LOCUS       NM_001395719            3905 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus cAMP-regulated phosphoprotein 19 (Arpp19),
            transcript variant 4, mRNA.
ACCESSION   NM_001395719
VERSION     NM_001395719.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3905)
  AUTHORS   Gharbi-Ayachi,A., Labbe,J.C., Burgess,A., Vigneron,S., Strub,J.M.,
            Brioudes,E., Van-Dorsselaer,A., Castro,A. and Lorca,T.
  TITLE     The substrate of Greatwall kinase, Arpp19, controls mitosis by
            inhibiting protein phosphatase 2A
  JOURNAL   Science 330 (6011), 1673-1677 (2010)
   PUBMED   21164014
REFERENCE   2  (bases 1 to 3905)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
REFERENCE   3  (bases 1 to 3905)
  AUTHORS   Yoshikawa,A., Mitsuhashi,H., Sasagawa,N., Tsukahara,T., Hayashi,Y.,
            Nishino,I., Goto,Y. and Ishiura,S.
  TITLE     Expression of ARPP-16/19 in rat denervated skeletal muscle
  JOURNAL   J Biochem 134 (1), 57-61 (2003)
   PUBMED   12944371
REFERENCE   4  (bases 1 to 3905)
  AUTHORS   Irwin,N., Chao,S., Goritchenko,L., Horiuchi,A., Greengard,P.,
            Nairn,A.C. and Benowitz,L.I.
  TITLE     Nerve growth factor controls GAP-43 mRNA stability via the
            phosphoprotein ARPP-19
  JOURNAL   Proc Natl Acad Sci U S A 99 (19), 12427-12431 (2002)
   PUBMED   12221279
  REMARK    GeneRIF: ARPP-19 is an important link between NGF signaling and
            post-transcriptional control of neuronal gene expression.
REFERENCE   5  (bases 1 to 3905)
  AUTHORS   Dulubova,I., Horiuchi,A., Snyder,G.L., Girault,J.A., Czernik,A.J.,
            Shao,L., Ramabhadran,R., Greengard,P. and Nairn,A.C.
  TITLE     ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated
            phosphoproteins
  JOURNAL   J Neurochem 77 (1), 229-238 (2001)
   PUBMED   11279279
REFERENCE   6  (bases 1 to 3905)
  AUTHORS   Heron,L., Virsolvy,A., Peyrollier,K., Gribble,F.M., Le Cam,A.,
            Ashcroft,F.M. and Bataille,D.
  TITLE     Human alpha-endosulfine, a possible regulator of
            sulfonylurea-sensitive KATP channel: molecular cloning, expression
            and biological properties
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 8387-8391 (1998)
   PUBMED   9653196
REFERENCE   7  (bases 1 to 3905)
  AUTHORS   Girault,J.A., Horiuchi,A., Gustafson,E.L., Rosen,N.L. and
            Greengard,P.
  TITLE     Differential expression of ARPP-16 and ARPP-19, two highly related
            cAMP-regulated phosphoproteins, one of which is specifically
            associated with dopamine-innervated brain regions
  JOURNAL   J Neurosci 10 (4), 1124-1133 (1990)
   PUBMED   2158525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2817093.1,
                                           SRR26360186.233775.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               JAXUCZ010000008.1  84660397-84660542
            147-269             JAXUCZ010000008.1  84674433-84674555
            270-3905            JAXUCZ010000008.1  84679377-84683012
FEATURES             Location/Qualifiers
     source          1..3905
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..3905
                     /gene="Arpp19"
                     /gene_synonym="Arpp-19"
                     /note="cAMP-regulated phosphoprotein 19"
                     /db_xref="GeneID:60336"
                     /db_xref="RGD:71054"
     exon            1..146
                     /gene="Arpp19"
                     /gene_synonym="Arpp-19"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..440
                     /gene="Arpp19"
                     /gene_synonym="Arpp-19"
                     /note="isoform b is encoded by transcript variant 4;
                     cyclic AMP phosphoprotein, 19 kDa; cyclic AMP
                     phosphoprotein, 19kD"
                     /codon_start=1
                     /product="cAMP-regulated phosphoprotein 19 isoform b"
                     /protein_id="NP_001382648.1"
                     /db_xref="GeneID:60336"
                     /db_xref="RGD:71054"
                     /translation="MSAEVPEAASAEEQKEMEDKVTSPEKAEEAKLKARYPHLGQKPG
                     GSDFLRKRLQKGQKYFDSGDYNMAKAKMKNKQLPAAAPDKTEVTGDHIPTPQDLPQRK
                     PSLVASKLAG"
     exon            147..269
                     /gene="Arpp19"
                     /gene_synonym="Arpp-19"
                     /inference="alignment:Splign:2.1.0"
     exon            270..3905
                     /gene="Arpp19"
                     /gene_synonym="Arpp-19"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgccggcc cggcgggcag cggggcaggc agaaggtggc gggcagtctt gcctcccggt
       61 aatctgtctt ctcctggcgt ctcttctgca gaaggagcac catgtccgcg gaagtccccg
      121 aggcagcgtc ggcggaggag caaaaagaaa tggaagataa agtaactagt ccagagaaag
      181 ctgaagaagc aaagttaaaa gcaaggtatc ctcatttggg acaaaagcct ggtggttctg
      241 actttttaag gaaaagattg cagaaagggc aaaagtattt tgattctggg gattacaaca
      301 tggcaaaagc aaagatgaag aacaagcagc ttcctgctgc agccccggat aagacagagg
      361 tcactggtga ccacattccc actccacagg acctccctca gcggaaacca tccctggttg
      421 ctagcaagct ggctggctga ttaaaagagc tgaactgcat gagtcttcta atgtccttta
      481 tttctcctta ctacgttact tacccacttc tgtttccttt cactcactct catttgagac
      541 tgacagcttt gcaggtagtg gtagtgtgtg ctactcttgt aagggagcat ccatgtgtag
      601 aggttttggt tagtttcaca gtgcactgat gcagaggaca tggaacagca acataagtaa
      661 atgacgtgac aataattgta cattacctag ctggtgtagg gctggctcca gcaagtagca
      721 agcaagtttt accgctttaa tgctctggct ttctttattc tctcctactt gcagctttgt
      781 atgtcacctt atttaataga acctctgttg tgttgatttc ttctgcatct tccttttgaa
      841 ttttgtaaga cagaagttta agaccacaag ttggaagaca agacacataa tccaaacaca
      901 agtaaatggg ctgcaaaaga tttgatggct tggacttgac ggccttaaac ctgctgttcc
      961 agctttaaca agagcatctt atctgggcga tatttgcccg ctctggtgtg acttgtgtga
     1021 ctccagtgct taccagctgt cactgaagct agtgttcttc ctcggttctg cagtgtgtgg
     1081 ggacagcttt ctctgttgaa gatgtgaatg ggcgtgcatg tgcactgact attgcattca
     1141 cttttgtgcc atttttgtaa atacaatagt tttgcacaac cttttacaaa tgtctgtatt
     1201 aatttcacca tattagaaag tagataatgt gccaaccaga agcacaagaa ttcctacaca
     1261 aatttgcctg ccattactgc ttttttataa gaatagttta caatcttgag cttattagaa
     1321 taccaaactg aaatatactc agcctgctac agagttaagt tttttcattt gttactaata
     1381 ttcatgactt tcagtggcct tgtacaaata tgatatgttg cttaggcata tcttttgttc
     1441 tatgcagaac atttcatttt gacttttaca aaaaaattac aattcatata atttatatag
     1501 actttcttag tgtagaaact ttttacttcc acattcagct ttgggcatac taaagtaaaa
     1561 ctttcgttct ctgtcttctg ttctcttctc agcccccgtc tgctctttgc ttctgtgact
     1621 cgtattgggt tatctcattt atataaaagc ctatgtgtct atctttactt ttaaaacttg
     1681 cttaaataaa agaatttttg tgagggtttt ttgttatact gagaatcaaa ccactgtctc
     1741 acatgtgctt agtaagcact gtaccacaga actattctta tttctaaagg aactttatga
     1801 tgaagcaagg agttgaaaag agttttctag aataagctga attctgttaa ataattttaa
     1861 ataattagga tgaactagga gaatagggct aataattaca gtgatttgtg tgataggtaa
     1921 aacatgcata ttaaaatatt taggtatctt ctataatgtc attttaaaca ttagcagact
     1981 ttattcagac acacttatta ttcgagctct tcccccagga tgtcaggctg tagcatattg
     2041 aactgtagca gcctgagctg atgagttctt cctcttcacc ttgggctagg gtgaggccta
     2101 ctcccctatg gaatccaggc atcatttgta ttatgactac atttgtgcac ctgctttcct
     2161 atggctccgt actagtgatt agtcctgctc cactcaacct gaggcagaaa agcagcatac
     2221 tttacactcc acattggtaa ttttacagct cagttctata taaatgtatt tgtaatgagc
     2281 aaatgagtta ttccataata tgtgcaattc ctcataagat tgctagtctt ttcccccgtg
     2341 gagatttgta agcccagccc cattgagttc agatagatga ctctgaggta agagtgaccg
     2401 tgctcttcct caacagcaga cttacagtct gacatgagta acacctgctt gcattttgat
     2461 ttgtaaaagg acactgatgt ttaacctacc tcaagacttg aggatctgtg aagtactaag
     2521 tgccccaaat attactatct tttcaaaaat agatttcctc actaaaccaa cctgccttct
     2581 ataaagtagc agtgcttaaa atctcaggat tttccactag gaaagacctg ttaaggattt
     2641 gtatgtatcg ctgcatggct tccattggtg cttgagagag gttttacatt tttctggttt
     2701 ttgttctact tcaaagctca attgtagata cttttgcagg ctctttggtc atttagtaga
     2761 ttttgatgaa atgggcttaa tttccgtgtc aaagctgtgc ctgaggaatg gctaatttta
     2821 atgttagagt aacttgaggt tgaggaaaat actaaaggcc aactggctaa agcctaaatc
     2881 tgttttgttc agtagctcat aaacatctga aggctatgtc tgactaacac ttgcacctca
     2941 tgtctagttg gaatagcatt tggatggttt ggagggaaca tgtttgcagt tctacaggtt
     3001 gttagagaat cttgtactgc tggtctgaag gtatgtctaa aaagttcaag gcagtcatga
     3061 caaggcctct acttgttatt acttccacag ttagaattag ttgctctttt tacttgatgt
     3121 aaccaaagta tacctctgaa tatgtttcgc tattcattac taagtcagac ttgtattctt
     3181 gatctggata tcacaaagtc ttatcaaagc tgaaatatca acccaaactg taaacttagt
     3241 gattgccggt cagaagcagg tagtctgtga gaagaactgt tctgagcggt taccaaggcc
     3301 ttgtctgtga tcgcctcatc acatcctcca accttcagac tacataattg taacccaatt
     3361 tcctcactat gtccacccct gaagcccact gtaagcactt cacttacatt ttctaaagca
     3421 ccatcttaat ctcacttggc atgtcctgcc aatcttaacc caagatgctt tctccaactt
     3481 attactgcta cggttaagaa attgggatta aaagtacctg tggtgtttga tatatagatg
     3541 acagttagac gcttactagt tctagccttc aaaggaggta gaccttgggt ttcatcctat
     3601 aaatttctgg tggtggtgat aactcataaa tgtatgtttg tatggtattt atcaactaaa
     3661 tagcagtaga aatagagatc caattccttt agtaccgtgc cctcaaatct gtcaatgcat
     3721 ctccaccatt tgatatgcaa taggacactg cctgtttgca gagggccaac ataaatgcct
     3781 tttcttgtta aagatgtctg tagagttggc agttaatgct gaagtttgtc aaatagctca
     3841 tccaaactta tacttgtaaa atacacccaa aataaatgga tctacctaat ttttattgat
     3901 tttaa
//
