LOCUS       NM_001113521            4839 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus Rho guanine nucleotide exchange factor 7
            (Arhgef7), transcript variant 1, mRNA.
ACCESSION   NM_001113521 XM_008771379
VERSION     NM_001113521.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4839)
  AUTHORS   Liu,S., Premont,R.T., Park,K.H. and Rockey,D.C.
  TITLE     beta-PIX cooperates with GIT1 to regulate endothelial nitric oxide
            synthase in sinusoidal endothelial cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 323 (5), G511-G522 (2022)
   PUBMED   36044673
  REMARK    GeneRIF: beta-PIX cooperates with GIT1 to regulate endothelial
            nitric oxide synthase in sinusoidal endothelial cells.
REFERENCE   2  (bases 1 to 4839)
  AUTHORS   Shin,E.Y., Lee,C.S., Kim,H.B., Park,J.H., Oh,K., Lee,G.W.,
            Cho,E.Y., Kim,H.K. and Kim,E.G.
  TITLE     Kinesin-1-dependent transport of the betaPIX/GIT complex in
            neuronal cells
  JOURNAL   BMB Rep 54 (7), 380-385 (2021)
   PUBMED   34154701
  REMARK    GeneRIF: Kinesin-1-dependent transport of the betaPIX/GIT complex
            in neuronal cells.
REFERENCE   3  (bases 1 to 4839)
  AUTHORS   Sahin,G.S., Luis Rodriguez-Llamas,J., Dillon,C., Medina,I.,
            Appleyard,S.M., Gaiarsa,J.L. and Wayman,G.A.
  TITLE     Leptin increases GABAergic synaptogenesis through the Rho guanine
            exchange factor beta-PIX in developing hippocampal neurons
  JOURNAL   Sci Signal 14 (683) (2021)
   PUBMED   34006608
  REMARK    GeneRIF: Leptin increases GABAergic synaptogenesis through the Rho
            guanine exchange factor beta-PIX in developing hippocampal neurons.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4839)
  AUTHORS   Rathor,N., Chung,H.K., Wang,S.R., Qian,M., Turner,D.J., Wang,J.Y.
            and Rao,J.N.
  TITLE     beta-PIX plays an important role in regulation of intestinal
            epithelial restitution by interacting with GIT1 and Rac1 after
            wounding
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 314 (3), G399-G407 (2018)
   PUBMED   29191942
  REMARK    GeneRIF: Induced association of beta-PIX with GIT1 is essential for
            the stimulation of intestinal epithelial restitution by activating
            Rac1, and this signaling pathway is tightly regulated by cellular
            polyamines.
REFERENCE   5  (bases 1 to 4839)
  AUTHORS   Chia,R., Haddock,S., Beilina,A., Rudenko,I.N., Mamais,A.,
            Kaganovich,A., Li,Y., Kumaran,R., Nalls,M.A. and Cookson,M.R.
  TITLE     Phosphorylation of LRRK2 by casein kinase 1alpha regulates
            trans-Golgi clustering via differential interaction with ARHGEF7
  JOURNAL   Nat Commun 5, 5827 (2014)
   PUBMED   25500533
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4839)
  AUTHORS   Shin,E.Y., Shin,K.S., Lee,C.S., Woo,K.N., Quan,S.H., Soung,N.K.,
            Kim,Y.G., Cha,C.I., Kim,S.R., Park,D., Bokoch,G.M. and Kim,E.G.
  TITLE     Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine
            nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is
            required for basic fibroblast growth factor-induced neurite
            outgrowth
  JOURNAL   J Biol Chem 277 (46), 44417-44430 (2002)
   PUBMED   12226077
  REMARK    GeneRIF: has a role in bFGF-induced neurite outgrowth via the ERK
            cascade
REFERENCE   7  (bases 1 to 4839)
  AUTHORS   Paris,S., Za,L., Sporchia,B. and de Curtis,I.
  TITLE     Analysis of the subcellular distribution of avian p95-APP2, an
            ARF-GAP orthologous to mammalian paxillin kinase linker
  JOURNAL   Int J Biochem Cell Biol 34 (7), 826-837 (2002)
   PUBMED   11950598
REFERENCE   8  (bases 1 to 4839)
  AUTHORS   Koh,C.G., Tan,E.J., Manser,E. and Lim,L.
  TITLE     The p21-activated kinase PAK is negatively regulated by POPX1 and
            POPX2, a pair of serine/threonine phosphatases of the PP2C family
  JOURNAL   Curr Biol 12 (4), 317-321 (2002)
   PUBMED   11864573
REFERENCE   9  (bases 1 to 4839)
  AUTHORS   Premont,R.T., Claing,A., Vitale,N., Perry,S.J. and Lefkowitz,R.J.
  TITLE     The GIT family of ADP-ribosylation factor GTPase-activating
            proteins. Functional diversity of GIT2 through alternative splicing
  JOURNAL   J Biol Chem 275 (29), 22373-22380 (2000)
   PUBMED   10896954
REFERENCE   10 (bases 1 to 4839)
  AUTHORS   Manser,E., Loo,T.H., Koh,C.G., Zhao,Z.S., Chen,X.Q., Tan,L.,
            Tan,I., Leung,T. and Lim,L.
  TITLE     PAK kinases are directly coupled to the PIX family of nucleotide
            exchange factors
  JOURNAL   Mol Cell 1 (2), 183-192 (1998)
   PUBMED   9659915
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000283.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001113521.3.
            
            On or before Aug 30, 2022 this sequence version replaced
            XM_008771379.2, NM_001113521.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               JACYVU010000283.1  26957941-26958299   c
            360-446             JACYVU010000283.1  26925818-26925904   c
            447-531             JACYVU010000283.1  26904418-26904502   c
            532-662             JACYVU010000283.1  26902940-26903070   c
            663-864             JACYVU010000283.1  26899637-26899838   c
            865-953             JACYVU010000283.1  26891160-26891248   c
            954-1048            JACYVU010000283.1  26883684-26883778   c
            1049-1144           JACYVU010000283.1  26883364-26883459   c
            1145-1267           JACYVU010000283.1  26878272-26878394   c
            1268-1406           JACYVU010000283.1  26874121-26874259   c
            1407-1466           JACYVU010000283.1  26873479-26873538   c
            1467-1613           JACYVU010000283.1  26872770-26872916   c
            1614-1700           JACYVU010000283.1  26870415-26870501   c
            1701-1779           JACYVU010000283.1  26867405-26867483   c
            1780-1919           JACYVU010000283.1  26867106-26867245   c
            1920-2144           JACYVU010000283.1  26864301-26864525   c
            2145-2238           JACYVU010000283.1  26862557-26862650   c
            2239-2328           JACYVU010000283.1  26859767-26859856   c
            2329-2505           JACYVU010000283.1  26857170-26857346   c
            2506-2605           JACYVU010000283.1  26850422-26850521   c
            2606-2660           JACYVU010000283.1  26850126-26850180   c
            2661-4839           JACYVU010000283.1  26847043-26849221   c
FEATURES             Location/Qualifiers
     source          1..4839
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..4839
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /note="Rho guanine nucleotide exchange factor 7"
                     /db_xref="GeneID:114559"
                     /db_xref="RGD:620624"
     exon            1..359
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..2783
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /note="isoform a is encoded by transcript variant 1;
                     beta-Pix; PAK-interacting exchange factor beta; Rho
                     guanine nucleotide exchange factor (GEF) 7"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     a"
                     /protein_id="NP_001106993.2"
                     /db_xref="GeneID:114559"
                     /db_xref="RGD:620624"
                     /translation="MNSAEQTVTWLITLGVLESPKKTISDPEVFLQASLKDGVVLCRL
                     LERLLPGTIEKVYPEPRNESECLSNIREFLRACGASLRLETFDANDLYQGQNFNKVLS
                     SLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSSHSRTSKLLQSQYRSLDMTD
                     NANSQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVR
                     EIKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETEHEYSKELQSVLSTY
                     LWPLQTSEKLSSANTSYLMGNLEEISSFQQVLVQSLEECTKSPEAQQRVGGCFLSLMP
                     QMRTLYLAYCANHPSAVSVLTEHSEDLGEFMETKGASSPGILVLTTGLSKPFMRLDKY
                     PTLLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEPIRSWEG
                     DDIKTLGSVTYMSQVTIQCAGSEEKNERYLLLFPNLLLMLSASPRMSGFIYQGKLPTT
                     GMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLHEWVEHLQRQTKVTSVSNPTI
                     KPHSVPSHTLPSHPLTPSSKHADSKPVALTPAYHTLPHPSHHGTPHTTISWGPLEPPK
                     TPKPWSLSCLRPAPPLRPSAALCYKEDLSRSPKTMKKLLPKRKPERKPSDEEFAVTKS
                     TAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQSSLDSLGRRSS
                     LSRLEPSDLSEDSEYDSLWTAHSYRMGSASRSRKESAPQVLLPEEEKIIVEETKSNGQ
                     TVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPA
                     WDETNL"
     exon            360..446
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            447..531
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            532..662
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            663..864
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            865..953
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1048
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1144
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1267
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1406
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1466
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1613
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1700
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1779
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1919
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2144
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2238
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2328
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2505
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2605
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..2660
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..4839
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttgacagc gggccagggc gcgcgcgagc ccgcggagcc gagcgggacc tgctgggccg
       61 gccgggccaa tcgccggcgc gcggccgccc atgggcgcgg aggcggcggg ggcgcgggtg
      121 gccgcggccc gggccgctcc gaggtgatcg cgcgcggcgc cccctctgtg cgcgcagccc
      181 gagccgccgc agcgatgaat tctgccgagc agaccgttac gtggctcatc accctgggcg
      241 tgctggagtc gcccaagaaa accatttcgg acccggaggt cttcttgcag gcgtcgctca
      301 aggacggggt ggtcctatgc cggctgctgg agcgcttgct gcccgggacc atcgagaaag
      361 tctacccgga gccgcggaac gagagcgagt gcctgagcaa catccgcgag ttcctgcgcg
      421 cctgcggggc gtccctgcgc ctggagactt ttgatgcaaa tgatttgtat caggggcaga
      481 actttaacaa ggtcctcagc tccttggtga cactaaataa agtgacagca gacattggac
      541 taggaagtga ttctgtgtgt gcccggccct cgtcacatag gataaagtct tttgattccc
      601 tgggatccca gtcttcacac agtaggactt caaaattgct gcagagccag taccgaagct
      661 tggacatgac tgataacgcc aacagccaac tggtagtacg agccaagttt aacttccagc
      721 agaccaatga agatgagctc tccttctcga agggtgacgt catccatgtc actcgagtgg
      781 aggaaggagg ctggtgggaa ggcacacaca atggcaggac cggctggttc cccagcaact
      841 acgtacgaga gatcaagcca agtgagaagc ctgtgtcacc caaatcaggg accttgaaga
      901 gccctcccaa agggttcgat acgactgcca tcaacaagag ctattacaat gtggtgctac
      961 agaacatcct ggaaacagag catgagtatt ccaaggagct gcagtctgtg ctgtcaacct
     1021 acctgtggcc gctgcagacc agcgagaagt tgagttcagc aaacacttca tatttaatgg
     1081 gaaatctaga ggaaatatct tccttccagc aagtgcttgt acagtcccta gaagaatgca
     1141 caaagtctcc tgaagcccag cagagagtcg gtggctgctt cctgagcctg atgccgcaga
     1201 tgaggaccct gtaccttgcc tactgtgcca accacccatc tgctgtgagc gtcctcacag
     1261 agcacagtga ggacctggga gagttcatgg agacaaaagg tgccagcagc cctgggatcc
     1321 tggtgctgac taccggcctg agcaagccct tcatgcgcct ggacaagtac cccacactgc
     1381 tgaaggagct ggagagacac atggaggatt atcatcctga tagacaagat attcagaaat
     1441 ctatgactgc cttcaaaaac ctttcagccc agtgtcaaga agtacgaaaa aggaaagagc
     1501 tggagctgca gatcctgaca gagcccatca ggagctggga gggggatgac ataaagacgt
     1561 tgggcagtgt tacatacatg tcccaagtca caattcagtg tgcaggaagc gaggagaaga
     1621 atgagaggta cctcctgctc ttcccaaacc ttctgctcat gttgtctgcc agtcccagga
     1681 tgagcggttt catctatcag ggaaagctgc caacaacagg aatgacaatc acaaaactcg
     1741 aggacagtga gaaccatagg aatgcatttg agatatcagg gagcatgatc gagcgcatcc
     1801 tggtgtcctg caacaaccaa caggacttgc acgaatgggt ggagcatctg cagaggcaga
     1861 cgaaggtcac gtctgtgagc aaccccacca tcaagcccca ctcggtgcca tcgcacacac
     1921 ttccttccca tcctctcact ccatccagca aacacgcgga cagcaagcct gtggcactga
     1981 cgcctgcgta ccacacactc ccccacccct ctcaccatgg caccccacat accaccatca
     2041 gctggggacc cctggagcct ccgaagaccc ccaagccttg gagcctgagt tgcctgcggc
     2101 ctgcccctcc cctccggccc tcagctgctc tctgctacaa ggaggatctc agcaggagtc
     2161 ccaagaccat gaaaaagctg ctgccaaaac gcaagcccga gcgcaagcct tcagacgagg
     2221 agttcgctgt gaccaagagc acagccgctc tggaggaaga cgctcagatc ctgaaggtta
     2281 ttgaagctta ctgcacaagt gcaaagacga ggcagaccct gaactcaaca tggcaaggca
     2341 ctgacctgat gcataatcac gtcttggctg atgacgacca atcaagtcta gactccttgg
     2401 gtcgtcgcag tagcctttct cgtttggagc cctcagacct ctcggaagac tctgagtatg
     2461 acagtctatg gacagcccat agttacagaa tgggttctgc atcccgttca cgcaaagagt
     2521 ctgctccaca agtgttgctt ccagaagaag agaaaattat agtcgaagaa accaaaagca
     2581 acgggcagac agtgatagag gaaaagagcc tcgtggatac cgtgtacgca ctaaaggatg
     2641 aagtccaaga gttacgacag gataacaaga agatgaagaa atccttagag gaggaacaga
     2701 gggcccgcaa ggacctagag aagctggtga ggaaggttct aaagaacatg aacgaccctg
     2761 cttgggatga gaccaatcta taggctgact tcattctcat aggctgaaga ccagcagctc
     2821 ctggacaagg ctggggccct tggtccccag cacagtgaca ttcaggacta aggaggtggt
     2881 cttcaaaagg caagcagcag tgatgagctg ttgctgaagt agctacatgt gagttctaga
     2941 caccgaggcc tgggctgagt gagcacctcg ctgtacacct ctccctgcag tgactgacca
     3001 gagtcctcgg ctttgggact tgagttgaat ctataaatag cttacctgtg tactccttgt
     3061 aaatactgag atctgaatga acatgtacct gagaggtgac taggctaacc ctcttgctag
     3121 gatttccttc tcagcctttc tggccacagg gatctgaagt tgtgttccta aagtgttgga
     3181 agcagagagg tgaagggatg cccgggcagc atctgactcg tgtgcagtgt aggctccttg
     3241 gtgccatcag gagcaggcac tcaggcacag tggatttgtg tgtctctttt aactgcagta
     3301 ttccagtccc gagctacggc agtacccagg gcaccatggg ttctaggagg gtgagactgg
     3361 tgcccgcctc tgctgcgctg tcctgcctgg gccctgggtc acagtgtgga gtagtgggct
     3421 agcctggtgt atcttggccc tgtacatagt tgtgttattt attccatatt ctttagccgg
     3481 tgctgccggg cagggtttgg ctgcaggccg ttttcatcca caacctctgc tctgcctttg
     3541 gctgcagcca gcgttgtcca ggccactgag agccctctta accctgagca agactaaagc
     3601 aatacacacc gcactggagc agcgcggaga gcctcagtgc tgtgcccccg ccctcccttg
     3661 ctgcctcccc aggcccagat gggccctgga aggctggtgg cttccaagag gccctgcttc
     3721 tgttgggcca ggcttgccct tgatttggca acagtgacag tgacctcagg agcttagctg
     3781 tccccttcct ttctccaaag aggttgtttt gaagtcagag atacttcccc atagaaaggt
     3841 gtttgtcttt aaacactgag gagcagtgtg gctggggcct cagcatagcc taggttgtga
     3901 cccagctcct ggccgctcgt cctccgtgca ggtttctgag tgggtgtgtg gaggcccttt
     3961 gtgctctcct tcctccacac tctggctggg tgcagcgtct gtcaggatcc accagagcct
     4021 cccgctcctg ttagcatttt accagcccag tctgtgccgg gtgagaaaag ctgaggtgtt
     4081 ctttctcttt ggtaagccct gcttcccaag cactctccga cccaaaagac actacagcag
     4141 aggacagtgt gttcgctgtc acagtggacc tcacctcagg aacaacgctc cttgcaactc
     4201 cactgctggc gactggtgcc tggggttgct ggacagctcc tccgccaaga gcaagcgaag
     4261 accatctctg acgcggtcct caccccgccg aggtggctgt gcaggcccca aggacagttt
     4321 ttacagacct gccttaatga ttcgcttgga gacttccatg agtatcccta ccctggacag
     4381 ggtggtagcg ttgtgtcagc acgccaccct gtccttctga gatccagtgt cttccaggct
     4441 ctcagggagc gagaatctgc acccggagca gtccttttta aagctggcac acaccccgtt
     4501 ctcctcctgc atctctgcgg tggagctctg acacccacag cacagggtgc ctctcaccaa
     4561 ctccaactcc tccgcgctct gtgagggatg agggggatta agccatttcc tgtcctctag
     4621 tgaagcactt tccgttctga accatgctgc tgcgtgcagc ctctgaagct ccactcttcc
     4681 ctcccagttg ttgcccacgc tccctgtgca cctcatgcca acccctcctt ccctgcgaca
     4741 ctgcaggagc cggtgctggc agaccgcacc ggtgtgactg ctgcagtgtg tgtgctgccc
     4801 cctccaatta ttaaactcct tattttccta tctcaccaa
//
