LOCUS       NM_012910               1353 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Rattus norvegicus arrestin, beta 1 (Arrb1), mRNA.
ACCESSION   NM_012910
VERSION     NM_012910.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1353)
  AUTHORS   Dan,X., Gu,X., Zi,Y., Xu,J., Wang,C., Li,C., Hu,X., Wu,Z., Yu,Y.
            and Ma,B.
  TITLE     ARRB1 inhibits extracellular matrix degradation and apoptosis of
            nucleus pulposus cells by promoting autophagy and attenuates
            intervertebral disc degeneration
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (7), 119769 (2024)
   PUBMED   38838859
  REMARK    GeneRIF: ARRB1 inhibits extracellular matrix degradation and
            apoptosis of nucleus pulposus cells by promoting autophagy and
            attenuates intervertebral disc degeneration.
REFERENCE   2  (bases 1 to 1353)
  AUTHORS   Wang,W., Sun,J.C., Ye,P., Tan,X., Gao,Y., Duan,W., Wang,Y.K. and
            Wang,W.Z.
  TITLE     miR-22-3p in the rostral ventrolateral medulla promotes
            hypertension through inhibiting beta-arrestin-1
  JOURNAL   J Physiol 602 (2), 317-332 (2024)
   PUBMED   38152023
  REMARK    GeneRIF: miR-22-3p in the rostral ventrolateral medulla promotes
            hypertension through inhibiting beta-arrestin-1.
REFERENCE   3  (bases 1 to 1353)
  AUTHORS   Kang,H., Yang,H.S., Ki,A.Y., Ko,S.B., Kim,K.W., Shim,C.Y., Kim,K.,
            Choi,H.J. and Chung,K.Y.
  TITLE     Conformational Dynamics and Functional Implications of
            Phosphorylated beta-Arrestins
  JOURNAL   Structure 28 (3), 314-323 (2020)
   PUBMED   31948726
  REMARK    GeneRIF: Conformational Dynamics and Functional Implications of
            Phosphorylated beta-Arrestins.
REFERENCE   4  (bases 1 to 1353)
  AUTHORS   Philip,J.L., Xu,X., Han,M., Akhter,S.A. and Razzaque,M.A.
  TITLE     Regulation of cardiac fibroblast-mediated maladaptive ventricular
            remodeling by beta-arrestins
  JOURNAL   PLoS One 14 (7), e0219011 (2019)
   PUBMED   31269046
  REMARK    GeneRIF: Knockdown of beta-arrestin1 or 2 in the post-MI cardiac
            fibroblasts (CF) inhibited transformation to myofibroblasts as well
            as basal and TGF-beta-stimulated collagen synthesis. These data
            suggest that beta-arrestins can regulate CF biology.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1353)
  AUTHORS   Negussie,S., Lymperopoulos,A. and Clark,M.A.
  TITLE     Role of betaarrestin1 in AT1 R-mediated mitogen-activated protein
            kinase activation in Wistar and SHR brainstem astrocytes
  JOURNAL   J Neurochem 148 (1), 46-62 (2019)
   PUBMED   30347436
  REMARK    GeneRIF: Our results indicate reduced involvement of betaarr1 in
            dampening Angiotensin II-induced mitogen-activated protein kinase
            activation and diminished betaarr1-mediated ERK and p38 activation
            in spontaneously hypertensive rat brainstem astrocytes
REFERENCE   6  (bases 1 to 1353)
  AUTHORS   Cheng,Z.J., Zhao,J., Sun,Y., Hu,W., Wu,Y.L., Cen,B., Wu,G.X. and
            Pei,G.
  TITLE     beta-arrestin differentially regulates the chemokine receptor
            CXCR4-mediated signaling and receptor internalization, and this
            implicates multiple interaction sites between beta-arrestin and
            CXCR4
  JOURNAL   J Biol Chem 275 (4), 2479-2485 (2000)
   PUBMED   10644702
REFERENCE   7  (bases 1 to 1353)
  AUTHORS   Orsini,M.J., Parent,J.L., Mundell,S.J., Marchese,A. and
            Benovic,J.L.
  TITLE     Trafficking of the HIV coreceptor CXCR4. Role of arrestins and
            identification of residues in the c-terminal tail that mediate
            receptor internalization
  JOURNAL   J Biol Chem 274 (43), 31076-31086 (1999)
   PUBMED   10521508
  REMARK    Erratum:[J Biol Chem 2000 Aug 18;275(33):25876. Marchese, Adriano
            [added]]
REFERENCE   8  (bases 1 to 1353)
  AUTHORS   McDonald,P.H., Cote,N.L., Lin,F.T., Premont,R.T., Pitcher,J.A. and
            Lefkowitz,R.J.
  TITLE     Identification of NSF as a beta-arrestin1-binding protein.
            Implications for beta2-adrenergic receptor regulation
  JOURNAL   J Biol Chem 274 (16), 10677-10680 (1999)
   PUBMED   10196135
REFERENCE   9  (bases 1 to 1353)
  AUTHORS   Conner,D.A., Mathier,M.A., Mortensen,R.M., Christe,M., Vatner,S.F.,
            Seidman,C.E. and Seidman,J.G.
  TITLE     beta-Arrestin1 knockout mice appear normal but demonstrate altered
            cardiac responses to beta-adrenergic stimulation
  JOURNAL   Circ Res 81 (6), 1021-1026 (1997)
   PUBMED   9400383
REFERENCE   10 (bases 1 to 1353)
  AUTHORS   Attramadal,H., Arriza,J.L., Aoki,C., Dawson,T.M., Codina,J.,
            Kwatra,M.M., Snyder,S.H., Caron,M.G. and Lefkowitz,R.J.
  TITLE     Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene
            family
  JOURNAL   J Biol Chem 267 (25), 17882-17890 (1992)
   PUBMED   1517224
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M91589.1.
            
            On Aug 31, 2012 this sequence version replaced NM_012910.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M91589.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1353              M91589.1           4-1356
FEATURES             Location/Qualifiers
     source          1..1353
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1353
                     /gene="Arrb1"
                     /gene_synonym="BARRES"
                     /note="arrestin, beta 1"
                     /db_xref="GeneID:25387"
                     /db_xref="RGD:2156"
     exon            1..52
                     /gene="Arrb1"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1289
                     /gene="Arrb1"
                     /gene_synonym="BARRES"
                     /codon_start=1
                     /product="beta-arrestin-1"
                     /protein_id="NP_037042.1"
                     /db_xref="GeneID:25387"
                     /db_xref="RGD:2156"
                     /translation="MGDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVD
                     PEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQE
                     RLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHK
                     RNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNV
                     HVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLTP
                     FLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGL
                     LGDLASSDVAVELPFTLMHPKPKEEPPHREVPESETPVDTNLIELDTNDDDIVFEDFA
                     RQRLKGMKDDKDEEDDGTGSPHLNNR"
     exon            53..83
                     /gene="Arrb1"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            84..144
                     /gene="Arrb1"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            145..189
                     /gene="Arrb1"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            190..386
                     /gene="Arrb1"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            387..446
                     /gene="Arrb1"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            447..514
                     /gene="Arrb1"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            515..650
                     /gene="Arrb1"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            651..735
                     /gene="Arrb1"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            736..808
                     /gene="Arrb1"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            809..946
                     /gene="Arrb1"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1030
                     /gene="Arrb1"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1054
                     /gene="Arrb1"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1125
                     /gene="Arrb1"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1177
                     /gene="Arrb1"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1353
                     /gene="Arrb1"
                     /gene_synonym="BARRES"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgcggac ctccctgcgg ccgccgcgga ccatgggcga caaagggaca cgagtgttca
       61 agaaggcaag ccccaatgga aagctcaccg tctacctggg aaagcgggac tttgtggacc
      121 acattgacct ggtggacccc gtggatggcg tggtcctggt ggatcctgag tatctcaaag
      181 aaaggcgagt ctacgtgaca ctgacctgcg ccttccggta tggccgggaa gacctggatg
      241 tcttgggtct gacttttcgc aaagacctgt ttgtggctaa cgtgcagtcc ttcccaccgg
      301 cccctgagga caagaagcca ctgactcggc tacaagagcg actcatcaag aagctgggcg
      361 agcatgccta ccccttcacc tttgagatcc cgccaaacct tccgtgctca gtcacattgc
      421 aacctgggcc tgaggacaca gggaaggcct gcggtgtgga ttatgaagtg aaagccttct
      481 gtgctgagaa cctggaggag aagatccaca aaaggaattc tgtgcggcta gtcatccgga
      541 aggttcaata tgcccctgag aggcctggcc ctcagcccac ggctgagacc accagacagt
      601 tcctcatgtc ggacaagccc ctgcaccttg aggcatctct ggataaggag atctattatc
      661 atggagaacc catcagcgtc aatgtccatg tcaccaacaa caccaacaag actgtgaaga
      721 agatcaagat ctcggtgcgc cagtatgcag acatctgtct cttcaacaca gctcagtaca
      781 agtgcccagt ggccatggag gaagctgatg atactgtggc acccagctca acattctgca
      841 aggtctacac actgactccc ttcctggcaa acaacagaga gaagcggggg cttgccctcg
      901 acgggaagct caagcatgaa gacacaaatc tggcttccag cactctgttg cgggaaggcg
      961 ccaaccgtga aatcctgggt atcattgttt cctacaaagt caaagtgaag ctggtggtgt
     1021 cccggggcgg cctgttggga gaccttgcat ccagtgatgt ggctgtggaa ctgcccttta
     1081 ccttaatgca ccccaagcct aaagaggagc ccccacatcg ggaagttcca gagagcgaga
     1141 ctccagtaga caccaatctc atagagcttg acaccaatga tgacgacatt gtgtttgagg
     1201 actttgctcg tcagcggctg aaaggcatga aggatgacaa ggacgaagag gatgatggca
     1261 ccggctctcc acacctcaac aacagataga ctggggccag cctcagccca gcagctccag
     1321 gttcactctc gcactcggat gctttctcgt ctc
//
