LOCUS       NM_012911               1723 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus arrestin, beta 2 (Arrb2), mRNA.
ACCESSION   NM_012911 XM_346400
VERSION     NM_012911.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1723)
  AUTHORS   Meinhardt,M.W., Giannone,F., Hirth,N., Bartsch,D., Spampinato,S.M.,
            Kelsch,W., Spanagel,R., Sommer,W.H. and Hansson,A.C.
  TITLE     Disrupted circadian expression of beta-arrestin 2 affects
            reward-related micro-opioid receptor function in alcohol dependence
  JOURNAL   J Neurochem 160 (4), 454-468 (2022)
   PUBMED   34919270
REFERENCE   2  (bases 1 to 1723)
  AUTHORS   Bae,W.Y., Choi,J.S., Nam,S. and Jeong,J.W.
  TITLE     beta-arrestin 2 stimulates degradation of HIF-1alpha and modulates
            tumor progression of glioblastoma
  JOURNAL   Cell Death Differ 28 (11), 3092-3104 (2021)
   PUBMED   34007068
REFERENCE   3  (bases 1 to 1723)
  AUTHORS   Karavidha,K.K., Burmeister,M. and Greenwald,M.K.
  TITLE     beta-Arrestin 2 (ARRB2) Polymorphism is Associated With Adverse
            Consequences of Chronic Heroin Use
  JOURNAL   Am J Addict 30 (4), 351-357 (2021)
   PUBMED   33783060
REFERENCE   4  (bases 1 to 1723)
  AUTHORS   Sun,Y.Y., Wu,D.Q., Yin,N.N., Yang,L., Chen,X., Li,H.D., Li,X.F.,
            Huang,C., Meng,X.M., Wang,H. and Li,J.
  TITLE     Arrb2 causes hepatic lipid metabolism disorder via AMPK pathway
            based on metabolomics in alcoholic fatty liver
  JOURNAL   Clin Sci (Lond) 135 (10), 1213-1232 (2021)
   PUBMED   33871024
REFERENCE   5  (bases 1 to 1723)
  AUTHORS   Sadek,K., Abouzed,T., Nasr,S. and Shoukry,M.
  TITLE     Licochalcone B Ameliorates Liver Cancer via Targeting of Apoptotic
            Genes, DNA Repair Systems, and Cell Cycle Control
  JOURNAL   Iran J Pharm Res 19 (4), 372-386 (2020)
   PUBMED   33841550
REFERENCE   6  (bases 1 to 1723)
  AUTHORS   Bohn,L.M., Lefkowitz,R.J., Gainetdinov,R.R., Peppel,K., Caron,M.G.
            and Lin,F.T.
  TITLE     Enhanced morphine analgesia in mice lacking beta-arrestin 2
  JOURNAL   Science 286 (5449), 2495-2498 (1999)
   PUBMED   10617462
REFERENCE   7  (bases 1 to 1723)
  AUTHORS   Komori,N., Cain,S.D., Roch,J.M., Miller,K.E. and Matsumoto,H.
  TITLE     Differential expression of alternative splice variants of
            beta-arrestin-1 and -2 in rat central nervous system and peripheral
            tissues
  JOURNAL   Eur J Neurosci 10 (8), 2607-2616 (1998)
   PUBMED   9767391
REFERENCE   8  (bases 1 to 1723)
  AUTHORS   Craft,C.M., Whitmore,D.H. and Wiechmann,A.F.
  TITLE     Cone arrestin identified by targeting expression of a functional
            family
  JOURNAL   J Biol Chem 269 (6), 4613-4619 (1994)
   PUBMED   8308033
  REMARK    Erratum:[J Biol Chem 1994 Jul 1;269(26):17756]
REFERENCE   9  (bases 1 to 1723)
  AUTHORS   Attramadal,H., Arriza,J.L., Aoki,C., Dawson,T.M., Codina,J.,
            Kwatra,M.M., Snyder,S.H., Caron,M.G. and Lefkowitz,R.J.
  TITLE     Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene
            family
  JOURNAL   J Biol Chem 267 (25), 17882-17890 (1992)
   PUBMED   1517224
REFERENCE   10 (bases 1 to 1723)
  AUTHORS   Horton,J.E., Koopman,W.J., Farrar,J.J., Fuller-Bonar,J. and
            Mergenhagen,S.E.
  TITLE     Partial purification of a bone-resorbing factor elaborated from
            human allogeneic cultures
  JOURNAL   Cell Immunol 43 (1), 1-10 (1979)
   PUBMED   157224
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            [WARNING] On May 3, 2024 this sequence was replaced by NM_012911.3.
            
            On Nov 20, 2020 this sequence version replaced NM_012911.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087578.1, M91590.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               JAXUCZ010000010.1  55645602-55645702
            102-132             JAXUCZ010000010.1  55648433-55648463
            133-193             JAXUCZ010000010.1  55649076-55649136
            194-238             JAXUCZ010000010.1  55649241-55649285
            239-435             JAXUCZ010000010.1  55649472-55649668
            436-495             JAXUCZ010000010.1  55649768-55649827
            496-563             JAXUCZ010000010.1  55650213-55650280
            564-702             JAXUCZ010000010.1  55650416-55650554
            703-787             JAXUCZ010000010.1  55650783-55650867
            788-860             JAXUCZ010000010.1  55651165-55651237
            861-998             JAXUCZ010000010.1  55651481-55651618
            999-1082            JAXUCZ010000010.1  55652323-55652406
            1083-1162           JAXUCZ010000010.1  55652504-55652583
            1163-1217           JAXUCZ010000010.1  55652690-55652744
            1218-1723           JAXUCZ010000010.1  55652980-55653485
FEATURES             Location/Qualifiers
     source          1..1723
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1723
                     /gene="Arrb2"
                     /gene_synonym="BARRES"
                     /note="arrestin, beta 2"
                     /db_xref="GeneID:25388"
                     /db_xref="RGD:2157"
     exon            1..101
                     /gene="Arrb2"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1311
                     /gene="Arrb2"
                     /gene_synonym="BARRES"
                     /codon_start=1
                     /product="beta-arrestin-2"
                     /protein_id="NP_037043.1"
                     /db_xref="GeneID:25388"
                     /db_xref="RGD:2157"
                     /translation="MGEKPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLV
                     DPDYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLFIATYQAFPPMPNPPRPPTRLQ
                     DRLLKKLGQHAHPFFFTIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSIEEKSH
                     KRNSVRLIIRKVQFAPETPGPQPSAETTRHFLMSDRRSLHLEASLDKELYYHGEPLNV
                     NVHVTNNSAKTVKKIRVSVRQYADICLFSTAQYKCPVAQLEQDDQVSPSSTFCKVYTI
                     TPLLSDNREKRGLALDGQLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRG
                     GDVSVELPFVLMHPKPHDHITLPRPQSAPREIDIPVDTNLIEFDTNYATDDDIVFEDF
                     ARLRLKGMKDDDCDDQFC"
     exon            102..132
                     /gene="Arrb2"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            133..193
                     /gene="Arrb2"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            194..238
                     /gene="Arrb2"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            239..435
                     /gene="Arrb2"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            436..495
                     /gene="Arrb2"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            496..563
                     /gene="Arrb2"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            564..702
                     /gene="Arrb2"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            703..787
                     /gene="Arrb2"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            788..860
                     /gene="Arrb2"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            861..998
                     /gene="Arrb2"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1082
                     /gene="Arrb2"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1162
                     /gene="Arrb2"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1217
                     /gene="Arrb2"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1723
                     /gene="Arrb2"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggacctgg cagcgggtga gaaggctgcg agcgagccgc gaacccggcg ggtggagggc
       61 ggcgagcgcg cgcgcaccat gggtgaaaaa cccgggacca gggtcttcaa gaagtcgagc
      121 cctaactgca agctcaccgt gtacttgggc aagcgtgact ttgtggatca cttggacaaa
      181 gtggatcctg tcgatggtgt ggtgcttgtg gatcctgact acttgaagga ccggaaagtg
      241 tttgtgaccc tcacctgtgc cttccgctat ggccgagaag acctggatgt actgggcctg
      301 tctttccgca aagatctgtt catcgccacc taccaggcct tcccccccat gcccaaccca
      361 cctcggcccc ccacccgcct acaggaccga ctgctgaaga agttgggcca gcatgcccac
      421 cccttttttt tcacaatacc ccagaatttg ccttgctccg tcacactgca gccaggaccg
      481 gaggacacag ggaaggcctg tggagtagac tttgagattc gagccttctg tgccaaatct
      541 atagaagaaa aaagccacaa aaggaactcc gtgcggctta tcatcagaaa ggtacagttt
      601 gctcctgaga cacccggccc ccagccatca gctgaaacca cacgccactt cctcatgtct
      661 gaccggaggt ccctgcacct agaggcttcc ctggacaaag agctgtacta ccatggggaa
      721 cccctcaatg tcaacgtcca cgtcaccaac aattctgcca agaccgtcaa gaagatcaga
      781 gtgtctgtga gacagtatgc cgacatttgc ctcttcagca ccgcgcagta caagtgtcct
      841 gtggctcagc ttgaacaaga tgaccaggtg tctcccagtt ccacattctg caaggtgtac
      901 accataaccc cgctgctcag tgacaaccga gagaagcgtg gccttgccct tgatgggcaa
      961 ctcaagcacg aagacaccaa cctggcttcc agcaccattg tgaaggaggg agccaacaag
     1021 gaggtgctgg gaatcctagt atcctacagg gtcaaggtga agctggtggt gtctcgaggc
     1081 ggggatgtct ccgtggagct acctttcgtc ctaatgcacc ccaagcccca cgaccacatc
     1141 acccttcccc gaccccagtc agccccccgg gaaatagaca tccctgtgga taccaacctc
     1201 attgaattcg ataccaacta tgccacagac gacgacatcg tgtttgagga ctttgcgagg
     1261 cttcggctga aggggatgaa ggatgacgac tgtgatgacc agttctgcta ggaagagggg
     1321 ctgggagagg taggggtggg caggactgag gtcccactgc ccttgcgggt aggagggtcc
     1381 cagcctctcc tccttccccg tccgtccacc cgagatacac actggaccca tcactcgttg
     1441 aaagtgggca ttaatctttt gacttcagct ctgccacccc agccctgctc cctagggtgg
     1501 caagctgtgt acacacctaa agttttggga agggaacact gaaagcaagg agtgaatgta
     1561 gagaaaagga gtagaaagga cacccatgtt tggcctcata ccaacccact cccagtcacc
     1621 acttctgcct cccaatcctt gaagatgaga tttcagggga gggaccagca aggccatatc
     1681 ttcgtttctg agcataggga agaaataaac cttttaatag gca
//
