LOCUS       NM_001400956            2251 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus Rho guanine nucleotide exchange factor 25
            (Arhgef25), mRNA.
ACCESSION   NM_001400956 XM_006241454
VERSION     NM_001400956.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2251)
  AUTHORS   Ongherth,A., Pasch,S., Wuertz,C.M., Nowak,K., Kittana,N.,
            Weis,C.A., Jatho,A., Vettel,C., Tiburcy,M., Toischer,K.,
            Hasenfuss,G., Zimmermann,W.H., Wieland,T. and Lutz,S.
  TITLE     p63RhoGEF regulates auto- and paracrine signaling in cardiac
            fibroblasts
  JOURNAL   J Mol Cell Cardiol 88, 39-54 (2015)
   PUBMED   26392029
  REMARK    GeneRIF: In cultured neonatal cardiac fibroblasts, p63RhoGEF
            regulated the angiotensin II (Ang II)-dependent RhoA activation,
            the activation of the serum response factor, and the expression and
            secretion of CTGF.
REFERENCE   2  (bases 1 to 2251)
  AUTHORS   Yao,H., Jia,Y., Zhou,J., Wang,J., Li,Y., Wang,Y., Yue,W. and Pei,X.
  TITLE     RhoA promotes differentiation of WB-F344 cells into the biliary
            lineage
  JOURNAL   Differentiation 77 (2), 154-161 (2009)
   PUBMED   19281775
  REMARK    GeneRIF: cells with ectopically active RhoA expression were found
            to form bile-duct-like structures even without Matrigel treatment
REFERENCE   3  (bases 1 to 2251)
  AUTHORS   Qu,M.J., Liu,B., Qi,Y.X. and Jiang,Z.L.
  TITLE     Role of Rac and Rho-GDI alpha in the frequency-dependent expression
            of h1-calponin in vascular smooth muscle cells under cyclic
            mechanical strain
  JOURNAL   Ann Biomed Eng 36 (9), 1481-1488 (2008)
   PUBMED   18566890
  REMARK    GeneRIF: the frequency-dependent expression of h1-calponin under
            cyclic strain is mediated at least partly by the regulation of Rac
            and Rho-GDI alpha expression on the activation of p38 pathway
REFERENCE   4  (bases 1 to 2251)
  AUTHORS   Smith,T.K., Hager,H.A., Francis,R., Kilkenny,D.M., Lo,C.W. and
            Bader,D.M.
  TITLE     Bves directly interacts with GEFT, and controls cell shape and
            movement through regulation of Rac1/Cdc42 activity
  JOURNAL   Proc Natl Acad Sci U S A 105 (24), 8298-8303 (2008)
   PUBMED   18541910
REFERENCE   5  (bases 1 to 2251)
  AUTHORS   Guo,X., Stafford,L.J., Bryan,B., Xia,C., Ma,W., Wu,X., Liu,D.,
            Songyang,Z. and Liu,M.
  TITLE     A Rac/Cdc42-specific exchange factor, GEFT, induces cell
            proliferation, transformation, and migration
  JOURNAL   J Biol Chem 278 (15), 13207-13215 (2003)
   PUBMED   12547822
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jan 31, 2022 this sequence version replaced XM_006241454.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.25400.1,
                                           SRR26643294.28669.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               JAXUCZ010000007.1  64898174-64898333   c
            161-275             JAXUCZ010000007.1  64897805-64897919   c
            276-490             JAXUCZ010000007.1  64895442-64895656   c
            491-586             JAXUCZ010000007.1  64895215-64895310   c
            587-663             JAXUCZ010000007.1  64894645-64894721   c
            664-730             JAXUCZ010000007.1  64894418-64894484   c
            731-834             JAXUCZ010000007.1  64894135-64894238   c
            835-904             JAXUCZ010000007.1  64893857-64893926   c
            905-994             JAXUCZ010000007.1  64893657-64893746   c
            995-1087            JAXUCZ010000007.1  64893480-64893572   c
            1088-1138           JAXUCZ010000007.1  64893300-64893350   c
            1139-1216           JAXUCZ010000007.1  64893024-64893101   c
            1217-1417           JAXUCZ010000007.1  64892645-64892845   c
            1418-1598           JAXUCZ010000007.1  64892336-64892516   c
            1599-1795           JAXUCZ010000007.1  64891886-64892082   c
            1796-2251           JAXUCZ010000007.1  64891260-64891715   c
FEATURES             Location/Qualifiers
     source          1..2251
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2251
                     /gene="Arhgef25"
                     /gene_synonym="Geft"
                     /note="Rho guanine nucleotide exchange factor 25"
                     /db_xref="GeneID:314904"
                     /db_xref="RGD:735210"
     exon            1..160
                     /gene="Arhgef25"
                     /gene_synonym="Geft"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1903
                     /gene="Arhgef25"
                     /gene_synonym="Geft"
                     /note="guanine nucleotide exchange factor GEFT;
                     RhoA/RAC/CDC42 exchange factor; rac/Cdc42/Rho exchange
                     factor GEFT; rhoA/Rac/Cdc42 guanine nucleotide exchange
                     factor GEFT; Rho guanine nucleotide exchange factor (GEF)
                     25"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 25"
                     /protein_id="NP_001387885.1"
                     /db_xref="GeneID:314904"
                     /db_xref="RGD:735210"
                     /translation="MKPPDRPTPGRTDRILGVMGGMLRACAVPGQEGPQERDPLGPGS
                     TKTESECTEEDQTGEREREVLAWAPQPESYSIAGSEGSMSASAVSGLAALSGPSSGLS
                     SHPCSPVPPGPVTGLRRWLDHSKHCLSVETEADSGQTRQCENWMLEPTLTTGQELPEL
                     TLLTTLLEGPGVKAQPAEEETLSQAPKNEEEQKKTALERSMFVLSELVETERMYVDDL
                     GQIVEGYMATMATQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQQCLKDPDWLAQ
                     LFIKHERRLHMYVVYCQNKPKSEHVLSEFGDSYFEELRQQLGHRLQLSDLLIKPVQRI
                     MKYQLLLKDFLKYYRRAGMDTEELEQAVEVMCFVPKRCNDMMSLGRLRGFEGKLTAQG
                     KLLGQDTFLVTEPEAGGLLSSRGRERRVFLFEQIVIFSEALGGGGRGGTQPGYVYKNS
                     IKVSCLGLEGNLQGNACRFALTSRGPEGGIQRYVLQASDPAVSQAWIKQVAQILESQR
                     DFLNALQSPIEYQRRESQTNSLGRSGGPGVGSPGRMAQVSMHTPINGSLPSLLLLPRG
                     EVPRAPLPLDTQALSETPLTPYDPPALPTVNSPPGQARLAKLDEDEL"
     exon            161..275
                     /gene="Arhgef25"
                     /gene_synonym="Geft"
                     /inference="alignment:Splign:2.1.0"
     exon            276..490
                     /gene="Arhgef25"
                     /gene_synonym="Geft"
                     /inference="alignment:Splign:2.1.0"
     exon            491..586
                     /gene="Arhgef25"
                     /gene_synonym="Geft"
                     /inference="alignment:Splign:2.1.0"
     exon            587..663
                     /gene="Arhgef25"
                     /gene_synonym="Geft"
                     /inference="alignment:Splign:2.1.0"
     exon            664..730
                     /gene="Arhgef25"
                     /gene_synonym="Geft"
                     /inference="alignment:Splign:2.1.0"
     exon            731..834
                     /gene="Arhgef25"
                     /gene_synonym="Geft"
                     /inference="alignment:Splign:2.1.0"
     exon            835..904
                     /gene="Arhgef25"
                     /gene_synonym="Geft"
                     /inference="alignment:Splign:2.1.0"
     exon            905..994
                     /gene="Arhgef25"
                     /gene_synonym="Geft"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1087
                     /gene="Arhgef25"
                     /gene_synonym="Geft"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1138
                     /gene="Arhgef25"
                     /gene_synonym="Geft"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1216
                     /gene="Arhgef25"
                     /gene_synonym="Geft"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1417
                     /gene="Arhgef25"
                     /gene_synonym="Geft"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1598
                     /gene="Arhgef25"
                     /gene_synonym="Geft"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1795
                     /gene="Arhgef25"
                     /gene_synonym="Geft"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..2251
                     /gene="Arhgef25"
                     /gene_synonym="Geft"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcccccc agcttccgtg gcccctaggc cctgaaactt gaagcagggt aggggtccag
       61 catgaagccc ccggaccgcc ccacccctgg ccgcactgac cggatactgg gggtcatggg
      121 gggcatgctg cgcgcatgcg ccgtacccgg gcaggagggg ccccaggaga gagatccctt
      181 agggcctggg agtaccaaga cagagagtga atgtaccgag gaggatcaga caggggagcg
      241 cgaacgtgag gtcctcgcct gggctccgca gcccgaatcc tattctattg ctggcagtga
      301 ggggagcatg tcagcgtctg ctgtctcagg gctggctgcc ctgtctggcc ccagctctgg
      361 cctcagctct catccatgtt ctccggtccc ccctggacca gtaactggcc tgaggagatg
      421 gttggatcat tccaaacatt gcctcagtgt ggaaaccgag gcagacagtg gtcagacaag
      481 gcaatgtgag aactggatgc tggagccaac tctaaccaca ggacaggagt tgccagaact
      541 gacgttattg actacactgc tggagggtcc tggagtcaag gcccagccag ccgaagagga
      601 aactttgtct caagctccca agaatgagga agagcagaag aagacagccc tggaaaggag
      661 tatgtttgtc ctgagtgagc tggtagaaac agaaagaatg tatgtggacg acttgggaca
      721 gattgtagag ggttacatgg ctaccatggc tacacagggt gtccctgaga gtctccgagg
      781 tcgtgacagg attgtgtttg ggaacattca gcagatctat gagtggcacc gagattattt
      841 cctgcaggag ctacagcagt gtttgaaaga tcctgattgg ttggctcagc tgttcatcaa
      901 acatgagcgc cgactacata tgtatgtggt gtactgccag aataaaccca agtcagaaca
      961 tgtgctgtca gaatttgggg acagctactt tgaggagctc aggcagcagc tgggacaccg
     1021 tctgcagctc agtgacctcc tcattaaacc ggtgcagcga atcatgaaat accagttgct
     1081 gctgaaggat tttctaaagt attacagaag agctggcatg gatactgagg agctggagca
     1141 agctgtggag gtcatgtgct tcgtacccaa gcgctgcaat gatatgatgt ccctggggag
     1201 acttcgggga tttgagggaa aactgactgc tcaggggaag ctcttgggcc aggacacgtt
     1261 cttggttaca gagcctgaag ctgggggtct cctttcttcc cggggtcggg agaggcgtgt
     1321 cttcctgttt gagcaaattg tcatcttcag tgaggccctg ggaggaggag gtcgaggtgg
     1381 cacacagcct ggctatgttt acaagaacag catcaaggtg agctgcctag ggctggaggg
     1441 gaatctccaa ggcaacgctt gccgttttgc gctgacctct agggggccag aaggtgggat
     1501 ccagcgctat gttcttcagg cttcagaccc tgctgtcagt caagcctgga tcaagcaagt
     1561 ggcccagatc ctggaaagcc agcgtgactt tctcaacgca ttgcagtccc ctatcgagta
     1621 ccagagacgg gagagccaga ccaacagtct ggggcgatca ggagggccag gggtagggag
     1681 ccctggaaga atggcccagg tcagcatgca cacacccatc aatggctctc tcccctccct
     1741 gctccttctg cccagagggg aggtgcccag agcgcctttg cccctggata cacaggctct
     1801 cagtgagacc cccctgactc cttatgaccc cccagccctt cccactgtga acagtccccc
     1861 gggtcaggcc aggctcgcca agctggatga agatgagctg taaccctgaa agccttggaa
     1921 tgctgttggc tcaggcatga cctctcaacg aatttggggg gaatcctggc aacgtgcctg
     1981 aatccattct tcccggtgtt tggaggatgg gagagcctgg gagagagatc agtgtggagg
     2041 gcagttaact agacctgaaa ggactccttt ctccccaagg aacacaggat ccgtcagctc
     2101 cactccctgc atgcaccatg accccctcaa gtggaggata tgtaggggct tggagggagg
     2161 gcgagggcag ggaccagata gaaattattg gtttgggttg tgattttgtt ttcgagtttt
     2221 cctgtgaata aaacttttgc tatatcaccg a
//
