LOCUS       XM_039108652            6525 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus Rho guanine nucleotide exchange factor
            5 (Arhgef5), transcript variant X2, mRNA.
ACCESSION   XM_039108652
VERSION     XM_039108652.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051339.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039108652.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6525
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..6525
                     /gene="Arhgef5"
                     /note="Rho guanine nucleotide exchange factor 5; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 17 ESTs, 6 Proteins, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     17 samples with support for all annotated introns"
                     /db_xref="GeneID:140898"
                     /db_xref="RGD:620718"
     CDS             150..4919
                     /gene="Arhgef5"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 5"
                     /protein_id="XP_038964580.1"
                     /db_xref="GeneID:140898"
                     /db_xref="RGD:620718"
                     /translation="MEAEEPEHGACTPVPDIEELGAIPEGIMRSSQIPALDPEAQEGQ
                     DPSYKWTDGHRSLMDQSKVLRDVSDHTPNSVAIFFKKDSSAMATSQEILLAEARDTAD
                     QQEAVTQSLQDRLSTTVAAPELLGCAVQEEWLDIPSKLDSRVEAELQPELMSLTLAVS
                     KEKEEEESSPDTSTPGFWPPSKIHPGETDQTEGSGMELLRQGKQLQLEATQENRGQQG
                     LLQPQEAQGLEEQEGQEVEIQEEGTLREDICFGGLLGEQKEVEEDFNDNKEEQKQEQI
                     QSYMLLGGQWESEGLSGELEGLNYNERSQEERERRVCGQRDSKEEGQDQELREVEERR
                     VGTQCAENQMLEEISENVRRRQEDHDQAGQAMHVGDQKEVVDSGDREQGTWDSGGQAA
                     EERSRTGEDNKPCLPMTSIAPGVLSPGTLFPAIPSSVDDMSQIQREPVPEELTTQAPT
                     PAPEPTEWSHQHISPPASFATEEALDNRTHDSQQEEFKLRKGTISNQGTENVSASISV
                     APSGTPDLPPFTPPNVFPTTATFSLVSSSVILPEKETPAASISADISPHYGPCETPPL
                     PAKSTRDPCATSDTANPHSPLTSYTGVTQHLRSNSFPGSHRTEQTPDSMGMSLSFSHL
                     ELPQRPPKTAIYGSLIPRRNRRSRDGVVFSESSAALFALKQDSEEFTSNPESSSNPHG
                     SQPWGSPQNSAFAIGSPVNVSSPPTVSMDMIHEALPPPPPEKRHSYSHIVERDGLFHE
                     VAATLKRHSHPPPLTLSSGLHRSPKGSFSLVPDSVVARQHRPLPSTPEGSHHTQTSIP
                     SRLRYNKPLPPTPDMPEPCHSSISSSNISRIYRPLPPVPITDPSSEPPPLPPKSRERS
                     RSVQVGVMHSMGQANPRTTGQDWTVSTLSVGRTSWPPATGRSTESLPPTSRCNSEVSP
                     GLAFSNMTNLLSPSSPTTPWSPELQIPTSKDESGLTEESAPPVRGSFRRPALQEEFNN
                     TRRSALGSRKKSEKPIHYQLEKASSWPHRRDTARTSESSSEQVVLGQAPNKQKGWNRQ
                     GLRRPSILPESSSDLRNPAAGRLPGSSDSVVFREKKPKEGMGGFSRRCSKLINSSQLL
                     YQEYSDVVLNKEIQSQQRLDSLAEPPGISSPRYRRKALVSSDSYLQRLSMASSGSLWQ
                     EIPVVRNSTVLLSMTHEDQKLQEAKFELIVSEASYLRSLNIAVDHFQHSTQLRATLSN
                     QDHQWLFSRLQDVRDVSTTFLSDLEENFENNIFSFQVCDVVLDHAPDFHRVYLPYVTN
                     QTYQERTFQSLMNSNSSFREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNIL
                     KRTQPGSSEEAEATKAHHALEKLIRDCNSNVQRMRRTEELIYLSQKIEFECKIFPLIS
                     QSRWLVKSGELTALEFSVSPGLKRKLTTRPVHLHLFNDCLLLSRPREGSRFLVFDHAP
                     FSSIRGEKCEMKLHGAHKNLFRLFLLHNAQGTQAEFLFRTETQSEKLRWISALAMPRE
                     ELDLLECYDSPQVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGEQGW
                     FPLQQVEFISNPEVRVQNLKEAHRVKTAKLQLVEQQV"
ORIGIN      
        1 atggacaccc tgccccgaga tgttaccggg ccaatactcc gaactttttt ccacgccgaa
       61 agtcggggcc ctgaggaaag ctctaacttt tatgataaag aatttttgag attcagtttc
      121 tagacggttc cttacctgat tcagccctga tggaggctga ggagcctgaa catggagcat
      181 gcacacctgt ccctgacata gaagaacttg gagctatccc tgaaggtatc atgaggagca
      241 gtcagatccc tgccttggat cctgaagctc aagaaggcca agacccatcc tataagtgga
      301 ctgatggaca cagatccttg atggaccagt caaaagtgtt aagggacgtg agtgaccata
      361 cacctaatag tgtggcaatt ttcttcaaga aagattcttc agctatggcg acaagccagg
      421 aaatactttt ggctgaggcc cgtgacactg cagaccagca ggaagctgtg acccagagcc
      481 ttcaagacag attgtcaaca acagtagccg cccctgagct cctgggctgt gctgtccagg
      541 aagaatggct agacataccc agcaaactag acagcagagt ggaggctgaa ttgcagccag
      601 aacttatgtc tttgacttta gcagttagca aagagaaaga agaagaagaa agctctccag
      661 acacctcaac ccctggattt tggcctccct ccaaaattca ccctggtgag actgaccaga
      721 ctgagggcag tggaatggaa ttgcttagac aggggaaaca gctgcagttg gaggccacac
      781 aagaaaatcg agggcaacag ggcctcctcc aacctcagga agcccaggga ctagaggagc
      841 aggaaggaca ggaagtagaa attcaagagg aaggaactct gagggaagac atttgttttg
      901 gtgggctcct gggagaacag aaagaggtgg aagaggactt taatgacaac aaggaagaac
      961 aaaagcagga acagatccaa agctatatgc tacttggagg acaatgggaa agtgaggggc
     1021 tcagtgggga attagaaggt ctgaattaca atgagaggag ccaagaggaa agggaaagga
     1081 gggtttgtgg tcagagagat tcaaaagagg agggacagga ccaggaatta agggaggtgg
     1141 aagagaggag ggtaggcact cagtgtgcag agaatcaaat gttagaagag atatcagaga
     1201 atgtaaggag acggcaggaa gatcatgatc aagcaggaca agcgatgcat gtaggggacc
     1261 agaaggaggt tgtagactca ggtgacaggg agcaagggac ctgggacagc ggtgggcagg
     1321 cagcagagga aaggagcaga acaggagagg acaacaagcc ttgtcttcca atgacttcca
     1381 tagctcctgg ggtcctctcc ccaggtacat tattcccagc tattccttcc tctgtggatg
     1441 atatgtcaca gattcagagg gagcctgtgc ctgaggaact gaccacccaa gctccaactc
     1501 ctgcaccaga gccaacagaa tggtctcacc agcacatttc tccacctgcc tcttttgcta
     1561 ctgaagaagc ccttgataat aggactcacg acagccagca agaagaattc aagctaagga
     1621 aggggacaat atccaatcag gggactgaga atgtgtctgc tagtatatcc gtggcccctt
     1681 cggggacacc agatttacct cctttcactc ctcccaacgt tttccccacc actgccacct
     1741 tttcacttgt tagctcttca gttatccttc ctgagaagga gaccccagca gcttctatct
     1801 cagctgacat ttcacctcat tatgggccat gtgagactcc tccactacct gcaaaatcca
     1861 ccagggaccc atgtgccacc tctgacacag ccaaccctca cagccctctt accagctaca
     1921 ctggagtcac ccaacatcta agaagcaact ccttcccagg ctctcacagg acagagcaga
     1981 ctccagactc tatgggaatg tcactctctt tctctcattt ggaattacct cagaggcccc
     2041 ccaaaacagc catctatggc tctctgatcc caagaagaaa cagaagaagt agggatggtg
     2101 tcgtcttttc agaatcctct gctgctttat ttgctttgaa acaggactct gaagaattca
     2161 cgtcaaatcc agagagttcc agcaatcctc atggtagtca accatggggc tccccacaga
     2221 actcagcctt tgccataggc tctcctgtga atgtttcttc tccacccact gtttccatgg
     2281 atatgataca tgaagctttg ccccctcctc ccccagagaa gagacatagc tacagtcaca
     2341 tagtggaaag agatggcctt tttcatgaag tagctgccac actgaagcgg catagtcatc
     2401 ctcctccatt gaccctaagt tcagggctcc ataggtctcc taaaggctca ttttccctag
     2461 ttcctgactc tgttgttgca aggcagcacc gccctctgcc atccacccca gaaggctccc
     2521 accatactca gacctccatc ccctccaggc tgagatacaa caaaccatta cccccaactc
     2581 ctgatatgcc tgagccctgc cattcatcca tctcttcctc taatatctca aggatataca
     2641 ggcctctacc cccagtccct atcacagatc cttcctctga accaccccca ttacccccaa
     2701 agtccaggga aagaagcagg agtgtccagg taggagttat gcattcaatg ggtcaagcca
     2761 acccaagaac tactggtcaa gattggacag tttctactct ctctgttgga cggacctcct
     2821 ggcccccagc cacaggcaga tcaacagaat ctttgcctcc caccagtagg tgtaatagtg
     2881 aagtgtcccc tggtctggct ttcagcaaca tgacaaacct tctaagtccc tcttccccta
     2941 ctactccttg gagcccagag cttcagatac ccaccagtaa ggatgagtca gggctcactg
     3001 aagagtctgc acctccagtg agaggatcat ttaggaggcc agcccttcag gaggaattta
     3061 ataatacaag gagatcagct ttaggatcaa gaaagaagtc agaaaaacct atccactacc
     3121 aactggaaaa ggcatccagc tggcctcaca gacgggatac agcaaggaca tcagagagta
     3181 gcagtgaaca ggttgtcctg ggccaggcac ccaacaagca aaagggctgg aaccggcagg
     3241 gccttcgtag accttcaatt ttgcctgaga gctcttcaga tttacgaaat ccagctgcgg
     3301 ggagacttcc tggctcttca gattctgttg ttttccggga gaagaaacca aaggagggga
     3361 tgggaggttt ttcaagacgt tgctccaagc tcatcaactc ctctcagctg ctttatcagg
     3421 agtatagtga tgttgttctc aacaaggaga ttcagagcca gcagcggcta gacagcctgg
     3481 ccgagccacc tgggatctct tccccacgat atcggcgaaa ggcactggtc tcttcagact
     3541 cctacctaca gcgcctctcc atggcctcca gtggctccct ctggcaggaa atccctgtgg
     3601 tgcgcaatag cacagtgctg ctctccatga cccacgaaga tcaaaaactg caagaggcca
     3661 agtttgagct gattgtgtcc gaggcatctt acctgcgcag tctaaacata gcagtagacc
     3721 atttccaaca ctcaacccag ctgcgggcca ccctgtccaa ccaggatcat caatggctct
     3781 tctctcgttt gcaggatgta cgagatgtca gcaccacgtt cctttcagac ctagaagaaa
     3841 acttcgagaa caacatcttc tccttccaag tgtgtgatgt tgtcttggat catgctccag
     3901 acttccacag agtctacctg ccttatgtca ccaaccagac ctatcaggaa cgcaccttcc
     3961 aaagtctaat gaatagcaac agcagtttcc gagaggtctt agagaagctg gagagtgacc
     4021 ctgtctgcca acgcctgtct ctcaagtcct ttctgatact gcccttccaa cgcatcacac
     4081 gtctcaagct gctgctccag aacattctga agagaaccca gcctggctcc tcagaagagg
     4141 cagaggccac aaaggcacac catgccctag agaagctaat tcgagactgc aatagcaatg
     4201 tgcagagaat gcggcggaca gaggagctca tctacctgag ccagaagatt gagtttgagt
     4261 gcaaaatttt cccacttatt tcacaatctc gatggctggt gaagagtggg gagctgacgg
     4321 ccctggagtt cagtgtctcc ccagggctga agaggaaact gaccactcgt ccagtccacc
     4381 tacatctctt caacgactgt ctgttgctgt ctcggccccg agagggcagc cggttcctgg
     4441 tatttgacca tgctccgttc tcctccattc gaggggagaa gtgtgaaatg aagctgcacg
     4501 gagctcacaa aaacctcttc cgtctctttc tcctgcacaa cgcacagggc acccaagctg
     4561 aattcctctt ccgcactgag actcaaagtg aaaagcttcg gtggatctca gccttggcca
     4621 tgcccagaga ggagttggac ctacttgagt gttacgactc cccacaagtt cagtgcctcc
     4681 gtgcctacaa accccgagag aatgatgagt tggcactaga gaaggcggat gtggtgatgg
     4741 tgactcagca aagcagcgat ggctggctgg agggtgtaag actgtcggat ggggagcaag
     4801 gctggtttcc tctccaacag gtagagttca tttcaaatcc agaggtccga gttcagaacc
     4861 tcaaggaagc ccatcgagta aagactgcca aactacagct ggtagaacag caagtctaac
     4921 tgttccttgg tgaggagtct tctgagctca tgaacaagca ttcctggaga tgactaggcc
     4981 tagaaaccta ctgcagaagc cttctgggga ccaggaactt ggctgtctga aagccaaagg
     5041 atgagctctg tcccttgctg cagtatttct ttatattttg tgcttggtag ggaatgttga
     5101 gtgactgcac actggattct gggaaccttt cttcatagga aaagggactg tggggcctga
     5161 gcctaggtgc tggactttgg ctgccagatg gtacttgtac atcatctgct actgtagtgc
     5221 aaattcagag ctggctggat ctaaggttgt gggtatatgt taccagatag acctcagccc
     5281 actcactgga gggaggtgtt taatggggat tggtacatca ggtgaacctg gtggcctcta
     5341 gaatatcttc caatctgaga ttgtcctcag tgcatgtgcc cttgcagttc ttggtttttg
     5401 gtggcaatgt gagagtggca ttctctcact ctaataaact tggcacttct ttcagtgttt
     5461 tcttctcaga ttacttagta ctcactgaac caagtttaca atgcagagtc tcataagaac
     5521 tccagcctat atggcagtgt tatgaaaaaa catacatgta cagataatat cgcctactag
     5581 cttcttctaa taagacattg gagcttagcc agttgactct gctttgtagc ttcagagctt
     5641 gtagaaggaa ttagaaggca caagtgggta gtgagagtct gttcaaataa ttgagcacat
     5701 ccataggcac agataggtta atttgggtgg atttggcaaa tgttattcca accatttgtg
     5761 actttctgct gtgacttcaa ttgccatgaa gatgccagcc taggtgttca atcttctggt
     5821 aaaagtcagt ggaaagagtc ctagcatcca gttaccatgc tgccacgagt cagtcagtcc
     5881 atatccctaa acagcacccg atcaatacac tgcaaagtcc aagccaagca gacaatcatt
     5941 ctctgtctcc tttaacattg cctttgttgg ttgaagaatg tcaccaccat tgtttttcct
     6001 gtctagcatc tcacctgaca gcgcatggca tcctttgtcc catcttttaa gcaggatccc
     6061 tatagtcctt ccttggtcat tctattatag tttatgatta agaggactcc agggcagagc
     6121 tgcattgcgg ctttgcacaa gggtaagaat gaagcaaaat gtgttaataa cataatgtaa
     6181 ataaaatgtg ttcattaaca aattattaac agtttgttaa aagtgtatgt taatactaac
     6241 tcttgacaac acactgcttt tttaacccat tctaaaattc aagtaagctt gcttgccttt
     6301 tttaaaatat acaaatattt tatttgaggc agaatgagga ctaaatctac actagggata
     6361 gttttaggga agcccagttg atatgttcac aactgacttt aatattgtga catattttgt
     6421 atatgtatat taatatgtaa tttaatgaaa ttcatattag tccctgtggt aaatacattc
     6481 caaactattt gtgtaaataa cattaaagta gagagttaca tacaa
//
