LOCUS       NM_001107303            2314 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus arrestin domain containing 2 (Arrdc2), mRNA.
ACCESSION   NM_001107303 XM_001070067 XM_224720
VERSION     NM_001107303.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2314)
  AUTHORS   Shea,F.F., Rowell,J.L., Li,Y., Chang,T.H. and Alvarez,C.E.
  TITLE     Mammalian alpha arrestins link activated seven transmembrane
            receptors to Nedd4 family e3 ubiquitin ligases and interact with
            beta arrestins
  JOURNAL   PLoS One 7 (12), e50557 (2012)
   PUBMED   23236378
REFERENCE   2  (bases 1 to 2314)
  AUTHORS   Nichols,C.D. and Sanders-Bush,E.
  TITLE     Molecular genetic responses to lysergic acid diethylamide include
            transcriptional activation of MAP kinase phosphatase-1, C/EBP-beta
            and ILAD-1, a novel gene with homology to arrestins
  JOURNAL   J Neurochem 90 (3), 576-584 (2004)
   PUBMED   15255935
  REMARK    GeneRIF: data suggest that various splice isoforms of ILAD-1
            respond differently at the transcriptional level to LSD
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Apr 8, 2021 this sequence version replaced NM_001107303.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.58471.1,
                                           SRR26643429.50257.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-618               JAXUCZ010000016.1  18635883-18636500
            619-685             JAXUCZ010000016.1  18636583-18636649
            686-833             JAXUCZ010000016.1  18636794-18636941
            834-936             JAXUCZ010000016.1  18637647-18637749
            937-1193            JAXUCZ010000016.1  18637828-18638084
            1194-1356           JAXUCZ010000016.1  18638172-18638334
            1357-1514           JAXUCZ010000016.1  18638828-18638985
            1515-2314           JAXUCZ010000016.1  18639216-18640015
FEATURES             Location/Qualifiers
     source          1..2314
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2314
                     /gene="Arrdc2"
                     /gene_synonym="ILAD1"
                     /note="arrestin domain containing 2"
                     /db_xref="GeneID:306344"
                     /db_xref="RGD:1309659"
     exon            1..618
                     /gene="Arrdc2"
                     /gene_synonym="ILAD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..1568
                     /gene="Arrdc2"
                     /gene_synonym="ILAD1"
                     /note="induced by lysergic acid diethylamide-1"
                     /codon_start=1
                     /product="arrestin domain-containing protein 2"
                     /protein_id="NP_001100773.2"
                     /db_xref="GeneID:306344"
                     /db_xref="RGD:1309659"
                     /translation="MLFDKVKAFVVELDGTRAGTEPVFHGGQAVAGRVLLELAGAARV
                     GALRLRARGRARAHWTESRSAGSSTAYTQSYSERVEVVNHRATLLAPDSGDIVMLPAG
                     RHEFPFSFQLPISLVTSFEGKHGSVRYSIKATLHRPWVPARRARKVFTVIEPVDINTP
                     ALLEPQAGAREKVARSWYCTRGLVSLSAKIDRKGYTPGEVIPIFAEIDNGSTRAVQPR
                     AALVQTQTFMARGARKQKCAVVASVDGEPVGPGRRALWPGRALRIPPVGPSILHCRVL
                     SVDYSLKVCVDIPGSSKLLLELPLVIGTVPLHPLGSRSASVGSRASFLQDWGLCALME
                     RPEAPPEYSEVVRESPQVAASQGLFSFLHDPDVTTEGPYFACLQEFRYRPPPLYSEED
                     PNPPSEAARPRCMTC"
     exon            619..685
                     /gene="Arrdc2"
                     /gene_synonym="ILAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            686..833
                     /gene="Arrdc2"
                     /gene_synonym="ILAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..936
                     /gene="Arrdc2"
                     /gene_synonym="ILAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1193
                     /gene="Arrdc2"
                     /gene_synonym="ILAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1356
                     /gene="Arrdc2"
                     /gene_synonym="ILAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1514
                     /gene="Arrdc2"
                     /gene_synonym="ILAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..2314
                     /gene="Arrdc2"
                     /gene_synonym="ILAD1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtcttttc ctgaaggtgt ggctttctcc tcaggccatc ccttcgccgc actattggcc
       61 tagtcttttc tgtgggactc agcattctcc ctctggcccc gcccctactg tcctgtttac
      121 agagtctctt ccggtaggcg cggtcttttc cccaggcccc gccctcgccc tgttgtataa
      181 gagcgacgct ggcgcgggtc accagtggtc ttcggtcctg ctgtccggtg tgtacgtgta
      241 cgtagttcga gcctgctgcg ctcgtagtct atctagatag ctcttcctca tcgcgggttc
      301 gagcacctgg tcggtctgtt tttgggttcg cgtccgtcac ctcaatgctg ttcgataagg
      361 tgaaggcgtt cgtggtagag ctggatggga cacgcgcggg caccgagccc gtgttccacg
      421 gaggccaggc agtggcgggc cgggtattgt tggagctggc gggcgcggca cgagtgggcg
      481 cgctcaggct gcgcgctcgg gggcgcgcgc gcgcgcactg gacagagtcg cgcagcgcag
      541 gctccagcac tgcttatact cagagttaca gcgagcgcgt ggaagtcgtg aaccaccgcg
      601 ccacgctgct cgcgccagac tcgggggaca tcgtcatgct tcccgctgga cgccacgagt
      661 ttcccttcag cttccagctg cctatctccc tggtgacatc cttcgagggc aaacacggca
      721 gcgtccgcta ttccatcaaa gccaccctgc accggccatg ggtccctgca cgccgcgccc
      781 ggaaggtgtt cactgtcatt gaacccgtgg acataaacac acctgccctg ctggaacccc
      841 aggctggagc ccgggagaaa gtggcacgat cctggtactg cacccgtggc ctggtgtctc
      901 tctcagccaa gattgaccgt aaaggctaca ctccaggtga agtcatccct atctttgcgg
      961 agattgacaa tggttccacg agagctgtgc agccccgagc cgccctagta cagacacaga
     1021 ccttcatggc ccgaggtgcc cgcaagcaga aatgtgctgt ggtggccagc gtggacgggg
     1081 agcctgtggg ccctggtcgc cgtgcgctct ggcctggccg tgcgctgcgt atccccccag
     1141 tgggcccgtc catcttgcac tgccgggtac tcagtgtgga ctactccctc aaggtctgcg
     1201 tggacatccc aggctcttcc aagctgctgc tggagctgcc gctggtcatc ggcacggtcc
     1261 ccctgcatcc tctgggcagc cgctccgcta gcgtgggcag ccgtgccagc ttcctgcaag
     1321 actggggcct gtgtgccctg atggagcggc cagaggcccc tcctgagtac tcagaggtgg
     1381 tgagggagag cccgcaggta gcggcatcac agggcctctt ctccttcctg catgaccctg
     1441 atgtgaccac agaagggccc tactttgcct gtctccagga gttccgctac cgcccgcctc
     1501 ctctgtactc ggaggaggat cctaacccac cctcggaggc tgcaaggcca cgctgcatga
     1561 cctgctgatc cacgggctga cacctcggta acggttcaca tgtctttggc cactgcagtc
     1621 ctgccacctg ctttgggaac acagggttag atgaggtctt gtgtcttcca atgtcgtaca
     1681 ggacttagaa gcagcacatg gcttccgtgg acaggtcaaa gcttctggtt ctctgcattg
     1741 acccaccagg agccagcagt gctagggaga gagatgagtc taggggtgga cacttcagcc
     1801 tcatgggacc agaagccgct agaagtccag agggaggcag aaggcttcca aagggcattt
     1861 cagtggaggc tctatcgtcc gctcagcacg caggcagcac agagccaatg gtcagagcag
     1921 acagcgctta ctccttcctg gggttgggag cccaggcatt taagtgcctt agacatggcc
     1981 tccctgtgag gttagcagga cagagggcct cacggacaga cacaaagggg aagtcggtgg
     2041 gacctgaggg tccaggagtt caacttttga ggaccaagga ctggtggtcc agatgagccc
     2101 agaactgtgg ttgtgatctg ccatccatgt tcagaacctc aagcctccct cagggatcaa
     2161 gatccagaca aagacatcgc acggaggaca ggcgactggg ggcagctggg cacccccatc
     2221 ccccacccta gatctggccg ggacttgcca ttttcacggt ctgaagaatg gaccactttt
     2281 gtatattaat aaataaataa acaaatgtgg gagg
//
