LOCUS       NM_001106615            1447 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus actin related protein 2/3 complex, subunit 4
            (Arpc4), mRNA.
ACCESSION   NM_001106615 XM_001078712 XM_238365
VERSION     NM_001106615.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1447)
  AUTHORS   Jakobsson,M.E., Moen,A., Bousset,L., Egge-Jacobsen,W.,
            Kernstock,S., Melki,R. and Falnes,P.O.
  TITLE     Identification and characterization of a novel human
            methyltransferase modulating Hsp70 protein function through lysine
            methylation
  JOURNAL   J Biol Chem 288 (39), 27752-27763 (2013)
   PUBMED   23921388
REFERENCE   2  (bases 1 to 1447)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 1447)
  AUTHORS   Chiu,T.T., Patel,N., Shaw,A.E., Bamburg,J.R. and Klip,A.
  TITLE     Arp2/3- and cofilin-coordinated actin dynamics is required for
            insulin-mediated GLUT4 translocation to the surface of muscle cells
  JOURNAL   Mol Biol Cell 21 (20), 3529-3539 (2010)
   PUBMED   20739464
REFERENCE   4  (bases 1 to 1447)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1447)
  AUTHORS   Weitzdoerfer,R., Fountoulakis,M. and Lubec,G.
  TITLE     Reduction of actin-related protein complex 2/3 in fetal Down
            syndrome brain
  JOURNAL   Biochem Biophys Res Commun 293 (2), 836-841 (2002)
   PUBMED   12054546
REFERENCE   6  (bases 1 to 1447)
  AUTHORS   Gournier,H., Goley,E.D., Niederstrasser,H., Trinh,T. and Welch,M.D.
  TITLE     Reconstitution of human Arp2/3 complex reveals critical roles of
            individual subunits in complex structure and activity
  JOURNAL   Mol Cell 8 (5), 1041-1052 (2001)
   PUBMED   11741539
REFERENCE   7  (bases 1 to 1447)
  AUTHORS   Zhao,X., Yang,Z., Qian,M. and Zhu,X.
  TITLE     Interactions among subunits of human Arp2/3 complex: p20-Arc as the
            hub
  JOURNAL   Biochem Biophys Res Commun 280 (2), 513-517 (2001)
   PUBMED   11162547
REFERENCE   8  (bases 1 to 1447)
  AUTHORS   Welch,M.D., DePace,A.H., Verma,S., Iwamatsu,A. and Mitchison,T.J.
  TITLE     The human Arp2/3 complex is composed of evolutionarily conserved
            subunits and is localized to cellular regions of dynamic actin
            filament assembly
  JOURNAL   J Cell Biol 138 (2), 375-384 (1997)
   PUBMED   9230079
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK478610.1, BC167049.1 and BQ781452.1.
            
            On Jan 15, 2011 this sequence version replaced NM_001106615.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC167049.1, CV109491.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                CK478610.1         1-12
            13-889              BC167049.1         1-877
            890-1173            BQ781452.1         29-312
            1174-1447           BC167049.1         1161-1434
FEATURES             Location/Qualifiers
     source          1..1447
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1447
                     /gene="Arpc4"
                     /note="actin related protein 2/3 complex, subunit 4"
                     /db_xref="GeneID:297518"
                     /db_xref="RGD:1310096"
     exon            1..33
                     /gene="Arpc4"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..537
                     /gene="Arpc4"
                     /codon_start=1
                     /product="actin-related protein 2/3 complex subunit 4"
                     /protein_id="NP_001100085.2"
                     /db_xref="GeneID:297518"
                     /db_xref="RGD:1310096"
                     /translation="MTATLRPYLSAVRATLQAALCLENFSSQVVERHNKPEVEVRSSK
                     ELLLQPVTISRNEKEKVLIEGSINSVRVSIAVKQADEIEKILCHKFMRFMMMRAENFF
                     ILRRKPVEGYDISFLITNFHTEQMYKHKLVDFVIHFMEEIDKEISEMKLSVNARARIV
                     AEEFLKNF"
     exon            34..152
                     /gene="Arpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            153..264
                     /gene="Arpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            265..360
                     /gene="Arpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            361..531
                     /gene="Arpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            532..1423
                     /gene="Arpc4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccgctttc cggcccagac agcgcccgcg atgactgcca ctctccgccc ctaccttagt
       61 gccgtgcggg ccacactgca ggccgccctc tgcctggaga acttctcttc ccaggtcgtg
      121 gaacgacaca acaagccaga ggttgaagtc aggagtagca aagaactcct attgcaacct
      181 gttaccatca gcaggaatga gaaggaaaag gttctgattg aaggctccat caattctgtc
      241 cgggtcagca ttgctgtgaa acaggctgat gagattgaga agattttatg ccataaattc
      301 atgcgcttca tgatgatgcg agcagagaac ttctttatcc ttcgaaggaa acctgtggag
      361 ggttatgaca tcagctttct catcaccaac ttccatacgg agcagatgta caaacacaaa
      421 ctggtggact ttgtaatcca cttcatggag gagatcgaca aggagatcag tgagatgaaa
      481 ctgtcagtca atgcccgggc tcgtatcgtg gctgaggagt tcctcaagaa cttttagacc
      541 atctagctgg atctcgcagc cttccccctt ggcctcccct gtgtctctgc gtctgcgaag
      601 gtgtcctgga gtcactcccc ggagcagcgg tgcagcagca gcagcagcag cagcagcagg
      661 aagctgggtt gggtgggcat tggatgcggg aggcgggtgt ggtgagcttg ctggctgtgc
      721 agaaaggcag cagtggacct gccccatggc cacatgcgtc tggtctggct agcttctgat
      781 gctcagtccc ctgggccggg acagcctttt ttttttaaat gtcttgaaac ctaaactctg
      841 tgcttgtaga agactgtaac cttttttgtc tttttttttt tttttttttt aaaccaacct
      901 ccacctccag tggctgtgac tggccccagt gattgtacct tattggtcgc tgtggtctgg
      961 gcgggcctgg agccagaagg cgactatttt tccccagagc caccccaggt ggggagagag
     1021 ggaaatttca gactatagtt ttttttcttg ctgtcttacc cacaagcccc cttgggcctt
     1081 gtagaggtgg tatggaccct ctgctagctt cttgagttct gcctgaagat gcccactgca
     1141 ctggttggga acaagggctg attccatgat tgccgggcag gcctaggagc tggggtcaga
     1201 agccaggcaa acttctggcc gcagggactg cctggtgtcc atccaacacc cttccagctg
     1261 agaggcccca aggttggccc atctgggtac agtgcctgtg ctggaggtgc agaggtgagt
     1321 cctgcctgct caggcccctc tgctcccatg ctcgctgtct ctgattctga tcaattcccc
     1381 cgccctaatt aaagtctttt tctgcccctt tggggctgca tgaaaaaaaa aaaaaaaaaa
     1441 aaaaaaa
//
