LOCUS       NM_001012275            3755 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ariadne RBR E3 ubiquitin protein ligase 2
            (Arih2), mRNA.
ACCESSION   NM_001012275 XM_236665 XM_343486
VERSION     NM_001012275.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3755)
  AUTHORS   Wu,C., Xu,G., Bao,G., Gao,H., Chen,J., Zhang,J., Chen,C., Hong,H.,
            Xue,P., Jiang,J., Liu,Y., Huang,J., Sun,Y., Fu,J., Li,Y. and Cui,Z.
  TITLE     Ubiquitin ligase Triad1 promotes neurite outgrowth by inhibiting
            MDM2-mediated ubiquitination of the neuroprotective factor
            pleiotrophin
  JOURNAL   J Biol Chem 298 (10), 102443 (2022)
   PUBMED   36055408
  REMARK    GeneRIF: Ubiquitin ligase Triad1 promotes neurite outgrowth by
            inhibiting MDM2-mediated ubiquitination of the neuroprotective
            factor pleiotrophin.
REFERENCE   2  (bases 1 to 3755)
  AUTHORS   Wu,C., Zhang,H., Hong,H., Chen,C., Chen,J., Zhang,J., Xue,P.,
            Jiang,J. and Cui,Z.
  TITLE     E3 ubiquitin ligase Triad1 promotes neuronal apoptosis by
            regulating the p53-caspase3 pathway after spinal cord injury
  JOURNAL   Somatosens Mot Res 39 (1), 21-28 (2022)
   PUBMED   34641746
  REMARK    GeneRIF: E3 ubiquitin ligase Triad1 promotes neuronal apoptosis by
            regulating the p53-caspase3 pathway after spinal cord injury.
REFERENCE   3  (bases 1 to 3755)
  AUTHORS   Wu,C., Bao,G., Xu,G., Sun,Y., Wang,L., Chen,J., Zhang,J., Chen,C.,
            Zhu,Q. and Cui,Z.
  TITLE     Triad1 regulates the expression and distribution of EHD1
            contributing to the neurite outgrowth of neurons after spinal cord
            injury
  JOURNAL   J Cell Biochem 120 (4), 5355-5366 (2019)
   PUBMED   30320922
  REMARK    GeneRIF: Our data delineate a novel interaction between Triad1 and
            EHD1 that may contribute to the regulation of neurite outgrowth for
            neurons after the spinal cord injury.
REFERENCE   4  (bases 1 to 3755)
  AUTHORS   Jiang,R., Liu,Q., Zhu,H., Dai,Y., Yao,J., Liu,Y., Gong,P.P. and
            Shi,W.
  TITLE     The expression of TRIAD1 and DISC1 after traumatic brain injury and
            its influence on NSCs
  JOURNAL   Stem Cell Res Ther 9 (1), 297 (2018)
   PUBMED   30409224
  REMARK    GeneRIF: the expression of TRIAD1 and DISC1 change after traumatic
            brain injury and that their interaction may affect the
            proliferation and differentiation of neural stem cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3755)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   6  (bases 1 to 3755)
  AUTHORS   Kelsall,I.R., Duda,D.M., Olszewski,J.L., Hofmann,K., Knebel,A.,
            Langevin,F., Wood,N., Wightman,M., Schulman,B.A. and Alpi,A.F.
  TITLE     TRIAD1 and HHARI bind to and are activated by distinct neddylated
            Cullin-RING ligase complexes
  JOURNAL   EMBO J 32 (21), 2848-2860 (2013)
   PUBMED   24076655
REFERENCE   7  (bases 1 to 3755)
  AUTHORS   Marteijn,J.A., van der Meer,L.T., Smit,J.J., Noordermeer,S.M.,
            Wissink,W., Jansen,P., Swarts,H.G., Hibbert,R.G., de Witte,T.,
            Sixma,T.K., Jansen,J.H. and van der Reijden,B.A.
  TITLE     The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and
            Ubc13 interacting domains
  JOURNAL   Leukemia 23 (8), 1480-1489 (2009)
   PUBMED   19340006
REFERENCE   8  (bases 1 to 3755)
  AUTHORS   Marteijn,J.A., van Emst,L., Erpelinck-Verschueren,C.A.,
            Nikoloski,G., Menke,A., de Witte,T., Lowenberg,B., Jansen,J.H. and
            van der Reijden,B.A.
  TITLE     The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth
            of primary myeloid progenitor cells
  JOURNAL   Blood 106 (13), 4114-4123 (2005)
   PUBMED   16118314
REFERENCE   9  (bases 1 to 3755)
  AUTHORS   Martinez-Noel,G., Niedenthal,R., Tamura,T. and Harbers,K.
  TITLE     A family of structurally related RING finger proteins interacts
            specifically with the ubiquitin-conjugating enzyme UbcM4
  JOURNAL   FEBS Lett 454 (3), 257-261 (1999)
   PUBMED   10431818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1, BF284740.1, CV126331.1, CV114328.1 and
            CB702620.1.
            
            On Apr 26, 2006 this sequence version replaced NM_001012275.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 JAXUCZ010000008.1  118234277-118234284 c
            9-575               BF284740.1         1-567
            576-1115            CV126331.1         80-619
            1116-1512           CV114328.1         90-486              c
            1513-1797           CB702620.1         19-303              c
            1798-3755           JAXUCZ010000008.1  118175267-118177224 c
FEATURES             Location/Qualifiers
     source          1..3755
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3755
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1"
                     /note="ariadne RBR E3 ubiquitin protein ligase 2"
                     /db_xref="GeneID:316005"
                     /db_xref="RGD:1305839"
     exon            1..24
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            25..88
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            89..441
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..1668
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1"
                     /EC_number="2.3.2.27"
                     /note="ariadne homolog 2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase ARIH2"
                     /protein_id="NP_001012275.1"
                     /db_xref="GeneID:316005"
                     /db_xref="RGD:1305839"
                     /translation="MSVDMNSQGSDSNEEDYDPNCEEEEEEEEDPGDIEDYYVGVASD
                     VEQQGADAFDPEEYQFTCLTYKESEGALHEHMTSLASALKVSHSVAKLILVNFHWQVS
                     EILDRYRSNSAQLLVEARVQPNPSKHVPTAHPPHHCAVCMQFVRKENLLSLTCQHQFC
                     RSCWEQHCSVLVKDGVGVGISCMAQDCPLRTPEDFVFPLLPNEELRDKYRRYLFRDYV
                     ESHYQLQLCPGADCPMVIRVQEPRARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWL
                     TKCADDSETANYISAHTKDCPKCNICIEKNGGCNHMQCSKCKHDFCWMCLGDWKTHGS
                     EYYECSRYKENPDIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQRIHEKI
                     QERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLE
                     AEIENLSWKVERADSYDRGDLENQMHIAEQRRRTLLKDFHDT"
     exon            442..509
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..573
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            574..724
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..846
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            847..956
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1074
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1125
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1147
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1299
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1443
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1512
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1596
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..3755
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccgcga ggtcgcggct cccgatggaa atcctatgac acagacaatt tgggtgatat
       61 ctgcaggaaa gagctttaaa cattacagaa gacaaaaaac actaatgcat ttgagaaaac
      121 gataaaagtt ggggggagga ggagaaaaag caactgcttt cctgatctgc tacttgactg
      181 gatgttaaga tgtccgtgga catgaacagc caagggtctg acagcaatga agaggactat
      241 gacccaaact gtgaggaaga ggaagaagag gaagaggacc ctggggacat agaggactac
      301 tatgtgggag tagccagtga tgtggagcag cagggggctg atgcttttga tcccgaagag
      361 tatcaattca cttgcttgac ctataaggag tctgagggcg ccctccatga gcatatgacc
      421 agcttagcct ctgccttaaa ggtatctcat tcagttgcaa agcttatatt agttaatttc
      481 cactggcaag tctcagagat tctggacagg tacaggtcta attctgctca gctgcttgtt
      541 gaggcgcgag ttcaacctaa tccatccaaa cacgtcccca cagcccaccc ccctcaccac
      601 tgtgcagtgt gtatgcagtt tgtgcggaag gaaaacctgc tctctctgac ctgccagcat
      661 cagttttgcc gaagctgttg ggagcaacat tgctcagtcc tcgtcaaaga tggtgtcggt
      721 gtaggaatct catgtatggc tcaggattgt ccgcttcgaa caccagagga ctttgtgttt
      781 cccttgcttc ccaacgaaga gttgagagat aaatacaggc gctacctctt tagggactat
      841 gtggagagtc attaccagct ccagctgtgc cctggtgcag actgccccat ggttattcgg
      901 gtacaggagc cgagagctcg ccgagtgcag tgcaatcggt gcaacgaggt cttctgtttc
      961 aagtgtcgac agatgtatca cgcccccaca gactgcgcca caatccggaa atggctcacc
     1021 aagtgtgcgg acgactccga aacagctaac tacattagtg ctcacactaa agactgtccc
     1081 aagtgcaaca tctgtatcga gaagaatgga ggctgcaatc acatgcaatg ctccaagtgt
     1141 aagcatgact tctgctggat gtgtctagga gactggaaga cgcatggtag tgagtactat
     1201 gaatgtagtc ggtacaagga gaatcctgac attgtcaacc agagccagca agcacaggcc
     1261 agggaggccc tcaagaagta cttgttctac tttgagaggt gggaaaatca caacaaaagc
     1321 ttgcagctgg aggcacaaac ataccagcgg attcacgaga agattcaaga gagggttatg
     1381 aacaatctgg gaacgtggat tgactggcag tacctgcaga atgccgccaa gctgttggcc
     1441 aagtgtcgat acaccctgca atatacctat ccatatgcat actacatgga atccggcccc
     1501 aggaagaagc tgtttgaata ccagcaggct cagctggagg ctgagatcga aaacctttca
     1561 tggaaagttg agcgtgcaga cagctatgac agaggggact tggaaaacca gatgcacata
     1621 gcagagcagc ggagaagaac cctgctaaag gattttcacg acacctaaac cgggctgtgg
     1681 atgtgccggg gtgaggaaga tgtagctgtg aggccacccg gctaccgaac tgcatgctgc
     1741 aggctctgcc tttcacgacc caggcaacag ccagggcccc actcctgaaa gacactggca
     1801 acacacctct tagtccattt gttttcttct catctttttg ctttttgttt ctaccagggt
     1861 agaggccatg ttgagctggc ctctagtgag gactttaaat ttcccctgga tggttgttgg
     1921 gcgggaggga actttttttc tgaatggcta ttaatagtat tagatcatta caacttatgt
     1981 aattttcaaa ggttgtacga ttataaagaa aagaggcaaa ccataggtaa cacggagccc
     2041 gtctaaaata aattggcttt ggagtgcttc accctttagc tacatgactt agaatgtaac
     2101 ttgatactgc ccgcccaccc agtctcagcg tctacactgc cggagccctg gcgtggcctc
     2161 tgctttcccc tggagctgga gctctagggg agaatgtggg tggcagatag ggatctgagt
     2221 tggcctgtac aataggcacg ggtacagagt cacactcctt ctggacagcc agggcacaga
     2281 gcagagcacg gtctcactgc aggctggctt tattcttgaa tgtgaggttt acctgagtca
     2341 ggccacccag gccagcaccc acagcagagg tgggcgggct aacgcacccc tgaactggga
     2401 gactggttca gcatggtgct tccttttgtt tcataaagat aaggaatcca cctttgtaag
     2461 gaatcgtccc ccgatgtgtt tccttttcct tggtcgttcc ttttgatcca gtattcaggt
     2521 ggtggactct gacgagagtc actgtcttgt tgtgttctta tgaacagagt tcacaaggtc
     2581 agagttcagc atgcatggct cttagaccaa gggcatgggc cttgtgactc aagaggtttg
     2641 cacaagttat ttttatgttc acctagagtg tggccagaag ctgctccgtg gtggggtgtg
     2701 gtcccctttg cctagtgcag ctgccagaag tccccgtctc tgtggtctgg gagtctaagg
     2761 ccaggagaat ccctgctttg tggtctcagt tcctgtacga gaaggggctg gccagaagaa
     2821 aggaccagtt ctgcacagtt gagtgccgtg tccttcctat cttgaacctg gtcctgtggg
     2881 cctttgaaaa gttagatctg tgatctctgg ggtttccatg gctttgctca gtgcctcccc
     2941 tctgagactg gcagagctgt ctatacttga caggacctcc ttgaactcct aggagagcct
     3001 atgagaaatc tgtgaatact atgatgcaga ttctttgata ttcatacatt ttcacctcca
     3061 gtcaacaatt tcctaggtac catgtaaagc tgtaaaattg agttattctt gacaggtgac
     3121 agctgtgact cttggggtac atgaccagct gtacatcctc tttcaccttg tctcttcatg
     3181 tcgtccctga caagtgagat tgtgaggtgg attaggagta gtagtttggg gtatggtgaa
     3241 tgaacccaga ataccaatgg gagctgattg tgagccagga gtgtacctgc tgcaggccca
     3301 gggtggtgtg tgatgctggt aaccagacct ttccatccag tccttttggt ggcactgcca
     3361 tgacatagga ccagagtttc agctctgcag cctaacttcc ccttgggtac tttctgaact
     3421 gcacagctgc cgtcctccca ctgctcagct gtgaccctga cctttggccc tgcaggaggc
     3481 tctgccaacc tgtagctggc acctcacctg tggagacctt tgttctgcac cctcggtgct
     3541 tgtccttcgt taacatcaga acatctgaga ggtcaggcag gaggcgaggg tttggtttgg
     3601 tttagtttgg tgtttttgcc ctgcaaaggg tagagaaaga cagtgttttc atgaactgac
     3661 cagatccttg tctttcttca aagaaaagtt gaggtaatgt catctcacaa agttgagtgg
     3721 tttattcaaa ataaattcac tttctgatta taaaa
//
