LOCUS       NP_036913                712 aa            linear   ROD 30-MAR-2024
DEFINITION  aryl hydrocarbon receptor nuclear translocator 2 [Rattus
            norvegicus].
ACCESSION   NP_036913
VERSION     NP_036913.3
DBSOURCE    REFSEQ: accession NM_012781.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 712)
  AUTHORS   Wu,D., Su,X., Potluri,N., Kim,Y. and Rastinejad,F.
  TITLE     NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS
            family as multi-ligand binding transcription factors
  JOURNAL   Elife 5, e18790 (2016)
   PUBMED   27782878
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 712)
  AUTHORS   Zhang,Z., Fei,P., Mu,J., Li,W. and Song,J.
  TITLE     Hippocampal expression of aryl hydrocarbon receptor nuclear
            translocator 2 and neuronal PAS domain protein 4 in a rat model of
            depression
  JOURNAL   Neurol Sci 35 (2), 277-282 (2014)
   PUBMED   23861074
  REMARK    GeneRIF: Relative hippocampal NPAS4 expression was significantly
            lower in depression model rats compared to controls but there was
            no significant difference in hippocampal ARNT2 expression between
            groups
REFERENCE   3  (residues 1 to 712)
  AUTHORS   Bersten,D.C., Bruning,J.B., Peet,D.J. and Whitelaw,M.L.
  TITLE     Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim
            (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt
            function
  JOURNAL   PLoS One 9 (1), e85768 (2014)
   PUBMED   24465693
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 712)
  AUTHORS   Webb,E.A., AlMutair,A., Kelberman,D., Bacchelli,C., Chanudet,E.,
            Lescai,F., Andoniadou,C.L., Banyan,A., Alsawaid,A., Alrifai,M.T.,
            Alahmesh,M.A., Balwi,M., Mousavy-Gharavy,S.N., Lukovic,B.,
            Burke,D., McCabe,M.J., Kasia,T., Kleta,R., Stupka,E., Beales,P.L.,
            Thompson,D.A., Chong,W.K., Alkuraya,F.S., Martinez-Barbera,J.P.,
            Sowden,J.C. and Dattani,M.T.
  TITLE     ARNT2 mutation causes hypopituitarism, post-natal microcephaly,
            visual and renal anomalies
  JOURNAL   Brain 136 (Pt 10), 3096-3105 (2013)
   PUBMED   24022475
REFERENCE   5  (residues 1 to 712)
  AUTHORS   Keith,B., Johnson,R.S. and Simon,M.C.
  TITLE     HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth
            and progression
  JOURNAL   Nat Rev Cancer 12 (1), 9-22 (2011)
   PUBMED   22169972
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 712)
  AUTHORS   Hosoya,T., Oda,Y., Takahashi,S., Morita,M., Kawauchi,S., Ema,M.,
            Yamamoto,M. and Fujii-Kuriyama,Y.
  TITLE     Defective development of secretory neurones in the hypothalamus of
            Arnt2-knockout mice
  JOURNAL   Genes Cells 6 (4), 361-374 (2001)
   PUBMED   11318878
REFERENCE   7  (residues 1 to 712)
  AUTHORS   Drutel,G., Kathmann,M., Heron,A., Gros,C., Mace,S., Schwartz,J.C.
            and Arrang,J.M.
  TITLE     Two splice variants of the hypoxia-inducible factor HIF-1alpha as
            potential dimerization partners of ARNT2 in neurons
  JOURNAL   Eur J Neurosci 12 (10), 3701-3708 (2000)
   PUBMED   11029639
REFERENCE   8  (residues 1 to 712)
  AUTHORS   Maltepe,E., Keith,B., Arsham,A.M., Brorson,J.R. and Simon,M.C.
  TITLE     The role of ARNT2 in tumor angiogenesis and the neural response to
            hypoxia
  JOURNAL   Biochem Biophys Res Commun 273 (1), 231-238 (2000)
   PUBMED   10873592
REFERENCE   9  (residues 1 to 712)
  AUTHORS   Ema,M., Morita,M., Ikawa,S., Tanaka,M., Matsuda,Y., Gotoh,O.,
            Saijoh,Y., Fujii,H., Hamada,H., Kikuchi,Y. and Fujii-Kuriyama,Y.
  TITLE     Two new members of the murine Sim gene family are transcriptional
            repressors and show different expression patterns during mouse
            embryogenesis
  JOURNAL   Mol Cell Biol 16 (10), 5865-5875 (1996)
   PUBMED   8927054
REFERENCE   10 (residues 1 to 712)
  AUTHORS   Hirose,K., Morita,M., Ema,M., Mimura,J., Hamada,H., Fujii,H.,
            Saijo,Y., Gotoh,O., Sogawa,K. and Fujii-Kuriyama,Y.
  TITLE     cDNA cloning and tissue-specific expression of a novel basic
            helix-loop-helix/PAS factor (Arnt2) with close sequence similarity
            to the aryl hydrocarbon receptor nuclear translocator (Arnt)
  JOURNAL   Mol Cell Biol 16 (4), 1706-1713 (1996)
   PUBMED   8657146
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 24, 2007 this sequence version replaced NP_036913.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.3773.1,
                                           SRR26643297.2544.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..712
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     Protein         1..712
                     /product="aryl hydrocarbon receptor nuclear translocator
                     2"
                     /note="ARNT protein 2"
                     /calculated_mol_wt=77828
     Region          1..20
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q78E60.1)"
     Region          35..74
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q78E60.1)"
     Site            42
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q61324; propagated from
                     UniProtKB/Swiss-Prot (Q78E60.1)"
     Region          62..124
                     /region_name="bHLH-PAS_ARNT"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in aryl hydrocarbon receptor nuclear
                     translocator (ARNT) and similar proteins; cd18947"
                     /db_xref="CDD:381517"
     Site            order(64..65,68..69,72,75..76,80,101..102)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381517"
     Site            order(79,82,85..86,103,106..107,110,112..114,116)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381517"
     Region          137..243
                     /region_name="PAS"
                     /note="PAS fold; pfam00989"
                     /db_xref="CDD:395786"
     Region          336..436
                     /region_name="PAS_11"
                     /note="PAS domain; pfam14598"
                     /db_xref="CDD:464214"
     Region          573..712
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q78E60.1)"
     CDS             1..712
                     /gene="Arnt2"
                     /coded_by="NM_012781.4:86..2224"
                     /db_xref="GeneID:25243"
                     /db_xref="RGD:2154"
ORIGIN      
        1 matpaavnpp emasdipgsv tlpvapmaat gqvrmagamp arggkrrsgm dfddedgegp
       61 skfsrenhse ierrrrnkmt qyitelsdmv ptcsalarkp dkltilrmav shmksmrgtg
      121 nkstdgaykp sflteqelkh lileaadgfl fvvaaetgrv iyvsdsvtpv lnqpqsewfg
      181 stlyeqvhpd dveklreqlc tsensmtgri ldlktgtvkk egqqssmrmc mgsrrsficr
      241 mrcgnapldh lplnrittmr krfrnglgpv kegeaqyavv hctgyikawp pagmsipeed
      301 advgqgskyc lvaigrlqvt sspvcmdmsg msvpteflsr hnsdgiitfv dprcisvigy
      361 qpqdllgkdi lefchpedqs hlresfqqvv klkgqvlsvm yrfrtknrew llirtssftf
      421 qnpysdeiey victntnvkq lqqqqaelev hqrdglssyd lsqvpvpnlp tgvheagkpv
      481 ekadaifsqe rdprfaemfa gisasekkmm ssasasgsqq iysqgspfpa ghsgkafsss
      541 vvhvpgvndi qsssstgqni sqisrqlnqg qvawtgsrpp fpgqpsktqs safgigsshp
      601 ypadpssysp lsspaassps gnaypslanr tpgfaesgqs ggqfqgrpse vwsqwqsqhh
      661 gqqsgeqhsh qqpgqtevfq dmlpmpgdpt qgtgnynied fadlgmfppf se
//
