LOCUS       NM_001107101            3535 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus ARF like GTPase 13B (Arl13b), mRNA.
ACCESSION   NM_001107101 XM_001055321 XM_221604
VERSION     NM_001107101.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3535)
  AUTHORS   Jiang,L., Yang,S., Deng,L., Luo,J., Zhang,X., Chen,S. and Dong,Z.
  TITLE     ARL13B promotes cell cycle through the sonic hedgehog signaling
            pathway to alleviate nerve damage during cerebral
            ischemia/reperfusion in rats
  JOURNAL   Biochem Pharmacol 227, 116446 (2024)
   PUBMED   39038552
  REMARK    GeneRIF: ARL13B promotes cell cycle through the sonic hedgehog
            signaling pathway to alleviate nerve damage during cerebral
            ischemia/reperfusion in rats.
REFERENCE   2  (bases 1 to 3535)
  AUTHORS   Wang,C., Li,J., Takemaru,K.I., Jiang,X., Xu,G. and Wang,B.
  TITLE     Centrosomal protein Dzip1l binds Cby, promotes ciliary bud
            formation, and acts redundantly with Bromi to regulate ciliogenesis
            in the mouse
  JOURNAL   Development 145 (6) (2018)
   PUBMED   29487109
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3535)
  AUTHORS   Li,Y., Tian,X., Ma,M., Jerman,S., Kong,S., Somlo,S. and Sun,Z.
  TITLE     Deletion of ADP Ribosylation Factor-Like GTPase 13B Leads to Kidney
            Cysts
  JOURNAL   J Am Soc Nephrol 27 (12), 3628-3638 (2016)
   PUBMED   27153923
REFERENCE   4  (bases 1 to 3535)
  AUTHORS   Nechipurenko,I.V., Olivier-Mason,A., Kazatskaya,A., Kennedy,J.,
            McLachlan,I.G., Heiman,M.G., Blacque,O.E. and Sengupta,P.
  TITLE     A Conserved Role for Girdin in Basal Body Positioning and
            Ciliogenesis
  JOURNAL   Dev Cell 38 (5), 493-506 (2016)
   PUBMED   27623382
REFERENCE   5  (bases 1 to 3535)
  AUTHORS   Seixas,C., Choi,S.Y., Polgar,N., Umberger,N.L., East,M.P., Zuo,X.,
            Moreiras,H., Ghossoub,R., Benmerah,A., Kahn,R.A., Fogelgren,B.,
            Caspary,T., Lipschutz,J.H. and Barral,D.C.
  TITLE     Arl13b and the exocyst interact synergistically in ciliogenesis
  JOURNAL   Mol Biol Cell 27 (2), 308-320 (2016)
   PUBMED   26582389
REFERENCE   6  (bases 1 to 3535)
  AUTHORS   Qin,J., Lin,Y., Norman,R.X., Ko,H.W. and Eggenschwiler,J.T.
  TITLE     Intraflagellar transport protein 122 antagonizes Sonic Hedgehog
            signaling and controls ciliary localization of pathway components
  JOURNAL   Proc Natl Acad Sci U S A 108 (4), 1456-1461 (2011)
   PUBMED   21209331
REFERENCE   7  (bases 1 to 3535)
  AUTHORS   Ko,H.W., Norman,R.X., Tran,J., Fuller,K.P., Fukuda,M. and
            Eggenschwiler,J.T.
  TITLE     Broad-minded links cell cycle-related kinase to cilia assembly and
            hedgehog signal transduction
  JOURNAL   Dev Cell 18 (2), 237-247 (2010)
   PUBMED   20159594
REFERENCE   8  (bases 1 to 3535)
  AUTHORS   Cantagrel,V., Silhavy,J.L., Bielas,S.L., Swistun,D., Marsh,S.E.,
            Bertrand,J.Y., Audollent,S., Attie-Bitach,T., Holden,K.R.,
            Dobyns,W.B., Traver,D., Al-Gazali,L., Ali,B.R., Lindner,T.H.,
            Caspary,T., Otto,E.A., Hildebrandt,F., Glass,I.A., Logan,C.V.,
            Johnson,C.A., Bennett,C., Brancati,F., Valente,E.M., Woods,C.G. and
            Gleeson,J.G.
  CONSRTM   International Joubert Syndrome Related Disorders Study Group
  TITLE     Mutations in the cilia gene ARL13B lead to the classical form of
            Joubert syndrome
  JOURNAL   Am J Hum Genet 83 (2), 170-179 (2008)
   PUBMED   18674751
REFERENCE   9  (bases 1 to 3535)
  AUTHORS   Caspary,T., Larkins,C.E. and Anderson,K.V.
  TITLE     The graded response to Sonic Hedgehog depends on cilia architecture
  JOURNAL   Dev Cell 12 (5), 767-778 (2007)
   PUBMED   17488627
REFERENCE   10 (bases 1 to 3535)
  AUTHORS   Garcia-Garcia,M.J., Eggenschwiler,J.T., Caspary,T., Alcorn,H.L.,
            Wyler,M.R., Huangfu,D., Rakeman,A.S., Lee,J.D., Feinberg,E.H.,
            Timmer,J.R. and Anderson,K.V.
  TITLE     Analysis of mouse embryonic patterning and morphogenesis by forward
            genetics
  JOURNAL   Proc Natl Acad Sci U S A 102 (17), 5913-5919 (2005)
   PUBMED   15755804
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474112.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001055321.1, XM_221604.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3535
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11p12"
     gene            1..3535
                     /gene="Arl13b"
                     /note="ARF like GTPase 13B"
                     /db_xref="GeneID:304037"
                     /db_xref="RGD:1584979"
     exon            1..353
                     /gene="Arl13b"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..1578
                     /gene="Arl13b"
                     /note="ADP-ribosylation factor-like 13B; ADP-ribosylation
                     factor like GTPase 13B"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 13B"
                     /protein_id="NP_001100571.1"
                     /db_xref="GeneID:304037"
                     /db_xref="RGD:1584979"
                     /translation="MFNLMANCCNLFKRWREPVRKVTLVMVGLDNAGKTATAKGIQGE
                     HPEDVAPTVGFSKIDLRQGKFEVTIFDLGGGKRIRGIWKNYYAESYGVIFVVDSSDED
                     RMEETKETMSEVLRHPRISGKPILVLANKQDKEGALGEADVIECLSLEKLVNEHKCLC
                     QIEPCSAVLGYGKKIDKSIKKGLYWLLHIIAKDFDALSERIQKDTTEQRALEEQEKCE
                     RAERVRKLREEREQEQTELDGTSGLAEMDSGPVLTNPFQPIAAVIIENEKKQEKEKKK
                     KTAEKDSDVGHPEHKGEQEGAESQNEAGGCLRNPHRDVVNSYKEALSQQLDNEDELDQ
                     RVSEPGDNSKKKTKKLRMKRSHRVEPVNTDESAPKSPTPPPPPPPVGWGTPKVTRLPK
                     LEPLGETRHNDFYGKPLPPLAVRQRPNGDAQDMIS"
     exon            354..424
                     /gene="Arl13b"
                     /inference="alignment:Splign:2.1.0"
     exon            425..674
                     /gene="Arl13b"
                     /inference="alignment:Splign:2.1.0"
     exon            675..780
                     /gene="Arl13b"
                     /inference="alignment:Splign:2.1.0"
     exon            781..983
                     /gene="Arl13b"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1089
                     /gene="Arl13b"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1315
                     /gene="Arl13b"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1432
                     /gene="Arl13b"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1501
                     /gene="Arl13b"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..3535
                     /gene="Arl13b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggccttcgg agcttcgggg acgtcagcac gtcgacgcgg ggggtttgtc tggagtcaca
       61 ctaacgccgc tccggtgttc ctgagcctgt gttcggtctg tcccggggcg gcgggcggac
      121 acggttaggg gccggaccct gcgatccgtc ccggtcaccg ccctcccggc ctgccctttg
      181 tctagtccat cctaggggag cgtgaggacg tggggcctct gagccgggcc cggtagcttg
      241 gggcccatcc tgtcccgaga ctcggatggg aggtggcggg aggagagacc tgggatgttc
      301 aatctgatgg ccaactgctg caacttgttc aagcggtggc gggagcctgt cagaaaggtg
      361 acacttgtga tggtcggact tgataatgct ggtaaaacag ccacagcaaa gggaatccaa
      421 ggagagcatc ctgaagacgt ggctcccact gttggatttt ctaaaattga tctgagacaa
      481 ggaaagtttg aagttaccat ctttgactta ggaggtggaa aaagaattcg gggaatttgg
      541 aagaattatt atgctgaatc ctatggggta atatttgttg tggattccag tgatgaagac
      601 agaatggaag aaacgaagga gacaatgtca gaagtgctaa gacaccctcg gatatcagga
      661 aagcctatat tggtgttggc aaataaacaa gacaaggagg gggctttagg agaagctgat
      721 gtgattgagt gtctgtctct ggaaaagctg gtcaatgagc acaagtgcct gtgtcagata
      781 gaaccttgtt cagcagtctt gggatatgga aagaaaatcg acaagtccat taaaaagggg
      841 ctttattggc tactgcatat cattgcaaaa gattttgatg ccttaagtga acgcatccag
      901 aaagacacaa ctgaacagcg agctcttgag gaacaagaga aatgtgagag ggctgaaaga
      961 gtaaggaagt tacgagaaga aagagaacaa gaacagacgg aacttgatgg gaccagtggt
     1021 ctggcagaga tggactcagg accagttctt acaaatcctt tccaacccat agcagctgtc
     1081 atcattgaga atgaaaagaa acaggaaaaa gagaaaaaga agaagactgc ggagaaggac
     1141 agtgatgttg gccacccaga acataaaggg gaacaggagg gagcagagtc gcagaatgag
     1201 gcaggtggct gcctcaggaa ccctcacagg gatgtggtaa atagttacaa ggaggcactg
     1261 tcacagcaac tggacaacga ggatgagcta gaccaacgag tgtcagaacc aggtgataac
     1321 agtaagaaga aaaccaagaa attaagaatg aaaaggagtc atcgggtaga accagtcaat
     1381 acagacgagt ctgctcctaa gagtcccacg ccgcccccac ctccccctcc tgttggctgg
     1441 ggaaccccca aagtcactag acttccaaaa cttgagcctc ttggtgaaac acgtcataat
     1501 gatttctatg ggaagccgct gcctcccctg gctgtgcgac aaagacctaa tggtgatgct
     1561 caggacatga tctcataacc aggtctgatg ggttagtctt tttcatatta gcaaggtgaa
     1621 ctgagacctt tccccaaagc agaaaagccc tgaatgctga tgcctggggc aagacaacca
     1681 taatgatttc aaggatgaaa gaatacccaa gaacttgacc tgataattta cttctccatg
     1741 ttatatggtt aaagcagaaa ggaaacaaaa tgaccagtag ctgacaagag catctggcca
     1801 agttagctag tcatgttatt gattctttgg tttacacatc ctgacttttg gacatactcc
     1861 tgaagaaaca cctcagaagt tgagccagtg gactctacat acctgattat ttaataatct
     1921 gtatttctat gcattaaaca tgttttataa ggtacatgta catgaaaggg gaattcctgg
     1981 gaatttataa cctaaatttt aactattttt atattttttc taaacctttt gtttaagttt
     2041 gctattgtat tgactacaca ctctctacag atgctctgtt taaactgtcc ggatagaaag
     2101 ttgatttact gaacacatat gaagtataca agaaggtatg ctttgtgata acattgtttc
     2161 taaaatgtac actctgtctt gatgtaattt taaaatgtta ctattttaaa aagcaaaata
     2221 tctgctcttt aatctaccaa attacatgat ttgaaagtgt tacccaaaga gaggattcag
     2281 ttgtcatttg ttttccttgg tgatgacctc aataaatgtt aagacatctg agatattttt
     2341 aagaaaacaa ctaaatttgt taattggtaa aaaatgtgtc ctgtgagata tgactcaaag
     2401 tcctgataga gagcactaag ggacaaggca tttcctgagc tcaggggccc tctccatgtt
     2461 ctgttagcag ctttattgac cacttagggt tgtttccctt cgtccatgcc ttgaaattaa
     2521 agtaagaaga cttataaagg ctcctgcagg tctagagact tcaggtttac aaccagtata
     2581 gtcatacgaa tgaaaatgtt ggctcaagtc ctttcataaa gaactagttc taacatgact
     2641 ttttaattta gatgacgaca cttgttctgc tcttgaatgt cattcataag gctctctatc
     2701 catctgccct ttaccaacct tgagagatag tttggtaatg atttataatg taatattcaa
     2761 tggaaggcat gctttaggtc aaggtgacaa taacaaggat caagtctctt atccccctgt
     2821 taagatcggt accatatacc ggcaatggat atactctgct tctgaacgta aagtctccta
     2881 aggcagactg atttgatcat ttgcctttta aatgtttaaa tgtattgtat tcacagttta
     2941 gctcttctga cctggactag tcggctgaca tgatgctact catcactagt agagtttctc
     3001 tgagtttggg catggtacta cctctcacac tgaaggataa aaaaaggttt aatttctatg
     3061 caaagcccat atgtagaatt agcaggtggc tcagatagca gaatcacaag acaggatgta
     3121 aattctgaac tggattttag aggaaaaaat gttcatcttc ttggttcatt ttgtaatatt
     3181 taaattccct tttaaaactg aacttatact tttgctatct tttaatgttc atctgttttg
     3241 aagatattct tgcttcctac caatgtttac tgtaaagtac aataattacc gactctagtt
     3301 catgataacc gttttgaaat tgaatgtaac ataaaccaga attgatgttt tctatggcac
     3361 tcccaaaaaa ttaatgtttt cttaaagctg tataaaaaat cctttaaaaa ctgttttgta
     3421 aatcctgtca gattttaata tttcagtgct tattttgtta tattatacat tttcatttta
     3481 ttcatcatga attataacat ttcacacaat aaaatttatt tacaatatac cattt
//
