgcc aacccgcaga ggattcgata cgtacttcgg atacctccta ggcagtgaag
      601 actactacac ccacgaggcc tgtgcaccga ttgagtgtct gaacggtacc cgctgtgcgc
      661 ttgatctccg agatggcgaa gaacctgcaa aagagtatac agatatttac tcaacaaaca
      721 tatttaccaa aagggctaca accctcatag ctaaccaccc ccccgagaaa ccactgttcc
      781 tctaccttgc tttccagtct gtccacgatc ccctgcaggt ccccgaggag tacatggagc
      841 catatgactt catccaagac aagcacagac gtatttatgc agggatggta tccctcctgg
      901 acgaagcagt ggggaatgtc accaaagcct tgaaaagccg agggctctgg aacaacacgg
      961 tcctcatctt ctccacagac aacggcgggc agactaggtc tggaggcaac aactggccac
     1021 ttcgaggaag gaaagggacc ctgtgggaag gtggcatccg aggagcaggt ttcgtggcaa
     1081 gccccttgct gaaacagaaa ggtgtgaaga gccgggagct catgcacatc accgattggc
     1141 ttccaacgct ggtgaatctg gctgggggaa gcacccatgg aaccaaacct ctggatggct
     1201 tcgacgtgtg ggaaacaatc agtgaaggaa gcccatcccc aagagtggag ctgctactta
     1261 acatcgatcc agactttttc gatggcttac catgtcctgg caagaacacg actccagaaa
     1321 agaacgattc ttttccttta gaacattctg cctttaacac atctatccat gctgggatca
     1381 gatacaaaaa ctggaaactc ctcacgggct acccaggctg tggttactgg ttcccgccac
     1441 cgtctcagtc caacatctct gaggtacctt cagtggactc accaaccaag actctctggc
     1501 tctttgacat caatcgggac cctgaagaaa gacatgacgt gtcccgggaa catccccaca
     1561 tcgtccagaa ccttctttcc cgcctacagt actaccatga acattctgtg ccttcttact
     1621 tcccaccttt ggacccccgc tgtgatccca agggtaccgg tgtatggagc ccctggatgt
     1681 agggctcagg ggaggtgggg ctggagtaca tttctgtgca ggctagccct caggcccata
     1741 ctctcctggc ttctccatca tcccccaccc tgtcacctgg ccctcacgct gtataaccca
     1801 ctgagggagt ccaatttcaa cccacagtac atttttaaag ccagtaaaat ctggaaggat
     1861 cc
//
