LOCUS       NM_001005565            4417 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Rattus norvegicus Rac/Cdc42 guanine nucleotide exchange factor 6
            (Arhgef6), mRNA.
ACCESSION   NM_001005565 XM_343833
VERSION     NM_001005565.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4417)
  AUTHORS   Seong,M.W., Park,J.H., Yoo,H.M., Yang,S.W., Oh,K.H., Ka,S.H.,
            Park,D.E., Lee,S.T. and Chung,C.H.
  TITLE     c-Cbl regulates alphaPix-mediated cell migration and invasion
  JOURNAL   Biochem Biophys Res Commun 455 (3-4), 153-158 (2014)
   PUBMED   25450678
  REMARK    GeneRIF: c-Cbl negatively regulates alphaPix-mediated cell
            migration and invasion; the lack of c-Cbl in C6 and A172 glioma
            cells is responsible for their malignant behavior
REFERENCE   2  (bases 1 to 4417)
  AUTHORS   Liang,Y., Cucchetti,M., Roncagalli,R., Yokosuka,T., Malzac,A.,
            Bertosio,E., Imbert,J., Nijman,I.J., Suchanek,M., Saito,T.,
            Wulfing,C., Malissen,B. and Malissen,M.
  TITLE     The lymphoid lineage-specific actin-uncapping protein Rltpr is
            essential for costimulation via CD28 and the development of
            regulatory T cells
  JOURNAL   Nat Immunol 14 (8), 858-866 (2013)
   PUBMED   23793062
REFERENCE   3  (bases 1 to 4417)
  AUTHORS   Totaro,A., Tavano,S., Filosa,G., Gartner,A., Pennucci,R.,
            Santambrogio,P., Bachi,A., Dotti,C.G. and de Curtis,I.
  TITLE     Biochemical and functional characterisation of alphaPIX, a specific
            regulator of axonal and dendritic branching in hippocampal neurons
  JOURNAL   Biol Cell 104 (9), 533-552 (2012)
   PUBMED   22554054
  REMARK    GeneRIF: alphaPIX and GIT2 are required for neuronal
            differentiation.
REFERENCE   4  (bases 1 to 4417)
  AUTHORS   Momboisse,F., Lonchamp,E., Calco,V., Ceridono,M., Vitale,N.,
            Bader,M.F. and Gasman,S.
  TITLE     betaPIX-activated Rac1 stimulates the activation of phospholipase
            D, which is associated with exocytosis in neuroendocrine cells
  JOURNAL   J Cell Sci 122 (Pt 6), 798-806 (2009)
   PUBMED   19261846
  REMARK    GeneRIF: betaPix is identified as the guanine nucleotide-exchange
            factor integrating Rac1 activation to PLD1 and the exocytotic
            process.
REFERENCE   5  (bases 1 to 4417)
  AUTHORS   Matsuda,C., Kameyama,K., Suzuki,A., Mishima,W., Yamaji,S.,
            Okamoto,H., Nishino,I. and Hayashi,Y.K.
  TITLE     Affixin activates Rac1 via betaPIX in C2C12 myoblast
  JOURNAL   FEBS Lett 582 (8), 1189-1196 (2008)
   PUBMED   18325335
REFERENCE   6  (bases 1 to 4417)
  AUTHORS   Hoffert,J.D., Pisitkun,T., Wang,G., Shen,R.F. and Knepper,M.A.
  TITLE     Quantitative phosphoproteomics of vasopressin-sensitive renal
            cells: regulation of aquaporin-2 phosphorylation at two sites
  JOURNAL   Proc Natl Acad Sci U S A 103 (18), 7159-7164 (2006)
   PUBMED   16641100
REFERENCE   7  (bases 1 to 4417)
  AUTHORS   Kutsche,K., Yntema,H., Brandt,A., Jantke,I., Nothwang,H.G.,
            Orth,U., Boavida,M.G., David,D., Chelly,J., Fryns,J.P., Moraine,C.,
            Ropers,H.H., Hamel,B.C., van Bokhoven,H. and Gal,A.
  TITLE     Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor
            for Rho GTPases, in patients with X-linked mental retardation
  JOURNAL   Nat Genet 26 (2), 247-250 (2000)
   PUBMED   11017088
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Sep 2, 2022 this sequence version replaced NM_001005565.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY725848.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-229               JAXUCZ010000021.1  140301349-140301577 c
            230-313             JAXUCZ010000021.1  140300005-140300088 c
            314-398             JAXUCZ010000021.1  140262422-140262506 c
            399-523             JAXUCZ010000021.1  140260180-140260304 c
            524-725             JAXUCZ010000021.1  140257156-140257357 c
            726-796             JAXUCZ010000021.1  140244452-140244522 c
            797-891             JAXUCZ010000021.1  140232613-140232707 c
            892-987             JAXUCZ010000021.1  140228210-140228305 c
            988-1110            JAXUCZ010000021.1  140226114-140226236 c
            1111-1249           JAXUCZ010000021.1  140206443-140206581 c
            1250-1309           JAXUCZ010000021.1  140203126-140203185 c
            1310-1456           JAXUCZ010000021.1  140200587-140200733 c
            1457-1543           JAXUCZ010000021.1  140196723-140196809 c
            1544-1622           JAXUCZ010000021.1  140195886-140195964 c
            1623-1768           JAXUCZ010000021.1  140194911-140195056 c
            1769-1894           JAXUCZ010000021.1  140193693-140193818 c
            1895-1915           JAXUCZ010000021.1  140192128-140192148 c
            1916-2009           JAXUCZ010000021.1  140190894-140190987 c
            2010-2087           JAXUCZ010000021.1  140189489-140189566 c
            2088-2187           JAXUCZ010000021.1  140187367-140187466 c
            2188-2242           JAXUCZ010000021.1  140186140-140186194 c
            2243-4417           JAXUCZ010000021.1  140182734-140184908 c
FEATURES             Location/Qualifiers
     source          1..4417
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq36"
     gene            1..4417
                     /gene="Arhgef6"
                     /note="Rac/Cdc42 guanine nucleotide exchange factor 6"
                     /db_xref="GeneID:363509"
                     /db_xref="RGD:1359674"
     exon            1..229
                     /gene="Arhgef6"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..2383
                     /gene="Arhgef6"
                     /note="Rac/Cdc42 guanine nucleotide exchange factor (GEF)
                     6"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 6"
                     /protein_id="NP_001005565.2"
                     /db_xref="GeneID:363509"
                     /db_xref="RGD:1359674"
                     /translation="MNPEERVVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKL
                     ISRLLPGSVEKYCQEPQTEADCIDNINDFLKGCATLQVEVFEPDDLYSGANFSKVLNT
                     LLAVNKATEDQLSERPCGRSSSLSATTSSQTNPQAAVPSTTPEQQSEEKAAEMTENGS
                     HQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIK
                     PSERPLSPKAVKGFDTAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNN
                     LSTVEFTCLLGNFEEVCTFQQTLCQALEECSKSPENQHKVGGCLLNLMPHFKSMYLAY
                     CANHPSAVNVLTQHSDDLERFMENQGASSPGILILTTSLSKPFMRLEKYVTLLQELER
                     HMEDTHPDHQDILKAIIAFKSLMGQCQDLRKRKQLELQILSEPIQAWEGDDIKTLGNV
                     IFMSQVVMQHGACEEKEERYFLLFSSVLIMLSASPRMSGFMYQGKVPIAGMVVTRLDE
                     IEGNDCTFEITGSTVERIVVHCNNNQDFQEWMEQLNRLTKGPASCSSLSKTSSSSCST
                     HSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPLRPSAALGYKERMSYILKESSKSPK
                     TMKKFLHKRKTERKTSEEEYVIRKSTAALEEDAQILKVIEAYCTSASFQQGTRKDSVP
                     QVLLPEEEKLIIEETRSNGQTIIEEKSLVDTVYALKDEVKELKQENKKMKQCLEEELK
                     SRKDLEKLVRKLLKQTDECIRAESSSKTSILQ"
     exon            230..313
                     /gene="Arhgef6"
                     /inference="alignment:Splign:2.1.0"
     exon            314..398
                     /gene="Arhgef6"
                     /inference="alignment:Splign:2.1.0"
     exon            399..523
                     /gene="Arhgef6"
                     /inference="alignment:Splign:2.1.0"
     exon            524..725
                     /gene="Arhgef6"
                     /inference="alignment:Splign:2.1.0"
     exon            726..796
                     /gene="Arhgef6"
                     /inference="alignment:Splign:2.1.0"
     exon            797..891
                     /gene="Arhgef6"
                     /inference="alignment:Splign:2.1.0"
     exon            892..987
                     /gene="Arhgef6"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1110
                     /gene="Arhgef6"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1249
                     /gene="Arhgef6"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1309
                     /gene="Arhgef6"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1456
                     /gene="Arhgef6"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1543
                     /gene="Arhgef6"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1622
                     /gene="Arhgef6"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1768
                     /gene="Arhgef6"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1894
                     /gene="Arhgef6"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..1915
                     /gene="Arhgef6"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2009
                     /gene="Arhgef6"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2087
                     /gene="Arhgef6"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2187
                     /gene="Arhgef6"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2242
                     /gene="Arhgef6"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..4417
                     /gene="Arhgef6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acggatgtgg cttagtcctc acagctgccc cgagagctgt tcagagcgta cgagagcctc
       61 agtcatgaat ccagaagaac gcgttgtgac ctggcttata tctttgggag ttctagagtc
      121 ccccaaaaag accatctgtg atccagaaga gttcttgaag tcttcgctga aaaatggggt
      181 agtgttgtgc aaactcataa gcagacttct gcctggctcg gtggagaagt attgtcagga
      241 accccaaact gaggccgact gcatcgacaa catcaatgac ttcctgaaag gatgtgcaac
      301 ccttcaagtg gaagtgtttg agcctgatga cctctattct ggggccaatt tctccaaggt
      361 tctgaatacc cttctagctg tcaacaaagc gacagaagat cagctatcag aaagaccatg
      421 tggacggtcc tcttctctta gtgctacgac cagctctcag acaaacccac aggcagccgt
      481 tcccagcaca actccagagc agcaaagcga ggaaaaggca gcggagatga cggaaaatgg
      541 aagtcaccag ttgatagtaa aggcaagatt caacttcaag cagaccaatg aagatgaatt
      601 gtcagtgtgt aaaggggaca tcatttatgt cactcgagtt gaagaaggag gctggtggga
      661 aggcacatta aatgggagaa ccggatggtt ccctagtaat tatgttcgag aaattaaacc
      721 cagtgagaga cctctgtccc ctaaggctgt caaaggattt gacactgctc cacttaccaa
      781 gaattactac actgtggtgt tacagaacat cttggacact gaaaaagaat atgccaaaga
      841 acttcagtct cttcttgtta cttacctaag acctttgcag tctaataaca acctgagtac
      901 tgtggagttt acatgcttat tgggaaactt tgaagaagta tgcacatttc aacagacact
      961 ctgccaagcc ctggaagaat gctcaaagtc tccagaaaac cagcacaaag taggaggctg
     1021 cctactgaac ctcatgcctc attttaaatc gatgtacctg gcttactgtg caaatcatcc
     1081 ttcagctgtc aacgtgctca cccagcatag tgatgatcta gaacgattca tggaaaatca
     1141 aggtgcatcc agccccggta tcctcatttt aacaacaagt ctcagcaaac cattcatgcg
     1201 actggaaaag tatgttactc tcttgcaaga actggaacgg catatggagg acactcatcc
     1261 agatcatcag gatattctga aagctatcat agcattcaaa agcctcatgg ggcagtgcca
     1321 agatctgaga aagagaaagc agctggaatt gcagatcctt tcggaaccta ttcaggcatg
     1381 ggaaggagat gatattaaga ctttgggaaa tgtgatcttt atgtcacaag tagtgatgca
     1441 gcatggagcc tgtgaggaaa aagaggaacg atattttctg ctcttttcaa gtgtcttgat
     1501 catgttgtct gcaagtccgc ggatgagtgg ctttatgtat cagggaaagg taccaatagc
     1561 agggatggtc gtgaccagat tggatgaaat tgaaggaaat gactgtacat tcgaaatcac
     1621 cggtagcacg gtagagagaa ttgtggtcca ctgcaacaat aaccaggact tccaggagtg
     1681 gatggagcag ctgaacagac tgaccaaagg accagcctcc tgcagttcat tgtctaagac
     1741 ctcctcatca tcatgtagta ctcattcttc ttttagctct accggacagc cccgaggacc
     1801 cttggagcct cctcaaatta taaaaccgtg gagtttaagt tgcctacgac ctgcacctcc
     1861 acttagacca tcagcagcac taggttataa agagaggatg tcttatatct taaaggaatc
     1921 tagtaagagc cccaaaacga tgaagaagtt tcttcacaaa agaaagacgg agagaaagac
     1981 atccgaggaa gaatacgtga ttaggaaaag tactgctgcc ctggaagagg atgctcagat
     2041 tcttaaggtg attgaagctt attgcaccag cgccagtttt caacaaggta ctcgtaaaga
     2101 ttcagttcca caagtactcc tccccgagga agagaaactc attattgaag aaactagaag
     2161 taatgggcag accatcattg aagagaagag ccttgttgat actgtctatg ccttgaagga
     2221 tgaggtcaag gaattgaagc aggagaataa aaaaatgaag caatgtctgg aagaagaatt
     2281 gaagtcgagg aaggacctag aaaaactggt ccggaagctg ttgaagcaaa ccgatgaatg
     2341 cattcgcgct gaatccagca gcaagacctc gattcttcag taaccatcac tgtgcagggg
     2401 agcacagtgc cttcagcaca tgttaaaatg gccagctgaa tgatataact gtgcacttaa
     2461 gctttgtgct ttgtggtgtt gggattcttt ctctcttctt ccctcctctc ctaccccctc
     2521 cccctcctcc cacccctgct gtttgattca gtgtttgttg cttggttatc agttgattga
     2581 cacttgtttt aacaggggaa atagcctgag gtggtggtaa aaatggcccc gatattttgc
     2641 tctgcccaac agcccttaac tacctaatct gctggaggct aagcttctca ggctttgttt
     2701 agagtaggtg aaaatgaaca cctttgccca gtgacccagc tgcacctccc ctgactgtca
     2761 tacggcccct ttcagtactg taaaaattta ttgcccatgt tgtctgttaa gatcaggaac
     2821 agtgtagtgc ccttataccc tttgtgctgg tggccattta aggtcagtgt ggtaggagct
     2881 ccaactgtcc acactggcag caagtctatc agcaaattgc ttcaggcagt cccccctcag
     2941 cagggcagag ccgtttgatg gagcagatat ccctagtgta gtgtagcttt acagcccaac
     3001 cttctgcctc ttcgtacgtt ttctacctcc ccccaaccct gtgcttttag ccagccataa
     3061 aaagtgcggt gtaaatgatc atggatttgc tttgtttatt tcgtcaaaca gttactataa
     3121 gcagtgactt cactttgaat attctaatga caaccttttc acctttctga acaacctggg
     3181 tgagaagata ttgtgcccta atacacacct tccatcccat cttaccaagt tctggtttct
     3241 gctgtgagaa gactcatcat gggcccctac tatgatgaga cagattatac acccagtaaa
     3301 agggcccctc ctagctgacc aggttgtcag tgaagctgat tgtttgaaac tggtttgctc
     3361 aagttgttta taatgtccaa ccattgactt tgtaagtagt ccaggaaagt gacctgtgga
     3421 aaaagcagat tttgaagaga gcccagaaca ctgtatacct aaattcaaca caagtcaaaa
     3481 taggccgagg atggaggagc agagctcttg cctacctcct tagatgacag gacaccttgg
     3541 ccagatggca gagtcactag aaagagatgc ggaacgccaa ccaaacactt acacgtacat
     3601 ttgattgggg cctgtaagtg ctgcttcaaa accaaactca agacctaaaa gtttgttgag
     3661 gagctctttt tctttgtggt atggaggctc tcacagtttc cattattcca tgggtacagt
     3721 gctattgtct catgttacat ggtcaacatt atagcaccca caggatatgg aatattcctg
     3781 aagtccaaca tcagacaatc gcacacagcc atctttgtca gcttagaggg taaaggttta
     3841 taagagtggc tgtcccaatt ctaagcccag agatttctat gagacatctt tcatgtaaaa
     3901 gtattttaca aaaggaataa cagcaacaac ccatatgttc acatgtgtcc tgtctgtgct
     3961 tagtcaacag tttgcaatca gtatgcaaat tttgtccata ggaaaaacac ttttgtggtc
     4021 gacaaataat ttagttcgtc gattaagaca ttgaaaggtc ataaaggatg tgtacatacg
     4081 catgcttggg gactttgccc ttccaaggag agcccttggt actctggata atgaaacttg
     4141 tgcagtgggc tgcccatgct tacagactaa ataatataaa ggaaatgaag ccatgttagc
     4201 cccaaagtca tgtctccata gttgtgttgt ttacaatact ctctaaatgg gttcccctta
     4261 ctctaattac actgctgccc ttaggggtct ttcagtttcc cttctgttat gtcccttctt
     4321 ataggagctc agatttttct aaacttgttt ttattttaaa gacttttaaa atgaacattt
     4381 tcaataaaca agaataaaca gtgctttata aataaaa
//
