LOCUS       XM_006252575            3776 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus Rho guanine nucleotide exchange factor
            3 (Arhgef3), transcript variant X2, mRNA.
ACCESSION   XM_006252575
VERSION     XM_006252575.4
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051351.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_006252575.5.
            
            On Jan 21, 2021 this sequence version replaced XM_006252575.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3776
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..3776
                     /gene="Arhgef3"
                     /note="Rho guanine nucleotide exchange factor 3; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 24 ESTs, 11 Proteins, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     94 samples with support for all annotated introns"
                     /db_xref="GeneID:290541"
                     /db_xref="RGD:1310672"
     CDS             186..1841
                     /gene="Arhgef3"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 3 isoform
                     X1"
                     /protein_id="XP_006252637.1"
                     /db_xref="GeneID:290541"
                     /db_xref="RGD:1310672"
                     /translation="MNQCIYRGMEEHKERPKRPRQNNFSMFPSPKAWNFRGRKRKQSA
                     QDEDAVSLCSLDISEPSNKRVKPLSRVTSLANLIPPVKTTPLKRFSQTLQRSISFRNE
                     SRPDILAPRAWSRNATSSSTKRRDSKLWSETFDVCVSQVLTAKEIKRQEAIFELSQGE
                     EDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDG
                     STEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKL
                     DLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGES
                     ECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTH
                     NEQLCYQLYRQPIPVKDLTLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQS
                     QTHSLQANDTFNKQQWLNCIRQAKETVLSAAGQAGLLDSESLSQSPGTENRELRGETK
                     LEQMDQSDSESDCSMDTSEVSLECERMEQTDASCANSRPEENV"
ORIGIN      
        1 cttctgcccg cgtccgctcc tgccggggac cccaacttcg gtcctccgat agctcctggg
       61 agaaagttcc tggagccact tccgggaggg aggcgccacc tgtctggggc gcgccctgac
      121 gctggacttg tccaggaaag aagagctgga cctggcaagc tgagtctgca gagcatttca
      181 cagtgatgaa tcagtgcatt tacagaggga tggaggagca caaggaaaga cccaagcggc
      241 caaggcagaa caacttctcc atgtttccct ctcccaaagc ctggaatttc agagggcgga
      301 aacggaagca gagtgcccag gatgaagatg ccgtcagcct atgcagtctt gacataagtg
      361 aacctagtaa caaaagggtc aaaccccttt ccagagtcac atcgctagca aacctcatcc
      421 cacctgtgaa gaccacaccg ttaaagcgct tcagccaaac cttgcagcgg tccatcagct
      481 tccgcaatga gagccgcccc gacatcctcg cccctagagc ctggtccaga aatgccacct
      541 cctcaagcac gaagcggagg gacagcaaac tctggagtga gaccttcgat gtgtgtgtca
      601 gtcaggtgct cacagccaag gagatcaaga gacaggaggc aatttttgag ctttctcaag
      661 gtgaagagga tttgatagag gacttgaaat tagcaaaaaa ggcctaccat gaccccatgc
      721 tgaaactctc aataatgaca gaacaagagc tgaatcagat ttttggaaca ctggactctc
      781 taatccctct ccatgaagac ctccttagtc agcttcgaga tgttcggaag cccgatggct
      841 cgacggaaca cgttggtccc atcctcgtgg gctggctgcc ttgtctcagc tcctatgaca
      901 gctactgcag caatcaagtt gctgccaaag ccctgctgga ccacaagaag caggaccaca
      961 gagtgcagga tttcctccag cgctgcttag aatcaccctt cagccgcaaa ctcgacctct
     1021 ggaatttcct tgatattccc cggagccggc tagtgaagta ccctctgctc cttcgagaaa
     1081 tcctgaggca tacgccaaac gataatccag accagcagca cctggaagaa gctataaaca
     1141 tcattcaggg aattgtggca gaaatcaaca ccaagactgg ggaatcggaa tgccgttatt
     1201 acaaagagcg gcttctttac ttggaagaag gccagaaaga ttccctgatt gacagctcaa
     1261 gggtcctgtg ttgtcatgga gagctgaaaa ataaccgggg tgtgaaactc catgttttcc
     1321 tgttccaaga agtgctggtg attactcgag ctgtcacgca caatgagcaa ctctgctatc
     1381 agttgtaccg gcagcccatc cctgtgaagg acctcactct ggaagacctg caggatggag
     1441 aagtgcggct gggtggctcc ctgcgtgggg ccttcagcaa caatgagaga attaaaaact
     1501 tcttcagagt cagtttcaag aacggatccc aaagtcagac ccactcactg caagccaacg
     1561 acaccttcaa caaacaacag tggctcaact gtatccgtca ggccaaagaa acggttctgt
     1621 ctgctgccgg gcaggctggc ttgcttgact ccgagagcct gtcccagagt cctggcactg
     1681 agaacaggga gctgcgggga gaaacaaaac ttgagcagat ggaccaatcg gacagtgagt
     1741 cggactgcag tatggacaca agcgaggtca gcctcgaatg cgagcggatg gaacagacag
     1801 acgcttcctg tgcaaacagt aggcccgagg agaacgtctg acagaggctg tgaccctgcc
     1861 agcagcaggc ccgtgtctta cctgtacagt gtttgtattc cacacgggaa cagtttggag
     1921 aggcactttg taatactcct gtgcctgtgt tggcctagcc cctgtgtcta ctccttgtcc
     1981 ctagcactgt aactgccacc cagtctgtgt cagcttgcag cagcccttac cctgttgctg
     2041 tatcccacaa gcatctggat gagtgcggag gaatggacca tgttacttcg agttgtccta
     2101 cattcaaaac agaaagactc tctaaactac tgttgtgcat ggcaaggcct ttgtctcatg
     2161 cttgcctagt gttcctctag ctctgacata gtcgctgaag tcctggcact gggagagctc
     2221 tgcagaatac tgagatcgca ttgaagggaa ggcagaaagt ctgattaacc cttggaggga
     2281 actccagttt tgagttaatt caactagaaa gcatgaaaag catctctggg ggtttctgag
     2341 gttggatttt tgcaaaggag gaagccttgt tttgaagcct gtggtttcat ccagtgcaag
     2401 ttgaatgtga ataatctgtg aagacctgaa acagaggtgg ctttagaaag ggccaagaca
     2461 agagcagctg ccggacaggc aagcagaggc aggaagatgc ggagttcaag aacagccttg
     2521 gctacttacc aaattctagt tcaaactgaa ttccaccgta aaaacaaaac aaagctaaaa
     2581 gcaccagcca gctctgaata ttcagctgaa gttgggggtg gatattggag gcgtttgtca
     2641 tggccaatgg cttgccatta gaagagccct ttctagccta caacatcagg attgccagga
     2701 ccagagaaga tctgccaggg tcatgtgacc ccatcagcat tatgtttcat cctcctcagc
     2761 cactcctctt ttccagtggt aatagggggc tgggggatag ggacacagag actgtgactg
     2821 catccagtga ctgttgacaa acaagagaga aggacttggg ggtgagaaat gtgtcactgt
     2881 cacccaaggc tcctgcgtga accacagaaa ttgaagttac tccggagggt ctcaagattt
     2941 cctgctctgc ttttgggcct ggttctagag ctacagacgg actggtggtt aattcccctc
     3001 gaggctggtt tcattagctc ttattaacta gaaccggcta gccaaactgg aaagttcttt
     3061 gttaaagcct tgctttacag agcaaggatg ggtaaaaaga ccttgagggc gtggtggaaa
     3121 aaaccgttca caaactagac agagcagctt ctgcaagtgt aaatacttag aggatttgta
     3181 taaaattata cccacaccag cactagtagt aatgattcta aattattgcc aaaaagtttt
     3241 ttttgtttgt tgttgttaat ttttgcatct atcaaaagtt tacagaaaag aaagcaaaat
     3301 gcaaagttgt ccctttacta tgcacatgtg tcgtgcgcac tgaaagaagc cgtgtggcaa
     3361 gagcaaccaa tagaaaaaca aggtatatga cattattatt tttcaagacc tattttgacc
     3421 agtttctacc ctgtaaagcc tatttctgta tttatagttt ttaaccatgg tgaaaatttt
     3481 tttctattat gagtttattt aaaaccattt tgtctctcaa gttgctgatg tagcgaataa
     3541 acctgctccg ggcagacaca gtaggaagct gagacggacc gggcactgga cgatagagaa
     3601 aagcctgaaa tgttctctac agagccattg tgaccagcga gttaaggaag ggtctctgtc
     3661 agggtcagcc tgtgggaaga gagtgaatga atgttctggt gaaatgaata cttttgtata
     3721 atggccttaa acttttctgg aagcatttca aataaattgc attaagaata cctttc
//
