LOCUS       NM_001034933            2998 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus arylsulfatase A (Arsa), mRNA.
ACCESSION   NM_001034933 XM_235566
VERSION     NM_001034933.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2998)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 2998)
  AUTHORS   Jean,S., Kasinathan,C., Buyske,S. and Manowitz,P.
  TITLE     Ethanol decreases rat hepatic arylsulfatase A activity levels
  JOURNAL   Alcohol Clin Exp Res 30 (11), 1950-1955 (2006)
   PUBMED   17067361
REFERENCE   3  (bases 1 to 2998)
  AUTHORS   Sardiello,M., Annunziata,I., Roma,G. and Ballabio,A.
  TITLE     Sulfatases and sulfatase modifying factors: an exclusive and
            promiscuous relationship
  JOURNAL   Hum Mol Genet 14 (21), 3203-3217 (2005)
   PUBMED   16174644
REFERENCE   4  (bases 1 to 2998)
  AUTHORS   Zito,E., Fraldi,A., Pepe,S., Annunziata,I., Kobinger,G., Di
            Natale,P., Ballabio,A. and Cosma,M.P.
  TITLE     Sulphatase activities are regulated by the interaction of
            sulphatase-modifying factor 1 with SUMF2
  JOURNAL   EMBO Rep 6 (7), 655-660 (2005)
   PUBMED   15962010
  REMARK    Erratum:[EMBO Rep. 2016 Dec;17 (12 ):1901. PMID: 27909074]
REFERENCE   5  (bases 1 to 2998)
  AUTHORS   Ngernsoungnern,A., Weerachatyanukul,W., Saewu,A.,
            Thitilertdecha,S., Sobhon,P. and Sretarugsa,P.
  TITLE     Rat sperm AS-A: subcellular localization in testis and epididymis
            and surface distribution in epididymal sperm
  JOURNAL   Cell Tissue Res 318 (2), 353-363 (2004)
   PUBMED   15503159
REFERENCE   6  (bases 1 to 2998)
  AUTHORS   Wojczyk,B., Hoja,D. and Litynska,A.
  TITLE     Purification of rat liver arylsulfatase A and its
            microheterogeneity assayed by crossed
            affinity-immunoelectrophoresis
  JOURNAL   Acta Biochim Pol 39 (4), 355-367 (1992)
   PUBMED   1363453
REFERENCE   7  (bases 1 to 2998)
  AUTHORS   van der Pal,R.H., Klein,W., van Golde,L.M. and Lopes-Cardozo,M.
  TITLE     Developmental profiles of arylsulfatases A and B in rat cerebral
            cortex and spinal cord
  JOURNAL   Biochim Biophys Acta 1081 (3), 315-320 (1991)
   PUBMED   1671824
REFERENCE   8  (bases 1 to 2998)
  AUTHORS   Zachariah,E. and Moudgal,N.R.
  TITLE     Enzymic changes in the cervix of the rat and hamster during the
            oestrous cycle and the effect of steroids
  JOURNAL   J Endocrinol 72 (2), 153-161 (1977)
   PUBMED   15040
REFERENCE   9  (bases 1 to 2998)
  AUTHORS   Sanghavi,P. and Koenig,H.
  TITLE     Autophagy-related changes of arylsulphatases A and B in rat liver
            lysosomes
  JOURNAL   Biochem J 155 (3), 725-728 (1976)
   PUBMED   8037
REFERENCE   10 (bases 1 to 2998)
  AUTHORS   Srinivas,L. and Rao,P.B.
  TITLE     Studies on urinary arylsulphatase activity in vitamin A deficient
            rats
  JOURNAL   Int J Vitam Nutr Res 46 (1), 3-10 (1976)
   PUBMED   4403
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Oct 12, 2022 this sequence version replaced NM_001034933.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.10670.1,
                                           SRR26643297.26776.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-608               JAXUCZ010000007.1  122426364-122426971 c
            609-849             JAXUCZ010000007.1  122425993-122426233 c
            850-1068            JAXUCZ010000007.1  122425664-122425882 c
            1069-1238           JAXUCZ010000007.1  122425421-122425590 c
            1239-1363           JAXUCZ010000007.1  122425000-122425124 c
            1364-1491           JAXUCZ010000007.1  122424780-122424907 c
            1492-1594           JAXUCZ010000007.1  122424475-122424577 c
            1595-2998           JAXUCZ010000007.1  122422971-122424374 c
FEATURES             Location/Qualifiers
     source          1..2998
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2998
                     /gene="Arsa"
                     /note="arylsulfatase A"
                     /db_xref="GeneID:315222"
                     /db_xref="RGD:1310381"
     exon            1..608
                     /gene="Arsa"
                     /inference="alignment:Splign:2.1.0"
     CDS             391..1914
                     /gene="Arsa"
                     /EC_number="3.1.6.8"
                     /codon_start=1
                     /product="arylsulfatase A precursor"
                     /protein_id="NP_001030105.2"
                     /db_xref="GeneID:315222"
                     /db_xref="RGD:1310381"
                     /translation="MGALGTLVLALAAGLSTASPPNIMLIFADDLGYGDLGSYGHPSS
                     TTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGRLPVRSGMYPGVLGPSSQGGLPL
                     EEVTLAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLT
                     CFPPDITCSGGCDQGLVPIPLLANLTVEAQPPWLPGLEARYVSFSRDLMADAQRQGRP
                     FFLYYASHHTHYPQFSGQSFTKRSGRGPFGDSLMELDGAVGALMTAVGDLGLLGETLV
                     IFTADNGPELMRMSDGGCSGLLRCGKGTTFEGGVREPALVYWPGHITPGVTHELASSL
                     DLLPTLAALTGAPLPNITLDGVDISPLLLGTGKSPRNSVFFYPPFPDEIHGVFAVRNG
                     KYKAHFFTQGSAHSDTTPDPACHAANRLTAHEPPLLYDLSKDPGENYNLLDSTEEVSP
                     EALQALKHIELLKAEYDAAMTFSPSQIAKGEDPALQICCQPSCTPHPVCCHCPDSHS"
     exon            609..849
                     /gene="Arsa"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1068
                     /gene="Arsa"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1238
                     /gene="Arsa"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1363
                     /gene="Arsa"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1491
                     /gene="Arsa"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1594
                     /gene="Arsa"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..2998
                     /gene="Arsa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttccgaac cgccctcgtc ccatggcgcc ggagcctccc gggtcaatgt gaagtgacgc
       61 ctactcctga tcccaagtct gtgctggcac ctctgggtga acagggtcag atccccgcgc
      121 gagaagttaa agaagccctg gaccttaggg gctctgtgga gctacacccc agtccaccca
      181 cttccgagtt ctgacagatt cgctggagct tcagaaagtg gacctacaga cagacggagt
      241 atttgggtct gggagctcag gggaggagga gggctcgggt ccagggcctc aggtgggggc
      301 tggcctgggc gctcagggaa cgagcctgct ggaatcgccc tgccttccct accaagggtc
      361 tgaggacaca ggcctgtctg tatccctgcc atgggggccc tggggaccct cgttttggca
      421 ttggctgcag gcctgagcac tgctagccca cctaacatca tgctgatctt tgctgatgac
      481 ctgggctatg gggacctcgg ctcctatggg caccccagtt ctaccacccc caacttggat
      541 cagttggctg cagggggact acggttcaca gatttctatg tgcctgtgtc tctgtgcact
      601 ccgtctcggg ctgccctcct gactggccgg ctcccagttc gatcaggcat gtaccctgga
      661 gttctggggc ccagttccca agggggcctg cccttggagg aggtgacgtt ggccgaagtc
      721 ctggctgctc gaggctatct aacagggatg gctggcaagt ggcatcttgg agtagggcca
      781 gagggggcct tcctgccccc acatcagggc ttccatcgat tcctgggcat cccatattcc
      841 catgaccagg gtccctgtca gaacctgacc tgcttcccac cagacatcac ctgcagtggt
      901 ggctgtgacc aaggcctagt tcccatccca ctgctggcca acctgactgt ggaggcccag
      961 cccccttggc tgcctggact agaggcccgg tatgtgtctt tctcccgaga cctcatggcg
     1021 gatgcccagc gccagggccg accattcttc ctgtactacg cttcccacca cacccactac
     1081 cctcagttca gtggacagag cttcaccaag cgctcaggcc gtgggccctt tggggactcc
     1141 ttgatggagc tggatggagc tgtgggggcc ttgatgacag ctgtggggga cctaggtctg
     1201 ctgggagaga cactggtcat cttcactgca gataacggtc ctgaattgat gcgtatgtcc
     1261 gatggcggct gctccggcct cttgagatgt ggaaaaggaa caacttttga aggtggcgtc
     1321 cgggaacccg ccttggtcta ctggccaggt cacattactc ctggtgtcac ccacgagctg
     1381 gccagctctc tggacctgct gcccaccctg gcagcactga ccggggctcc gctgcccaat
     1441 atcaccttgg atggtgttga catcagcccc ttgctgctag gcacaggcaa gagcccacgg
     1501 aattctgtct tcttctaccc accgttccca gacgagatcc atggagtctt cgcggttcgg
     1561 aatgggaagt acaaggctca tttctttacc cagggctccg cccacagtga caccactcca
     1621 gatcctgcct gtcatgccgc caaccgtctg acagctcacg agcccccact gctctacgac
     1681 ttgtctaagg accctggtga gaactacaat cttttggata gtacagagga ggtctctcca
     1741 gaagctctcc aggctttgaa gcacattgag ctgctcaagg ccgagtatga tgcagctatg
     1801 accttcagcc ccagccagat agccaagggt gaggaccctg cccttcagat ctgctgtcag
     1861 ccgagctgca ctccccaccc agtctgctgc cactgcccag actcccactc ctgaggggac
     1921 tggagaaatc cctcaagggt agcccaggac ccctggccct gtcctgagcg tgtaacggtt
     1981 caccagaggg acaggggcaa gtgtgtagtt tgtatctggt aatgtaataa catcagctga
     2041 gacttgcggg cgtgctaatt catctagtcc ttgtggtaac tctgaagtca gtgctattct
     2101 gctgtgctac aaacaaggac gttgaagcgt agggaatctc gtggacctgt ccacgagagc
     2161 ttgaactagg ttttgaaccc aggcatccag gaactgaaac gtgttccacc ctgatgatct
     2221 gcacgtgtcc atggaccacg tcactgaggc gtgagcatgt ccattcacag aaactggtag
     2281 tgagtttcaa gtaccaggaa ctgtgaggga ggggtggcga gggcagaaag accctaaaga
     2341 tgccatgcct ctggaagaca ggttttcctc aagaagcact gttagaggcc ctggacctgg
     2401 ccaccgtggt tcttaaagaa atcagtcttc tggagttagg taataaactg atgattccag
     2461 gtagagttaa ggaactgagg accctgtgag attccaggaa ggaccattag cagctcctga
     2521 gaccgcctca cggggttttc ctttctccca aattccgcat ttctcttttg tgcgtccttc
     2581 agctccccca gtcctatcta accctctacc aaaaaagaaa aaacattgtc tacaaagtaa
     2641 tcttttaaaa acacctatca gggaccagta agatgactct gggggaaagt gcttaccgtg
     2701 caaacctggc aacttgagtc caatccccag aagcgcatat gaaaaagcca catctctaac
     2761 cccagcattc tcgggggaga caggaaaaag gcaggagaat tgtccagaat cttgcagacc
     2821 ggctacccta gcatatacag cacagtagat ataagagaga cccgccccaa cgagatagga
     2881 agagaaccag atcccccaaa ttgtgtcctg acctccgcat atgctctgtg gcccacacgt
     2941 ctcaacttac atacatcaca cacgcaagca acagtaataa taaatgtaaa aaaaaaaa
//
