LOCUS       NM_012780               4416 bp    mRNA    linear   ROD 06-OCT-2023
DEFINITION  Rattus norvegicus aryl hydrocarbon receptor nuclear translocator
            (Arnt), transcript variant 1, mRNA.
ACCESSION   NM_012780 XM_008761280 XM_346629
VERSION     NM_012780.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4416)
  AUTHORS   Coelho NR, Tomkiewicz C, Correia MJ, Goncalves-Dias C, Barouki R,
            Pereira SA, Coumoul X and Monteiro EC.
  TITLE     First evidence of aryl hydrocarbon receptor as a druggable target
            in hypertension induced by chronic intermittent hypoxia
  JOURNAL   Pharmacol Res 159, 104869 (2020)
   PUBMED   32416216
REFERENCE   2  (bases 1 to 4416)
  AUTHORS   Hsu CN, Lin IC, Yu HR, Huang LT, Tiao MM and Tain YL.
  TITLE     Maternal Tryptophan Supplementation Protects Adult Rat Offspring
            against Hypertension Programmed by Maternal Chronic Kidney Disease:
            Implication of Tryptophan-Metabolizing Microbiome and Aryl
            Hydrocarbon Receptor
  JOURNAL   Int J Mol Sci 21 (12), 4552 (2020)
   PUBMED   32604820
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4416)
  AUTHORS   Hsu CN, Lin YJ and Tain YL.
  TITLE     Maternal Exposure to Bisphenol A Combined with High-Fat
            Diet-Induced Programmed Hypertension in Adult Male Rat Offspring:
            Effects of Resveratrol
  JOURNAL   Int J Mol Sci 20 (18), 4382 (2019)
   PUBMED   31489946
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4416)
  AUTHORS   Schulte KW, Green E, Wilz A, Platten M and Daumke O.
  TITLE     Structural Basis for Aryl Hydrocarbon Receptor-Mediated Gene
            Activation
  JOURNAL   Structure 25 (7), 1025-1033 (2017)
   PUBMED   28602820
REFERENCE   5  (bases 1 to 4416)
  AUTHORS   Seok SH, Lee W, Jiang L, Molugu K, Zheng A, Li Y, Park S, Bradfield
            CA and Xing Y.
  TITLE     Structural hierarchy controlling dimerization and target DNA
            recognition in the AHR transcriptional complex
  JOURNAL   Proc Natl Acad Sci U S A 114 (21), 5431-5436 (2017)
   PUBMED   28396409
REFERENCE   6  (bases 1 to 4416)
  AUTHORS   Wang GL, Jiang BH, Rue EA and Semenza GL.
  TITLE     Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS
            heterodimer regulated by cellular O2 tension
  JOURNAL   Proc Natl Acad Sci U S A 92 (12), 5510-5514 (1995)
   PUBMED   7539918
REFERENCE   7  (bases 1 to 4416)
  AUTHORS   Semenza GL, Roth PH, Fang HM and Wang GL.
  TITLE     Transcriptional regulation of genes encoding glycolytic enzymes by
            hypoxia-inducible factor 1
  JOURNAL   J Biol Chem 269 (38), 23757-23763 (1994)
   PUBMED   8089148
REFERENCE   8  (bases 1 to 4416)
  AUTHORS   Carver LA, Hogenesch JB and Bradfield CA.
  TITLE     Tissue specific expression of the rat Ah-receptor and ARNT mRNAs
  JOURNAL   Nucleic Acids Res 22 (15), 3038-3044 (1994)
   PUBMED   8065918
REFERENCE   9  (bases 1 to 4416)
  AUTHORS   Semenza GL and Wang GL.
  TITLE     A nuclear factor induced by hypoxia via de novo protein synthesis
            binds to the human erythropoietin gene enhancer at a site required
            for transcriptional activation
  JOURNAL   Mol Cell Biol 12 (12), 5447-5454 (1992)
   PUBMED   1448077
REFERENCE   10 (bases 1 to 4416)
  AUTHORS   Reyes H, Reisz-Porszasz S and Hankinson O.
  TITLE     Identification of the Ah receptor nuclear translocator protein
            (Arnt) as a component of the DNA binding form of the Ah receptor
  JOURNAL   Science 256 (5060), 1193-1195 (1992)
   PUBMED   1317062
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000076.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_012780.4.
            
            On Mar 11, 2021 this sequence version replaced NM_012780.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               JACYVU010000076.1  1200785-1200937
            154-265             JACYVU010000076.1  1215115-1215226
            266-310             JACYVU010000076.1  1217910-1217954
            311-355             JACYVU010000076.1  1224278-1224322
            356-400             JACYVU010000076.1  1227362-1227406
            401-614             JACYVU010000076.1  1230248-1230461
            615-828             JACYVU010000076.1  1233934-1234147
            829-931             JACYVU010000076.1  1235505-1235607
            932-997             JACYVU010000076.1  1239859-1239924
            998-1083            JACYVU010000076.1  1240956-1241041
            1084-1160           JACYVU010000076.1  1243687-1243763
            1161-1295           JACYVU010000076.1  1244911-1245045
            1296-1370           JACYVU010000076.1  1248085-1248159
            1371-1522           JACYVU010000076.1  1249181-1249332
            1523-1633           JACYVU010000076.1  1252056-1252166
            1634-1766           JACYVU010000076.1  1252307-1252439
            1767-1890           JACYVU010000076.1  1252734-1252857
            1891-1993           JACYVU010000076.1  1253029-1253131
            1994-2141           JACYVU010000076.1  1253518-1253665
            2142-2301           JACYVU010000076.1  1256079-1256238
            2302-2468           JACYVU010000076.1  1256776-1256942
            2469-4416           JACYVU010000076.1  1257691-1259638
FEATURES             Location/Qualifiers
     source          1..4416
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..4416
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /note="aryl hydrocarbon receptor nuclear translocator"
                     /db_xref="GeneID:25242"
                     /db_xref="RGD:2153"
     exon            1..153
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..2558
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dioxin receptor, nuclear translocator; HIF1-beta;
                     HIF-1-beta; hypoxia-inducible factor 1-beta; Aryl
                     hydrocarbon receptor nuclear translocator 1"
                     /codon_start=1
                     /product="aryl hydrocarbon receptor nuclear translocator
                     isoform 1"
                     /protein_id="NP_036912.3"
                     /db_xref="GeneID:25242"
                     /db_xref="RGD:2153"
                     /translation="MAATTANPEMTSDVPSLGPTIASGNPGPGIQGGGAVVQRAIKRR
                     SGLDFDDEGEVNSKFLRCDDEQMCNDKERFARSDDEQSSADKERLARENHSEIERRRR
                     NKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLT
                     DQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDV
                     DKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGTSSVDP
                     VSMNRLSFLRNRCRNGLGSVKEGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSK
                     FCLVAIGRLQVTSSPNCTDMSNICQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELL
                     GKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRAKNREWLWMRTSSFTFQNPY
                     SDEIEYIICTNTNVKNSSQEPRPTLSNTIQRSQLGPTTNLSLEMGTGQLASRQQQQQQ
                     QQQQQQQQQQQQQQQQQQQTELDMVPGRDGLASYSHSQVSVQPVATAGSEHSKPLEKS
                     EGLFVQDRDPRFSEIYPNISADQSKGLSSSTVPATQQLFSQGSSFPPNPRPAENFRNS
                     GLTPPVTIVQPSSSAGQILAQISRHSNLTQGSAPTWTSSTRPGFSAQLPTQATAKTRS
                     SQFGVNNFQTSSSFSAMSLPGAPTASPSTAAYPTLPNRGSNFPPETGQTTGQFQTRTA
                     EGVGVWPQWQGQQPHHRSSSNEQHVQPTSAQPSSQPEVFQEMLSMLGDQSNTYNNEEF
                     PDLTMFPPFSE"
     exon            154..265
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            266..310
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            311..355
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            356..400
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..614
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            615..828
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            829..931
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..997
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1083
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1160
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1295
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1370
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1522
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1633
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1766
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1890
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..1993
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2141
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2301
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2468
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..4416
                     /gene="Arnt"
                     /gene_synonym="Arnt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcttggatt tcgcggtagc ggtggcagcg gtaaggtgcc gattctgtag agtgtctttc
       61 ccctccccca gctcggtggc ggctgcccct cccactgagg gtggcgcagc gacggtgcca
      121 cctcgaccat ggcggcgact acagctaacc cagaaatgac atcagatgtg ccatcactgg
      181 gtcccaccat tgcttctgga aatcccggac ctgggattca aggtggagga gctgttgtcc
      241 agagggctat taagcgacgg tcagggctgg attttgatga tgaaggagaa gtgaacagta
      301 aatttttgag atgtgatgat gagcagatgt gtaacgacaa agagcggttt gccaggtcgg
      361 atgatgagca gagctctgcg gataaagaga gacttgccag ggaaaatcat agtgaaatag
      421 agcggcggcg acggaacaag atgacagctt acatcacaga actgtcagac atggtaccta
      481 cctgtagtgc cctggctcga aaaccagaca agctaaccat cttacgcatg gctgtttctc
      541 acatgaagtc cttgagggga acgggcaata catccactga cggctcctac aagccgtcct
      601 tcctcactga tcaggaactg aaacatttga ttttggaggc agcagatggt tttctgttta
      661 ttgtctcttg tgagactggc cgagtggtgt atgtctctga ctcggtgact cccgttttga
      721 accagccaca gtctgaatgg tttgggagca cactgtatga ccaagtgcac ccagatgatg
      781 tggataaact tcgagagcag ctttctactt cagaaaatgc cctaacaggg cggatcctgg
      841 atctgaagac tggaacagtg aaaaaggaag gtcagcagtc ttccatgagg atgtgcatgg
      901 gctcaagaag atcgttcatc tgccggatga ggtgtggcac cagctctgtg gaccctgttt
      961 ccatgaatag actgagcttt ttgaggaaca gatgcaggaa tggacttggc tctgtgaagg
     1021 aaggagagcc tcactttgtg gtagtccact gcacaggtta catcaaggcc tggccaccag
     1081 caggtgtctc cctcccagat gatgatccag aggctggcca ggggagcaaa ttctgcctag
     1141 tggccattgg caggctgcag gtaaccagtt ctcctaactg tacagatatg agtaacatct
     1201 gtcagccaac agagttcatc tccagacata acattgaagg gatattcact tttgtagatc
     1261 atcgttgtgt ggctactgtt ggctaccagc cacaggagct cttaggaaag aatattgtag
     1321 aattttgtca tcctgaagac caacaacttc taagagacag ctttcagcag gtggtgaaat
     1381 taaaaggcca agtgctgtct gtcatgttcc gattccgagc taagaaccga gaatggctgt
     1441 ggatgagaac aagctccttt actttccaaa acccgtattc agatgaaatt gagtatatta
     1501 tctgcaccaa caccaacgtg aagaactcta gccaggaacc acggcctaca ttgtctaaca
     1561 caatccagag gtcacagcta ggtccgacaa ctaatttatc cctagagatg ggtacagggc
     1621 agctggcatc caggcagcag cagcagcagc agcagcagca gcagcagcag cagcagcagc
     1681 agcagcagca gcagcagcag cagcagcaga cagaattgga tatggtacca ggaagagatg
     1741 ggctggccag ctatagtcat tcccaggttt ctgtccagcc cgtggcaact gcaggatcag
     1801 aacacagcaa gccccttgag aagtcagaag gtctctttgt gcaggacaga gatccgaggt
     1861 tttcagaaat ctatcccaac atcagtgcag atcagagtaa aggcctctcc tccagcactg
     1921 tccctgccac ccaacagctg ttctcccagg gcagctcatt ccctcctaac ccccggccgg
     1981 cagaaaattt caggaatagt ggtcttaccc ctcccgtaac cattgtccag ccgtcatctt
     2041 ctgcagggca gatattggcc cagatttctc gtcactccaa ccttacccag ggatcagcac
     2101 caacttggac ctctagcact cgcccaggtt tctctgccca gctgcctact caggctacag
     2161 ccaagactcg ttcttcacaa tttggtgtga acaactttca gacttcgtcc tccttcagtg
     2221 ccatgtctct tccgggtgct cccactgcct cacccagtac tgctgcctac cctactcttc
     2281 ctaaccgtgg atccaacttt cctcctgaga ctggacagac aacaggacag ttccagaccc
     2341 ggacagcaga gggtgtgggt gtctggccac agtggcaagg ccagcagccc catcaccggt
     2401 ctagttccaa tgagcaacat gttcagccaa catcagcaca accaagtagc cagcctgagg
     2461 tctttcaaga aatgctgtcc atgctgggag accagagcaa cacctacaac aatgaagagt
     2521 ttcctgatct aactatgttt cccccttttt ctgaatagag ctattggggt gaggataggg
     2581 tggggaaatc actgttttta aaagcaaatc ttctgtaaac agaataaaag ttcctctccc
     2641 ttcccttccc tcacccctga catgtaccct tttcacccct tgactctctg agtaacatta
     2701 tagaagaaat taaatgaatt tcacaggctt ttaggatcct ctgaaatttt gaggataggt
     2761 gaggttagaa ttcttgtcct tatatcttct gaccagaagt tgcacagaaa tgatttgtgc
     2821 tggagtcaag gggcagaata gaggaatccg gcagccatga attggatact gtggcttgtt
     2881 tggatagaaa ttctgaatag agtggaggaa gggagaaata tcctcataac tgaggatcat
     2941 gaaaatatgg tagggtatat gctggagcct tagaagtgag cagtctccag aaagagacca
     3001 gaaagagcat gaacacttgt gtttgtgtgt gagtgcatat gtgcgtgtgc gtgtgtgtgt
     3061 gtgtgtctgt ctgtctgtct gtctgtctgt gtgtgtgtgt gtgtgtgtgt gtgtgtgaga
     3121 gagagagaga gagagagaga gagagagaga gagagagaga gagcgctttt gagttcctgt
     3181 tttgttttct ccctgttaga gagtatatgc aaaatttgtc ccagattttc tttatctttg
     3241 tttgctcttc aaagtgtcct gtgaaaaata atttttccag gtatttttct atttagtgtt
     3301 gcagccaaag agtatttaaa ttaagtcttt gctgcactta aatccatacc cagccaaaat
     3361 ggaactgtaa gccaactccg agccttccgt tgatagggtt agcctaatac agacacattc
     3421 agtggtcaag ctggattact cctgctcttt ggtgctttca atttatcggg aagatctgca
     3481 gatattacca aaataggctg gctacattaa cactgtcaga aaacccagac ttgcccataa
     3541 gaataatgct gcatttttct gtcagagtca cacgtgttct ggagaggtta tttctgcatg
     3601 gaaactcaac ttcttggatt agctatctcg agtcgtcctc accgacgagt gtgtaaacca
     3661 aatagaagcc ctcctgcaca gtagcctctc ctttctgtca ccaaaacagc tttaggtcgt
     3721 ctgaagtcta gagttcttta atccttctct tatcttgaaa ttgggttttg ctttagagca
     3781 caaacataag tctgtgttag gtggactcaa tcccaacagg gtcctttgat aattacagcc
     3841 atagaagcag gttactgctt tcacccatgt ccgtcctcag gtgagcctcc tacatcagca
     3901 gccttttttt ttttttctgt taaactggct cctgtcaaag attaaattaa tgtggaaaag
     3961 atctattctg tgtattgatg ggggatgaga agcccaggta gagaggctca tggagaggct
     4021 gagggaatgt tactgtttcc ctccatttgt ctccagtccg gtgccaggta atagagtgga
     4081 caaggaggct atttttttat tctatgtgca cacatacagt atacatatat atttatatca
     4141 cattttactg aaccaaaaag ttgggtttcc aatgaaatac ttgtttttta ataatcaact
     4201 tgtttttaaa tgtgatctga attataatgt acagttatta cagggctttt gaagggtggg
     4261 gagggagaag cttctctgag gggtttgttc tgcttttcct tcagggtttt atttttgatt
     4321 gttttttctt gttggccatc tgtgctaagc cttaacagtg gcaaaaataa tgacatgtag
     4381 caaagatttt aaaacaaagt atttttcttt tataaa
//
