LOCUS       NM_001395655            6309 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus Rho/Rac guanine nucleotide exchange factor 18
            (Arhgef18), mRNA.
ACCESSION   NM_001395655
VERSION     NM_001395655.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6309)
  AUTHORS   Tornavaca O, Chia M, Dufton N, Almagro LO, Conway DE, Randi AM,
            Schwartz MA, Matter K and Balda MS.
  TITLE     ZO-1 controls endothelial adherens junctions, cell-cell tension,
            angiogenesis, and barrier formation
  JOURNAL   J Cell Biol 208 (6), 821-838 (2015)
   PUBMED   25753039
REFERENCE   2  (bases 1 to 6309)
  AUTHORS   Nakajima H and Tanoue T.
  TITLE     Lulu2 regulates the circumferential actomyosin tensile system in
            epithelial cells through p114RhoGEF
  JOURNAL   J Cell Biol 195 (2), 245-261 (2011)
   PUBMED   22006950
REFERENCE   3  (bases 1 to 6309)
  AUTHORS   Kang D, Oh S, Ahn SM, Lee BH and Moon MH.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   4  (bases 1 to 6309)
  AUTHORS   Niu J, Profirovic J, Pan H, Vaiskunaite R and Voyno-Yasenetskaya T.
  TITLE     G Protein betagamma subunits stimulate p114RhoGEF, a guanine
            nucleotide exchange factor for RhoA and Rac1: regulation of cell
            shape and reactive oxygen species production
  JOURNAL   Circ Res 93 (9), 848-856 (2003)
   PUBMED   14512443
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000223.1.
            
            [WARNING] On Apr 4, 2024 this sequence was replaced by
            NM_001395655.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760400,
                              SAMN06680412 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               JACYVU010000223.1  1395092-1395394
            304-428             JACYVU010000223.1  1409534-1409658
            429-681             JACYVU010000223.1  1426964-1427216
            682-827             JACYVU010000223.1  1428531-1428676
            828-942             JACYVU010000223.1  1432158-1432272
            943-1000            JACYVU010000223.1  1433761-1433818
            1001-1045           JACYVU010000223.1  1434361-1434405
            1046-1123           JACYVU010000223.1  1435031-1435108
            1124-1226           JACYVU010000223.1  1435390-1435492
            1227-1368           JACYVU010000223.1  1435661-1435802
            1369-1510           JACYVU010000223.1  1474774-1474915
            1511-1623           JACYVU010000223.1  1476462-1476574
            1624-1764           JACYVU010000223.1  1476725-1476865
            1765-2015           JACYVU010000223.1  1479845-1480095
            2016-2141           JACYVU010000223.1  1481433-1481558
            2142-2259           JACYVU010000223.1  1484213-1484330
            2260-2508           JACYVU010000223.1  1487004-1487252
            2509-2585           JACYVU010000223.1  1488654-1488730
            2586-2764           JACYVU010000223.1  1491636-1491814
            2765-2853           JACYVU010000223.1  1493943-1494031
            2854-3039           JACYVU010000223.1  1495679-1495864
            3040-3177           JACYVU010000223.1  1497441-1497578
            3178-3311           JACYVU010000223.1  1497918-1498051
            3312-3368           JACYVU010000223.1  1498632-1498688
            3369-3416           JACYVU010000223.1  1498781-1498828
            3417-3887           JACYVU010000223.1  1498938-1499408
            3888-4218           JACYVU010000223.1  1499865-1500195
            4219-4344           JACYVU010000223.1  1500907-1501032
            4345-6309           JACYVU010000223.1  1501118-1503082
FEATURES             Location/Qualifiers
     source          1..6309
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p12"
     gene            1..6309
                     /gene="Arhgef18"
                     /note="Rho/Rac guanine nucleotide exchange factor 18"
                     /db_xref="GeneID:304193"
                     /db_xref="RGD:1311448"
     exon            1..303
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            304..428
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            429..681
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            682..827
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     CDS             765..4508
                     /gene="Arhgef18"
                     /note="rho/rac guanine nucleotide exchange factor (GEF)
                     18"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 18"
                     /protein_id="NP_001382584.1"
                     /db_xref="GeneID:304193"
                     /db_xref="RGD:1311448"
                     /translation="MGRRLGSKDAYCQWDTSTSSKEGNSPEKRLRSKSVPVSCEEISC
                     LEPASGSDVCAPPVQGLEPPVLECLEKDHVEPDHVLIVQQVLQELRQYHGARQRARMS
                     ISPGGPHSNLTWFEFLSESEDGVCKNEKTDKSTRVKRSLSSLRSRVTRQKEKGKNPAH
                     LKDKIQDVPGKRECVNGHQLVRGTFSGHSSCPLCGKPLLSSASLKEHPRTALLSDGSS
                     PAPSRNVGMTVSQKGGLQPTPSPAGSGVRLGPIAGDMDEADSVFLKLKQTADDSLSLT
                     SSNAESVFIEDPYTASLRCEIESDAHEFEAESWSLSVDVAYAKKQKKEVVKRQDVLYE
                     LMQTEAHHVRTLKIMLKVYSRALQEELQFSVQAVSRLFPCADDLLDMHSHFLARLKER
                     RQEFLEEDSDRNYVIQKIGDVLVQQFSGETGERMKEKYGVFCSGHKDAVGHYKLLLQQ
                     SKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYKDLS
                     QALNLIKDIISQVDAKVSECEKDQRLKEIVAKMDSKSSGKLKNGRTFRKEDMLQRQLH
                     LDSTLCWKSTSGRLKDVLAVLLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREV
                     ANEEKAMFLISASMQGPEMYEIYTSSKEDRNIWMAHIRRAVESCPDEEEGIFLEAEER
                     RMAEARTMKLRDFQERLSLKDQLIAQSLLEKQQIYLEMAQLSGLDESAQCRGLFRGGG
                     DPSETLRGEQILRSAMSEIEGIQSLICRHVGSTSSQVEEGGVSAGLPRRAETFGGYDS
                     VGSPNKGGSFKRKVYNSDPRPQDWQGPASSPDSMPCDTTTPSGCCEESPQAVEMPSAE
                     SSPCLPTVLESELVHRVQTLSQLLLSLQAVIAQQDSYVEMQRMAIQEREKQFRLQSTR
                     GNLLLEQERQRNFEKQREERAGVEKLQNQLRQEQQRWERERARQQQELELAGARLQER
                     EGEARQLRQRLDQERTELERQRQAYQHDLERLREAQRAVDRERERLELLRRFKKQNTV
                     PGALPPEVLAEAQPASHPLNFNGDGLEGHLAPAKAPGTQGSMLHGTGPEYGERAEVAR
                     WDSAPAESRPAKSDVPIQLLSATNQIQRQTAVQQQIPTKLAASTKGGKDKNSKSRGSQ
                     RWESSASFDLKQQPLFNKLMGKDENASRNRRSLSPVLPAAHGSAPAPDPCFPAPSPVP
                     AATAPEAFKSGGTSLPPASPAPSLPTTPPTITDEVGKEDVIFF"
     exon            828..942
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1000
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1045
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1123
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1226
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1368
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1510
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1623
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1764
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..2015
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2141
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2259
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2508
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2585
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2764
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2853
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            2854..3039
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..3177
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            3178..3311
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            3312..3368
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            3369..3416
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            3417..3887
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            3888..4218
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            4219..4344
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
     exon            4345..6309
                     /gene="Arhgef18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttccccat gatacctaca gcaggtacag gctgagggtg gactcccaga ttctcacacc
       61 ccacctccga ctgttctcta ctctcctcgc tgatccctga tgctgctgcc tgctgcctgc
      121 cattgacgaa gaagaaaaat aaaagccggt agatgagaaa gaggaaattg ggcagagttt
      181 agccactctg tggttagcct ggcccatgtg tcccttgaaa ccctggctgt gtgacatggg
      241 gggaacttca agagctgtta acaaagccag tcacctactt gagcaagaat cgagctccag
      301 tgggctctga gcccaagccg tatgcccagc ccttggactc tggaacggca gcttcaacca
      361 ccaggggtgg ccatggaccc aggaaacctg agaatccaga tttcttctca accatggagg
      421 atgagcagga agatggtttt ctgaggcacc tcagcgagag cgcataagac ctcagcctgg
      481 acctgggagc ccttcagggc agcgagtacc tccgggatct gggcttgggg ggccccttct
      541 gacctccatc agttctgaag tggttatgga tcctgagacc cccagaagag agtccttcca
      601 cacaagctgt gagggagctt cagccctgcc tcaaagacac agctgggaga gaccccggag
      661 ctgctcagag agggttcgaa ggcacagcct tgatgcctct gaggtggatg agggggcctg
      721 tctcccccgg actctggcta gcctcgctct gaatctgtct ggagatgggc agaagacttg
      781 gatccaagga tgcttactgt cagtgggaca ccagcacctc aagcaaggaa ggcaacagcc
      841 ctgagaaaag gctaagatcc aagtcagtac ctgtgtcctg tgaagagatc agctgtctgg
      901 aaccggcttc tggctcagat gtgtgtgctc cacctgtaca aggccttgaa cccccggtgc
      961 tggagtgttt ggaaaaggac cacgtggagc cagaccatgt gctgatagtg caacaggtgc
     1021 ttcaggagct gaggcagtac cacggggccc gtcagcgagc tcgcatgtcc atcagccctg
     1081 gaggacccca ctccaacctc acctggttcg agttcctgtc agagagcgag gatggtgtgt
     1141 gcaagaatga gaagacggac aagagcacca gagtgaagcg cagcctgagc tccctccgca
     1201 gcagggtcac gaggcagaag gagaagggga agaacccagc acatctaaaa gataagattc
     1261 aggatgttcc aggaaagcgg gagtgtgtca acgggcacca gctggtgcga ggaaccttct
     1321 cgggccactc cagctgtcct ctgtgtggca aacctttgct gagctcagcc tccctgaagg
     1381 agcacccccg gaccgcactt ctgtctgatg gcagcagccc ggctccctcc cggaatgtcg
     1441 gcatgaccgt ctctcagaaa gggggtctcc agccaacacc gagcccagct ggatctgggg
     1501 tgcgacttgg accgatcgct ggagacatgg atgaagctga ctccgtgttt ttaaagctga
     1561 aacagacggc tgatgactct ctgtcactca catcctcgaa tgctgagtct gttttcatag
     1621 aagatcctta cactgcctcg ctgaggtgtg agatcgaatc agatgcccat gagtttgagg
     1681 ccgagtcctg gagcctctcg gtggatgtag catatgccaa gaaacaaaag aaggaggtgg
     1741 tcaagagaca ggacgtcctg tatgagctga tgcagacaga ggcgcatcac gtgcgcacgc
     1801 tgaagatcat gctgaaagta tactccagag ccctgcagga ggagctgcag ttcagcgtcc
     1861 aggcagtcag ccgcctgttc ccatgcgccg acgacttact ggacatgcac agccacttcc
     1921 tcgcccgcct taaggagcgc cggcaggagt tcctagagga ggacagtgat cggaattatg
     1981 tcatccagaa gatcggagat gtcctggtcc agcagttctc aggagaaacc ggggagagaa
     2041 tgaaggagaa atacggtgtg ttctgtagcg gccacaagga tgcggtcggg cactacaagt
     2101 tactgctgca gcagagcaag aagtttcaaa acttaatcaa gaaaattggc aacttttcca
     2161 tcgtgcgaag gctgggagtg caggagtgta tccttctggt cacacagcgt ataaccaagt
     2221 acccggtgct agtggaacgc atcatccaga acacggaagc tggcactgag gactacaagg
     2281 acctgagcca ggccctgaac ctcatcaaag acatcatctc acaagtggat gccaaagtca
     2341 gtgagtgtga gaaggaccag cgcctcaagg agatcgtagc caagatggac tcgaagtcat
     2401 ccggcaaact caagaacggg cgaaccttcc gaaaggagga tatgctgcag cgccagctcc
     2461 acctggacag caccctgtgc tggaagtcca cgtcggggcg cttgaaagat gtcctcgctg
     2521 tcctgttgac cgatgtgctt ttgctgctgc aagaaaagga tcaaaaatac gtctttgctt
     2581 ctgtggactc aaagccaccc gtcatctctc tgcaaaagct cattgtgaga gaggtagcca
     2641 acgaggagaa ggccatgttt ctgatcagcg cctccatgca gggaccagag atgtacgaga
     2701 tctacaccag ttccaaagag gacaggaaca tctggatggc ccacatccga cgggccgtgg
     2761 agagctgtcc tgacgaggag gagggcattt tcctcgaggc tgaggagaga aggatggctg
     2821 aagcccgcac catgaaactc cgggactttc aagagcgact gagcctgaaa gaccagctga
     2881 tcgcccagag ccttctggag aaacagcaga tctacctgga gatggctcag ctgagcgggc
     2941 tggatgagtc ggcccagtgc cgaggcctct tccgaggagg aggggacccc tctgagaccc
     3001 tacgagggga gcagattctc agatcagcca tgagtgagat tgagggcatc cagagcctga
     3061 tctgccggca cgtgggcagc accagtagcc aagtggaaga gggaggtgtc tctgcaggcc
     3121 tgcctcggag ggctgagacc ttcgggggct atgacagcgt gggcagcccc aacaagggtg
     3181 gcagctttaa aaggaaggtg tacaacagtg accccaggcc ccaagactgg caagggcctg
     3241 ctagcagccc ggactccatg ccctgtgaca ccaccacccc cagtggctgc tgcgaggaat
     3301 caccacaggc tgtggagatg cctagcgcag agagtagccc atgtctgccc actgtcctgg
     3361 aatcagagct ggtccaccgg gtccagaccc tgtcgcagct gcttcttagt ctccaggcag
     3421 tcatcgctca acaggatagc tacgtggaga tgcagcgaat ggccatccag gagcgtgaga
     3481 agcagttccg gctgcaatca acgcgtggga acctgcttct agagcaagag cggcaacgca
     3541 actttgagaa gcagcgtgag gagcgcgcgg gtgtggagaa gctgcaaaac cagctgcgcc
     3601 aggagcagca gcgatgggag cgggagcggg cacgccagca gcaggaactg gagctggcag
     3661 gcgcgcgact gcaggagaga gagggcgagg cgcgccagct gcgccagcgg ctggaccagg
     3721 agcgcacaga gctggagaga cagcgccagg cctaccagca tgatctggag cgtctgcgcg
     3781 aggcccagag agcagtggac cgtgaacgtg agcgcctgga actactgcgc aggttcaaga
     3841 aacagaacac tgtaccgggg gcactgcccc cggaagtgct ggcagaggcc cagcctgcaa
     3901 gccaccctct caacttcaat ggggatgggc tggagggcca cttggcccca gccaaagcac
     3961 caggaacaca ggggagcatg ctacacggca caggacctga gtacggagag cgagctgagg
     4021 tggcccgctg ggacagtgcc cctgctgaga gccggccagc caagagtgat gtgcccatcc
     4081 agctgctcag tgccaccaat cagattcaga ggcagacagc cgtgcagcag cagatcccca
     4141 ccaagttggc cgcctccacc aaggggggca aggataagaa cagcaagagc aggggttccc
     4201 agcgctggga gagctcagca tccttcgacc tgaagcagca gccactcttc aacaagctca
     4261 tgggcaagga cgagaacgcg tcccgaaacc gccgctcact gagccccgtc ctacctgcag
     4321 cccatggatc tgcacctgcc ccagacccct gcttcccagc cccaagcccg gtcccggccg
     4381 ccacagcccc cgaggccttc aagtcaggag gcacgtcact gccacctgcc tccccagctc
     4441 cctcgctgcc aaccacaccg cccaccatca cagatgaagt tggcaaggaa gacgtcatct
     4501 tcttctgagg ggccgtggcc ccaagagcag acccctttcc ctttctgtcc tgataaccct
     4561 ttgtgtctct ggggaaccct gtgggtgact gttctgtctg gccatcccct tcccctgcac
     4621 agccaggcac ttgctcatct gagattgccc acatggtggt ctcacagttc tctatagatt
     4681 tagtgggtag ccccttgaac gaacatacat acacacacac acacacacac acatattata
     4741 tatatatata tgtatatata tatatatata tatatataca tatatatgta tatatatata
     4801 tatgtatata tatatatata tatatatata tatatatata tgctcaaaca aagttctttt
     4861 aagttgaagg tggagcccca gctaaaccac agagctgttt taaaccagag gcagcagagg
     4921 gagccaggag acagagcagg caggtctgag aagacaccag ccccaggggc agactccata
     4981 acccccagga atctctggat tgaactgagt cattaagcac cgggtaacta cagagggcca
     5041 cggggttgga aagacttagg cagccccagg caacccatgg agcaacagac tgtgggttca
     5101 gaaatcagtc tgaagagggg ttaacaatgg tcactcctgg tggtaggcca gggtttttcc
     5161 caactctgct tctcggggcg ccggccatgt cctcccaccc actgtatctg agctgcagaa
     5221 ctccaggctc agcagggcag cacatatccc acagacagtg ttcggttgcc gtaagcgagt
     5281 tggctttcct agtcccttca gtggtctgcc aggaaggcag cgctaaccca ttcagggaca
     5341 ttgccaggga gcagcctgtg caggacagca gctggtccag cctggtcttg ttcccagaat
     5401 caccccttac ccaggtttcc ctgctgcacc tgccctgagg tactaacgag caggaccaag
     5461 tcctacactg atggttctta gtcacagaaa ggacaagtca gtctccagag ccagcatcct
     5521 aaggaaccat ttccaagagc cctgctgccc tgtgatacct ggcgcagaca gccaggccat
     5581 ccccaccact gtggacaggg aggcgtcaga ggctgctggc atgagccaag acttcagcac
     5641 tcagaagctc agggagcgtc tgcaggtgtg gtaaccaagc ttaagagcga tggcctctga
     5701 cgacttcaga gtgtgccagg agtggtgtgc ctggggaccc cagtcccgaa cagcctttat
     5761 tctggtcctt ctgtccccgt cttgtgtcca gagtgtatct accagacctc attgtgccat
     5821 gttgctaagc agtgttttgt ggttttgtac tgagatgcat cagagcactt taggaaagct
     5881 ggcgtttaag tttccactct gaagagaaca ttccagtccc caaccagagc tgggtgggct
     5941 caccatcaga caccttgagt ttttggattt tgaagttcag atggtttcca cttggccctg
     6001 ggaaggattc agtatatccc cgcctggtgg ccgggtggtt ctcagctgtg tactgtacac
     6061 agtaggacag cgtcataagt tatctgtcac cagtggccct gggctccttc ctagcagatc
     6121 tcgtttgtaa agacggtggg ccagcagcat tcgatctctg aggttgagtg gcacccctcg
     6181 tcagtcatga ccgccatctt cgcctaccct ttattatttt cacagtgata acagcatccc
     6241 agcaacaggg tgttctggaa ctgccctaga acttatgacc agattctagc aataaaatta
     6301 tccaaggga
//
