LOCUS       NM_031146               1627 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus actin related protein 2/3 complex, subunit 1A
            (Arpc1a), mRNA.
ACCESSION   NM_031146 XM_346424
VERSION     NM_031146.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1627)
  AUTHORS   Baas,D., Caussanel-Boude,S., Guiraud,A., Calhabeu,F., Delaune,E.,
            Pilot,F., Chopin,E., Machuca-Gayet,I., Vernay,A., Bertrand,S.,
            Rual,J.F., Jurdic,P., Hill,D.E., Vidal,M., Schaeffer,L. and
            Goillot,E.
  TITLE     CKIP-1 regulates mammalian and zebrafish myoblast fusion
  JOURNAL   J Cell Sci 125 (Pt 16), 3790-3800 (2012)
   PUBMED   22553210
REFERENCE   2  (bases 1 to 1627)
  AUTHORS   Chiu,T.T., Patel,N., Shaw,A.E., Bamburg,J.R. and Klip,A.
  TITLE     Arp2/3- and cofilin-coordinated actin dynamics is required for
            insulin-mediated GLUT4 translocation to the surface of muscle cells
  JOURNAL   Mol Biol Cell 21 (20), 3529-3539 (2010)
   PUBMED   20739464
REFERENCE   3  (bases 1 to 1627)
  AUTHORS   Laurila,E., Savinainen,K., Kuuselo,R., Karhu,R. and Kallioniemi,A.
  TITLE     Characterization of the 7q21-q22 amplicon identifies ARPC1A, a
            subunit of the Arp2/3 complex, as a regulator of cell migration and
            invasion in pancreatic cancer
  JOURNAL   Genes Chromosomes Cancer 48 (4), 330-339 (2009)
   PUBMED   19145645
REFERENCE   4  (bases 1 to 1627)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1627)
  AUTHORS   Prabakaran,S., Swatton,J.E., Ryan,M.M., Huffaker,S.J., Huang,J.T.,
            Griffin,J.L., Wayland,M., Freeman,T., Dudbridge,F., Lilley,K.S.,
            Karp,N.A., Hester,S., Tkachev,D., Mimmack,M.L., Yolken,R.H.,
            Webster,M.J., Torrey,E.F. and Bahn,S.
  TITLE     Mitochondrial dysfunction in schizophrenia: evidence for
            compromised brain metabolism and oxidative stress
  JOURNAL   Mol Psychiatry 9 (7), 684-697 (2004)
   PUBMED   15098003
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DY310102.1, CO396710.1, CO562802.1 and CB327105.1.
            
            On May 4, 2007 this sequence version replaced NM_031146.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ214345.1, SRR8487231.58555.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785, SAMN16676809
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-709               DY310102.1         1-709
            710-1173            CO396710.1         178-641
            1174-1603           CO562802.1         16-445              c
            1604-1627           CB327105.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..1627
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..1627
                     /gene="Arpc1a"
                     /note="actin related protein 2/3 complex, subunit 1A"
                     /db_xref="GeneID:81824"
                     /db_xref="RGD:620834"
     exon            1..119
                     /gene="Arpc1a"
                     /inference="alignment:Splign:2.1.0"
     exon            120..213
                     /gene="Arpc1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1262
                     /gene="Arpc1a"
                     /note="suppressor of profilin/p41 of actin-related complex
                     2/3"
                     /codon_start=1
                     /product="actin-related protein 2/3 complex subunit 1A"
                     /protein_id="NP_112408.1"
                     /db_xref="GeneID:81824"
                     /db_xref="RGD:620834"
                     /translation="MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWTK
                     AHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGIWKPTLVILRINRAATFV
                     KWSPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAG
                     SCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSR
                     LAWVSHDSTVSVADASKSVQVSTLRTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDD
                     RGCLTFVSKLDVPKQSIQRNMSAMERFRNMDKRATTEDRNTALETLHQNSITQVSIYE
                     VDKQDCRKFCTTGIDGAMTIWDFKTLESSIQGLRIM"
     exon            214..318
                     /gene="Arpc1a"
                     /inference="alignment:Splign:2.1.0"
     exon            319..541
                     /gene="Arpc1a"
                     /inference="alignment:Splign:2.1.0"
     exon            542..649
                     /gene="Arpc1a"
                     /inference="alignment:Splign:2.1.0"
     exon            650..862
                     /gene="Arpc1a"
                     /inference="alignment:Splign:2.1.0"
     exon            863..938
                     /gene="Arpc1a"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1132
                     /gene="Arpc1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1223
                     /gene="Arpc1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1612
                     /gene="Arpc1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtcagccg ctccctctag gcctccctcc tccgtccgcg cccgccggag cctgttcgcg
       61 tcgactgacc agagtccgcg aatcgttcgc tccggacctc ccgacctccc ctaccccagc
      121 tttctgacct gtgaaaacac gtaggaatca tgtctctgca tcagtttctg ctagagccaa
      181 tcacctgcca tgcctggaac agggatcgga cccagatcgc actgagcccc aataatcatg
      241 aagtgcacat ctacaagaag aatgggagtc agtggacgaa agctcacgag ctgaaggaac
      301 ataacggaca catcacaggt attgactggg ctcctaagag cgaccgtatt gtcacttgtg
      361 gggcggaccg caacgcctat gtctggagtc agaaagatgg catctggaag ccgaccctgg
      421 tgatcctgag gattaaccgt gcagccactt tcgtgaagtg gtctccactc gagaacaagt
      481 ttgctgtggg gagtggagcc cggctcatct ctgtctgcta ctttgagtct gaaaatgact
      541 ggtgggtcag caagcacatt aagaagccga tccgctccac agtcctcagc ctggactggc
      601 atcccaacaa cgttttgctg gctgcaggct cctgtgactt caaatgcaga gtattttcgg
      661 cctacatcaa agaggtggat gagaagccag ccagcacgcc ctggggcagc aagatgcctt
      721 ttggtcagct gatgtctgag tttggtggca gtggcactgg tggctgggtg cacggggtca
      781 gcttctctgc cagtgggagc cggctggcct gggtcagcca cgacagcaca gtgtctgtcg
      841 ctgatgcctc aaaaagtgtg caggtttcaa ctctgagaac ggagttcctg ccgctgctca
      901 gtgtgtcatt tgtctcagag aacagcgttg tggctgccgg ccatgactgc tgcccgatgc
      961 tctttaacta cgatgaccgt ggctgtttga cctttgtgtc caagctagac gtcccaaaac
     1021 agagcatcca gcgcaacatg tctgctatgg aacgcttccg taacatggat aagagggcca
     1081 ctaccgagga ccgcaacaca gccttggaaa cactgcacca gaacagcatc actcaagtgt
     1141 ctatttatga agtggacaag caagattgtc gcaaattttg cactactggc atcgatggag
     1201 ccatgacaat ctgggatttc aagactctag agtcttccat ccagggtctc cggataatgt
     1261 gaagccgagt gagcctctgc catccagcat gaggaacggg actgagcagt ctgcctgccg
     1321 ttcacatggt ggtgaggatc ctggccccag gaaacactgt cacactgaag ccactagcgt
     1381 gtatccgtgt ggatgtcgtg ggcgaagcgt gggatttaga gcagcagtgg tttgttttgc
     1441 tttttctttc attttgtttt gttttgtttt gattttgcta tctcattcca tttttgacca
     1501 aagcttctct ttaagtagtt tattatggaa gattgtcaca ctaacttaaa ggggaaggga
     1561 cgtgtgtaca ttgtgtgcta aaaaaattaa agaaaaatcc caagtgtgca aaaaaaaaaa
     1621 aaaaaaa
//
