LOCUS       NM_001414295            4388 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus Rho guanine nucleotide exchange factor 15
            (Arhgef15), mRNA.
ACCESSION   NM_001414295 XM_008767792
VERSION     NM_001414295.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4388)
  AUTHORS   Takase H, Matsumoto K, Yamadera R, Kubota Y, Otsu A, Suzuki R,
            Ishitobi H, Mochizuki H, Kojima T, Takano S, Uchida K, Takahashi S
            and Ema M.
  TITLE     Genome-wide identification of endothelial cell-enriched genes in
            the mouse embryo
  JOURNAL   Blood 120 (4), 914-923 (2012)
   PUBMED   22535667
REFERENCE   2  (bases 1 to 4388)
  AUTHORS   Margolis SS, Salogiannis J, Lipton DM, Mandel-Brehm C, Wills ZP,
            Mardinly AR, Hu L, Greer PL, Bikoff JB, Ho HY, Soskis MJ, Sahin M
            and Greenberg ME.
  TITLE     EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a
            developmental brake on excitatory synapse formation
  JOURNAL   Cell 143 (3), 442-455 (2010)
   PUBMED   21029865
REFERENCE   3  (bases 1 to 4388)
  AUTHORS   Ogita H, Kunimoto S, Kamioka Y, Sawa H, Masuda M and Mochizuki N.
  TITLE     EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically
            in vascular smooth muscle cells
  JOURNAL   Circ Res 93 (1), 23-31 (2003)
   PUBMED   12775584
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000220.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001414295.2.
            
            On Nov 17, 2022 this sequence version replaced XM_008767792.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132268, SAMD00132285
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                JACYVU010000220.1  10488086-10488127   c
            43-225              JACYVU010000220.1  10487635-10487817   c
            226-881             JACYVU010000220.1  10486151-10486806   c
            882-1232            JACYVU010000220.1  10485548-10485898   c
            1233-1290           JACYVU010000220.1  10485222-10485279   c
            1291-1349           JACYVU010000220.1  10483493-10483551   c
            1350-1561           JACYVU010000220.1  10483202-10483413   c
            1562-1722           JACYVU010000220.1  10482915-10483075   c
            1723-1875           JACYVU010000220.1  10482609-10482761   c
            1876-2005           JACYVU010000220.1  10481984-10482113   c
            2006-2080           JACYVU010000220.1  10479705-10479779   c
            2081-2173           JACYVU010000220.1  10479514-10479606   c
            2174-2334           JACYVU010000220.1  10479273-10479433   c
            2335-2487           JACYVU010000220.1  10479021-10479173   c
            2488-2570           JACYVU010000220.1  10478593-10478675   c
            2571-2675           JACYVU010000220.1  10478377-10478481   c
            2676-4388           JACYVU010000220.1  10475379-10477091   c
FEATURES             Location/Qualifiers
     source          1..4388
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..4388
                     /gene="Arhgef15"
                     /gene_synonym="E5"
                     /note="Rho guanine nucleotide exchange factor 15"
                     /db_xref="GeneID:287418"
                     /db_xref="RGD:1306961"
     exon            1..42
                     /gene="Arhgef15"
                     /gene_synonym="E5"
                     /inference="alignment:Splign:2.1.0"
     exon            43..225
                     /gene="Arhgef15"
                     /gene_synonym="E5"
                     /inference="alignment:Splign:2.1.0"
     exon            226..881
                     /gene="Arhgef15"
                     /gene_synonym="E5"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..2827
                     /gene="Arhgef15"
                     /gene_synonym="E5"
                     /note="ephexin-5; Rho guanine nucleotide exchange factor
                     (GEF) 15"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 15"
                     /protein_id="NP_001401224.1"
                     /db_xref="GeneID:287418"
                     /db_xref="RGD:1306961"
                     /translation="MSAQSLPAATPPTLKPPRIIRPRPPSRHRAPHSPGPPHNGSSPK
                     ALPQISNDASASVCTSIFWEPPTGSLKPPALLPPSVSRASLDSQTSPDSPSSTPSPSP
                     VSRRSISPEPAPCSPVPPPKPSGSSRTPLPLGPVPLQDGSASAPGTVRRLAGKFEWGA
                     EGKAQSADSLERCSQGSTDVNGEKETLQVGLSGNGSQENGTPDAALACPPCCPCVCHV
                     AKPGLELRWVPVGSSDDILRAPCRASPLRASRSRINPPVISHPPVVLTSYRSTAERKL
                     LPPLKPPKPTRVRQDTSTSGELPQPDLELPSEDGIQAAPKAWEGDRPEEAPQNAPPPV
                     ALEGREEEGLEGLKELQWELPLQDEPLYQTYRAAVLSEELWGVGEDGGPSPANPGEAP
                     TFSRLPGPRNTLWQELPAVRGSGLLESLSPQERRMQESLFEVVTSEASYLRSLRLLTD
                     TFVLSQALRDTLTPRDHHTLFSNVQRVQSVSERFLGTLLSRVRSSPHISDLCDVVHAH
                     AVGPFSVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPF
                     QRITRLRMLLQNILSQTEEGSSRQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLT
                     QRLRFHKVKALPLVSWSRRLELQGELTELGCRRGGVLFTSRPRFTPLCLLLFSDLLLI
                     TQPKSGQRLQVLDYAHRSLVQAQQVPDPSGPPTFRLSLLSNHQGRPTHRLLQAASLSD
                     MQRWLGAFPTPGPLPCSPDTIYEDCECSQELCSEPSTPSKTEGQSLESKAPRKHLHKN
                     PEGWLKGLPGAFPAQLVCEVTGEHERRKHLRQHQKLLEAAGPSSDTPDTPQP"
     exon            882..1232
                     /gene="Arhgef15"
                     /gene_synonym="E5"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1290
                     /gene="Arhgef15"
                     /gene_synonym="E5"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1349
                     /gene="Arhgef15"
                     /gene_synonym="E5"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1561
                     /gene="Arhgef15"
                     /gene_synonym="E5"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1722
                     /gene="Arhgef15"
                     /gene_synonym="E5"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1875
                     /gene="Arhgef15"
                     /gene_synonym="E5"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2005
                     /gene="Arhgef15"
                     /gene_synonym="E5"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2080
                     /gene="Arhgef15"
                     /gene_synonym="E5"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2173
                     /gene="Arhgef15"
                     /gene_synonym="E5"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2334
                     /gene="Arhgef15"
                     /gene_synonym="E5"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2487
                     /gene="Arhgef15"
                     /gene_synonym="E5"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2570
                     /gene="Arhgef15"
                     /gene_synonym="E5"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2675
                     /gene="Arhgef15"
                     /gene_synonym="E5"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..4388
                     /gene="Arhgef15"
                     /gene_synonym="E5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcagccct cggaggtgac tgggagtgga gggaactgga ggggaatttt gaggctctct
       61 tgtgtcccag ctctgcttcc caacctcctg gtcctcaaga ggaagagcag cacaggtccc
      121 accgtccttg cgctgctggt tctgtgcctt ggcttggact cgtaaccacc tccctgacat
      181 tagacccagc atcccactgg agcttctttc tatgaccaga cccaggggat gacttccgca
      241 gaacacccca ctccttggaa acactcagaa gacaatgtca gctcagtctc tccctgcagc
      301 aacgccccct accctgaagc cccctcggat catccgcccc cgacccccat ctcggcatag
      361 ggctccacac tccccggggc ctccgcacaa tggctcctct ccgaaagcac ttcctcaaat
      421 atccaatgat gcatcagcct cagtgtgcac ctccatcttc tgggaacccc ccacgggttc
      481 cctgaagccc cctgctcttc tgcctccctc agtttctaga gccagcctgg actctcagac
      541 ttcccctgac tcaccttcca gcacaccgag tcccagccca gtgtcccggc gctccatctc
      601 cccagaacca gctccctgct ctccggtacc cccgcccaag ccctctggat cttcccgaac
      661 acctttgccc ttgggccccg tgcctctcca ggatggctct gcctcagccc ctggcacggt
      721 tcgcagactg gccggcaagt ttgaatgggg agctgaaggc aaggcccagt cggcagactc
      781 cctggaacgg tgctcccaag ggagcacgga tgtgaatggg gagaaagaga ctctccaagt
      841 cggcctttcg gggaatgggt cccaggagaa tggcactccc gatgctgccc tggcctgccc
      901 tccatgctgt ccctgtgtct gccatgtagc aaaacccggc ctggagctcc gatgggtgcc
      961 tgtgggaagt tctgacgaca tcctcagggc tccctgccgg gcatctccac tccgagcctc
     1021 ccgctcccgt atcaaccctc cagtcatcag tcaccctcca gttgtgctca catcctatcg
     1081 ctccactgcg gagcgcaaac tcctacctcc cctcaagcct cccaagccaa ctagagtcag
     1141 acaggacacc agcacctctg gggagcttcc acagccggac ctggaactgc cttcagaaga
     1201 tggaatccaa gcagctccaa aggcctggga aggggacaga cctgaagaag ctcctcagaa
     1261 cgctcctcct ccggtagcct tggagggaag ggaggaggaa gggctggagg ggctgaagga
     1321 gctgcagtgg gagctgcccc tgcaggacga acctttatac cagacttacc gagcagctgt
     1381 gctgtcagag gagctgtggg gtgtgggtga ggatgggggt ccctctccag ctaatcctgg
     1441 agaagctccc accttctcca ggctccctgg acctcgaaac actctgtggc aggagctccc
     1501 ggctgtgcga ggcagtggtc tcttagagag tctaagcccc caggaaaggc gcatgcagga
     1561 gagcctgttt gaggtggtga catcagaggc ctcctacctg cgctccctga ggctgctgac
     1621 cgacaccttc gtcctgagcc aggctctccg ggacaccctc actcctcggg atcatcatac
     1681 gctcttctcc aatgtgcaga gagtccagag tgtcagtgag cggtttctag gaacactgct
     1741 gtcacgtgtt cgttcctccc cacacatctc tgacctgtgt gacgtggtgc acgcccacgc
     1801 agttggtcct ttctccgtgt atgtggatta cgttcggaac cagcagtatc aagaggagac
     1861 gtatagccgc cttatggata caaacgtgcg attctctgcg gagctgcgca ggctacagag
     1921 cctccccaaa tgcgagcggc tcccactgcc atctttcctg ctactgccct tccagcgcat
     1981 cacccgcctc cggatgttgt tacagaatat cctaagccag acagaggagg ggtccagtcg
     2041 tcaggagaat gcccagaagg ccttgggtgc tgtgagcaag atcattgagc gctgcagcgc
     2101 tgaggtgggg cgcatgaagc agactgaaga gctcatccga ctcacccaaa ggttgcgctt
     2161 tcacaaagtc aaggctctcc cgctggtctc ctggtcacgg cgcctggaat tgcaggggga
     2221 gctgaccgag ttggggtgtc ggaggggtgg tgtgctcttc acctcccgcc cgcgcttcac
     2281 tcccctctgc ctgctgctct tcagtgacct gctgcttata actcagccca agagtgggca
     2341 gcggctgcag gttctggact atgcccatcg ctccctggtg caggcccagc aggttcctga
     2401 cccatctgga ccccctacat tccgactctc gcttctcagc aaccaccagg gccgccccac
     2461 ccacaggcta ctccaagcgg cctcactgtc agacatgcag cgctggctag gagccttccc
     2521 taccccaggc ccccttccct gttccccaga caccatctat gaggactgtg agtgttccca
     2581 ggagctatgt tcagagccat ctacaccttc caagactgag gggcaaagtc tggagtccaa
     2641 ggctccccga aagcatctgc acaagaatcc agaaggttgg cttaaggggc ttcctggagc
     2701 tttccctgcc caactggtgt gtgaagtcac aggagaacat gaaaggagaa agcatcttcg
     2761 ccagcatcag aagctccttg aggctgcagg accctcttca gacactcctg acacccctca
     2821 accttagggc agcctaggga ggaacagatt gggacactgg cagcagcatg gggaagacaa
     2881 agtctgccca tccatccatc aaccatccat ctgtccatcc atccatttat ctgctgtcag
     2941 tggaaacact acctctagag gcaaccaata ggaatagagc agctaatgaa acaagaccat
     3001 ctaagcccac aacaagaaag aatggggaca gctcgaattg tgttgccaat ggagacagag
     3061 gccctggcca gtgagcatca cagtatgtct acaaccatgg aagatgaagc aggggcattg
     3121 tattgagaaa tggtgtcatt ggagtagtct gtcctataga caacagggat gggatgggac
     3181 ccatccagcc aaagtgattt aggcccaagt aatcattctt ggttttacag aagctactgg
     3241 tcctgctttt tgagtatagg aagtattaaa ttaatctaat acttctgttt tggggctact
     3301 ttctctgccc gcttaaacca ctttctttct tctagaagaa tccagagtgg agactgcacc
     3361 tcagagaaca tgagtgcatg tatgtccatg tatatgtgta tctaggaagg caactgtgct
     3421 gaatggtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtctatg
     3481 agagagagag agagagagag agagagagag agagagagag agcacatacc tctcctgtcg
     3541 gtgactgaat acatcttttt ctttttctct cctgtttatc ctctcatttt ctacaaagaa
     3601 gccatatgcc ctgagttcta aaagagagta ccaatcttta gcttgcctaa agattggggc
     3661 tgtgatgaga gccatggatt ctggtctctt ggtactctct gggttctatg acagttgaag
     3721 ggtggtatcg tgaagcagtt ggtggcctgc caaggaaggc actgaggact aagcagttgg
     3781 ggaatgagat cctctgcagt ctgtgggcct cttcctgttc caagcattga cctcagtgat
     3841 ccatgtctgc tatgcatcat ctcccagctt gaattgtcat cgtgatgcca gccagcctca
     3901 gcctcaggct gcagagcaag gtggatccca ggccagccag caacaatcct gagcctctcc
     3961 tatcctgatc ctttcagaag cagaaggctg aactcaggag agaatagaga actggtggtg
     4021 ttgctcagac tcaaccaagg tttgtgctgg agaacctgtc ctgtgtggtg ctggagaggt
     4081 gaaggcgaag acagtagaac agagagttgc tgggcttgtg gcaagggctt cctagatctt
     4141 cacaactgtg caatactgtt ccttcatgca tgacaacctg cccagataga gactgcccgg
     4201 atgactatgg gaggggtaca atgactctgg ggacttgaag acagaagggc actttgcgtg
     4261 tccatagttt tcatccagca aagtgccagc cacatgggaa accttcaata aatgtcggtg
     4321 gcatcatacc agggctcttc agagctggaa agagcagtgg tctacaaata aagttttgtg
     4381 tgggggca
//
