LOCUS       NM_001127591            2795 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Rho guanine nucleotide exchange factor 16
            (Arhgef16), mRNA.
ACCESSION   NM_001127591
VERSION     NM_001127591.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2795)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2795)
  AUTHORS   Oliver,A.W., He,X., Borthwick,K., Donne,A.J., Hampson,L. and
            Hampson,I.N.
  TITLE     The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which
            activates Cdc42
  JOURNAL   Br J Cancer 104 (2), 324-331 (2011)
   PUBMED   21139582
REFERENCE   3  (bases 1 to 2795)
  AUTHORS   Hiramoto-Yamaki,N., Takeuchi,S., Ueda,S., Harada,K., Fujimoto,S.,
            Negishi,M. and Katoh,H.
  TITLE     Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent
            mechanism
  JOURNAL   J Cell Biol 190 (3), 461-477 (2010)
   PUBMED   20679435
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166429.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166429.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2795
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2795
                     /gene="Arhgef16"
                     /note="Rho guanine nucleotide exchange factor 16"
                     /db_xref="GeneID:687105"
                     /db_xref="RGD:1588981"
     exon            1..24
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            25..134
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            135..746
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..2282
                     /gene="Arhgef16"
                     /note="Rho guanine nucleotide exchange factor (GEF) 16"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 16"
                     /protein_id="NP_001121063.1"
                     /db_xref="GeneID:687105"
                     /db_xref="RGD:1588981"
                     /translation="MSQRHSDSSLDEKLLEYRFHAELRLDANGNPVPGLPMVRGSLKA
                     RANAAFEPDAPESLQPPPPGDEEPRPIILSTQSPAALKMGTQQLIPKSLAVASKAKTK
                     SPARHQSFGAAVLSKEAARRTPQLLPAPSFSLDDMDMDAVTGGNLKRNLRNQSYRAAM
                     KGLGPPSSKEDSVRLGPKLQALAEEAAQPPARHPAKNKKTWKRANKGSFKDDPQLYQE
                     IRERGLNTSHESDDDILDEPSSSGGTQRGDTTIVVKTYRPAQLTWSQLPEVLESGILD
                     TLSVEERKRQEAIFEILTSEFSYLHSLKILVNEFLQSQELKTTMTQTEHHHLFSNISD
                     VLAASQKFFESLEQRHKAQVCVEDISDILEDHAENHFHPYIAYCSNEVYQQRTLQKLS
                     NSNTAFREVLREIEKLPACGGLPMISFLILPMQRVTRLPLLTDTLCLKTQGHPERYKA
                     ASRALKAISKLVKQCNEGAHKMERTEQMYTLHMQLDFGKVKSLPLISASRWLLKRGEL
                     LLLEESSIFRKIASRPTCYLFLFNDVLVVTKKKSEESYLVQDYAQLDHVQVRKVEPSE
                     LPLPGGSSRSSSVPYPFQVNLLHNSEGRQEQILLSSDSASDRARWITALSYKERQWQG
                     ISNKGELPQVEVTKAYFAKQADEITLQQADVVLVLQEEDGWLYGERLRDGETGWFPES
                     FAHCITSRVAVEGNVRRMERLRVETDV"
     exon            747..786
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            787..956
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1013
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1174
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1327
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1457
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1532
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1625
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1777
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1966
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2040
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2142
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2731
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgcccttc cgcggcgcgc acagatttga agattgaaac cgagaggtgg cgtctttaat
       61 cattgaggac accaggtttc cagcccccca acagggcagc tcctgacaag tgtggaggac
      121 ccccagtcac ggaggcctcc tctgtcacca gcatgtccca gaggcattct gacagctccc
      181 tggatgagaa actactggag taccgcttcc acgcggagct gcgactcgac gccaacggga
      241 accccgtgcc tggactcccc atggtccggg gttccttaaa agccagagcc aacgctgcct
      301 ttgagcccga tgccccagaa tccttacagc cgccaccgcc tggagatgag gagcctcggc
      361 ccatcatcct cagcacacaa agccctgcgg ccctcaagat gggcacgcag cagctcatcc
      421 ccaagagctt ggcggtggcc agcaaggcca agaccaagtc gcccgcccgc caccagagct
      481 ttggggcagc tgtgctcagt aaggaggccg cgaggcggac tcctcagctc ctcccagccc
      541 ccagtttctc tctggatgat atggacatgg acgccgtcac aggtgggaac ctgaaacgca
      601 acctgaggaa ccaatcctac agggcagcca tgaagggcct ggggccaccc agtagcaagg
      661 aagactcagt ccgcctcggc cccaagctcc aggccctcgc tgaggaggct gctcagcctc
      721 ctgcccggca cccagccaaa aataagaaaa cttggaaacg cgcaaacaag ggctcgttca
      781 aagatgaccc ccaactttac caggagatcc gagagcgggg tttgaatact agtcacgagt
      841 ctgatgatga catactggac gagccctcca gctctggggg cactcagaga ggggacacca
      901 ccattgtggt taagacctat cgccctgctc agctcacctg gagccagctc ccagaggtgc
      961 tggagtcagg tatcctggac acactgtcag tggaagagcg gaagagacag gaggccatct
     1021 tcgagatcct cacgtctgag ttctcctatc tgcacagcct gaagatcctg gtgaatgaat
     1081 tcctacagtc ccaagagctg aagaccacca tgacgcagac agaacaccac cacctcttct
     1141 ccaacatctc ggatgtgctg gctgccagtc agaagttctt tgaatccctg gagcagcggc
     1201 acaaagctca ggtgtgtgtg gaggacatca gcgacatctt ggaggaccat gccgagaacc
     1261 acttccaccc ttacatcgcc tactgctcca acgaggtcta tcagcagcgc accctgcaga
     1321 agctgtcgaa cagcaacaca gccttccggg aagttctgag ggagatagag aaactgcctg
     1381 cgtgtggggg cctgcccatg atctccttcc tgattctccc catgcagagg gtgacccggc
     1441 tgcctctgtt gacggataca ctctgcctga agacacaagg ccatcccgaa cggtataaag
     1501 ccgccagccg cgccctgaag gccatcagca agctggtgaa acaatgtaac gagggggccc
     1561 acaaaatgga gcgcacagag cagatgtaca cactgcacat gcagctggac ttcggtaagg
     1621 tcaagtccct cccactcatc tctgcctctc gctggttact gaaacgtgga gagctcctcc
     1681 tcttggaaga atccagtatc tttaggaaaa ttgctagccg acccacgtgc tacctgttcc
     1741 tattcaatga cgtcctggtt gtcaccaaga agaaaagtga ggaaagttac ttggtccaag
     1801 actacgcgca gctagaccac gtgcaggtca ggaaggtgga accctcggag ctcccactgc
     1861 caggaggcag cagccgcagc tcttccgtgc cctacccttt ccaagtgaac ctgctacaca
     1921 acagcgaggg ccgccaggag cagatactgc tgtcttctga ctccgcgagt gaccgggccc
     1981 ggtggatcac agcactcagc tacaaggaga gacagtggca gggcatcagc aacaaaggag
     2041 aactgcccca ggtggaggtc accaaggcat actttgccaa gcaggctgat gagatcacac
     2101 tgcaacaggc agacgtcgtc ctggtcctgc aggaagagga tggctggctt tatggtgagc
     2161 ggcttcggga cggagagacc ggctggtttc ccgagagctt tgctcactgc atcaccagcc
     2221 gtgtggccgt ggaaggcaat gtgcgcagga tggagcggct gcgggtggag acagatgtgt
     2281 agctggacag ctcggaagcc aagctgtggc agacacacct tcaatcctcc aaccagcaag
     2341 ccgagcggtc ctgcctgccc ccaggagtgg gcggggttca tcatgggacg cagatccttc
     2401 tcatgggctc acggttgagt gcagaacact gaacttgtat acattcgctt gcctaaacac
     2461 ctctgaggca agctccaggg gcccacattc tggaaagagc cttagcctgg cctctcactg
     2521 gacacctgag ctacaccagc taacagtgat acaggactgt tgccttcatt gaagacacca
     2581 tagggccacc tgacagctgc acccctccat cccaggtggg accaaaaggg gccggtgctc
     2641 tgagaggaca gtgctggtga caggtgacct gaggtaccag cagggatgtt gtgatttaca
     2701 gagttcaata acattaaaat atttctttta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2761 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
