LOCUS       NM_001025717            1778 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus actin related protein 2/3 complex, subunit 5
            (Arpc5), mRNA.
ACCESSION   NM_001025717 XM_341131
VERSION     NM_001025717.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1778)
  AUTHORS   Chazeau,A., Mehidi,A., Nair,D., Gautier,J.J., Leduc,C., Chamma,I.,
            Kage,F., Kechkar,A., Thoumine,O., Rottner,K., Choquet,D.,
            Gautreau,A., Sibarita,J.B. and Giannone,G.
  TITLE     Nanoscale segregation of actin nucleation and elongation factors
            determines dendritic spine protrusion
  JOURNAL   EMBO J 33 (23), 2745-2764 (2014)
   PUBMED   25293574
REFERENCE   2  (bases 1 to 1778)
  AUTHORS   Liu,C.R., Miao,J., Zhang,Y.L., Liu,Y.M. and Yu,B.G.
  TITLE     Effects of hypothyroidism on expression of CRMP2B and ARPC5 during
            development of the rat frontal cortex
  JOURNAL   Int J Biol Sci 9 (2), 209-218 (2013)
   PUBMED   23459330
  REMARK    GeneRIF: CRMP2B and ARPC5 may participate in CNS injury mediated by
            hypothyroidism by inducing neurite outgrowth inhibition and
            cytoskeletal protein disorganization.
REFERENCE   3  (bases 1 to 1778)
  AUTHORS   Kinoshita,T., Nohata,N., Watanabe-Takano,H., Yoshino,H., Hidaka,H.,
            Fujimura,L., Fuse,M., Yamasaki,T., Enokida,H., Nakagawa,M.,
            Hanazawa,T., Okamoto,Y. and Seki,N.
  TITLE     Actin-related protein 2/3 complex subunit 5 (ARPC5) contributes to
            cell migration and invasion and is directly regulated by
            tumor-suppressive microRNA-133a in head and neck squamous cell
            carcinoma
  JOURNAL   Int J Oncol 40 (6), 1770-1778 (2012)
   PUBMED   22378351
REFERENCE   4  (bases 1 to 1778)
  AUTHORS   Moriya,Y., Nohata,N., Kinoshita,T., Mutallip,M., Okamoto,T.,
            Yoshida,S., Suzuki,M., Yoshino,I. and Seki,N.
  TITLE     Tumor suppressive microRNA-133a regulates novel molecular networks
            in lung squamous cell carcinoma
  JOURNAL   J Hum Genet 57 (1), 38-45 (2012)
   PUBMED   22089643
REFERENCE   5  (bases 1 to 1778)
  AUTHORS   Liu,C.R., Yu,B.G., Liu,Y.Q., Liu,Y.M., Yang,S.W. and Zhang,Y.L.
  TITLE     [Proteomic changes in cerebral cortex of neonatal rats with
            experimental congenital hypothyroidism]
  JOURNAL   Zhonghua Er Ke Za Zhi 49 (3), 209-213 (2011)
   PUBMED   21575372
REFERENCE   6  (bases 1 to 1778)
  AUTHORS   Korobova,F. and Svitkina,T.
  TITLE     Arp2/3 complex is important for filopodia formation, growth cone
            motility, and neuritogenesis in neuronal cells
  JOURNAL   Mol Biol Cell 19 (4), 1561-1574 (2008)
   PUBMED   18256280
REFERENCE   7  (bases 1 to 1778)
  AUTHORS   Llado,A., Timpson,P., Vila de Muga,S., Moreto,J., Pol,A.,
            Grewal,T., Daly,R.J., Enrich,C. and Tebar,F.
  TITLE     Protein kinase Cdelta and calmodulin regulate epidermal growth
            factor receptor recycling from early endosomes through Arp2/3
            complex and cortactin
  JOURNAL   Mol Biol Cell 19 (1), 17-29 (2008)
   PUBMED   17959830
REFERENCE   8  (bases 1 to 1778)
  AUTHORS   Liu,P., Ding,X.F., Zhang,Y.Y. and Qiao,J.
  TITLE     [Modulation of Jianjining Recipe on differential protein expression
            in rats with experimental autoimmune myasthenia gravis]
  JOURNAL   Zhong Xi Yi Jie He Xue Bao 5 (6), 642-646 (2007)
   PUBMED   17997938
REFERENCE   9  (bases 1 to 1778)
  AUTHORS   Mejillano,M.R., Kojima,S., Applewhite,D.A., Gertler,F.B.,
            Svitkina,T.M. and Borisy,G.G.
  TITLE     Lamellipodial versus filopodial mode of the actin nanomachinery:
            pivotal role of the filament barbed end
  JOURNAL   Cell 118 (3), 363-373 (2004)
   PUBMED   15294161
REFERENCE   10 (bases 1 to 1778)
  AUTHORS   Gournier,H., Goley,E.D., Niederstrasser,H., Trinh,T. and Welch,M.D.
  TITLE     Reconstitution of human Arp2/3 complex reveals critical roles of
            individual subunits in complex structure and activity
  JOURNAL   Mol Cell 8 (5), 1041-1052 (2001)
   PUBMED   11741539
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099238.1.
            
            On Jul 22, 2005 this sequence version replaced XM_341131.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099238.1, FQ223037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1778
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..1778
                     /gene="Arpc5"
                     /note="actin related protein 2/3 complex, subunit 5"
                     /db_xref="GeneID:360854"
                     /db_xref="RGD:1311791"
     exon            1..205
                     /gene="Arpc5"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..518
                     /gene="Arpc5"
                     /note="p16-ARC; arp2/3 complex 16 kDa subunit"
                     /codon_start=1
                     /product="actin-related protein 2/3 complex subunit 5"
                     /protein_id="NP_001020888.1"
                     /db_xref="GeneID:360854"
                     /db_xref="RGD:1311791"
                     /translation="MSKNTVSSARFRKVDVDEYDENKFVDEEDGGDGQAGPDEGEVDS
                     CLRQGNMTAALQAALKNPPINTKSQAVKDRAGSIVLKVLISFKANDIEKAVQSLDKNG
                     VDLLMKYIYKGFESPSDNSSAMLLQWHEKALAAGGVGSIVRVLTARKTV"
     exon            206..278
                     /gene="Arpc5"
                     /inference="alignment:Splign:2.1.0"
     exon            279..455
                     /gene="Arpc5"
                     /inference="alignment:Splign:2.1.0"
     exon            456..1751
                     /gene="Arpc5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctaggctc gctgaagaag aggcaccgcg gaggggaggc cagagttgca tcgcgatccg
       61 ggatgtcgaa gaacacggtg tcgtcggccc gcttccggaa ggtggacgtg gacgaatatg
      121 atgagaacaa gttcgtggac gaggaggacg gcggcgatgg ccaggccggg cccgacgagg
      181 gcgaggtgga ctcatgccta cggcaaggaa acatgaccgc tgccctacag gccgctctga
      241 aaaacccccc cattaacaca aagagccagg cagtgaagga ccgggcaggc agcatcgtct
      301 tgaaggtgct catctccttt aaagctaatg atattgaaaa ggctgttcag tctctggaca
      361 agaatggcgt ggacctccta atgaagtata tttataaagg ctttgagagc ccgtctgaca
      421 atagcagcgc tatgttacta cagtggcatg aaaaggcact tgctgctgga ggagtagggt
      481 ctatcgttcg tgttttgact gcaagaaaaa ccgtgtagtc cagctggaac tggacagtgt
      541 tcagaggagt gggagttgct ggtacaaaga ccaaaacaac caaatggcac cgctgcccca
      601 tgggtagcat ctgtttctct cagctttgcc ttcttgcttc ctttttcata tctataaaga
      661 agaaaattac atatcagttt cctttaatga aaattgaaat aatgtggaga aaattttgtc
      721 tcagtggggt gtttgatcct ttcataacca tgtcaataat gtgtatccca ttctgtaatt
      781 tatattcaag tttgtgcaat ttctaactct gttgactggt ttaagggttt tactttattt
      841 ttaaccaata ctgagagatg tgatcaaatt cgaggccagt ttcctaactc attgctggtc
      901 aggaagtgat ctttattttt aaaaacgaga gactggcagc tagtaacatt gcaaaactgg
      961 accacacttc ccttataaaa tgtgtttcca gagcaaggag tgggtgaacc ccactaccac
     1021 tttccagctt tctttctgct tgcctccaga tgatgctatg agtggaagtg tgtacttcct
     1081 gttagcatcc aattatcatg gcctctcaat ctctttgtgg tgacccaggg tccagagcaa
     1141 gaagtcttgc tctatataaa tgtatttaca caatataagc gcctctttgg cacaaacatc
     1201 ccatttcctt ctgataataa ggctgcctgg ggaagctatc ccaagtggga gaatggactc
     1261 cagcagcttc tgaatgaatg ctttcatcag aaataaggta gctgccttag acatttacac
     1321 aagggttcac tgtaacattt cacacgccca atggtgtcct cagtgttctt caggtaatgg
     1381 ggatctcaga aaatgtggtt ctgatccaaa tacatagtgt gtgtttcagc tcagtgtttt
     1441 ataagaaagg aaaatgccgc atagtaaaag aaaggtgtct actttgtcgg acaaaccaaa
     1501 ttggttctca aaaatgaccg gtgcttgtaa aaagttatta caaagtagtt ctgaaaccaa
     1561 ccacccgaat gcctgtggcc aagagggaag cagcccggtt gtcttcctaa gatgccaatt
     1621 ccagagtcgc tgactgaggt gagaaccagc acagaaacta taaactgctg tttttgatac
     1681 ctgctttttg ttttgttctg ttttgtaaaa ttatgataaa cttcagaaaa taaaatgtca
     1741 gtattgaata aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
