LOCUS       NM_001135045            3204 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus cAMP regulated phosphoprotein 21 (Arpp21),
            transcript variant 2, mRNA.
ACCESSION   NM_001135045 XM_001076474 XM_343492
VERSION     NM_001135045.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3204)
  AUTHORS   Rehfeld,F., Maticzka,D., Grosser,S., Knauff,P., Eravci,M., Vida,I.,
            Backofen,R. and Wulczyn,F.G.
  TITLE     The RNA-binding protein ARPP21 controls dendritic branching by
            functionally opposing the miRNA it hosts
  JOURNAL   Nat Commun 9 (1), 1235 (2018)
   PUBMED   29581509
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3204)
  AUTHORS   Bailey,M.J., Coon,S.L., Carter,D.A., Humphries,A., Kim,J.S.,
            Shi,Q., Gaildrat,P., Morin,F., Ganguly,S., Hogenesch,J.B.,
            Weller,J.L., Rath,M.F., Moller,M., Baler,R., Sugden,D.,
            Rangel,Z.G., Munson,P.J. and Klein,D.C.
  TITLE     Night/day changes in pineal expression of >600 genes: central role
            of adrenergic/cAMP signaling
  JOURNAL   J Biol Chem 284 (12), 7606-7622 (2009)
   PUBMED   19103603
  REMARK    GeneRIF: Expression of ARPP21 in the pineal gland increases at
            night more than 1000%.  This probably reflects circadian neural
            stimulation by the suprachiasmatic nucleus.
REFERENCE   3  (bases 1 to 3204)
  AUTHORS   Fujimoto,M., Oshima,K., Shinkawa,T., Wang,B.B., Inouye,S.,
            Hayashida,N., Takii,R. and Nakai,A.
  TITLE     Analysis of HSF4 binding regions reveals its necessity for gene
            regulation during development and heat shock response in mouse
            lenses
  JOURNAL   J Biol Chem 283 (44), 29961-29970 (2008)
   PUBMED   18755693
REFERENCE   4  (bases 1 to 3204)
  AUTHORS   Ivanova,T.I., Agalakova,N.I. and Gusev,G.P.
  TITLE     Activation of sodium transport in rat erythrocytes by inhibition of
            protein phosphatases 1 and 2A
  JOURNAL   Comp Biochem Physiol B Biochem Mol Biol 145 (1), 60-67 (2006)
   PUBMED   16875859
  REMARK    GeneRIF: Inhibition of protein phosphatase 1 by protein phosphatase
            inhibitors activates sodiun transport in rat erytrocytes
REFERENCE   5  (bases 1 to 3204)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   6  (bases 1 to 3204)
  AUTHORS   Ehrlich,M.E. and Greengard,P.
  TITLE     Characterization of rat ARPP-21 mRNA: sequence analysis, tissue
            distribution, and regulation
  JOURNAL   J Neurochem 57 (6), 1985-1991 (1991)
   PUBMED   1940913
REFERENCE   7  (bases 1 to 3204)
  AUTHORS   Hemmings,H.C. Jr., Girault,J.A., Williams,K.R., LoPresti,M.B. and
            Greengard,P.
  TITLE     ARPP-21, a cyclic AMP-regulated phosphoprotein (Mr = 21,000)
            enriched in dopamine-innervated brain regions. Amino acid sequence
            of the site phosphorylated by cyclic AMP in intact cells and
            kinetic studies of its phosphorylation in vitro
  JOURNAL   J Biol Chem 264 (13), 7726-7733 (1989)
   PUBMED   2540203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Mar 1, 2009 this sequence version replaced
            XM_001076474.1, XM_343492.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760386, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               JAXUCZ010000008.1  121031131-121031357 c
            228-388             JAXUCZ010000008.1  121029149-121029309 c
            389-430             JAXUCZ010000008.1  121028138-121028179 c
            431-520             JAXUCZ010000008.1  121027353-121027442 c
            521-665             JAXUCZ010000008.1  121022865-121023009 c
            666-744             JAXUCZ010000008.1  121021502-121021580 c
            745-804             JAXUCZ010000008.1  121020763-121020822 c
            805-945             JAXUCZ010000008.1  121019912-121020052 c
            946-1054            JAXUCZ010000008.1  121002422-121002530 c
            1055-1153           JAXUCZ010000008.1  121000160-121000258 c
            1154-1191           JAXUCZ010000008.1  120993675-120993712 c
            1192-1251           JAXUCZ010000008.1  120991920-120991979 c
            1252-1481           JAXUCZ010000008.1  120987764-120987993 c
            1482-1715           JAXUCZ010000008.1  120981782-120982015 c
            1716-1897           JAXUCZ010000008.1  120972174-120972355 c
            1898-2155           JAXUCZ010000008.1  120969438-120969695 c
            2156-2282           JAXUCZ010000008.1  120964379-120964505 c
            2283-2431           JAXUCZ010000008.1  120914887-120915035 c
            2432-3204           JAXUCZ010000008.1  120912970-120913742 c
FEATURES             Location/Qualifiers
     source          1..3204
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3204
                     /gene="Arpp21"
                     /gene_synonym="Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208;
                     RGD1307215"
                     /note="cAMP regulated phosphoprotein 21"
                     /db_xref="GeneID:363153"
                     /db_xref="RGD:1593239"
     exon            1..227
                     /gene="Arpp21"
                     /gene_synonym="Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208;
                     RGD1307215"
                     /inference="alignment:Splign:2.1.0"
     exon            228..388
                     /gene="Arpp21"
                     /gene_synonym="Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208;
                     RGD1307215"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..2689
                     /gene="Arpp21"
                     /gene_synonym="Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208;
                     RGD1307215"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein phosphatase 1, regulatory subunit 1C; protein
                     phosphatase 1, regulatory (inhibitory subunit 1C);
                     cAMP-regulated phosphoprotein (21 kDa); cyclic
                     AMP-regulated phosphoprotein, 21"
                     /codon_start=1
                     /product="cAMP-regulated phosphoprotein 21 isoform 2"
                     /protein_id="NP_001128517.1"
                     /db_xref="GeneID:363153"
                     /db_xref="RGD:1593239"
                     /translation="MSEQGELTPTILEEGRTEPESAPENGILKSESLDEEEKLELQRR
                     LAAQNQERRKSKSGAGKGKLTRSLAVCEESSARPGGESHQDQESIHLQLSSFPSLQEE
                     DKSRKDDSEREKEKDKNREKLSERPKIRMLSKDCSQEYTDSTGIDLHEFLINTLKNNS
                     RDRMILLKMEQEMIDFIADSNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTGKSV
                     IINKTSSTRIPEQRFCEHLKDEKSEESQKRFILKRDNSSIDKEDNQNRMHPFRDDRRS
                     KSIEEREEEYQRVRERIFAHDSVCSQESLFLDNSRLQEDMHICNETYKKRQLFRAHRD
                     SSGRTSGSRQSSSETELRWPDHQRAWSSTDSDSSNRNLKPTMTKTASFGGITVLTRGD
                     STSSTRSAGKLSKTGSESSSSAGSSGSLSRTHPPLQSTALTSSVAAGSPGCMAYSENG
                     MGGQVPPSSTSYILLPLESATGIPPGSILLNPHTGQPFVNPDGTPAIYNPPGSQQTLR
                     GTVSGQPQQPPPQQPSPQPQQQVQASQPQMTGPLVTQREEMAAQFSQLSMSRQSSGDT
                     PEPPSGPVYPASLMQAAQPPSYVITSAGQQLSTGGFSDSGPPISQQVLQAPPSPQGFV
                     QQPPPAQMSVYYYPSGQYPTSTTQQYRPLASVQYSAQRSQQIPQTAQQAGYQPVLSGQ
                     QSFQGLMGVQQSAHSQGVMSSQQGAPVHGVMVSYPTMSSYQVPMTQGSQAVPQQTYQP
                     PIMLPSQTGQGSLPATGMPVYCNITPPSPQNNLRLMGPHCPSSTVPVMSASCRTNCGS
                     MNNAGWPVKF"
     exon            389..430
                     /gene="Arpp21"
                     /gene_synonym="Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208;
                     RGD1307215"
                     /inference="alignment:Splign:2.1.0"
     exon            431..520
                     /gene="Arpp21"
                     /gene_synonym="Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208;
                     RGD1307215"
                     /inference="alignment:Splign:2.1.0"
     exon            521..665
                     /gene="Arpp21"
                     /gene_synonym="Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208;
                     RGD1307215"
                     /inference="alignment:Splign:2.1.0"
     exon            666..744
                     /gene="Arpp21"
                     /gene_synonym="Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208;
                     RGD1307215"
                     /inference="alignment:Splign:2.1.0"
     exon            745..804
                     /gene="Arpp21"
                     /gene_synonym="Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208;
                     RGD1307215"
                     /inference="alignment:Splign:2.1.0"
     exon            805..945
                     /gene="Arpp21"
                     /gene_synonym="Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208;
                     RGD1307215"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1054
                     /gene="Arpp21"
                     /gene_synonym="Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208;
                     RGD1307215"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1153
                     /gene="Arpp21"
                     /gene_synonym="Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208;
                     RGD1307215"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1191
                     /gene="Arpp21"
                     /gene_synonym="Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208;
                     RGD1307215"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1251
                     /gene="Arpp21"
                     /gene_synonym="Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208;
                     RGD1307215"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1481
                     /gene="Arpp21"
                     /gene_synonym="Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208;
                     RGD1307215"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1715
                     /gene="Arpp21"
                     /gene_synonym="Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208;
                     RGD1307215"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1897
                     /gene="Arpp21"
                     /gene_synonym="Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208;
                     RGD1307215"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2155
                     /gene="Arpp21"
                     /gene_synonym="Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208;
                     RGD1307215"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2282
                     /gene="Arpp21"
                     /gene_synonym="Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208;
                     RGD1307215"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2431
                     /gene="Arpp21"
                     /gene_synonym="Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208;
                     RGD1307215"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..3204
                     /gene="Arpp21"
                     /gene_synonym="Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208;
                     RGD1307215"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaaggccg cgactgttgc cacaatgatt tcctgttctt cctttttcag gttgtcgacc
       61 atgtgtcaag ctgtgtaggg aaactgcctg gagatggaca ttctggactg ctaatgggga
      121 catgggacgg cagttacctc tgatcacttg cgtggattct cctggagcag aaagacagaa
      181 gccgccagtc actcgtccgg atctagcact gggattctgt gctgaagggt ctaaaaactc
      241 gttttgattt ggatctggga gaatgtctga gcaaggagaa ctaaccccga ccatactgga
      301 agaagggcgg acagagccag aatctgcccc agaaaatggc atcctcaagt cagaaagtct
      361 ggatgaggag gagaagctgg aactgcagcg gcgactggca gctcagaacc aagagagaag
      421 aaaatccaag tcaggagcag gtaaagggaa gctgaccaga agtcttgctg tctgtgaaga
      481 gtcttcagcc agacctggag gggaaagtca ccaggatcag gaatcaattc acttacagct
      541 ttccagtttc cccagcctgc aagaggagga taaatctagg aaggatgact ctgagagaga
      601 aaaagaaaag gataagaaca gagagaaact ctctgagaga cccaagatca gaatgttatc
      661 gaaagattgc agccaagaat atacggattc tacaggcata gacttacatg agtttctaat
      721 taacacgctg aagaacaact ccagggacag gatgatactc ttgaaaatgg agcaggaaat
      781 gattgatttc attgctgaca gcaataacca ctataaaaag ttcccccaga tgtcatccta
      841 tcagaggatg ctggtccatc gggtggcagc gtacttcggg ttggaccaca atgtggatca
      901 aactggaaaa tctgtcatca tcaacaagac cagcagcacc agaataccag agcaaaggtt
      961 ttgtgaacat ttaaaagatg aaaagagtga agaatcccag aagcggttta tcttgaagcg
     1021 agataactct agtattgata aagaagacaa tcagaacaga atgcacccat ttagagatga
     1081 cagacgaagt aaatcaattg aagagagaga agaggaatat cagagagtga gggagagaat
     1141 atttgcacac gattcagttt gctcccagga aagcctattt ttggataaca gtaggctcca
     1201 ggaagatatg cacatatgca atgagaccta taagaaaaga cagctctttc gggctcaccg
     1261 agacagctca ggaagaactt ccgggagccg gcagagcagc tcagagactg agctcaggtg
     1321 gccagaccac cagcgagcct ggagcagcac agattctgac agctccaacc gcaatctgaa
     1381 gcccaccatg accaagactg caagttttgg gggcatcacg gtgctgacca ggggcgacag
     1441 cacatccagt actaggagtg ctgggaaact gtccaaaaca ggttctgagt cttccagcag
     1501 tgcaggctcc tcaggatcac tgtcccgcac ccacccgcct ctgcagagca cagccctgac
     1561 ctctagtgtg gcagctggct ctcctggctg tatggcctat tcagagaatg gaatgggggg
     1621 ccaggttcct cccagcagca ccagctacat cctcctccca cttgaaagcg cgactggcat
     1681 cccacctgga agcatccttc ttaatccaca cacaggtcag ccctttgtga acccggatgg
     1741 aactcctgcg atatacaacc ctcccggaag tcagcagacg ctgcgtggca ctgtcagtgg
     1801 gcagcctcaa caacccccac cacagcaacc gtctcctcag cctcagcagc aggtccaggc
     1861 atcacagcct cagatgacag ggccactggt cactcagaga gaagagatgg ctgcgcagtt
     1921 cagtcagctg agcatgagca ggcagtcctc gggagacact cctgaacctc cctctggtcc
     1981 agtctaccca gcctccctca tgcaagcagc tcagccacca agctacgtca tcacttctgc
     2041 aggccagcag ctctccacag ggggtttctc ggactctggc ccgcccatct cccagcaggt
     2101 cctgcaggcc ccgccctctc cccagggatt tgtacagcag cctccacctg cgcagatgtc
     2161 cgtatattac tacccatctg gtcagtaccc tacctcaacc acacagcagt accgacccct
     2221 ggcctcagtc cagtacagcg ctcagaggag tcagcaaata ccacagaccg cgcagcaagc
     2281 aggttaccag ccagtcttgt ctggtcaaca gagctttcaa ggcctgatgg gagtacagca
     2341 gtcagctcac agccaggggg tgatgagcag tcagcaagga gccccggtgc atggtgtgat
     2401 ggtctcctac ccaaccatgt cttcttatca ggtgccaatg acccaaggtt ctcaagcagt
     2461 gccccagcag acataccaac cgccaatcat gctgcccagt cagacaggcc aagggtcact
     2521 cccagccacc ggaatgcctg tgtactgtaa catcacaccg ccaagccctc agaacaacct
     2581 aaggttgatg ggtccacact gcccctccag cacggttcct gtcatgtctg ctagctgcag
     2641 aacaaactgt gggagcatga acaacgctgg ctggccggtc aagttctgag agtgctcggg
     2701 ctgcccgcgg tacacttcat catatgttaa ctcatggcct tcaaaggaag aggagacttc
     2761 gacagctggc tgaggacttc catatacatt gctgctggta ttctgtacaa actaatcaaa
     2821 gactaataca ttagctggtt aatggtgcat atttctgtca tgtctgctag gtatgccttt
     2881 ctagcttagc tagggacatg aattcatcaa ggtaagattt tctcctacca tgaataccac
     2941 tgtgtagatt acaatatccc tgattcggat tagttttgta ctttgtgttc agtttgtgat
     3001 gctaaaagta tttaaatata tatatatata aactaaatca cacggtacca aagctgtaac
     3061 ggaacaaaag gaaagagttg aggaatggaa ggaataattt atatacacta tagagttttc
     3121 ttttttaaat ggatatatat ggtattgtag tgtttaacgc aaataaaagc ttatttgacc
     3181 ttacggagga aggtcatgtt ttta
//
