LOCUS       NM_001012079            4188 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus Rho/Rac guanine nucleotide exchange factor 2
            (Arhgef2), mRNA.
ACCESSION   NM_001012079 XM_227406
VERSION     NM_001012079.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4188)
  AUTHORS   Ravindran,E., Hu,H., Yuzwa,S.A., Hernandez-Miranda,L.R.,
            Kraemer,N., Ninnemann,O., Musante,L., Boltshauser,E., Schindler,D.,
            Hubner,A., Reinecker,H.C., Ropers,H.H., Birchmeier,C., Miller,F.D.,
            Wienker,T.F., Hubner,C. and Kaindl,A.M.
  TITLE     Homozygous ARHGEF2 mutation causes intellectual disability and
            midbrain-hindbrain malformation
  JOURNAL   PLoS Genet 13 (4), e1006746 (2017)
   PUBMED   28453519
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4188)
  AUTHORS   Torres-Cruz,F.M., Rodriguez-Cruz,F., Escobar-Herrera,J.,
            Barragan-Andrade,N., Basurto-Islas,G., Ripova,D., Avila,J. and
            Garcia-Sierra,F.
  TITLE     Expression of Tau Produces Aberrant Plasma Membrane Blebbing in
            Glial Cells Through RhoA-ROCK-Dependent F-Actin Remodeling
  JOURNAL   J Alzheimers Dis 52 (2), 463-482 (2016)
   PUBMED   27003208
  REMARK    GeneRIF: Results indicated that Tau produced strong plasma membrane
            blebbing and F-Actin cytoskeleton remodeling by indirect activation
            of the GEF-H1-RhoA-ROCK pathway. All of these actions were
            initiated by abnormal, induced microtubule bundling and cytoplasmic
            release of GEF-H1.
REFERENCE   3  (bases 1 to 4188)
  AUTHORS   Arnette,C., Frye,K. and Kaverina,I.
  TITLE     Microtubule and Actin Interplay Drive Intracellular c-Src
            Trafficking
  JOURNAL   PLoS One 11 (2), e0148996 (2016)
   PUBMED   26866809
  REMARK    GeneRIF: regulation of c-Src trafficking requires both microtubules
            and actin polymerization, and GEF-H1 coordinates c-Src trafficking,
            acting as a molecular switch between these two mechanisms
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4188)
  AUTHORS   Luo,T., Roman,P., Liu,C., Sun,X., Park,Y. and Hu,B.
  TITLE     Upregulation of the GEF-H1 pathway after transient cerebral
            ischemia
  JOURNAL   Exp Neurol 263, 306-313 (2015)
   PUBMED   25447939
  REMARK    GeneRIF: upregulation of GEF-H1 activity may contribute to
            excitotoxicity, whereas the late upregulation of GEF-H1 protein may
            promote neuroplasticity after brain ischemia.
REFERENCE   5  (bases 1 to 4188)
  AUTHORS   Mouawad,F., Aoudjit,L., Jiang,R., Szaszi,K. and Takano,T.
  TITLE     Role of guanine nucleotide exchange factor-H1 in
            complement-mediated RhoA activation in glomerular epithelial cells
  JOURNAL   J Biol Chem 289 (7), 4206-4218 (2014)
   PUBMED   24356971
  REMARK    GeneRIF: complement-induced ERK-dependent GEF-H1 activation as the
            upstream mechanism of RhoA stimulation, and this pathway has a
            protective role against cell death.
REFERENCE   6  (bases 1 to 4188)
  AUTHORS   Fukazawa,A., Alonso,C., Kurachi,K., Gupta,S., Lesser,C.F.,
            McCormick,B.A. and Reinecker,H.C.
  TITLE     GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by
            Shigella effectors
  JOURNAL   PLoS Pathog 4 (11), e1000228 (2008)
   PUBMED   19043560
REFERENCE   7  (bases 1 to 4188)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   8  (bases 1 to 4188)
  AUTHORS   Ryan,X.P., Alldritt,J., Svenningsson,P., Allen,P.B., Wu,G.Y.,
            Nairn,A.C. and Greengard,P.
  TITLE     The Rho-specific GEF Lfc interacts with neurabin and spinophilin to
            regulate dendritic spine morphology
  JOURNAL   Neuron 47 (1), 85-100 (2005)
   PUBMED   15996550
REFERENCE   9  (bases 1 to 4188)
  AUTHORS   Krendel,M., Zenke,F.T. and Bokoch,G.M.
  TITLE     Nucleotide exchange factor GEF-H1 mediates cross-talk between
            microtubules and the actin cytoskeleton
  JOURNAL   Nat Cell Biol 4 (4), 294-301 (2002)
   PUBMED   11912491
REFERENCE   10 (bases 1 to 4188)
  AUTHORS   Ren,Y., Li,R., Zheng,Y. and Busch,H.
  TITLE     Cloning and characterization of GEF-H1, a microtubule-associated
            guanine nucleotide exchange factor for Rac and Rho GTPases
  JOURNAL   J Biol Chem 273 (52), 34954-34960 (1998)
   PUBMED   9857026
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001012079.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090078.1, SRR26643295.9620.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               JAXUCZ010000002.1  176388599-176388744
            147-291             JAXUCZ010000002.1  176397232-176397376
            292-359             JAXUCZ010000002.1  176399324-176399391
            360-423             JAXUCZ010000002.1  176399655-176399718
            424-553             JAXUCZ010000002.1  176400254-176400383
            554-663             JAXUCZ010000002.1  176400601-176400710
            664-810             JAXUCZ010000002.1  176400843-176400989
            811-1061            JAXUCZ010000002.1  176401800-176402050
            1062-1187           JAXUCZ010000002.1  176402342-176402467
            1188-1305           JAXUCZ010000002.1  176402949-176403066
            1306-1554           JAXUCZ010000002.1  176403212-176403460
            1555-1631           JAXUCZ010000002.1  176405890-176405966
            1632-1801           JAXUCZ010000002.1  176406926-176407095
            1802-1869           JAXUCZ010000002.1  176408310-176408377
            1870-2070           JAXUCZ010000002.1  176410332-176410532
            2071-2184           JAXUCZ010000002.1  176410806-176410919
            2185-2252           JAXUCZ010000002.1  176411020-176411087
            2253-2288           JAXUCZ010000002.1  176411219-176411254
            2289-2339           JAXUCZ010000002.1  176411448-176411498
            2340-2783           JAXUCZ010000002.1  176411684-176412127
            2784-2967           JAXUCZ010000002.1  176414064-176414247
            2968-4188           JAXUCZ010000002.1  176414954-176416174
FEATURES             Location/Qualifiers
     source          1..4188
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..4188
                     /gene="Arhgef2"
                     /note="Rho/Rac guanine nucleotide exchange factor 2"
                     /db_xref="GeneID:310635"
                     /db_xref="RGD:1304659"
     exon            1..146
                     /gene="Arhgef2"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..3041
                     /gene="Arhgef2"
                     /note="GEF-H1; guanine nucleotide exchange factor H1;
                     rho/rac guanine nucleotide exchange factor (GEF) 2"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 2"
                     /protein_id="NP_001012079.1"
                     /db_xref="GeneID:310635"
                     /db_xref="RGD:1304659"
                     /translation="MSRIESLTRARIDRSKEQATKTREKEKMKEAKDARYTNGHLFTT
                     ISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLRNN
                     TALQSVSLRSKTTTRERPTSAIYPSDSFRQSLLGSRRGLSSLSLAKSVSTTNIAGHFN
                     DESPLGLRQILSQSTDSLNMRNRTLSVESLIDEGVEVFYNELMSDFEMDEKDFEADSW
                     SLAVDSSFLQQHKKEVMKKQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELQMEPEV
                     VQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGSNAEQ
                     MRKTYSEFCSRHTKALKLYKELYARDKRFQQFIRKMTRSAVLKRHGVQECILLVTQRI
                     TKYPVLINRILQNSHGIEEEYQDLAAALGLVKELLSNVDQDVHELEKEARLQEIYNRM
                     DPRAQTPVPGKGPFGRDELLRRKLIHDGCLLWKTATGRFKDVLLLLMTDVLVFLQEKD
                     QKYIFTSLDKPSVVSLQNLIVRDIANQAKGMFLISSGPPEMYEVHAASRDDRTTWIRV
                     IQQSVRLCPSREDFPLIETEDKAYLRRIKTKLQQKNQALVELLQMNVELFAEMVHFQA
                     LKAGFIGMPPPTLPRGLFRLESFESLRGERLLKDALREVEGLKDLLLGPCVDLPLTAR
                     EPALPVEADSGSCPGVTANGEARTFNGSIELCRADSDSSQKDRNGNQLRSPQEEALQP
                     LVNLYGLLQGLQAVVVQQERLMEALFPEGPERWEKLSRANSRDGEAGRAAVASVTPEK
                     QATELALLQRQHSLLQEELRRCQRLGEERATEAGSLEARLRESEQARALLEREAEEIR
                     RQLAALGQNEPLPAEAPWARRPLDPRRRSLPAGDALYLSFNPPQPSRGHDRLDLPVTV
                     RSLHRPFDDREAQELGSPEDRLQDSSDPDTCSEEEVSSRLSPPHSPRDFTRMQDIPEE
                     TESRDGEPTASES"
     exon            147..291
                     /gene="Arhgef2"
                     /inference="alignment:Splign:2.1.0"
     exon            292..359
                     /gene="Arhgef2"
                     /inference="alignment:Splign:2.1.0"
     exon            360..423
                     /gene="Arhgef2"
                     /inference="alignment:Splign:2.1.0"
     exon            424..553
                     /gene="Arhgef2"
                     /inference="alignment:Splign:2.1.0"
     exon            554..663
                     /gene="Arhgef2"
                     /inference="alignment:Splign:2.1.0"
     exon            664..810
                     /gene="Arhgef2"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1061
                     /gene="Arhgef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1187
                     /gene="Arhgef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1305
                     /gene="Arhgef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1554
                     /gene="Arhgef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1631
                     /gene="Arhgef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1801
                     /gene="Arhgef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1869
                     /gene="Arhgef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2070
                     /gene="Arhgef2"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2184
                     /gene="Arhgef2"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2252
                     /gene="Arhgef2"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2288
                     /gene="Arhgef2"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2339
                     /gene="Arhgef2"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2783
                     /gene="Arhgef2"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..2967
                     /gene="Arhgef2"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..4188
                     /gene="Arhgef2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccgacgcg tgcggccgga cccctccccc gccggagctg gacacccggg gccgccgcgt
       61 cctcccgcgg ctcacgctgg attatgtctc ggatcgaatc cctcactcgc gcgcggatcg
      121 accggagcaa ggagcaggcg accaagaccc gggaaaagga gaagatgaag gaagctaaag
      181 atgcccgcta taccaacggc cacctcttca ccaccatctc ggtctccggc atgactatgt
      241 gctatgcctg taacaagagc attacagcca aggaagccct catttgtccc acatgtaacg
      301 tgaccatcca caaccgctgt aaggacacgc tggccaactg taccaaggtc aagcagaagc
      361 aacagaaagc tgcactgctg aggaacaaca ctgccttgca gtccgtctct ctccgaagta
      421 agacaaccac cagagagcgg ccaacgtctg ccatctaccc ttccgatagc ttccggcagt
      481 ccctcctggg ttctcgtcgt ggcctgtcct ccttgtcttt ggccaaaagt gtttccacta
      541 ccaacattgc tggacatttc aatgatgagt ctcctctggg gctgcgtcag atcctctccc
      601 agtccacaga ctccctcaac atgcggaacc gaaccctgtc cgtggagtcc cttattgatg
      661 aaggtgtaga agtgttctac aacgagctca tgagtgactt tgagatggac gagaaggact
      721 tcgaggcgga ttcatggagc cttgctgtgg acagcagctt cctgcaacag cataaaaagg
      781 aggtgatgaa gaagcaagat gtcatctacg agctgatcca gaccgagctg caccatgtga
      841 gaaccttgaa gattatgacc cgcctcttcc gcactgggat gctggaagag ttgcagatgg
      901 agccagaagt ggtccaggga ctgttcccct gtgtggacga gcttagtgac attcacacac
      961 gtttccttag tcagcttttg gaacggcggc gccaggccct gtgtccaggc agcacccgga
     1021 actttgtcat ccatcgtttg ggtgacttgc tcatcagcca gttctcaggt tccaacgctg
     1081 agcagatgcg caagacttac tcagagttct gcagccgcca caccaaggcc ttaaagctct
     1141 ataaggagct gtacgctcga gacaaacgct tccaacagtt catccggaaa atgacccgct
     1201 ctgctgtgct gaagcggcat ggggttcagg agtgcattct cctggtaact cagcggatta
     1261 ccaaataccc agtgctcatc aacaggatcc tgcagaattc ccatgggatt gaagaggagt
     1321 accaagactt ggcagcagcc ctagggctag taaaggagtt gttgtccaat gtggaccagg
     1381 atgtacacga gctggagaaa gaggcccgcc ttcaggagat ttacaaccga atggatcctc
     1441 gggctcagac ccctgttcct ggcaagggcc ccttcggccg agatgaactt ttgcggagaa
     1501 aacttatcca tgatggctgc ctgctctgga agacagccac aggccgcttt aaagatgtcc
     1561 tcttactact gatgacagat gtgctggtgt ttctccagga aaaggaccag aagtacattt
     1621 tcacgtccct ggacaagccc tcagtggtat ccttgcagaa tctcatcgta agagacattg
     1681 ccaaccaggc gaaagggatg tttctgatca gttctggccc acctgaaatg tatgaagtac
     1741 acgcagcatc tcgagatgac cgtactacct ggatccgtgt catccagcag agcgtgcgct
     1801 tatgcccgtc gagggaggac ttccctctga tcgagacaga ggataaggcg tacctccgga
     1861 ggatcaagac gaaactgcag cagaaaaacc aggcgctggt ggagctgcta cagatgaatg
     1921 ttgagctatt tgctgagatg gtccacttcc aggcattaaa agctggtttc atcggaatgc
     1981 ccccgcccac cctgcccagg ggccttttcc gtcttgagtc ctttgagtcc cttcgaggcg
     2041 agcgtctgct caaagatgcc ctccgtgaag tggaaggcct gaaagacctg ttgttgggcc
     2101 cttgtgtgga cctgcctttg acagcccgag aaccagcctt acccgtagaa gctgacagtg
     2161 gtagctgtcc tggggtcact gccaacggag aggccagaac cttcaatggc tccattgagc
     2221 tctgtagagc agactcagat tccagccaga aggatcggaa tggaaatcag ttgaggtcac
     2281 cacaggagga ggcgttacaa ccattggtca atctgtatgg actcctacaa ggcctgcagg
     2341 ctgttgtggt ccagcaagaa agattgatgg aagccctgtt ccctgaaggc cctgagcggt
     2401 gggaaaagct atcccgagcc aactctcggg atggcgaagc tggccgggct gcggttgctt
     2461 ctgtaactcc cgagaagcag gccacggagc tggcattact gcagaggcag cacagcctgt
     2521 tgcaggaaga gctgcggcgc tgccagcggc tcggggaaga gcgggcaact gaagctggca
     2581 gcctggaggc caggctgcgg gagagcgagc aagcccgggc cctgctggag cgggaggctg
     2641 aagagatccg ccggcagcta gcagccttgg gccaaaacga gccactcccg gcagaagcac
     2701 cctgggctcg caggcctctg gaccctcggc gccgcagcct tccagcaggc gacgctctgt
     2761 acttgagctt caatcccccc cagcctagtc gaggccatga ccgcctggat ttgcctgtga
     2821 ctgttcgttc cctccaccga ccctttgatg accgagaggc acaagaactt ggtagccccg
     2881 aggatcgact gcaggacagc agtgaccctg atacttgcag tgaggaggaa gtcagtagcc
     2941 ggctgtcccc accccacagt ccacgagact tcacccgaat gcaggacatt cccgaagaga
     3001 cagaaagccg agatggggag cctacggcct cagagagcta aggggacgct tccccctgcc
     3061 tggtgccccc cactgaagaa cattagtaaa ggggcaaacc ttgaaaggac tgccgattgt
     3121 ccttgccagt tcccaagacc cctggatacc taggggccat ggggatgggg acttagaggc
     3181 caccgcaccc ctggtgttct ccaacagtca caccacagat gccgatttta catgccttct
     3241 ccccctcctt aggaaaaatt atttatttat tgtttattgg ttgggggggt gatttaaagg
     3301 gccagagaca tgggaaccaa gccataggta tcagagggcc tctcctttaa taccactggg
     3361 atatgtttgg ccttagccac acaacctaac atcaacccca gtgacaccca tctgtggcca
     3421 tagaacctac tgcccctttc agaagggctg tgggtaggac catgtccctt ttcccactcc
     3481 ccttagcctc tttctgctgt tctttctctc catcctccat ggatttctgg ctccttggag
     3541 ttgatggagc aggtagccat aatgtattgg ggtggggaag gaagaataca gggaccagaa
     3601 tgttttgttt ttggttttgt tttcttattt tttttttttt tgtaccaaag ccaaccgcac
     3661 ctgttttata tttttaaaag aagattgtag gcacttctag ctccatgtct ttgaacttga
     3721 ggaattaggg agacagtgac ctatttcatc gaaggtcagg gggctcccat tcagaactct
     3781 tcctcagcca tttagagcca ttcctcttcc tcagaggaag ctctgaggtg ggttgggaaa
     3841 cctctaggaa ccctcacctc gtctcccacg gtggcaagca agaattgggg gagggggatt
     3901 tttttttcac tgcaacccta atgtccacca gcgatagcca tttttctgcc aattgaattg
     3961 ttaaacagaa aaaacacagt aacaacgaag caaagaaaga aaaagctctg gcagggaaaa
     4021 aattaaagac ctgacacgca tgaggtgctg tctcagtgcc cgttctgagg actgccgtgc
     4081 ctgcagcaag gcagtgacca cggtttctga aaaggggctg tcactacctc acagaagagg
     4141 gcatgaatgg atgcagctgc tcaaactctt attaaacatc tcaaaatt
//
