LOCUS       NM_001105933             872 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus actin related protein 2/3 complex, subunit 3
            (Arpc3), mRNA.
ACCESSION   NM_001105933 XM_001079492 XM_213782
VERSION     NM_001105933.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 872)
  AUTHORS   Doumatey AP, Xu H, Huang H, Trivedi NS, Lei L, Elkahloun A, Adeyemo
            A and Rotimi CN.
  TITLE     Global Gene Expression Profiling in Omental Adipose Tissue of
            Morbidly Obese Diabetic African Americans
  JOURNAL   J Endocrinol Metab 5 (3), 199-210 (2015)
   PUBMED   26504501
REFERENCE   2  (bases 1 to 872)
  AUTHORS   Kuo JC, Han X, Hsiao CT, Yates JR 3rd and Waterman CM.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   3  (bases 1 to 872)
  AUTHORS   Gonzalez-Aparicio R, Flores JA and Fernandez-Espejo E.
  TITLE     Antiparkinsonian trophic action of glial cell line-derived
            neurotrophic factor and transforming growth factor beta1 is
            enhanced after co-infusion in rats
  JOURNAL   Exp Neurol 226 (1), 136-147 (2010)
   PUBMED   20713051
REFERENCE   4  (bases 1 to 872)
  AUTHORS   Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M and
            Stoorvogel W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 872)
  AUTHORS   Chiu TT, Patel N, Shaw AE, Bamburg JR and Klip A.
  TITLE     Arp2/3- and cofilin-coordinated actin dynamics is required for
            insulin-mediated GLUT4 translocation to the surface of muscle cells
  JOURNAL   Mol Biol Cell 21 (20), 3529-3539 (2010)
   PUBMED   20739464
REFERENCE   6  (bases 1 to 872)
  AUTHORS   DesMarais V, Macaluso F, Condeelis J and Bailly M.
  TITLE     Synergistic interaction between the Arp2/3 complex and cofilin
            drives stimulated lamellipod extension
  JOURNAL   J Cell Sci 117 (Pt 16), 3499-3510 (2004)
   PUBMED   15252126
  REMARK    GeneRIF: documents the relative contributions of cofilin and Arp2/3
            complex in vivo and indicate that cofilin begins to initiate the
            generation of free barbed ends that act in synergy with the Arp2/3
            complex to create a large burst in nucleation activity
REFERENCE   7  (bases 1 to 872)
  AUTHORS   Gournier H, Goley ED, Niederstrasser H, Trinh T and Welch MD.
  TITLE     Reconstitution of human Arp2/3 complex reveals critical roles of
            individual subunits in complex structure and activity
  JOURNAL   Mol Cell 8 (5), 1041-1052 (2001)
   PUBMED   11741539
REFERENCE   8  (bases 1 to 872)
  AUTHORS   Goldberg DJ, Foley MS, Tang D and Grabham PW.
  TITLE     Recruitment of the Arp2/3 complex and mena for the stimulation of
            actin polymerization in growth cones by nerve growth factor
  JOURNAL   J Neurosci Res 60 (4), 458-467 (2000)
   PUBMED   10797548
REFERENCE   9  (bases 1 to 872)
  AUTHORS   Bailly M, Macaluso F, Cammer M, Chan A, Segall JE and Condeelis JS.
  TITLE     Relationship between Arp2/3 complex and the barbed ends of actin
            filaments at the leading edge of carcinoma cells after epidermal
            growth factor stimulation
  JOURNAL   J Cell Biol 145 (2), 331-345 (1999)
   PUBMED   10209028
REFERENCE   10 (bases 1 to 872)
  AUTHORS   Welch MD, DePace AH, Verma S, Iwamatsu A and Mitchison TJ.
  TITLE     The human Arp2/3 complex is composed of evolutionarily conserved
            subunits and is localized to cellular regions of dynamic actin
            filament assembly
  JOURNAL   J Cell Biol 138 (2), 375-384 (1997)
   PUBMED   9230079
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473973.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_001079492.1, XM_213782.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ219862.1, FQ221109.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..872
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..872
                     /gene="Arpc3"
                     /note="actin related protein 2/3 complex, subunit 3"
                     /db_xref="GeneID:288669"
                     /db_xref="RGD:1311985"
     exon            1..116
                     /gene="Arpc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..647
                     /gene="Arpc3"
                     /codon_start=1
                     /product="actin-related protein 2/3 complex subunit 3"
                     /protein_id="NP_001099403.1"
                     /db_xref="GeneID:288669"
                     /db_xref="RGD:1311985"
                     /translation="MPAYHSSLMDPDTKLIGNMALLPIRSQFKGPAPRETKDTDIVDE
                     AIYYFKANVFFKNYEIKNEADRTLIYITLYISECLKKLQKCNSRSQGEKEMYTLGITN
                     FPIPGEPGFPLNAIYAKPASKQEDETMRAYLQQLRQETGLRLCDKVFDPQNDKPSKWW
                     TCFVKRQFMNKSLSGPGQ"
     exon            117..216
                     /gene="Arpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            217..293
                     /gene="Arpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            294..362
                     /gene="Arpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            363..489
                     /gene="Arpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            490..584
                     /gene="Arpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            585..872
                     /gene="Arpc3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcctcttc cggcttattt ccgcccactc cacccagtct agtttgccgg aaacgctgct
       61 ccgctttacc tgggttcagc atctctagat cgaatccgga caccgacaaa atgccggctt
      121 accactcttc tctcatggac cctgacacca agctcattgg caacatggca ctgctgccca
      181 tccgaagcca gttcaaagga cccgcccctc gagagacgaa agacacggat attgtggatg
      241 aagccatcta ttacttcaag gccaacgtct tcttcaagaa ctatgaaatt aagaatgaag
      301 cggacaggac cttgatctac atcacactct acatttctga gtgtctaaag aagctccaaa
      361 agtgcaactc cagaagccaa ggcgagaaag aaatgtacac gctaggaatc accaactttc
      421 ccattcctgg cgagcctggc tttcccctca acgccattta cgccaaacct gccagcaaac
      481 aggaggatga aacgatgcgc gcgtacctac agcagctgag gcaagagacc ggactgaggc
      541 tttgtgacaa agtttttgac cctcagaatg ataaaccaag caagtggtgg acttgctttg
      601 tgaagagaca gttcatgaac aagagtcttt cggggcccgg gcagtgagag gagccatggt
      661 cagcatcgca ttgaggtgta cacagtccta tgtgtttgtt cttaacgtgt cacgagagga
      721 gagagcctgt ctaccgggaa agctctcggt caagagtttg gagggtgggt gtcgggtttg
      781 aatttcaagc tggtacttca tatgtaataa atgtcgctgc ttatgttaga cagacattga
      841 attaaaacat ttttgagaaa aagcgtacac aa
//
