LOCUS       NM_001007797            4055 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus arrestin domain containing 3 (Arrdc3), transcript
            variant 1, mRNA.
ACCESSION   NM_001007797 XM_226639
VERSION     NM_001007797.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4055)
  AUTHORS   Zhang,B., Wu,F., Li,P. and Li,H.
  TITLE     ARRDC3 inhibits liver fibrosis and epithelial-to-mesenchymal
            transition via the ITGB4/PI3K/Akt signaling pathway
  JOURNAL   Immunopharmacol Immunotoxicol 45 (2), 160-171 (2023)
   PUBMED   36154540
  REMARK    GeneRIF: ARRDC3 inhibits liver fibrosis and
            epithelial-to-mesenchymal transition via the ITGB4/PI3K/Akt
            signaling pathway.
REFERENCE   2  (bases 1 to 4055)
  AUTHORS   Shea,F.F., Rowell,J.L., Li,Y., Chang,T.H. and Alvarez,C.E.
  TITLE     Mammalian alpha arrestins link activated seven transmembrane
            receptors to Nedd4 family e3 ubiquitin ligases and interact with
            beta arrestins
  JOURNAL   PLoS One 7 (12), e50557 (2012)
   PUBMED   23236378
REFERENCE   3  (bases 1 to 4055)
  AUTHORS   Patwari,P., Emilsson,V., Schadt,E.E., Chutkow,W.A., Lee,S.,
            Marsili,A., Zhang,Y., Dobrin,R., Cohen,D.E., Larsen,P.R.,
            Zavacki,A.M., Fong,L.G., Young,S.G. and Lee,R.T.
  TITLE     The arrestin domain-containing 3 protein regulates body mass and
            energy expenditure
  JOURNAL   Cell Metab 14 (5), 671-683 (2011)
   PUBMED   21982743
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Oct 5, 2022 this sequence version replaced NM_001007797.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1751082.1,
                                           SRR22582416.549055.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-516               JAXUCZ010000002.1  12873202-12873717
            517-598             JAXUCZ010000002.1  12877152-12877233
            599-746             JAXUCZ010000002.1  12878748-12878895
            747-849             JAXUCZ010000002.1  12879798-12879900
            850-1106            JAXUCZ010000002.1  12880243-12880499
            1107-1269           JAXUCZ010000002.1  12880823-12880985
            1270-1424           JAXUCZ010000002.1  12881256-12881410
            1425-4055           JAXUCZ010000002.1  12883086-12885716
FEATURES             Location/Qualifiers
     source          1..4055
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q11"
     gene            1..4055
                     /gene="Arrdc3"
                     /gene_synonym="LRRGT00048"
                     /note="arrestin domain containing 3"
                     /db_xref="GeneID:309945"
                     /db_xref="RGD:1359478"
     exon            1..516
                     /gene="Arrdc3"
                     /gene_synonym="LRRGT00048"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..1481
                     /gene="Arrdc3"
                     /gene_synonym="LRRGT00048"
                     /note="liver regeneration-related protein LRRG00048"
                     /codon_start=1
                     /product="arrestin domain-containing protein 3"
                     /protein_id="NP_001007798.1"
                     /db_xref="GeneID:309945"
                     /db_xref="RGD:1359478"
                     /translation="MVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRV
                     KSLKIHARGHAKVRWTESRNAGSNTAYTQNYTEEVEYFNHKDILIGHERDDDNCEEGF
                     STIHSGRHEYAFSFELPQTPLATSFEGRHGSVRYWVKAELHRPWLLPVKLKKEFTVFE
                     HIDINTPSLLSPQAGTKEKTLCCWFCTSGPISLSAKIERKGYTPGESIQIFAEIENCS
                     SRMVVPKAAIYQTQAFYAKGKMKEVKQLVANLRGESLSSGKTETWDGKLLKIPPVSPS
                     ILDCSIIRVEYSLMVYVDIPGAMDLLLSLPLVIGTIPLHPFGSRTSSVSSQCSMNMNW
                     LGLSLPERPEAPPSYAEVVTEEQRRNNLAPVSACDDFERALQGPLFAYIQEFRFLPPP
                     LYSEIDPNPDQSSEDRPSCPSR"
     exon            517..598
                     /gene="Arrdc3"
                     /gene_synonym="LRRGT00048"
                     /inference="alignment:Splign:2.1.0"
     exon            599..746
                     /gene="Arrdc3"
                     /gene_synonym="LRRGT00048"
                     /inference="alignment:Splign:2.1.0"
     exon            747..849
                     /gene="Arrdc3"
                     /gene_synonym="LRRGT00048"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1106
                     /gene="Arrdc3"
                     /gene_synonym="LRRGT00048"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1269
                     /gene="Arrdc3"
                     /gene_synonym="LRRGT00048"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1424
                     /gene="Arrdc3"
                     /gene_synonym="LRRGT00048"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..4055
                     /gene="Arrdc3"
                     /gene_synonym="LRRGT00048"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctttgtaa ggagaccact gagacgagca ggagcgtgga gcagcggctt ctctgctgcc
       61 ctgacttttt aagaaatctc aatgaactat ttgtagacaa tcactgatcc tgcctgcaag
      121 attttttttt cttttgcacg gcaaagacac cgatcagtgt taagtgaaga tcacatctta
      181 tatgcgatct tgactttttt tggtcttatt atatttttat agattttgtt ataatcatgg
      241 tgctgggaaa ggtaaagagt ttgacaataa gctttgactg tcttaatgac agtaatgtcc
      301 ccgtgtattc tagcggggac actgtctcag gaagggtaaa tttagaagtt actggggaaa
      361 tcagagtaaa atctcttaaa attcatgcaa gaggacatgc gaaagtacgc tggactgaat
      421 caagaaacgc cggctccaat actgcctata cacagaatta cactgaagaa gtagaatatt
      481 tcaaccataa agacatctta attgggcacg aaagagatga tgataattgt gaagaaggct
      541 tcagcactat tcattcagga cggcatgaat atgcatttag cttcgagctt ccacagacac
      601 cacttgctac ctcatttgaa ggccgacatg gcagtgtgcg ctattgggtg aaggccgaat
      661 tgcataggcc ttggcttcta ccagtaaaat taaagaagga atttacagtc tttgagcaca
      721 tagatatcaa cactccttca ttactgtcac cccaagcagg cacaaaagaa aagacactct
      781 gttgctggtt ctgcacctca ggcccaatat ccttaagtgc caaaattgag aggaagggct
      841 acaccccagg tgaatcaata cagatatttg ctgagattga gaactgctct tcccgaatgg
      901 tagtgccaaa ggcagccatt taccaaacgc aggccttcta cgccaaaggg aaaatgaagg
      961 aagtaaaaca gctggtggca aacttacgtg gggaatcctt atcatctggg aagacggaga
     1021 cgtgggacgg caagctgctc aagatcccac cagtttcacc ctccatcctc gactgtagta
     1081 taatccgtgt ggagtattcg ctaatggtat acgtggatat tcccggggcc atggatttgc
     1141 ttctcagttt gccactagtc attgggacca tccctctaca tccatttggg agcagaacct
     1201 caagtgtgag cagtcagtgt agcatgaata tgaactggct cggtctatcc cttcctgaaa
     1261 gacctgaagc accacccagt tatgcagagg ttgtaacgga ggaacagaga cggaataatc
     1321 ttgcaccagt gagtgcttgt gatgattttg agagagctct tcaaggacca ctgttcgcat
     1381 atatccagga gttccggttc ctgcctccac ctctctattc agagattgat ccaaatcctg
     1441 atcagtcatc cgaggacaga ccatcatgcc cctctcgctg aaggaacact tgattgaatc
     1501 aagttgatgt gggttccgaa ctgtatctct tccggctgag gacagagaag tatcttggag
     1561 acacgttttc agaggaagtg gaattgcttt tgcccagaca aatggcaaac acgtgaaaca
     1621 accagtgatc atgctttaga atcctacagc atcattctgg gctgctccaa cacgcttgaa
     1681 gatctgagct ttccttaaaa ctaagggcag tcttcttagc ctgtgatcat gtgtcaagac
     1741 accgttgcaa agaaggatat tgtccttcct atttgaaaat ttgcacatgc tcaatgctta
     1801 cattgtgcag ttcaatgtca ctacagcttt tttccattta tgccagactc ttgatactct
     1861 taaaaactat gtggtcagca caacatggaa caaaagaaag ctttgaaaaa ctttgacatt
     1921 aaaaaacaaa aacgcactga caggtttgtt ttttgttttt gtttttgttt tttaagttaa
     1981 tgtagcctgg actctacctg cgtatgcaca tgctcagaat tgtcctacta ggctgaccat
     2041 gtatcacctc ttcagcttgg atcctattgt ggatttattt acaaacatca aatgccttca
     2101 agccaatcct tttgctgtat gttttgcagc ctactgtagt agataagcaa cagatacgag
     2161 gagaaaagag acgggaggag gaggccgccg agagactttg tagggctgtt gtgtgggttc
     2221 tatgagagtg ttgcctttct attgacagca gagcagcatt gtgttactga ctgcctacca
     2281 tcactcaatc tcaggtgaat gcatcacttg ccaaactgtc ggaatgccgt ctgtttcgtt
     2341 gcactgttac gttcttgttc ttgttcttgt cgttcttgtt atttggttgg ctttttggag
     2401 agggaacttc ggaaatggga catacacaaa actgataacc cacccacatt ccccttttta
     2461 ttattaaata taagaagaaa caaagctcag agtggagaaa gacagtaggg caagcaccag
     2521 cggagagtca agggctgttg ctctgaggaa gtatttttat tattttaaga atgagtggga
     2581 actgtccagt cactagggaa gggaggggaa agtgcattta tttttataca gagttactta
     2641 attacctcca aaacacatat gttggaaatc atttttgctg atgcaaagta cttcaataag
     2701 ccagaatatg tacatcaagg taatgatggg agacgctcca tttttacatt gctcacgttt
     2761 gagagaacga aatcccaaat ttgtttccac agtgaacaca ctttataagt agaaatacca
     2821 gaatgttttc tgggataaac agctttagtt tgtacatgta tagaatattg tttttcaaca
     2881 atttttttct atcatctaaa agaggaattg ataggtctct agctttgagt atatgtagat
     2941 caacacatca ataaattatt tttaaagata acttatggct atattgtaac catatactaa
     3001 cattcatgaa acaactaaaa ccccatcttc tcaaagtaca aagtagcgtg attttttttt
     3061 ttagagttca cttgtgtttc tagcagcacc agcatctctg atgttgcaac atatgtgtga
     3121 gatgggtgtt acatctgtcc accttgccat ctgacccaca gctcgagtga ctgagaatta
     3181 tagtaactct ggcctggtgc ttgacctggt taaatactgt cttaaagctt catacaaaat
     3241 aggcttttcc ataagtggcc tttaagaaaa catggaagat aattcatgtt tgaaataatg
     3301 ccgacagggt gaagaaagcc cattgtaaaa atggatcacg ttttaagtga ttcagttaaa
     3361 gggttatgtg ctcccatagc aaacaatact agataataag gagttggggg tgaattattt
     3421 ttttaattgt taaatcattt tgtgaatgtc ccccctcaga agaagctgat gggatatttg
     3481 gcataaaggg catttggtgg atttgttttt gttgggaggg attgtgtaaa aacacctgac
     3541 tctgtgttat gtctgactag ggaacaattg ttggtgtgca tggcctcggg gcgctcacta
     3601 ccatgttcta caaaatactt tattaagcaa gaatgaccaa tattctgata attggcattg
     3661 gtgacaaaat tattttaaga gttggtgaag taaagtttta tttttcccat taagtatttc
     3721 tttactcttt tgaggcatta cactattcta aatattggtc aattcctgac ataacatctg
     3781 agggtcacag ttgcgctcta gtattcaagc tatcttgaat tcctaatttt tcatttagga
     3841 aaagtaaaat ccaaaatgtt tgcgaaacaa agtgcaatat taaatgtttg ctttatagat
     3901 tatattctat ggctgttgta atcttttatt tggtgctgaa tatgtccttg taggctctgt
     3961 tttaagaaaa ccatgtggga aatgatttga cttttcctat tgctcttcct tgtggaaaat
     4021 aaaagtgttt tttttttttt cttttttttg taaaa
//
