LOCUS       NM_001415065            6228 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus Rho guanine nucleotide exchange factor 28
            (Arhgef28), mRNA.
ACCESSION   NM_001415065 XM_039102532
VERSION     NM_001415065.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6228)
  AUTHORS   Lin,H., Zhai,J. and Schlaepfer,W.W.
  TITLE     RNA-binding protein is involved in aggregation of light
            neurofilament protein and is implicated in the pathogenesis of
            motor neuron degeneration
  JOURNAL   Hum Mol Genet 14 (23), 3643-3659 (2005)
   PUBMED   16236762
REFERENCE   2  (bases 1 to 6228)
  AUTHORS   Rico,B., Beggs,H.E., Schahin-Reed,D., Kimes,N., Schmidt,A. and
            Reichardt,L.F.
  TITLE     Control of axonal branching and synapse formation by focal adhesion
            kinase
  JOURNAL   Nat Neurosci 7 (10), 1059-1069 (2004)
   PUBMED   15378065
REFERENCE   3  (bases 1 to 6228)
  AUTHORS   van Horck,F.P., Ahmadian,M.R., Haeusler,L.C., Moolenaar,W.H. and
            Kranenburg,O.
  TITLE     Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide
            exchange factor that interacts with microtubules
  JOURNAL   J Biol Chem 276 (7), 4948-4956 (2001)
   PUBMED   11058585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 21, 2022 this sequence version replaced XM_039102532.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.6608.1,
                                           SRR26360194.1296269.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                JAXUCZ010000002.1  31294375-31294471   c
            98-141              JAXUCZ010000002.1  31234535-31234578   c
            142-289             JAXUCZ010000002.1  31176179-31176326   c
            290-583             JAXUCZ010000002.1  31174079-31174372   c
            584-767             JAXUCZ010000002.1  31158070-31158253   c
            768-948             JAXUCZ010000002.1  31155318-31155498   c
            949-1015            JAXUCZ010000002.1  31149802-31149868   c
            1016-1071           JAXUCZ010000002.1  31130915-31130970   c
            1072-1132           JAXUCZ010000002.1  31130353-31130413   c
            1133-1254           JAXUCZ010000002.1  31098772-31098893   c
            1255-1535           JAXUCZ010000002.1  31094592-31094872   c
            1536-1740           JAXUCZ010000002.1  31089599-31089803   c
            1741-1852           JAXUCZ010000002.1  31087105-31087216   c
            1853-1895           JAXUCZ010000002.1  31083401-31083443   c
            1896-2019           JAXUCZ010000002.1  31080573-31080696   c
            2020-2152           JAXUCZ010000002.1  31080167-31080299   c
            2153-2208           JAXUCZ010000002.1  31073846-31073901   c
            2209-2257           JAXUCZ010000002.1  31072771-31072819   c
            2258-2402           JAXUCZ010000002.1  31071144-31071288   c
            2403-2530           JAXUCZ010000002.1  31070941-31071068   c
            2531-2671           JAXUCZ010000002.1  31069111-31069251   c
            2672-2919           JAXUCZ010000002.1  31064394-31064641   c
            2920-3042           JAXUCZ010000002.1  31059668-31059790   c
            3043-3160           JAXUCZ010000002.1  31058163-31058280   c
            3161-3415           JAXUCZ010000002.1  31055098-31055352   c
            3416-3492           JAXUCZ010000002.1  31053093-31053169   c
            3493-3671           JAXUCZ010000002.1  31047779-31047957   c
            3672-3763           JAXUCZ010000002.1  31046624-31046715   c
            3764-3946           JAXUCZ010000002.1  31045327-31045509   c
            3947-4078           JAXUCZ010000002.1  31043240-31043371   c
            4079-4173           JAXUCZ010000002.1  31040025-31040119   c
            4174-4212           JAXUCZ010000002.1  31037400-31037438   c
            4213-4260           JAXUCZ010000002.1  31037250-31037297   c
            4261-4746           JAXUCZ010000002.1  31031507-31031992   c
            4747-5041           JAXUCZ010000002.1  31030134-31030428   c
            5042-6228           JAXUCZ010000002.1  30998295-30999481   c
FEATURES             Location/Qualifiers
     source          1..6228
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..6228
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /note="Rho guanine nucleotide exchange factor 28"
                     /db_xref="GeneID:361882"
                     /db_xref="RGD:1307061"
     exon            1..97
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            98..141
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..5211
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /note="p190RhoGEF; p190-RhoGEF; 190 kDa guanine nucleotide
                     exchange factor; Rho-guanine nucleotide exchange factor;
                     Rho guanine nucleotide exchange factor (GEF) 28"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 28"
                     /protein_id="NP_001401994.1"
                     /db_xref="GeneID:361882"
                     /db_xref="RGD:1307061"
                     /translation="MELSCSEVPLYGQRTVYAKFGKNVYLPEDAEFYFIYDGSHQRHV
                     VIADRVEDNVLQSIIPGHWLQETVMVSVCLCSEGYSPVTMGSGSVTYVDNMACRLARL
                     LVTQADRLTPCSHQTLLTPFALTAEALPALDEELVLALTQLELPLGWTVLGNSSLEVC
                     LHRESLLHLAVRWALPKLFHFLLCLPGGVKALELPNEEATTPLDLALHGGHSMLVEDI
                     SNFQGRRSPGFSRLRLNEDATLQFDRSSETLTLTVNHTAEHLLEADIKLFRKYFWDRA
                     FLVKALDQEAKTERATMPSGAAETEEEVRNLESGRSPSEEEEDGQLVKSQADGPSEQE
                     DQDRLVLDHSFDGLKKSKHAPASLAAGQLSDVPNGGDEVYANCMVIDQVGDLDINYIN
                     IEGLSTHTSPESMRSTLGPQACKHILPPDTSPCGHLLCEDSDRTLDAAASQSCMSPPS
                     SHTSNLNLSFGLHGFVKEQSHLKKRSSSLDALVADSEEEGRSEPPICYAVGSQSSPRT
                     GLPGGDELDSFDANTEPDCNISRTESLSLSSTLHSKESLLSGIRSRSYSCSSPKISSG
                     KSRLVRDFTVCSSSEEQRSYSFQEPPGEKRIQEEEWDDYIIPAKAESEKHKVSRTFSF
                     LMNRMTSPRNKSKMKNKDTKDKEKLNRHQFVPGTFSGVLQCSGCDKTLLGKESLQCAN
                     CKANTHKGCKDTVPPCTKKFQDKYNKNKPQTILGSSSVRDVPPPGLSLHPSPSMPIGL
                     PAGRKETAGQAHPLSRSVPGTTLESFRRAVTSLESEGDSNSWRSRSHSDELFQSMGSS
                     PSTESFMMEDVVDSSLWSELSSDAQEFEAESWSLVVDPSFCSRQEKDVIKRQDVIFEL
                     MQTEVHHIQTLLIMSEVFRKGMKEELQLDHSTVDRIFPCLDELLETHKHFFFSMKERR
                     QESCTGNDRNFVINQIGDILVQQFSEENASKMKRIYGDFCSHHKEAMSLFKELQQNKK
                     FQNFIKIRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHRDLCRAL
                     GLIKDMIAAVDLKVSEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSQERALLH
                     DGLVYWKTATGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQKLIAREVA
                     NEERGMFLISASSAGPEMYEIHTSSKEERNNWMRRIQQAVESCPEEEGGRTSESDEER
                     RKADARVAKIQQCQEILSNQDQQICTYLEEKLHIYAELGELSGFEDVHLEPHLLIKPD
                     PGEPPQAASLLAAALREAESLQVAVKASKLADVSQPSEEGPGGAVLADTLSAQDAPAS
                     PTAFTEGTEGRGCWDVDPRLQGVVTDLAVSDAGEKVEYRSFSGSSQSEIIQAIQNLTR
                     LLYSLQAALTIQDSHIEIHKLVLQQQESLAPSHSFRGGPLQDQEKSRYLEKHREELAN
                     IHKLQYQFQQEQRRWHRTCDQQQREQEAQESWLQARERECQSQEELLLRHRSELDHQL
                     QEYQQNLERLREGQRMVERERQRMRDQQGLLGHCKHSRQRSLPAVFSPGSKEVTELNR
                     AESLCHEKSFFLNDAFTHMSLNTSNKPNPSGAPWDAHPPGGSHLDLARTSDSQIEVKM
                     DVSQPSDVNSELWTTGLGPQRPARQESIKDSCKNVADLNSFQTESPDPQDSNQRGPQP
                     QTLITEAKLTPPMAAGHGGDAGDGAEENIVYL"
     exon            142..289
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            290..583
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            584..767
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            768..948
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1015
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1071
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1132
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1254
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1535
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1740
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1852
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1895
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2019
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2152
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2208
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2257
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2402
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2530
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2671
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2919
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3042
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3160
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            3161..3415
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            3416..3492
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..3671
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            3672..3763
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            3764..3946
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            3947..4078
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            4079..4173
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            4174..4212
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            4213..4260
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            4261..4746
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            4747..5041
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
     exon            5042..6228
                     /gene="Arhgef28"
                     /gene_synonym="Rgnef"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccgcttcg ggcgacgctg gccggcgggt cgccctcggc aggcctcggg gacagcgcct
       61 ggccagggct ccgggcgctt ccgagccaca gctccagatg caggaaccat ggagctgagc
      121 tgcagtgaag tgcctcttta cggacagagg acggtctatg caaagttcgg caaaaacgtt
      181 tatcttcctg aagatgcgga gttttacttt atttatgatg ggtcgcatca gaggcacgtg
      241 gtgattgcgg atcgtgttga ggataatgtt ctccagtcta tcattccagg ccattggctt
      301 caagagacgg tgatggtatc tgtgtgcctc tgctcagaag ggtattcccc ggtgaccatg
      361 ggctctggct cagtgaccta tgtggacaac atggcctgca ggctggctcg tctgctggtc
      421 actcaggctg accgactcac gccctgtagt caccagacac tgctgacccc gtttgccctg
      481 acagcagaag cgctgcctgc cttggatgag gaactcgtgc tggctctgac ccaactggag
      541 ctgcctttgg gttggacagt cctgggaaat tcctcacttg aagtgtgtct acacagagag
      601 tctctcctgc acctggcagt gaggtgggcc ctgcctaagc tattccattt cctcttgtgc
      661 ctccctggag gagtcaaggc cttggagcta cctaatgaag aggccaccac accattagac
      721 ttagccttgc atggcggaca ctctatgctg gtggaagaca tctcaaattt tcagggtcgc
      781 cgctccccag gcttctcccg actgcgtctt aatgaagatg ccacgctgca gttcgatcgg
      841 tcatcagaaa cgttgacgct gaccgttaac cacacagctg agcatctgtt ggaagcagat
      901 atcaaactct tccggaagta tttctgggac agagcctttc ttgtcaaggc tcttgatcaa
      961 gaagccaaga cagagagagc aaccatgcct tctggagctg cggaaactga agaagaggtt
     1021 aggaatctgg agtctggcag atcaccctca gaagaggagg aggatggaca gctcgtcaaa
     1081 agccaggccg acgggccgag tgaacaggaa gaccaggacc gcctagtttt ggatcactcc
     1141 tttgatggcc tcaaaaagtc caagcacgcc ccagcgtccc ttgctgcagg ccagctctct
     1201 gacgtgccga atgggggtga cgaagtctac gctaactgta tggtgattga tcaggttggc
     1261 gatttggaca tcaactatat aaacatagag ggactctcca cccatactag cccggagtcc
     1321 atgaggtcca ctctggggcc tcaggcttgt aagcacatcc ttcctcctga caccagtccc
     1381 tgcgggcacc tgctctgtga ggacagtgac aggaccctgg atgctgcagc ctctcagtcc
     1441 tgcatgtcac cacccagttc tcacacttcc aacttgaacc tttcttttgg tctccatgga
     1501 tttgtaaagg agcagagtca tctcaagaaa agaagttcta gcctggatgc cctcgttgcc
     1561 gacagtgaag aggaagggcg ttctgagccc cccatctgct atgctgtcgg ctctcagagt
     1621 tcccccagaa ctgggctccc cggcggagat gaactggatt cttttgatgc gaacaccgaa
     1681 ccagactgta acatctctag gaccgaatca ctttccctgt ccagcactct gcattcgaag
     1741 gagtccctgc tttctgggat ccgatcacgc tcctactcct gctcatcacc caaaatctct
     1801 tcaggaaaat cccggctagt gcgcgatttc acagtgtgca gttccagtga agaacagaga
     1861 tcatatagtt tccaggagcc accgggagaa aaaagaattc aggaagaaga atgggacgac
     1921 tacatcattc ctgccaaagc agagtccgaa aagcacaaag tgagccggac tttcagcttc
     1981 ctcatgaaca ggatgaccag tcctcggaac aaatctaaga tgaaaaacaa ggacactaaa
     2041 gataaagaaa aactcaatcg acatcagttt gtcccgggaa cgttctctgg agttctgcag
     2101 tgttccggtt gtgacaaaac actcctgggg aaagagtcac tccagtgtgc caactgcaag
     2161 gccaacacac acaagggctg caaagacact gtgcctccgt gtaccaagaa attccaagac
     2221 aaatacaaca agaacaaacc acagaccatc ctcggaagct cttcagttag agacgtccca
     2281 ccgcctgggc tctccttgca cccttccccc tccatgccta ttggactgcc agctggaagg
     2341 aaggaaactg cagggcaggc acatccgttg tccagaagtg tcccaggcac cactttggaa
     2401 agcttcagga gggcagtgac atccttggag tctgagggtg acagtaacag ctggagaagc
     2461 aggtctcatt ccgatgagct gttccagtcc atgggctcgt ctccttccac ggagtcattc
     2521 atgatggaag atgtcgtgga ttcttctctg tggagtgagc tcagcagtga tgctcaagag
     2581 tttgaagctg agtcctggag tctcgtggtg gacccttcct tctgcagcag acaggagaag
     2641 gatgtcatca aaagacagga tgtcattttt gagctgatgc agacggaggt gcaccacatc
     2701 cagacactgc tcatcatgtc tgaagtcttc aggaagggca tgaaggagga gctgcagctg
     2761 gaccacagca cggtggacag gatcttcccc tgcttagatg agctgctgga gactcacaag
     2821 catttcttct tcagcatgaa ggagcgcagg caggagtcct gcaccggcaa tgacaggaac
     2881 tttgtgatca accaaatcgg agacattttg gtacaacagt tttcagaaga aaatgcaagc
     2941 aagatgaaga ggatctatgg agatttctgc agccatcaca aagaagccat gagcctcttt
     3001 aaagagctcc agcagaacaa aaagtttcag aattttatta agatccgaaa tagcaacctg
     3061 ttggcccgtc gccgtggaat cccagagtgc atcctgcttg tcacccagcg catcacgaag
     3121 tacccggtct tggtggagag gatcctgcag tacaccaagg aaaggaccga agagcacaga
     3181 gacctgtgta gagctcttgg cttaattaaa gacatgatcg cagccgtgga cctgaaagtc
     3241 agtgaatatg agaagaacca aaaatggctc gagatcctaa ataaaatcga gaacaaaaca
     3301 tacacaaagc tcaaaaatgg ccacgtgttt agaaagcagg cgctgatgag ccaagaaagg
     3361 gctcttctgc acgacgggct cgtttactgg aaaactgcga caggccgttt caaagacatc
     3421 ctggccctgc ttctcaccga tgtgctgctc ttcttgcaag aaaaagacca gaagtatatc
     3481 tttgcagctg ttgaccagaa gccttcagtt atttcccttc agaagctcat cgctagggaa
     3541 gtcgccaacg aggagagagg catgtttctc atcagtgctt cgtcagcggg tcccgagatg
     3601 tatgaaatcc acaccagttc caaagaggaa cggaataact ggatgaggcg gatccagcag
     3661 gcagtagaaa gttgtccaga agaagaagga ggaaggacaa gtgagtctga tgaagagagg
     3721 cggaaagctg acgctagagt ggccaaaatt cagcaatgtc aagagattct cagcaaccaa
     3781 gaccagcaga tctgcacata tttggaagaa aagctgcaca tctacgctga gcttggggaa
     3841 ctaagtggct ttgaggatgt ccacctagaa ccccatctgc tcatcaagcc cgaccccgga
     3901 gaacctcccc aggcagcctc cctgcttgca gcagccctga gagaagctga gagtctgcaa
     3961 gttgctgtga aggcttcaaa gctggctgat gtaagccagc catctgaaga aggccctgga
     4021 ggggctgtcc tggctgacac actcagtgca caagatgcac cagcatcgcc gactgccttc
     4081 acagaaggga cagaaggaag aggctgttgg gatgtggatc cccggctcca gggtgtggta
     4141 acggacttgg cggtctctga tgcaggggag aaggtggaat atagaagttt ttccggttct
     4201 tcacaatcag agattataca agcgatacag aacttaacgc gtctcctcta cagccttcag
     4261 gctgccttga ccatccagga cagccacatt gagatccaca agctagttct acagcagcag
     4321 gagagcttgg cccctagcca ctccttccga ggtggcccct tgcaagacca ggagaaatcc
     4381 cgttacctgg aaaagcatcg tgaagagctg gccaacatcc acaagctcca gtaccagttc
     4441 caacaagagc agcggcgttg gcaccgcaca tgtgaccagc aacagcgtga gcaggaggcc
     4501 caagagagct ggctgcaggc acgggaacgt gagtgccagt cgcaggagga attactgctg
     4561 cgccaccgta gcgaactgga ccaccaactc caggagtacc agcagaacct cgagcggttg
     4621 cgggagggcc agaggatggt ggagagggag aggcagagga tgcgtgacca gcagggtctg
     4681 ctgggccact gtaagcatag tcgccagagg agcctcccag ccgtcttctc tccggggagc
     4741 aaagaggtaa cggaacttaa tcgagctgag agtttgtgtc atgaaaaatc atttttcctc
     4801 aatgacgcct tcacacacat gtcgcttaac acatccaata aaccaaaccc atcaggtgcc
     4861 ccctgggacg ctcacccccc aggtgggtct catcttgatt tggcaaggac tagtgatagt
     4921 cagatagaag tgaagatgga cgtttctcag ccttccgatg tcaactctga actctggaca
     4981 acagggctgg gccctcagag acctgctcgc caagaaagca tcaaggattc ttgtaaaaat
     5041 gttgcagatt tgaactcctt ccagactgaa tccccagatc cccaggactc aaatcaacgt
     5101 ggccctcagc cacagacact cataacagaa gcaaaactaa ctcccccgat ggcggccgga
     5161 catggtggag atgctgggga tggagctgaa gagaacattg tttacctctg attgtgtggc
     5221 catttgtttt tccaagcaaa caaaaccact gtcactttgg ggagaacctt tctttggccc
     5281 cagtcctcgt gtgtgtgtga ttctctgtgc ccgaattgct ttaagaagaa tatttaatat
     5341 ttcatgtatg ttcaattttt gacatgagtc taataattaa attattaaaa aaaaaaccag
     5401 ctctctgcgt gtcatcttta actgatctca cccactttca agtttctaga ggagaaactt
     5461 cacttgaata agccgaaagc tatgaaaaag ttgttttcac tttgaaattc catattacac
     5521 gttgtaccca ttcatctgga gtgtgaaata cattttaaga taaagatgaa gccattttgg
     5581 tttggagaat gatctccccc agggctgaac tatcatagcg gtttgttatt gagggtagct
     5641 ttgatacccc aaagaaggca gaggaaggga tgggaaagat cttttctcac ttggttctta
     5701 caagtgaatg tcaggaggcc ttcagagttg gggtgctgtc accttcaatg cacagttctt
     5761 gtgtcctcaa aaacctgttc atactaggtt ggtgctgtgc cagaacacag tctggacacg
     5821 ctcgggaccc gagccaccct gccctgtggc tcactttctt gaacgaatgc tgctgggttc
     5881 tgagtctatt cagcaccatc ttttagccca gcccagagcc tctgtgacaa cttggctgta
     5941 aatagtgaaa cttccaagag agaaccctca cttgggcctt ctcaagctgg attgaatgtc
     6001 aaggacttcc atgactacaa ggaactcagc ctgcaggcct taaggacaaa ggggccagct
     6061 cttggtgaag cttgctgcct gcctgggctc ttctacagag ggacaacggg cgttcttgat
     6121 ttcacagtac tgtggctctc tctgagaaaa taaagcagga atgttctcat cttatttgga
     6181 aatatttgtc tgtgttccgg tcagtgtcaa taaatatctt ttgcttca
//
