LOCUS       NM_022385                893 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus ARF like GTPase 1 (Arl1), mRNA.
ACCESSION   NM_022385
VERSION     NM_022385.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 893)
  AUTHORS   Nishimoto-Morita,K., Shin,H.W., Mitsuhashi,H., Kitamura,M.,
            Zhang,Q., Johannes,L. and Nakayama,K.
  TITLE     Differential effects of depletion of ARL1 and ARFRP1 on membrane
            trafficking between the trans-Golgi network and endosomes
  JOURNAL   J Biol Chem 284 (16), 10583-10592 (2009)
   PUBMED   19224922
REFERENCE   2  (bases 1 to 893)
  AUTHORS   Derby,M.C., Lieu,Z.Z., Brown,D., Stow,J.L., Goud,B. and
            Gleeson,P.A.
  TITLE     The trans-Golgi network golgin, GCC185, is required for
            endosome-to-Golgi transport and maintenance of Golgi structure
  JOURNAL   Traffic 8 (6), 758-773 (2007)
   PUBMED   17488291
REFERENCE   3  (bases 1 to 893)
  AUTHORS   Wu,M., Lu,L., Hong,W. and Song,H.
  TITLE     Structural basis for recruitment of GRIP domain golgin-245 by small
            GTPase Arl1
  JOURNAL   Nat Struct Mol Biol 11 (1), 86-94 (2004)
   PUBMED   14718928
  REMARK    GeneRIF: crystal structure of Arl1-GTP in complex with the GRIP
            domain of golgin-245 shows that Arl1-GTP interacts with the GRIP
            domain predominantly in a hydrophobic manner, with the switch II
            region conferring the main recognition surface
REFERENCE   4  (bases 1 to 893)
  AUTHORS   Panic,B., Perisic,O., Veprintsev,D.B., Williams,R.L. and Munro,S.
  TITLE     Structural basis for Arl1-dependent targeting of homodimeric GRIP
            domains to the Golgi apparatus
  JOURNAL   Mol Cell 12 (4), 863-874 (2003)
   PUBMED   14580338
REFERENCE   5  (bases 1 to 893)
  AUTHORS   Lu,L., Horstmann,H., Ng,C. and Hong,W.
  TITLE     Regulation of Golgi structure and function by ARF-like protein 1
            (Arl1)
  JOURNAL   J Cell Sci 114 (Pt 24), 4543-4555 (2001)
   PUBMED   11792819
  REMARK    GeneRIF: Morphological and biochemical evidence shows that Arl1 is
            enriched at the trans site of the Golgi, marked by AP-1, is
            saturable in intact cells, dependent on N-terminal myristoylation
            and is necessary to maintain normal Golgi structure and function.
REFERENCE   6  (bases 1 to 893)
  AUTHORS   Lin,C.Y., Huang,P.H., Liao,W.L., Cheng,H.J., Huang,C.F., Kuo,J.C.,
            Patton,W.A., Massenburg,D., Moss,J. and Lee,F.J.
  TITLE     ARL4, an ARF-like protein that is developmentally regulated and
            localized to nuclei and nucleoli
  JOURNAL   J Biol Chem 275 (48), 37815-37823 (2000)
   PUBMED   10980193
REFERENCE   7  (bases 1 to 893)
  AUTHORS   Hong,J.X., Lee,F.J., Patton,W.A., Lin,C.Y., Moss,J. and Vaughan,M.
  TITLE     Phospholipid- and GTP-dependent activation of cholera toxin and
            phospholipase D by human ADP-ribosylation factor-like protein 1
            (HARL1)
  JOURNAL   J Biol Chem 273 (25), 15872-15876 (1998)
   PUBMED   9624189
REFERENCE   8  (bases 1 to 893)
  AUTHORS   Ding,M., Vitale,N., Tsai,S.C., Adamik,R., Moss,J. and Vaughan,M.
  TITLE     Characterization of a GTPase-activating protein that stimulates GTP
            hydrolysis by both ADP-ribosylation factor (ARF) and ARF-like
            proteins. Comparison to the ARD1 gap domain
  JOURNAL   J Biol Chem 271 (39), 24005-24009 (1996)
   PUBMED   8798635
REFERENCE   9  (bases 1 to 893)
  AUTHORS   Schurmann,A., Breiner,M., Becker,W., Huppertz,C., Kainulainen,H.,
            Kentrup,H. and Joost,H.G.
  TITLE     Cloning of two novel ADP-ribosylation factor-like proteins and
            characterization of their differential expression in 3T3-L1 cells
  JOURNAL   J Biol Chem 269 (22), 15683-15688 (1994)
   PUBMED   8195219
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X76920.1.
            
            On Jun 10, 2007 this sequence version replaced NM_022385.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X76920.1, BC061553.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..893
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..893
                     /gene="Arl1"
                     /note="ARF like GTPase 1"
                     /db_xref="GeneID:64187"
                     /db_xref="RGD:621326"
     exon            1..97
                     /gene="Arl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..639
                     /gene="Arl1"
                     /note="ADP-ribosylation factor-like 1; ADP-ribosylation
                     factor like GTPase 1"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 1"
                     /protein_id="NP_071780.1"
                     /db_xref="GeneID:64187"
                     /db_xref="RGD:621326"
                     /translation="MGGFFSSIFSSLFGTREMRILILGLDGAGKTTILYRLQVGEVVT
                     TIPTIGFNVETVTYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAVIYVVDSCDRDRIGI
                     SKSELVAMLEEEELRKAILVVFANKQDMEQAMTPSEMANALGLPALKDRKWQIFKTSA
                     TKGTGLDEAMEWLVETLKSRQ"
     exon            98..235
                     /gene="Arl1"
                     /inference="alignment:Splign:2.1.0"
     exon            236..317
                     /gene="Arl1"
                     /inference="alignment:Splign:2.1.0"
     exon            318..429
                     /gene="Arl1"
                     /inference="alignment:Splign:2.1.0"
     exon            430..608
                     /gene="Arl1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..893
                     /gene="Arl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagtggacgt ggcggcgccc cggctcaatt aggagtcgct gccgagtccc ggcctgtcac
       61 tgaggatcgg cgagggcgcg gcggcggtcc atcatgggtg gctttttctc aagtatattt
      121 tccagtctct ttggaaccag ggaaatgagg attttaattt tgggattaga tggtgctgga
      181 aaaacgacaa ttttgtacag attgcaggtt ggagaagttg ttactaccat tcccactatt
      241 ggatttaatg tagagacggt gacatacaaa aatctcaagt tccaagtttg ggacttaggc
      301 ggacagacaa gtatcaggcc atactggaga tgttattatt caaacacaga tgcagtcatc
      361 tatgtcgttg acagttgtga ccgagaccga attggcattt ccaagtcaga gttagttgcc
      421 atgttggagg aagaggagct gaggaaagcc attttagtgg tgtttgcaaa taaacaggac
      481 atggagcagg ccatgacgcc ctcagaaatg gccaatgcgc ttgggttacc cgccctgaag
      541 gaccggaagt ggcagatctt taaaacgtca gcaaccaaag gcaccggcct cgacgaggca
      601 atggaatggt tagttgaaac actgaaaagc agacagtgag tccattcaca tcagcgcctg
      661 tgaaccaaac gctccgtcac agactcactg aaccagtcag atgtacttct cgtgactggt
      721 ggaagggact gtgtgattct agcatataca gacctgactt cactatttgt aataaatata
      781 aaaagcaagt atctggtgag agggttagct tgatcgaatc acccaaatgg tttatgtaat
      841 gtaaaatatt tcttccttgt tttcttgtgt taaggtatat attctatttg tat
//
