LOCUS       NM_012781               6229 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus aryl hydrocarbon receptor nuclear translocator 2
            (Arnt2), mRNA.
ACCESSION   NM_012781
VERSION     NM_012781.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6229)
  AUTHORS   Wu,D., Su,X., Potluri,N., Kim,Y. and Rastinejad,F.
  TITLE     NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS
            family as multi-ligand binding transcription factors
  JOURNAL   Elife 5, e18790 (2016)
   PUBMED   27782878
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6229)
  AUTHORS   Zhang,Z., Fei,P., Mu,J., Li,W. and Song,J.
  TITLE     Hippocampal expression of aryl hydrocarbon receptor nuclear
            translocator 2 and neuronal PAS domain protein 4 in a rat model of
            depression
  JOURNAL   Neurol Sci 35 (2), 277-282 (2014)
   PUBMED   23861074
  REMARK    GeneRIF: Relative hippocampal NPAS4 expression was significantly
            lower in depression model rats compared to controls but there was
            no significant difference in hippocampal ARNT2 expression between
            groups
REFERENCE   3  (bases 1 to 6229)
  AUTHORS   Bersten,D.C., Bruning,J.B., Peet,D.J. and Whitelaw,M.L.
  TITLE     Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim
            (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt
            function
  JOURNAL   PLoS One 9 (1), e85768 (2014)
   PUBMED   24465693
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6229)
  AUTHORS   Webb,E.A., AlMutair,A., Kelberman,D., Bacchelli,C., Chanudet,E.,
            Lescai,F., Andoniadou,C.L., Banyan,A., Alsawaid,A., Alrifai,M.T.,
            Alahmesh,M.A., Balwi,M., Mousavy-Gharavy,S.N., Lukovic,B.,
            Burke,D., McCabe,M.J., Kasia,T., Kleta,R., Stupka,E., Beales,P.L.,
            Thompson,D.A., Chong,W.K., Alkuraya,F.S., Martinez-Barbera,J.P.,
            Sowden,J.C. and Dattani,M.T.
  TITLE     ARNT2 mutation causes hypopituitarism, post-natal microcephaly,
            visual and renal anomalies
  JOURNAL   Brain 136 (Pt 10), 3096-3105 (2013)
   PUBMED   24022475
REFERENCE   5  (bases 1 to 6229)
  AUTHORS   Keith,B., Johnson,R.S. and Simon,M.C.
  TITLE     HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth
            and progression
  JOURNAL   Nat Rev Cancer 12 (1), 9-22 (2011)
   PUBMED   22169972
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6229)
  AUTHORS   Hosoya,T., Oda,Y., Takahashi,S., Morita,M., Kawauchi,S., Ema,M.,
            Yamamoto,M. and Fujii-Kuriyama,Y.
  TITLE     Defective development of secretory neurones in the hypothalamus of
            Arnt2-knockout mice
  JOURNAL   Genes Cells 6 (4), 361-374 (2001)
   PUBMED   11318878
REFERENCE   7  (bases 1 to 6229)
  AUTHORS   Drutel,G., Kathmann,M., Heron,A., Gros,C., Mace,S., Schwartz,J.C.
            and Arrang,J.M.
  TITLE     Two splice variants of the hypoxia-inducible factor HIF-1alpha as
            potential dimerization partners of ARNT2 in neurons
  JOURNAL   Eur J Neurosci 12 (10), 3701-3708 (2000)
   PUBMED   11029639
REFERENCE   8  (bases 1 to 6229)
  AUTHORS   Maltepe,E., Keith,B., Arsham,A.M., Brorson,J.R. and Simon,M.C.
  TITLE     The role of ARNT2 in tumor angiogenesis and the neural response to
            hypoxia
  JOURNAL   Biochem Biophys Res Commun 273 (1), 231-238 (2000)
   PUBMED   10873592
REFERENCE   9  (bases 1 to 6229)
  AUTHORS   Ema,M., Morita,M., Ikawa,S., Tanaka,M., Matsuda,Y., Gotoh,O.,
            Saijoh,Y., Fujii,H., Hamada,H., Kikuchi,Y. and Fujii-Kuriyama,Y.
  TITLE     Two new members of the murine Sim gene family are transcriptional
            repressors and show different expression patterns during mouse
            embryogenesis
  JOURNAL   Mol Cell Biol 16 (10), 5865-5875 (1996)
   PUBMED   8927054
REFERENCE   10 (bases 1 to 6229)
  AUTHORS   Hirose,K., Morita,M., Ema,M., Mimura,J., Hamada,H., Fujii,H.,
            Saijo,Y., Gotoh,O., Sogawa,K. and Fujii-Kuriyama,Y.
  TITLE     cDNA cloning and tissue-specific expression of a novel basic
            helix-loop-helix/PAS factor (Arnt2) with close sequence similarity
            to the aryl hydrocarbon receptor nuclear translocator (Arnt)
  JOURNAL   Mol Cell Biol 16 (4), 1706-1713 (1996)
   PUBMED   8657146
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012781.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.3773.1,
                                           SRR26643297.2544.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               JAXUCZ010000001.1  147801768-147801883 c
            117-231             JAXUCZ010000001.1  147756217-147756331 c
            232-279             JAXUCZ010000001.1  147749342-147749389 c
            280-493             JAXUCZ010000001.1  147742168-147742381 c
            494-707             JAXUCZ010000001.1  147738605-147738818 c
            708-810             JAXUCZ010000001.1  147707989-147708091 c
            811-876             JAXUCZ010000001.1  147702472-147702537 c
            877-962             JAXUCZ010000001.1  147702048-147702133 c
            963-1039            JAXUCZ010000001.1  147686784-147686860 c
            1040-1174           JAXUCZ010000001.1  147684998-147685132 c
            1175-1249           JAXUCZ010000001.1  147683886-147683960 c
            1250-1401           JAXUCZ010000001.1  147677359-147677510 c
            1402-1474           JAXUCZ010000001.1  147669250-147669322 c
            1475-1598           JAXUCZ010000001.1  147668327-147668450 c
            1599-1698           JAXUCZ010000001.1  147665743-147665842 c
            1699-1837           JAXUCZ010000001.1  147663365-147663503 c
            1838-1988           JAXUCZ010000001.1  147662617-147662767 c
            1989-2125           JAXUCZ010000001.1  147651384-147651520 c
            2126-6229           JAXUCZ010000001.1  147645354-147649457 c
FEATURES             Location/Qualifiers
     source          1..6229
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..6229
                     /gene="Arnt2"
                     /note="aryl hydrocarbon receptor nuclear translocator 2"
                     /db_xref="GeneID:25243"
                     /db_xref="RGD:2154"
     exon            1..116
                     /gene="Arnt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..2224
                     /gene="Arnt2"
                     /note="ARNT protein 2"
                     /codon_start=1
                     /product="aryl hydrocarbon receptor nuclear translocator
                     2"
                     /protein_id="NP_036913.3"
                     /db_xref="GeneID:25243"
                     /db_xref="RGD:2154"
                     /translation="MATPAAVNPPEMASDIPGSVTLPVAPMAATGQVRMAGAMPARGG
                     KRRSGMDFDDEDGEGPSKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDK
                     LTILRMAVSHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRV
                     IYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTV
                     KKEGQQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQ
                     YAVVHCTGYIKAWPPAGMSIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMSGMSVP
                     TEFLSRHNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKL
                     KGQVLSVMYRFRTKNREWLLIRTSSFTFQNPYSDEIEYVICTNTNVKQLQQQQAELEV
                     HQRDGLSSYDLSQVPVPNLPTGVHEAGKPVEKADAIFSQERDPRFAEMFAGISASEKK
                     MMSSASASGSQQIYSQGSPFPAGHSGKAFSSSVVHVPGVNDIQSSSSTGQNISQISRQ
                     LNQGQVAWTGSRPPFPGQPSKTQSSAFGIGSSHPYPADPSSYSPLSSPAASSPSGNAY
                     PSLANRTPGFAESGQSGGQFQGRPSEVWSQWQSQHHGQQSGEQHSHQQPGQTEVFQDM
                     LPMPGDPTQGTGNYNIEDFADLGMFPPFSE"
     exon            117..231
                     /gene="Arnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            232..279
                     /gene="Arnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            280..493
                     /gene="Arnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            494..707
                     /gene="Arnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..810
                     /gene="Arnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            811..876
                     /gene="Arnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            877..962
                     /gene="Arnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1039
                     /gene="Arnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1174
                     /gene="Arnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1249
                     /gene="Arnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1401
                     /gene="Arnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1474
                     /gene="Arnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1598
                     /gene="Arnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1698
                     /gene="Arnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1837
                     /gene="Arnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1988
                     /gene="Arnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2125
                     /gene="Arnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..6229
                     /gene="Arnt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccgcggcg gcgctggccc gcgccgggtc ccggtccccg cccccgcccc gcccccgccc
       61 ggcgctccgg tcccttcccg gcaagatggc aaccccggcc gccgtcaacc ctccggaaat
      121 ggcttcagac atacctggat ctgtgacctt gcctgttgcc cccatggcgg ccacgggaca
      181 ggtgagaatg gcaggggcca tgcctgcccg aggaggaaag cggcgatccg gaatggactt
      241 tgatgacgaa gatggtgaag gtcccagtaa attttcaaga gagaaccaca gtgagattga
      301 gcggcgcagg cggaacaaga tgactcaata tattacggaa ctctccgaca tggttcccac
      361 ctgcagtgca ctagctagga agccagacaa gctcaccatt ctacgcatgg cggtctcaca
      421 catgaagtcc atgaggggca ccggcaacaa atctactgac ggcgcatata agccttcctt
      481 cctcactgag caggaactga agcatctcat ccttgaagct gctgacggat ttctgtttgt
      541 ggtggctgcc gagacaggga gagtaatcta cgtgtctgat tctgtcactc ctgtcctgaa
      601 ccagccacag tcagagtggt ttgggagcac actctatgaa caggtgcacc ctgatgacgt
      661 ggagaaactg agagaacagc tgtgtacttc agaaaactcc atgacaggcc gcatcctaga
      721 cctgaagact gggacagtga agaaggaggg acagcagtcg tccatgcgca tgtgtatggg
      781 ctcccggcgc tccttcatct gtagaatgag gtgtggaaat gctcccttgg accacctgcc
      841 tttgaacaga ataaccacca tgaggaaaag gttcaggaat ggccttggcc ctgtgaaaga
      901 aggagaagcc caatatgccg tggtccactg cacaggttac atcaaggctt ggccaccagc
      961 aggaatgagc atacccgaag aagatgctga tgttggacaa ggcagtaaat attgccttgt
     1021 ggcaatcggg aggctccagg tgaccagctc tcctgtgtgc atggacatga gtggcatgtc
     1081 agtgcccacg gagttcctgt ctcggcataa ctctgatggg atcatcacgt ttgtagaccc
     1141 aagatgcatc agtgtgattg gctaccagcc ccaggacctt ctgggaaaag atattttgga
     1201 attctgccac cctgaggatc agagccacct acgggagagc ttccagcagg tggttaaact
     1261 gaagggccaa gtgctgtcgg tcatgtacag gttccgcacc aagaaccggg agtggctgtt
     1321 gatccgcacc agcagcttca ccttccagaa cccctactct gatgagatcg agtatgtcat
     1381 ctgcaccaac accaacgtca agcaacttca gcagcagcag gcagagctgg aggtacacca
     1441 gcgagacggg ctgtcatcat atgacttgtc tcaggtcccg gtacccaacc tacccactgg
     1501 tgttcatgag gcagggaagc ctgtggaaaa ggcagatgcg atcttctccc aagagagaga
     1561 ccctcgtttt gctgagatgt ttgcaggcat cagtgcatcg gagaagaaga tgatgagctc
     1621 agcctcagca tccggcagcc agcagatcta ctcccaagga agtccattcc ctgccgggca
     1681 ctcgggcaag gccttcagct cttctgtggt ccatgtgcct ggagtgaatg acattcagtc
     1741 ctcctcctca acgggccaga acatatccca gatctcccgg cagctgaacc agggccaggt
     1801 ggcatggaca ggcagccgtc cacccttccc agggcagccc agcaagacgc agtcatctgc
     1861 cttcggaatt ggatcaagcc acccctaccc agccgaccct tcatcctaca gtcctctctc
     1921 cagcccagct gcctcctcac caagcggaaa cgcatacccc agtcttgcca acaggactcc
     1981 agggtttgct gagagtggac agagtggagg gcaattccag ggccggccct cagaggtctg
     2041 gtcccagtgg cagagccagc atcacggaca gcagagcggt gagcagcact cccaccagca
     2101 gcctggccag actgaagtgt tccaggacat gctacccatg ccgggcgacc cgacgcaggg
     2161 gactggcaac tataacatcg aggactttgc tgacctgggc atgttccctc cattttctga
     2221 gtagcttcag gcaaagccag gcttctactg cccaggcgct attatcatac catagatgcc
     2281 catgttcaaa gagtgccccc tcacccagct tgccctgctg cagaaccccc ggaaatctcc
     2341 cttattcccc atcctccccg gacatggcat ctcctggctc taatccacag cgctggcttc
     2401 ttggatttgg gtctttgtat ttattgtact ttatctgtgt gctcggaagg ggcctccagg
     2461 gtcttaaatc ccattgtgaa taatctatta atggacagtt tgcacccatc aagtgttgac
     2521 ttggcatcca caatggctgg cagcaccagc aggtctgccc ggtgcagaag ctgggtttct
     2581 ttctgctttt tccgcagctg ctgcctggag acttcgtgtc agagtgagag gcaataacct
     2641 ctacattctg tgctggagcc cagagaacag gatgtaagtc tcccactctc acccatcctt
     2701 gatggcctgg gaccaggtgt gctttaaaca gtgagagtca aagttgtggc ttggtagatg
     2761 tactgtggtg tgtcagtgtg tgtggccagt gagagtgaga agcagttccc attcagctgc
     2821 agcatttcaa aggagagcat gaatgcaacc cacggggctg actccccaga agtcagccct
     2881 ggggagctgc tcgctttgta aatcagttct ttggtcccct gcccttttac agacatcctc
     2941 cacttctagc ccttcctctt tgtgacctgt gagagcactc acccttctcc tactaggcct
     3001 gagggacagt gtgctgaatc catgaaggtc aatgcatttt ccctgctctg cagacagccg
     3061 agctgctttc tgcccagcgc cttcgggaag tcagacctgt acagggttag gatacctctc
     3121 ctctaagtgt gcctgatacc ttctgctcag taacctggaa agaagatggg gccacccttt
     3181 gggtggagaa gggttccctg ggccaccccg gcctctgtct tcatcaggca ggagaagtag
     3241 gagtatctca ggggacatag ccaggcctat gaggccaggg actctgctct gaccatgctt
     3301 ctacaaagac ctgaattcct cagtggtctt aaggtagaac tatgagctaa cttctaaaca
     3361 gtggttctca gcctgtgggc tgtgttgggg gtgtcagaca accatttcac aggggtcgta
     3421 tatcaggtct cctgcatatt tgaatattta cataatgata tataacagta aagatttaca
     3481 cttatgaaat agcaatgaaa atgattttat ggttgagggt caccactaca tgaggaacta
     3541 tattaaaggg tcacagagtt aagaaggttg agagccattg ttctagaagc ttctgcctgg
     3601 cttatctctg acatcagagt ccctgtgtca gccagatttt aaagaggttc agattccacc
     3661 cattccaccc tgcccttccc acactccatg tgcttctgtg agtttgcctc ccttcactta
     3721 atcaaccctc acctcaggta cctcacatca gtatcagccc actggtgtcc aaatgtgaga
     3781 gaaactacag aactacctta agcaggccct ggggtcctcc agagtccctt catgaacccc
     3841 ttgttagaac tatggcggtg catgctctca gaacagacgt gccttgctgc ctggctcccg
     3901 gggagctggg gtacaagagg ctccaggatg cacaggggca ggaggagcat ggagattaag
     3961 ggcctaggag aacaccgccc attcagaagc ccagctctgc ctggcatcga gggacaccag
     4021 tgttttcaca ggactcatgg caaacttaac ttggctcagc acactgccct tggcagcagc
     4081 ccgccctaag ggaccccgtt cctgacaaac tctggcccca gagatcctca agaagctttg
     4141 agtgcttcca tggagagtag taacacagtc tgagcttcat cgcagcctca gaacccccag
     4201 cagtctccta tgtgtgctgc ctgatttggc tcctgtcccc agcagcctgg agctggcctc
     4261 gggtggtgag caaaagttac aaaaggggga aagggcccaa agctagcttc aggagcaaag
     4321 aatgccttcc agtgatgaaa gtagccatga cctttagctt gtgagttaag aagtgtggga
     4381 gctatgggtt ttgttttatt gcctttggtg ggaagtgggg ggcttttctt gggtgtaaca
     4441 tgggctgtca cactgccttg ggttcagggc acaaaggtct gcagaaaaaa agaagaacag
     4501 aattcttgct tgcaatcatt tcatatcctc tctctgtaaa gaagtctagg gtatagtcac
     4561 ctcagccctt ggtcctgagg agcagagggg ggcgttcttg ggcaaccaca aaccagacaa
     4621 tagcaagcac tgataaaagg ctcctgcttg ccccgtcccc agtcttatct aggaaggtcc
     4681 acagctagaa ggtgggaact taggctggct tgagttctgc atcttttcta tacctcctct
     4741 gcttctatat tgtgattctc aaaagccaca tgtggaggag gtgggggaga atcccatccc
     4801 acaaggactt ctcacaccca agtgtttttg aaacacacgg gagtcagaat caaagctgtt
     4861 atcctgcaaa agatgtcccc tcatatgtcc cctgcagaga agccaatatg ctggcccttc
     4921 agttaatatc catccagctt cccgccctgg tggggtctta gctggctaga gagggacagg
     4981 ggatgttggc ttcctacagt tctgtacttc atcattccct gctgaagtcc aagtggctcc
     5041 ttttcggcta agcaagcagg agagggacat gtaaggacca cctgagtcat tggcaagggc
     5101 acaggagctc cagaagaatg ggccagagac tgccaggcca gccaaggatg gttctagaac
     5161 cctgccttga tgtcattcct gtttgtttcg ttgtggtttc agggagggag tgagccagca
     5221 tgaacatcca cattcatcac gctcagctca gcctcttgtg tcataaagtg actaatgtgg
     5281 atagtagtat ttgggttggt gacttaatcc actgaggagc tcacactccc ctgtcattag
     5341 gaggacagtg aggccccagg ttagcccact ggcaagcatc caggctccct tcagctccga
     5401 gctacagatc tggcaggtct gtcatctcat gtagcacagt ccagccaatg agcagtagcc
     5461 actcccactg tgagctcccc tgatcctgac atctatggcc tgtctcacaa gcaaaaacaa
     5521 gtcatttgct aatcaccaac agaaagacaa aattaaaacc ctctttgtat gtggccatgg
     5581 gttgctatgt cctaacttgc caatccatcc tcccctcccc tcccaagctg atgttcacct
     5641 gaagtgccac cactggagag actgaagcag gaagggtcat gagctcagga gttcaagacc
     5701 tacctgggca agataatgaa actaatctta aaaacaaatc tatagctgag tgacttggcc
     5761 acatttcatg tgctgaggag ccaccagctc cctggcagcc agtctcctcc attgcctaga
     5821 atctgggaca gctttaaaga ggtagctcac aagggcacgg gcacatttcc acatgtgaca
     5881 tgccctgtct tgtgccctaa gctgggttgg ttcaagtagc ctgcaaatcc ttgtgggtac
     5941 tggctatagc aaaatggagc tttttcacag gtcatccagg gcccaacagt ttgctttgtc
     6001 taactgtttc cttaaaactt cacaagcagg cttccaagaa caacaagcac ttactcatct
     6061 ctctcttagc ctttcttatg gatgtgaacc gtgccgtggg taaatcattt gtatttcttg
     6121 aatgttctgt atgactaaca ggtattaagt cactggttat atgtataact aatgtaactg
     6181 ccttttaaat tttcattaca ataaaaaatg actttgctct gaacagtga
//
