LOCUS       NM_019289               1496 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus actin related protein 2/3 complex, subunit 1B
            (Arpc1b), mRNA.
ACCESSION   NM_019289
VERSION     NM_019289.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1496)
  AUTHORS   Tunduguru,R., Zhang,J., Aslamy,A., Salunkhe,V.A., Brozinick,J.T.,
            Elmendorf,J.S. and Thurmond,D.C.
  TITLE     The actin-related p41ARC subunit contributes to p21-activated
            kinase-1 (PAK1)-mediated glucose uptake into skeletal muscle cells
  JOURNAL   J Biol Chem 292 (46), 19034-19043 (2017)
   PUBMED   28972183
  REMARK    GeneRIF: These results expand the model of insulin-stimulated
            glucose uptake in skeletal muscle cells by implicating p41ARC as a
            new component of the insulin-signaling cascade and connecting PAK1
            signaling to N-WASP-cortactin-mediated actin polymerization and
            GLUT4 vesicle translocation.
REFERENCE   2  (bases 1 to 1496)
  AUTHORS   Kumar,A., Dumasia,K., Deshpande,S. and Balasinor,N.H.
  TITLE     Direct regulation of genes involved in sperm release by estrogen
            and androgen through their receptors and coregulators
  JOURNAL   J Steroid Biochem Mol Biol 171, 66-74 (2017)
   PUBMED   28242260
  REMARK    GeneRIF: Data suggest that expression of spermiation-related genes
            is directly up-regulated by estrogen 17-beta-estradiol in testes of
            adult rats; a functional estrogen response element lies upstream of
            Arpc1b and Evl genes. (Arpc1b = actin related protein 2-3 complex,
            subunit 1B; Evl = enabled-VASP-like protein)
REFERENCE   3  (bases 1 to 1496)
  AUTHORS   Kumar,A., Dumasia,K., Deshpande,S., Gaonkar,R. and Balasinor,N.H.
  TITLE     Actin related protein complex subunit 1b controls sperm release,
            barrier integrity and cell division during adult rat
            spermatogenesis
  JOURNAL   Biochim Biophys Acta 1863 (8), 1996-2005 (2016)
   PUBMED   27113856
  REMARK    GeneRIF: Arpc1b knockdown in adult rat testis led to defects in
            spermiation caused by failure in Sertoli-cell tubulobulbar
            complexes formation.  Knockdown also compromised blood-testis
            barrier integrity and caused polarity defects of mature spermatids.
            Arpc1b reduction perturbed ability of germ cells to enter G2/M
            phase thus hindering cell division.
REFERENCE   4  (bases 1 to 1496)
  AUTHORS   Auzair,L.B., Vincent-Chong,V.K., Ghani,W.M., Kallarakkal,T.G.,
            Ramanathan,A., Lee,C.E., Rahman,Z.A., Ismail,S.M., Abraham,M.T. and
            Zain,R.B.
  TITLE     Caveolin 1 (Cav-1) and actin-related protein 2/3 complex, subunit
            1B (ARPC1B) expressions as prognostic indicators for oral squamous
            cell carcinoma (OSCC)
  JOURNAL   Eur Arch Otorhinolaryngol 273 (7), 1885-1893 (2016)
   PUBMED   26138391
REFERENCE   5  (bases 1 to 1496)
  AUTHORS   Kumar,A., Dumasia,K., Gaonkar,R., Sonawane,S., Kadam,L. and
            Balasinor,N.H.
  TITLE     Estrogen and androgen regulate actin-remodeling and
            endocytosis-related genes during rat spermiation
  JOURNAL   Mol Cell Endocrinol 404, 91-101 (2015)
   PUBMED   25637714
REFERENCE   6  (bases 1 to 1496)
  AUTHORS   Cai,L., Makhov,A.M., Schafer,D.A. and Bear,J.E.
  TITLE     Coronin 1B antagonizes cortactin and remodels Arp2/3-containing
            actin branches in lamellipodia
  JOURNAL   Cell 134 (5), 828-842 (2008)
   PUBMED   18775315
REFERENCE   7  (bases 1 to 1496)
  AUTHORS   Kaneda,A., Kaminishi,M., Sugimura,T. and Ushijima,T.
  TITLE     Decreased expression of the seven ARP2/3 complex genes in human
            gastric cancers
  JOURNAL   Cancer Lett 212 (2), 203-210 (2004)
   PUBMED   15279900
REFERENCE   8  (bases 1 to 1496)
  AUTHORS   Prabakaran,S., Swatton,J.E., Ryan,M.M., Huffaker,S.J., Huang,J.T.,
            Griffin,J.L., Wayland,M., Freeman,T., Dudbridge,F., Lilley,K.S.,
            Karp,N.A., Hester,S., Tkachev,D., Mimmack,M.L., Yolken,R.H.,
            Webster,M.J., Torrey,E.F. and Bahn,S.
  TITLE     Mitochondrial dysfunction in schizophrenia: evidence for
            compromised brain metabolism and oxidative stress
  JOURNAL   Mol Psychiatry 9 (7), 684-697 (2004)
   PUBMED   15098003
REFERENCE   9  (bases 1 to 1496)
  AUTHORS   Gournier,H., Goley,E.D., Niederstrasser,H., Trinh,T. and Welch,M.D.
  TITLE     Reconstitution of human Arp2/3 complex reveals critical roles of
            individual subunits in complex structure and activity
  JOURNAL   Mol Cell 8 (5), 1041-1052 (2001)
   PUBMED   11741539
REFERENCE   10 (bases 1 to 1496)
  AUTHORS   Welch,M.D., DePace,A.H., Verma,S., Iwamatsu,A. and Mitchison,T.J.
  TITLE     The human Arp2/3 complex is composed of evolutionarily conserved
            subunits and is localized to cellular regions of dynamic actin
            filament assembly
  JOURNAL   J Cell Biol 138 (2), 375-384 (1997)
   PUBMED   9230079
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 27, 2020 this sequence version replaced NM_019289.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062027.1, FQ228791.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676806, SAMN16676808
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000012.1  14609421-14609488   c
            69-151              JAXUCZ010000012.1  14602874-14602956   c
            152-256             JAXUCZ010000012.1  14601887-14601991   c
            257-479             JAXUCZ010000012.1  14600910-14601132   c
            480-587             JAXUCZ010000012.1  14599792-14599899   c
            588-794             JAXUCZ010000012.1  14598647-14598853   c
            795-870             JAXUCZ010000012.1  14598471-14598546   c
            871-1076            JAXUCZ010000012.1  14597159-14597364   c
            1077-1167           JAXUCZ010000012.1  14596400-14596490   c
            1168-1496           JAXUCZ010000012.1  14595939-14596267   c
FEATURES             Location/Qualifiers
     source          1..1496
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..1496
                     /gene="Arpc1b"
                     /gene_synonym="p41Arc"
                     /note="actin related protein 2/3 complex, subunit 1B"
                     /db_xref="GeneID:54227"
                     /db_xref="RGD:2155"
     exon            1..68
                     /gene="Arpc1b"
                     /gene_synonym="p41Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            69..151
                     /gene="Arpc1b"
                     /gene_synonym="p41Arc"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1206
                     /gene="Arpc1b"
                     /gene_synonym="p41Arc"
                     /note="p41-ARC; arp2/3 complex 41 kDa subunit;
                     Actin-related protein complex 1b"
                     /codon_start=1
                     /product="actin-related protein 2/3 complex subunit 1B"
                     /protein_id="NP_062162.1"
                     /db_xref="GeneID:54227"
                     /db_xref="RGD:2155"
                     /translation="MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWNK
                     VHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCV
                     RWAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAG
                     SCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSAGGSRVA
                     WVSHDSTVCLVDAEKKMAVATLASETLPLLAITFITENSLVAAGHDCFPVLFTYDNAA
                     GTLSFGGRLDVPKQNSQRGLTARERFQNLDKKASSEGGAATGAGLDSLHKNSVSQISV
                     LSGGKAKCSQFCTTGMDGGMSIWDVKSLESALKDLKIR"
     exon            152..256
                     /gene="Arpc1b"
                     /gene_synonym="p41Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            257..479
                     /gene="Arpc1b"
                     /gene_synonym="p41Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            480..587
                     /gene="Arpc1b"
                     /gene_synonym="p41Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            588..794
                     /gene="Arpc1b"
                     /gene_synonym="p41Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            795..870
                     /gene="Arpc1b"
                     /gene_synonym="p41Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1076
                     /gene="Arpc1b"
                     /gene_synonym="p41Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1167
                     /gene="Arpc1b"
                     /gene_synonym="p41Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1496
                     /gene="Arpc1b"
                     /gene_synonym="p41Arc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctgcgcgg gtctcagagc cggttcggcg cgtcgactgt ccagagtccg cggccgagga
       61 gacccgaggt ccaggagaca agtgactatg gcttaccaca gcttcctggt ggaacccatc
      121 agctgccatg cctggaacaa ggaccgtact cagatcgcca tctgccccaa caaccacgag
      181 gtgcacatct acgagaagag cggtgccaag tggaacaagg tgcacgagct caaggagcac
      241 aacgggcagg tgacaggcat cgactgggcc cccgagagta accgcattgt gacctgcggc
      301 acagaccgca atgcctatgt gtggacgctg aagggccgca cgtggaagcc cacgctggtc
      361 atccttcgga ttaatcgagc tgcccgctgc gtgcgctggg cccccaatga gaacaagttc
      421 gccgtgggca gtggctcccg tgtcatttcc atctgttatt ttgagcagga gaatgactgg
      481 tgggtgtgca aacacatcaa aaagcccatc cgctccactg tccttagcct ggactggcac
      541 cccaacaacg tgctcctggc tgcaggctcc tgtgacttca agtgcaggat cttctctgcc
      601 tatatcaagg aggtggagga acggccagcc cctacaccgt ggggctccaa gatgcccttt
      661 ggggagctga tgtttgaatc gagcagcagc tgtggctggg tgcatggtgt ctgcttctcg
      721 gccggtggga gccgagttgc ttgggtcagc catgacagca ctgtgtgcct ggtagatgct
      781 gagaagaaga tggccgtggc aaccctggcc tctgagacat taccgctcct ggccatcacc
      841 ttcatcacag aaaatagtct cgtggcagcg ggccacgact gcttcccggt gctgtttacc
      901 tatgacaacg ctgcggggac attgagcttt ggtggccggc tggatgtgcc caagcagaac
      961 tcccagcgtg gcctgacagc ccgagagcgc ttccagaacc tcgacaagaa ggccagctct
     1021 gaagggggtg cagccacagg ggctggcctg gattcactgc acaagaacag cgtcagtcaa
     1081 atctcggtgc tcagcggggg caaggccaag tgctcgcagt tctgcaccac aggcatggac
     1141 ggtggcatga gcatctggga tgtgaagagc ttggagtcag ccttgaagga cctgaagatc
     1201 agatgagctg tgaggagtgc tgtcctcatc ccacatgctg gggaggaggg aaaggggttg
     1261 gggaggctaa gggctgcttt gctgaatgct tctagggtgt agtacaggtc tgcaaagggg
     1321 atgctctctc tccaaagagg ggaagaggaa ggtggggaac tttcctattt aatgaaaatg
     1381 tgccttttaa agagatgctt tcattcattg caaaccaaaa acaagacaaa aaacccaaag
     1441 cacaatgctg gtcataaact gcttcaaaat gtgggctaat aaacatacca aatgtg
//
