LOCUS       NM_001013108            5130 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ariadne RBR E3 ubiquitin protein ligase 1
            (Arih1), mRNA.
ACCESSION   NM_001013108 XM_217157
VERSION     NM_001013108.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5130)
  AUTHORS   Scott,D.C., Rhee,D.Y., Duda,D.M., Kelsall,I.R., Olszewski,J.L.,
            Paulo,J.A., de Jong,A., Ovaa,H., Alpi,A.F., Harper,J.W. and
            Schulman,B.A.
  TITLE     Two Distinct Types of E3 Ligases Work in Unison to Regulate
            Substrate Ubiquitylation
  JOURNAL   Cell 166 (5), 1198-1214 (2016)
   PUBMED   27565346
REFERENCE   2  (bases 1 to 5130)
  AUTHORS   Kelsall,I.R., Duda,D.M., Olszewski,J.L., Hofmann,K., Knebel,A.,
            Langevin,F., Wood,N., Wightman,M., Schulman,B.A. and Alpi,A.F.
  TITLE     TRIAD1 and HHARI bind to and are activated by distinct neddylated
            Cullin-RING ligase complexes
  JOURNAL   EMBO J 32 (21), 2848-2860 (2013)
   PUBMED   24076655
REFERENCE   3  (bases 1 to 5130)
  AUTHORS   Duda,D.M., Olszewski,J.L., Schuermann,J.P., Kurinov,I.,
            Miller,D.J., Nourse,A., Alpi,A.F. and Schulman,B.A.
  TITLE     Structure of HHARI, a RING-IBR-RING ubiquitin ligase:
            autoinhibition of an Ariadne-family E3 and insights into ligation
            mechanism
  JOURNAL   Structure 21 (6), 1030-1041 (2013)
   PUBMED   23707686
REFERENCE   4  (bases 1 to 5130)
  AUTHORS   Elmehdawi,F., Wheway,G., Szymanska,K., Adams,M., High,A.S.,
            Johnson,C.A. and Robinson,P.A.
  TITLE     Human Homolog of Drosophila Ariadne (HHARI) is a marker of cellular
            proliferation associated with nuclear bodies
  JOURNAL   Exp Cell Res 319 (3), 161-172 (2013)
   PUBMED   23059369
REFERENCE   5  (bases 1 to 5130)
  AUTHORS   Parelkar,S.S., Cadena,J.G., Kim,C., Wang,Z., Sugal,R., Bentley,B.,
            Moral,L., Ardley,H.C. and Schwartz,L.M.
  TITLE     The parkin-like human homolog of Drosophila ariadne-1 (HHARI) can
            induce aggresome formation in mammalian cells and is
            immunologically detectable in Lewy bodies
  JOURNAL   J Mol Neurosci 46 (1), 109-121 (2012)
   PUBMED   21590270
REFERENCE   6  (bases 1 to 5130)
  AUTHORS   Wenzel,D.M., Lissounov,A., Brzovic,P.S. and Klevit,R.E.
  TITLE     UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT
            hybrids
  JOURNAL   Nature 474 (7349), 105-108 (2011)
   PUBMED   21532592
REFERENCE   7  (bases 1 to 5130)
  AUTHORS   Capili,A.D., Edghill,E.L., Wu,K. and Borden,K.L.
  TITLE     Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD
            motif reveals a novel zinc-binding domain distinct from a RING
  JOURNAL   J Mol Biol 340 (5), 1117-1129 (2004)
   PUBMED   15236971
REFERENCE   8  (bases 1 to 5130)
  AUTHORS   Tan,N.G., Ardley,H.C., Scott,G.B., Rose,S.A., Markham,A.F. and
            Robinson,P.A.
  TITLE     Human homologue of ariadne promotes the ubiquitylation of
            translation initiation factor 4E homologous protein, 4EHP
  JOURNAL   FEBS Lett 554 (3), 501-504 (2003)
   PUBMED   14623119
REFERENCE   9  (bases 1 to 5130)
  AUTHORS   Ardley,H.C., Tan,N.G., Rose,S.A., Markham,A.F. and Robinson,P.A.
  TITLE     Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that
            regulate its interaction with the ubiquitin-conjugating enzyme,
            Ubch7
  JOURNAL   J Biol Chem 276 (22), 19640-19647 (2001)
   PUBMED   11278816
REFERENCE   10 (bases 1 to 5130)
  AUTHORS   Martinez-Noel,G., Niedenthal,R., Tamura,T. and Harbers,K.
  TITLE     A family of structurally related RING finger proteins interacts
            specifically with the ubiquitin-conjugating enzyme UbcM4
  JOURNAL   FEBS Lett 454 (3), 257-261 (1999)
   PUBMED   10431818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC083881.1, DN956151.1, AW141789.1, CK478034.1, CA339823.1,
            CV126532.1, DY312590.1, DV714248.1 and CN544531.1.
            
            On Nov 25, 2008 this sequence version replaced NM_001013108.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1176              BC083881.1         1-1176
            1177-1597           DN956151.1         339-759
            1598-1966           AW141789.1         185-553
            1967-2683           CK478034.1         27-743
            2684-3104           CA339823.1         191-611
            3105-3690           CV126532.1         79-664
            3691-4165           DY312590.1         191-665
            4166-4756           DV714248.1         148-738
            4757-5130           CN544531.1         1-374               c
FEATURES             Location/Qualifiers
     source          1..5130
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..5130
                     /gene="Arih1"
                     /note="ariadne RBR E3 ubiquitin protein ligase 1"
                     /db_xref="GeneID:300756"
                     /db_xref="RGD:1308131"
     exon            1..640
                     /gene="Arih1"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..1939
                     /gene="Arih1"
                     /EC_number="2.3.2.27"
                     /note="ariadne ubiquitin-conjugating enzyme E2 binding
                     protein homolog 1; ariadne homolog, ubiquitin-conjugating
                     enzyme E2 binding protein, 1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase ARIH1"
                     /protein_id="NP_001013126.2"
                     /db_xref="GeneID:300756"
                     /db_xref="RGD:1308131"
                     /translation="MDSDEGYNYEFDEDEECSEEDSGAEEEEDDDEDEPDDDNLDLGE
                     VELVEPGLGVGGERDGLLCGETGGGGGSALGPGGGGGGGGGGGGPGHEQEEDYRYEVL
                     TAEQILQHMVECIREVNEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFAECH
                     VINPSKKSRTRQMNTRSSAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKI
                     MEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPA
                     PDCHHVVKVQYPDAKPVRCKCGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNW
                     IAANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNE
                     DDAKAARDAQERSRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSW
                     IEVQFLKKAVDVLCQCRATLMYTYVFAFYLKKNNQSIIFENNQADLENATEVLSGYLE
                     RDISQDSLQDIKQKVQDKYRYCESRRRVLLQHVHEGYEKDLWEYIED"
     exon            641..708
                     /gene="Arih1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..853
                     /gene="Arih1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..946
                     /gene="Arih1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1002
                     /gene="Arih1"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1069
                     /gene="Arih1"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1176
                     /gene="Arih1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1219
                     /gene="Arih1"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1291
                     /gene="Arih1"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1422
                     /gene="Arih1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1480
                     /gene="Arih1"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1741
                     /gene="Arih1"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1854
                     /gene="Arih1"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..5113
                     /gene="Arih1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgttttccg tccgagcccg gagcggagcg gcgtctgatt gaggccggca gtaagcggcc
       61 cccgcgctcc ctcccgctct gctccgcgcc ctcccggccg ccgccgccgc ccgcctccaa
      121 ccgccgcacc cggggagcag ccgcggccca cggggccgga accaggcctg cgtccggaca
      181 gcagccggag ccggagcgag agccggggcc tcggcgtccc cgccctctcc gcgccgcggc
      241 cagcgtctgc caggcccgcg cgcgtcgcgc catggactcg gacgagggct acaactacga
      301 gttcgacgag gacgaggagt gcagcgagga ggacagcggc gccgaggagg aggaggacga
      361 cgacgaggat gagccggacg atgataacct ggatctcggc gaggtggagc tggtggagcc
      421 cgggctgggc gtcggcgggg agcgggacgg actgctgtgc ggggagactg gcggcggcgg
      481 cggcagcgct ctgggtcccg gaggcggtgg cggcggtggc ggtggcggcg gcggcccggg
      541 gcacgagcag gaggaagatt accgctacga ggtgctcacg gccgaacaga tcctgcagca
      601 catggtggaa tgtatccggg aggtcaacga ggtcatccag aatccagcaa ctatcacgag
      661 aatactcctt agccacttca attgggataa agagaagcta atggaaaggt actttgatgg
      721 aaacctggag aagctctttg ctgagtgtca tgtaattaat ccaagtaaaa agtctcgaac
      781 tcgccagatg aatacaaggt catcagcaca ggatatgcct tgtcagatct gctacttgaa
      841 ttaccctaac tcgtatttta ctggccttga atgtggacat aagttttgta tgcagtgctg
      901 gagtgaatat ttaactacca aaataatgga agaaggcatg gggcagacta tctcgtgtcc
      961 tgcgcatggc tgtgatatct tagtggatga caacacagtt atgcgcctga tcacagattc
     1021 aaaagttaaa ttaaaatatc agcatttaat aacaaatagc tttgtagagt gcaaccgact
     1081 gttaaaatgg tgtcctgccc ccgattgcca ccatgttgtt aaagtccagt atcctgatgc
     1141 aaaaccagtt cgctgcaagt gtggccgcca gttttgcttt aactgtggcg aaaattggca
     1201 tgatccagtt aaatgtaagt ggttgaagaa gtggattaaa aagtgtgatg atgacagtga
     1261 aacttctaat tggattgcag ctaacacaaa ggaatgtccc aaatgccatg tcacaattga
     1321 gaaggatggt ggttgtaatc acatggtctg tcgtaaccag aactgtaaag cagagttttg
     1381 ctgggtgtgt cttggccctt gggaaccaca tggatctgcc tggtacaact gtaaccgcta
     1441 taatgaggat gatgcaaagg cagcaagaga tgcccaagag cgatctaggg cagccctgca
     1501 gaggtacctg ttctactgta atcgctatat gaaccacatg cagagtctac gctttgagca
     1561 taagctgtat gctcaggtga aacagaagat ggaggaaatg cagcagcaca acatgtcctg
     1621 gattgaggtg cagttcctga agaaagcagt tgatgtcctc tgccagtgtc gtgccacact
     1681 catgtacact tatgtcttcg ctttctacct caaaaagaat aaccagtcca ttatctttga
     1741 gaataatcaa gcagatctag aaaatgccac agaggtgctt tcgggctacc ttgaacgaga
     1801 tatttcccaa gattctctgc aagatataaa gcagaaagtc caagataagt acagatactg
     1861 tgagagtcga cgaagggttt tgttacagca tgtgcatgaa ggctatgaaa aagatctgtg
     1921 ggagtacatt gaggactgag cctggccctg cataaaatga actctgaaaa ctttaccatc
     1981 tagagtgctc atgcaattaa aacaaacaca aacaaggagg cactaagcct gttctgacac
     2041 cgctggtctc tagtaccaga attctgtttt gttaacggaa agtttaagta aattatattg
     2101 taataaaaaa ggtagataaa ccattgtaca acagtattct aggccgccaa cagtgtgaca
     2161 gacacacaaa agccctccaa ctctaacttg taacgtagct tcattctcaa agctgacttc
     2221 cttttcttct tcctgagtgt agtacagtta aacattcaga cagctcctcg acactgcttt
     2281 tcatgtccaa accagccatt tcgttgtact ttggtaaagg acctcttccc cttcctgccc
     2341 tgcacataca cacctccaca cacagtttca ctttctctca taccctaagg tcatgagtga
     2401 ataatgatta ttagctactt gtaaaggaaa ttcttgggag ggagaagggg gtaggcagca
     2461 agaggattaa acaaaaaaca caaaaacttt gtatatgact tttaaaacaa gaggacaaca
     2521 cagtattttt caaaattgta tatagcgcat atgcatggat aaagcaagcg tggcacgtgt
     2581 ttgcataatg tttaattaca aaaatattta ttctttaaaa agcttcaaga ttatgtctat
     2641 ttgctgtgca ttttctttca gttggcttta tctttccagg gttgggttgg gataaaggtg
     2701 tttgttaagc ccctctgcaa gacctaacta gagtgctttc cccttcctga ggtcagtttg
     2761 cccgctgtgg tttggttgta tcttttgctg gccatgggcc tcatgcctag aattctcagc
     2821 ttctggatct agatccagga agtcaagttc taagcaaatg gcttggtctg ttaaagggtt
     2881 tagttgcttc aattcatgaa tgatcctatc ccaacctact cctcagtggc cttgatgtcc
     2941 ccattttagc ctgtgtgccc atgccatgca cacagcgtag gctttctagg atccccatca
     3001 agtctggagg aggcatttca aaatctcctg ttttattttt cctgaattgc tgctttgagc
     3061 cttttaagtt tttagttctg gctcgtcttt catcccttct ttatgttagg gtgttgaata
     3121 caatgttttc actttaaata taaataaata gccattcact tagtctgaga ttgtggatta
     3181 aaatggtgga tactgaaatt actcgtgtgt gttgcggtgg gttcagtttg aaggcaaaca
     3241 ccactagaat atgatactcc catccagtgc atttgagtag gaatcactga gtttgcttct
     3301 tttctattgt cagcatatag gagaataatg cattttagct gtgatgtcca tttttatgaa
     3361 atttctacta aaagctatgt taaaagtaaa gggtggtggt ggttttatta actatatact
     3421 tgtttaggcc attctgcctg tggtattttt caacaggtca gcatccctaa gactgtcagt
     3481 tttatataag agtgcagagt gaactaggca actagatcaa gaggtaaaac tgttaaatgc
     3541 cagctttggc tgaggacctc tttgtcttcc tttaactgtc ttgtgcctag ggagtgttta
     3601 ccatttgtga ggcagctgtg tctgttcttg cattgtacat cttcttactc cattgggaag
     3661 taggctcact ttcctctggc cttttgccta agttaggctt tgctgaatca ccctactttt
     3721 ccttttagaa aggttgttac atgagatgca cttgcaactg ttcttttccc atcaaaaatc
     3781 agtgaatgtt tgctgagtat attatgctgc ttccttaaac cacttgtcgc tttaggatca
     3841 acttgtattt tttttcttcc ctttccttgt cacctcaggt ggcaaatctg aagtcaagtg
     3901 tctgttttcc atcctctctt tgtcctatca ttctccatta tccatttgac tttatttcaa
     3961 ataattgcac cgatcttaag acatttatca aaaccaacga gatttcaaag aaagctcaag
     4021 tatgttcctt ttcctggtga ctttgaaaag caaccagaat tgtcacatag acttgtggtc
     4081 ccttaaaatg ctttgtgtgt gttgtttaaa aagagttaac ttcacattat ctaggtctga
     4141 gtgtcataag ttctcttcat tccctgccct gcaacaagcg tctaaaaaga gtgcatctca
     4201 tagtctcagt ctcccaccat ggagggatag tgtagttggt gacactttct agtcccagtg
     4261 ctcacatggg acctgaggat attgcactca caatttgtgt ggatcaaggt gaactggccc
     4321 ttctgctaca tccaagtttt taacaaccgt ctccatatct gacagcattt ccagaattta
     4381 cctgcttctg tcagtagcta gcttcagtgc tcccatctgg gacaggcaag ccatattgtt
     4441 aacagcttcc ctatttgacc tacctaagtc tctcagaggg ctctacttac acatcagggt
     4501 ctccctgtgg tgttgagatc agttacattg tcagtgcatg catcatttga gcaattcatt
     4561 gagcaacagg tgaattttca atgatttaca ataaaatttt gatccaaagc tcaggagaca
     4621 taccatagtg gtaaatggag tagcatataa cattaccaga ctcttaaatt ctttgtaatt
     4681 tgctgcaacc cagattgtat atgttttatg tgtgttcaaa taaatatatt aaagacacac
     4741 gtgtatccat acacacaaat agatccaaga ctgacttgat ttgaaatcgt tgaatctgca
     4801 gtgtaatgtg tggttcacct gtaagtagga cttgaaattt agaacaagaa gagtaaaagg
     4861 cttaaatgta acaaattctt ttagctacat ccggtataga gcacttgggg gatgggatgg
     4921 ggtgggttgg tgagacaatc agatcgataa attgattaaa tgctcctaac cctgtaattt
     4981 tgtgcataga gcaccttgtg ctgtggaaat aactgttctt agattttcat tgtaactgga
     5041 ctgttcaggt tgcccagagg gaaagaacat tcctaattct aataaaataa acttttattt
     5101 tgttattcca ttaaaaaaaa aaaaaaaaaa
//
