LOCUS       NM_023972               1383 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus ARF like GTPase 6 interacting protein 5
            (Arl6ip5), mRNA.
ACCESSION   NM_023972
VERSION     NM_023972.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1383)
  AUTHORS   Wu,Y., Chen,R., Zhao,X., Li,A., Li,G. and Zhou,J.
  TITLE     JWA regulates chronic morphine dependence via the delta opioid
            receptor
  JOURNAL   Biochem Biophys Res Commun 409 (3), 520-525 (2011)
   PUBMED   21600884
  REMARK    GeneRIF: These observations suggest that JWA is directly involved
            in the regulation of chronic morphine dependence.
REFERENCE   2  (bases 1 to 1383)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 1383)
  AUTHORS   Akiduki,S. and Ikemoto,M.J.
  TITLE     Modulation of the neural glutamate transporter EAAC1 by the
            addicsin-interacting protein ARL6IP1
  JOURNAL   J Biol Chem 283 (46), 31323-31332 (2008)
   PUBMED   18684713
REFERENCE   4  (bases 1 to 1383)
  AUTHORS   Cao,Z., Li,C., Higginbotham,J.N., Franklin,J.L., Tabb,D.L.,
            Graves-Deal,R., Hill,S., Cheek,K., Jerome,W.G., Lapierre,L.A.,
            Goldenring,J.R., Ham,A.J. and Coffey,R.J.
  TITLE     Use of fluorescence-activated vesicle sorting for isolation of
            Naked2-associated, basolaterally targeted exocytic vesicles for
            proteomics analysis
  JOURNAL   Mol Cell Proteomics 7 (9), 1651-1667 (2008)
   PUBMED   18504258
REFERENCE   5  (bases 1 to 1383)
  AUTHORS   Zhou,J., Ye,J., Zhao,X., Li,A. and Zhou,J.
  TITLE     JWA is required for arsenic trioxide induced apoptosis in HeLa and
            MCF-7 cells via reactive oxygen species and mitochondria linked
            signal pathway
  JOURNAL   Toxicol Appl Pharmacol 230 (1), 33-40 (2008)
   PUBMED   18387645
REFERENCE   6  (bases 1 to 1383)
  AUTHORS   Liu,Y., Vidensky,S., Ruggiero,A.M., Maier,S., Sitte,H.H. and
            Rothstein,J.D.
  TITLE     Reticulon RTN2B regulates trafficking and function of neuronal
            glutamate transporter EAAC1
  JOURNAL   J Biol Chem 283 (10), 6561-6571 (2008)
   PUBMED   18096700
REFERENCE   7  (bases 1 to 1383)
  AUTHORS   Tao,F., Liaw,W.J., Zhang,B., Yaster,M., Rothstein,J.D., Johns,R.A.
            and Tao,Y.X.
  TITLE     Evidence of neuronal excitatory amino acid carrier 1 expression in
            rat dorsal root ganglion neurons and their central terminals
  JOURNAL   Neuroscience 123 (4), 1045-1051 (2004)
   PUBMED   14751295
  REMARK    GeneRIF: The expression and distribution of the neuronal glutamate
            transporter, excitatory amino acid carrier-1 (EAAC1), are
            demonstrated in the dorsal root ganglion neurons and their central
            terminals.
REFERENCE   8  (bases 1 to 1383)
  AUTHORS   Butchbach,M.E., Lai,L. and Lin,C.L.
  TITLE     Molecular cloning, gene structure, expression profile and
            functional characterization of the mouse glutamate transporter
            (EAAT3) interacting protein GTRAP3-18
  JOURNAL   Gene 292 (1-2), 81-90 (2002)
   PUBMED   12119102
REFERENCE   9  (bases 1 to 1383)
  AUTHORS   Abdul-Ghani,M., Gougeon,P.Y., Prosser,D.C., Da-Silva,L.F. and
            Ngsee,J.K.
  TITLE     PRA isoforms are targeted to distinct membrane compartments
  JOURNAL   J Biol Chem 276 (9), 6225-6233 (2001)
   PUBMED   11096102
REFERENCE   10 (bases 1 to 1383)
  AUTHORS   Lin,C.I., Orlov,I., Ruggiero,A.M., Dykes-Hoberg,M., Lee,A.,
            Jackson,M. and Rothstein,J.D.
  TITLE     Modulation of the neuronal glutamate transporter EAAC1 by the
            interacting protein GTRAP3-18
  JOURNAL   Nature 410 (6824), 84-88 (2001)
   PUBMED   11242046
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Oct 5, 2022 this sequence version replaced NM_023972.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ232358.1, FQ225681.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               JAXUCZ010000004.1  131372133-131372334
            203-420             JAXUCZ010000004.1  131391116-131391333
            421-1383            JAXUCZ010000004.1  131394349-131395311
FEATURES             Location/Qualifiers
     source          1..1383
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..1383
                     /gene="Arl6ip5"
                     /gene_synonym="Gtrap3-18"
                     /note="ARF like GTPase 6 interacting protein 5"
                     /db_xref="GeneID:66028"
                     /db_xref="RGD:708572"
     exon            1..202
                     /gene="Arl6ip5"
                     /gene_synonym="Gtrap3-18"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..593
                     /gene="Arl6ip5"
                     /gene_synonym="Gtrap3-18"
                     /note="aip-5; protein JWa; ARL-6-interacting protein 5;
                     ADP-ribosylation factor like GTPase 6 interacting protein
                     5; prenylated Rab acceptor protein 2; ADP-ribosylation
                     factor-like 6 interacting protein 5; glutamate transporter
                     EAAC1-interacting protein; ADP-ribosylation-like factor 6
                     interacting protein 5; ADP-ribosylation factor-like
                     protein 6-interacting protein 5"
                     /codon_start=1
                     /product="PRA1 family protein 3"
                     /protein_id="NP_076462.1"
                     /db_xref="GeneID:66028"
                     /db_xref="RGD:708572"
                     /translation="MDVNLAPLRAWDDFFPGSDRFARPDFRDISKWNNRVVSNLLYYQ
                     TNYLVVAAMMISVVGFLSPFNMILGGIIVVLVFTGFVWAAHNKDILRRMKKQYPTAFV
                     MVVMLASYFLISMFGGVMVFVFGITFPLLLMFIHASLRLRNLKNKLENKMEGIGLKKT
                     PMGIILDALEQQEDSINKFADYISKARE"
     exon            203..420
                     /gene="Arl6ip5"
                     /gene_synonym="Gtrap3-18"
                     /inference="alignment:Splign:2.1.0"
     exon            421..1383
                     /gene="Arl6ip5"
                     /gene_synonym="Gtrap3-18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcgaagct cgccaagcaa aggaacatgg acgtgaacct tgccccgctc cgtgcctggg
       61 atgatttctt cccgggctct gatcgtttcg cacggccgga cttcagggat atatccaaat
      121 ggaacaaccg tgtagtgagc aatctgctct attaccagac caactacctg gtggtggctg
      181 ccatgatgat ttcagtcgtt gggtttctga gccccttcaa catgatcctt ggaggaatca
      241 ttgtggtgct ggtgttcacg gggtttgtgt gggcagcaca caataaagac atcctccgcc
      301 ggatgaagaa gcagtaccca acggcctttg tcatggtggt catgctagcc agctacttcc
      361 tcatatccat gtttgggggt gtcatggtct ttgtgtttgg catcacgttt cccttattgt
      421 tgatgttcat ccatgcatcc ctgagacttc gaaacctcaa gaacaaactg gaaaataaaa
      481 tggagggaat aggcttgaag aaaacgccga tgggcatcat cctggatgcc ttggaacagc
      541 aggaagacag catcaataaa tttgctgact acatcagcaa agccagggag taagcacagc
      601 tcgcccagtg acggggccac agcgggcggg aatccggtcg cactttcccc ttgttcagac
      661 ccattttctg tctgtggttt tcaaacagaa ggtgcacgtc ttaccaccca actctccaag
      721 gcatcatgca tgcacaggcc cacggttaag atcaatgata taacccaagg aaggcctcag
      781 aaactgcaaa aaaacacaga cccactctcc cgttgtgtcc gaagtgtccg gtgtgttttc
      841 gaaagagaat gtggactgga cagccacagt gccattgtag tgtagggaag aagtcactgt
      901 agaactggag gcaatgtgga ggacattaag tcatttgaag tctaggatgc tgtgtgtgtt
      961 ggtctgtttc taatgctgtc tcctccaaaa tcctcccctc ccccagactc cgatgtgtct
     1021 gctctggtag tttagcagga ttatctttgt tgttttaaaa ccagaggtgg cttcagcggc
     1081 tgtttgatgt gcagcagaaa ctggatcagc ccgtttatgt tctgtttacg aatatgaagg
     1141 tagctgctta ggacaatgtt ttgttaaatt ttgtaacatt tttaaaagag tagtcatatg
     1201 ctttcaccag caggtgtttc ttgcaaacta aatgtcaacc tcctggggta gggttggggg
     1261 gtgggggtgg ttacaactct gtaacttctg ttattcttgt taaaaataaa taaaaataga
     1321 acttgagttc tgtttatatg acacattttt gttactacaa caataaagag gtgtccaaga
     1381 taa
//
