LOCUS       NM_023982               6736 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus Rho guanine nucleotide exchange factor 11
            (Arhgef11), mRNA.
ACCESSION   NM_023982
VERSION     NM_023982.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6736)
  AUTHORS   Johnson,A.C., Wu,W., Attipoe,E.M., Sasser,J.M., Taylor,E.B.,
            Showmaker,K.C., Kyle,P.B., Lindsey,M.L. and Garrett,M.R.
  TITLE     Loss of Arhgef11 in the Dahl Salt-Sensitive Rat Protects Against
            Hypertension-Induced Renal Injury
  JOURNAL   Hypertension 75 (4), 1012-1024 (2020)
   PUBMED   32148127
  REMARK    GeneRIF: Loss of Arhgef11 in the Dahl Salt-Sensitive Rat Protects
            Against Hypertension-Induced Renal Injury.
REFERENCE   2  (bases 1 to 6736)
  AUTHORS   Zhang,W., Su,R., Feng,H., Lin,L., Wang,C. and Yang,H.
  TITLE     Transgenerational Obesity and Alteration of ARHGEF11 in the Rat
            Liver Induced by Intrauterine Hyperglycemia
  JOURNAL   J Diabetes Res 2019, 6320839 (2019)
   PUBMED   31612150
  REMARK    GeneRIF: Intrauterine hyperglycemia could cause obesity and
            abnormal glycolipid metabolism in female transgenerational
            offspring; the programming effect of the intrauterine environment
            could cause a more obvious phenotype in the maternal line. Further
            exploration suggested that increased expression of ARHGEF11 in the
            liver could be involved.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6736)
  AUTHORS   Jia,Z., Johnson,A.C., Wang,X., Guo,Z., Dreisbach,A.W., Lewin,J.R.,
            Kyle,P.B. and Garrett,M.R.
  TITLE     Allelic Variants in Arhgef11 via the Rho-Rock Pathway Are Linked to
            Epithelial-Mesenchymal Transition and Contributes to Kidney Injury
            in the Dahl Salt-Sensitive Rat
  JOURNAL   PLoS One 10 (7), e0132553 (2015)
   PUBMED   26172442
  REMARK    GeneRIF: genetic variants in Arhgef11 via increased expression
            and/or protein activity play a role in promoting kidney injury in
            the Dahl salt-sensitive rat through changes in cell morphology
            (Rho-Rock and/or EMT) that impact the function of tubule cells
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6736)
  AUTHORS   Artamonov,M.V., Momotani,K., Stevenson,A., Trentham,D.R.,
            Derewenda,U., Derewenda,Z.S., Read,P.W., Gutkind,J.S. and
            Somlyo,A.V.
  TITLE     Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of
            Rho guanine nucleotide exchange factors (RhoGEFs) and response
            kinetics, a caged compound study
  JOURNAL   J Biol Chem 288 (47), 34030-34040 (2013)
   PUBMED   24106280
  REMARK    GeneRIF: Agonist-induced Ca2+ sensitization in smooth muscle:
            redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and
            response kinetics, a caged compound study.
REFERENCE   5  (bases 1 to 6736)
  AUTHORS   Siegert,P., Schmidt,G., Papatheodorou,P., Wieland,T., Aktories,K.
            and Orth,J.H.
  TITLE     Pasteurella multocida toxin prevents osteoblast differentiation by
            transactivation of the MAP-kinase cascade via the
            Galpha(q/11)--p63RhoGEF--RhoA axis
  JOURNAL   PLoS Pathog 9 (5), e1003385 (2013)
   PUBMED   23696743
  REMARK    GeneRIF: Pasteurella multocida toxin prevents osteoblast
            differentiation by transactivation of the MAP-kinase cascade via
            the Galpha(q/11)--p63RhoGEF--RhoA axis.
REFERENCE   6  (bases 1 to 6736)
  AUTHORS   Park,H.Y., Kim,J.H., Zuo,Z. and Do,S.H.
  TITLE     Ethanol increases the activity of rat excitatory amino acid
            transporter type 4 expressed in Xenopus oocytes: role of protein
            kinase C and phosphatidylinositol 3-kinase
  JOURNAL   Alcohol Clin Exp Res 32 (2), 348-354 (2008)
   PUBMED   18226120
  REMARK    GeneRIF: Acute ethanol exposure increases EAAT4 activity at
            clinically relevant concentrations and that PKC and PI3K may
            mediate this.
REFERENCE   7  (bases 1 to 6736)
  AUTHORS   Hilgers,R.H., Todd,J. Jr. and Webb,R.C.
  TITLE     Increased PDZ-RhoGEF/RhoA/Rho kinase signaling in small mesenteric
            arteries of angiotensin II-induced hypertensive rats
  JOURNAL   J Hypertens 25 (8), 1687-1697 (2007)
   PUBMED   17620967
REFERENCE   8  (bases 1 to 6736)
  AUTHORS   Yamada,T., Ohoka,Y., Kogo,M. and Inagaki,S.
  TITLE     Physical and functional interactions of the lysophosphatidic acid
            receptors with PDZ domain-containing Rho guanine nucleotide
            exchange factors (RhoGEFs)
  JOURNAL   J Biol Chem 280 (19), 19358-19363 (2005)
   PUBMED   15755723
REFERENCE   9  (bases 1 to 6736)
  AUTHORS   Jackson,M., Song,W., Liu,M.Y., Jin,L., Dykes-Hoberg,M., Lin,C.I.,
            Bowers,W.J., Federoff,H.J., Sternweis,P.C. and Rothstein,J.D.
  TITLE     Modulation of the neuronal glutamate transporter EAAT4 by two
            interacting proteins
  JOURNAL   Nature 410 (6824), 89-93 (2001)
   PUBMED   11242047
REFERENCE   10 (bases 1 to 6736)
  AUTHORS   Fukuhara,S., Murga,C., Zohar,M., Igishi,T. and Gutkind,J.S.
  TITLE     A novel PDZ domain containing guanine nucleotide exchange factor
            links heterotrimeric G proteins to Rho
  JOURNAL   J Biol Chem 274 (9), 5868-5879 (1999)
   PUBMED   10026210
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000069.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_023982.3.
            
            On Oct 3, 2022 this sequence version replaced NM_023982.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF225961.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1232              JACYVU010000069.1  39546815-39548046
            1233-1265           JACYVU010000069.1  39610194-39610226
            1266-1280           JACYVU010000069.1  39611455-39611469
            1281-1372           JACYVU010000069.1  39611787-39611878
            1373-1474           JACYVU010000069.1  39612725-39612826
            1475-1524           JACYVU010000069.1  39614531-39614580
            1525-1582           JACYVU010000069.1  39615240-39615297
            1583-1761           JACYVU010000069.1  39616156-39616334
            1762-1833           JACYVU010000069.1  39617137-39617208
            1834-1879           JACYVU010000069.1  39628878-39628923
            1880-1956           JACYVU010000069.1  39629459-39629535
            1957-2094           JACYVU010000069.1  39630226-39630363
            2095-2169           JACYVU010000069.1  39636131-39636205
            2170-2271           JACYVU010000069.1  39636423-39636524
            2272-2370           JACYVU010000069.1  39637592-39637690
            2371-2413           JACYVU010000069.1  39639348-39639390
            2414-2510           JACYVU010000069.1  39642980-39643076
            2511-2633           JACYVU010000069.1  39643190-39643312
            2634-2657           JACYVU010000069.1  39645860-39645883
            2658-2802           JACYVU010000069.1  39646899-39647043
            2803-2902           JACYVU010000069.1  39647305-39647404
            2903-3029           JACYVU010000069.1  39652043-39652169
            3030-3209           JACYVU010000069.1  39655510-39655689
            3210-3257           JACYVU010000069.1  39655768-39655815
            3258-3445           JACYVU010000069.1  39655977-39656164
            3446-3592           JACYVU010000069.1  39656389-39656535
            3593-3672           JACYVU010000069.1  39657166-39657245
            3673-3798           JACYVU010000069.1  39657395-39657520
            3799-3916           JACYVU010000069.1  39657992-39658109
            3917-4095           JACYVU010000069.1  39658618-39658796
            4096-4171           JACYVU010000069.1  39659354-39659429
            4172-4339           JACYVU010000069.1  39659680-39659847
            4340-4430           JACYVU010000069.1  39660547-39660637
            4431-4556           JACYVU010000069.1  39661317-39661442
            4557-4618           JACYVU010000069.1  39661906-39661967
            4619-4831           JACYVU010000069.1  39662832-39663044
            4832-5188           JACYVU010000069.1  39663308-39663664
            5189-5308           JACYVU010000069.1  39664562-39664681
            5309-5535           JACYVU010000069.1  39665586-39665812
            5536-5725           JACYVU010000069.1  39666110-39666299
            5726-6736           JACYVU010000069.1  39667372-39668382
FEATURES             Location/Qualifiers
     source          1..6736
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..6736
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /note="Rho guanine nucleotide exchange factor 11"
                     /db_xref="GeneID:78966"
                     /db_xref="RGD:619705"
     exon            1..1232
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     CDS             1201..5784
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /note="RhoGEF glutamate transport modulator GTRAP48;
                     glutamate transporter EAAT4 associated protein 48; Rho
                     guanine nucleotide exchange factor (GEF) 11"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 11"
                     /protein_id="NP_076472.2"
                     /db_xref="GeneID:78966"
                     /db_xref="RGD:619705"
                     /translation="MSIRLPHSIDRSASKKQSHLSSPIASWLSSLSSLGDSTPERTSP
                     SHHRQPSDTSETTAGLVQRCVIIQKDQHGFGFTVSGDRIVLVQSVRPGGAAMKAGVKE
                     GDRIIKVNGTMVTNSSHLEVVKLIKSGAYAALTLLGSSPPSVGVSGLQQNPSVAGVPR
                     VNPIIPPPPPPPPLPPPQHITGPKPLQDPEVQKHATQILRNMLRQEEKELQDILPPCG
                     ETSQRTCEGRLSVDSQEADSGLDSGTERFPSISESLMNRNSVLSDPGLDSPQTSPVIL
                     ARVAQHHRRQGSDAALLPLNHQGIDQSPKPLIIGPEEDYDPGYFNNESDIIFQDLEKL
                     KSHPAYLVVFLRYIFSQADPGPLLFYLCSEVYQQTNPKDSRSLGKDIWNIFLEKNAPL
                     RVKIPEMLQAEIDLRLRNNEDPRNVLCEAQEAVMLEIQEQINDYRSKRTLGLGSLYGE
                     NDLLGLDGDPLRERQMAEKQLAALGDILSKYEEDRSAPMDFAVNTFMSHAGIRLRESR
                     SSCTAEKTQSAPDKDKWLPFFPKTKKQSSNSKKEKDALEDKKRNPILRYIGKPKSSSQ
                     SIKPGNVRNIIQHFENSHQYDVPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLK
                     GREEMKRSRKAENVPRSRSDVDMDAAAEAARLHQSASSSASSLSTRSLENPTPPFTPK
                     MGRRSIESPNLGFCTDVILPHLLEDDLGQLSDLEPEPEVQNWQHTVGKDVVANLTQRE
                     IDRQEVINELFVTEASHLRTLRVLDLIFYQRMRKENLMPREELARLFPNLPELIEIHN
                     SWCEAMKKLREEGPIIRDISDLMLARFDGPAREELQQVAAQFCSYQSVALELIRTKQR
                     KESRFQLFMQEAESHPQCRRLQLRDLIVSEMQRLTKYPLLLENIIKHTEGGTSEHEKL
                     CRARDQCREILKFVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTR
                     KMIHEGPLTWRISKDKTLDLQVLLLEDLVVLLQRQEERLLLKCHSKTAVGSSDSKQTF
                     SPVLKLNAVLIRSVATDKRAFFIICTSELGPPQIYELVALTSSDKNIWMELLEEAVQN
                     ATKHPGAAPIPIHPSPPGSQEPAYQGSTSSRVEINDSEVYHTEKEPKKLPEGPGPEQR
                     VQDKQLIAQGEPVQEEDEEELRTLPRAPPSLDGENRGIRTRDPVLLALTGPLLMEGLA
                     DAALEDVENLRHLILWSLLPGHTVKTQAAGEPEDDLTPTPSVVSITSHPWDPGSPGQA
                     PTISDSTRLARPEGSQPEGEDVAVSSLAHLPPRTRSSGVWDSPELDRNPAAEAASTEP
                     AASYKVVRKVSLLPGGGVGAAKVAGSNAIPDSGQSESELSEVEGGAQATGNCFYVSMP
                     AGPLDSSTEPTGTPPSPSQCHSLPAWPTEPQPYRGVRGGQCSSLVRRDVDVIFHTIEQ
                     LTIKLHRLKDMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDYSLSPPAKEALAS
                     DSQNGQEQGSCPEEGSDIALEDSATDTAVSPGP"
     exon            1233..1265
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1280
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1372
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1474
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1524
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1582
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1761
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1833
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1879
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1956
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2094
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2169
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2271
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2370
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2413
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2510
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2633
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2657
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2802
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..2902
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            2903..3029
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            3030..3209
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3257
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            3258..3445
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..3592
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            3593..3672
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            3673..3798
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            3799..3916
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            3917..4095
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            4096..4171
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            4172..4339
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            4340..4430
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            4431..4556
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            4557..4618
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            4619..4831
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            4832..5188
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            5189..5308
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            5309..5535
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            5536..5725
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
     exon            5726..6736
                     /gene="Arhgef11"
                     /gene_synonym="Gtrap48"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggacgccg ggagcggccg agcggggagg ctgtggcggg cgggcgggca cggaggccga
       61 ggccgcggcc cgggctctcc gcgccgctgt ggagggcgcc ctggccctag ccgagccgca
      121 acaatagtag gagcgggtcg ccgggcagga tcggcgggcg aggagaaacg ggacctccgc
      181 tccagggcgc tgcgacgaga gagactttcc gagcctggac gtgcaggagc acacagagct
      241 gactgaggaa tttgtctgag aaaaaggccg atctgaggct gtggctgagc acgggactgg
      301 actaggtgga ggaacctgca ggtcgaaaag gaaaagaagg tttaagattt cctggggttt
      361 ggccaatgct accgttttga aggtagaaag cattgcgctt caggtgtttt gtgatttttg
      421 tgtgtctctc tgtgtctgca caattggctg tttcagaatt caaaaccttt actgtagaag
      481 attgttgttt tgttttgatt tttaagaatt ccacaaattt tgcttcccgg ggctgcactg
      541 gactttgtgt tgtgtgcata ctgctgtatg gttttattta ttttaactgt gcaaatcatc
      601 tggaagattt ttttccccca agtgccattt cggatttgtt cagccttttt gttttgtttt
      661 gtttttcctt ccctggaata attctactgt tggcatttta agcatttgaa aatcagagat
      721 atttcaacct ttggagctta aagcttccct gtcaacagaa ggacagctgg gaaaactgga
      781 ttgaaaggat ggtttttatc tgtctgcagc aaagactgat attttgaagt cagattcttt
      841 ctgtggttcg tttttttagc ccgtagggct aaccttgaag agatttgtgg ttaacatttt
      901 ggtttctaag aaggtcatag tttttccttt tttttttttt ttttactttc cattttcttc
      961 tttctttttt aagacaaggg gaggggaggg taaagggtta cggaaggaga ccatgttaac
     1021 tgatagaagc agactagcac cgcagttccc aaggtcctga cagctggagg aaacaagggt
     1081 tcagtcttca acttgggagg ccttcctctc accttccttg aaaattgcaa gggactcagg
     1141 cctgatcaag acgcccaaag aaacgacagg attccagaac tgtggaaaca cggagaaacc
     1201 atgagcatac gattgcccca tagtatagac agatcagcca gtaaaaagca gtctcacctg
     1261 tccagcccca ttgcatcctg gttaagtagc ctgtcttctc tgggagattc tacacctgaa
     1321 cgcacatccc cttctcacca ccgccagccc tctgacactt ctgagacaac agcaggtctt
     1381 gttcagcgct gtgtcatcat ccaaaaggac cagcatggct ttggcttcac agttagtgga
     1441 gatcgcattg tactggtgca gtccgtgcgc cctggaggcg cagccatgaa agctggtgtg
     1501 aaagagggtg accggatcat caaagtaaac ggcaccatgg tgaccaatag ctcacacctg
     1561 gaggtggtaa agcttatcaa atctggcgcc tatgctgcgc ttaccctcct aggctcttct
     1621 cctccctccg tcggcgtctc tgggctccag cagaatccat ctgtggcagg agtgcccaga
     1681 gttaacccca tcattcctcc accacctccc ccgccaccct tgccacctcc acagcacatt
     1741 actggaccca aacctcttca ggatcctgaa gtccaaaagc acgccactca aatcctcagg
     1801 aatatgctaa gacaggagga gaaagagtta caggacatac ttccaccctg tggtgagacc
     1861 agtcagagaa catgtgaggg ccgcctctct gtggactccc aggaggcaga cagtggcttg
     1921 gattctggga cagaacgctt tccctccatc agtgagtcat tgatgaatcg gaactcagta
     1981 ttgtcagatc ctggactaga cagccctcaa acctcccctg taatcctggc cagggtggcc
     2041 cagcaccaca ggcgacaggg ctcagatgca gcgttgctcc cgctcaacca ccagggtata
     2101 gatcaaagcc caaagcctct gattattggc ccagaggaag attatgaccc aggttatttc
     2161 aacaatgaga gtgacatcat cttccaagat cttgaaaaac tgaagtcaca tccagcttac
     2221 ttggtagttt ttctacgtta catcttctct caggcagacc ctggccccct gcttttttat
     2281 ttgtgttcag aagtttatca acagacaaat cccaaagatt cccgaagtct ggggaaagac
     2341 atctggaaca ttttcctaga gaaaaatgcg cctctcagag tgaagatccc tgagatgttg
     2401 caggctgaaa ttgacctacg cctgcggaac aatgaggacc ctcgcaatgt gctctgtgaa
     2461 gctcaggagg cagtcatgct ggaaatccag gagcagatca acgactacag atccaagcgt
     2521 actctgggcc tgggcagcct ctatggtgaa aatgacctgc taggcctgga tggggaccct
     2581 cttcgagaac gccaaatggc tgagaagcag ctggctgccc ttggagatat cttgtccaaa
     2641 tatgaggaag atcggagtgc ccccatggac tttgctgtta atacctttat gagccacgct
     2701 gggatccgtc ttcgggagtc tcgatcctcc tgcacggcag aaaagaccca gtctgcccct
     2761 gacaaggaca agtggctgcc cttcttccct aagaccaaga agcagagcag caattccaag
     2821 aaagaaaagg atgccttgga ggacaagaag cgaaacccca tcctcagata tattgggaag
     2881 cccaagagct cctctcagag cattaagcca ggcaatgtga ggaacatcat tcagcacttt
     2941 gagaacagcc atcagtatga tgtcccagag ccggggacac aacgactctc aacaggaagc
     3001 tttcctgagg acctgctgga gagtgacagt tcgcgctcag agattcgact gggccgctct
     3061 gagagcctca agggccggga agagatgaag cgatcccgga aagcagagaa cgtgccccgg
     3121 tctcgaagtg acgttgacat ggatgctgct gcagaggctg cccgccttca ccagtcagcc
     3181 tcgtcctctg cctccagcct ctccaccagg tctcttgaga acccaacccc tcccttcacc
     3241 cccaaaatgg gccgcaggag cattgagtcc cccaatctgg ggttctgtac agatgtcatc
     3301 cttccccacc tcctggagga tgatctgggc caattgtctg acctggagcc agagccagag
     3361 gtccaaaact ggcagcatac agtaggcaag gatgtggtgg ccaacctgac ccagagggaa
     3421 attgaccggc aagaggtcat caatgagctt tttgtgacag aagcatctca cctgcgcaca
     3481 ctccgagtcc tggacctcat cttctaccag cgcatgagaa aggagaacct aatgcctcgg
     3541 gaagagctag cgcggctctt ccctaacctg cctgagctca tagagattca caattcctgg
     3601 tgtgaggcca tgaagaagct ccgggaggag ggccccatta tcagagacat cagtgacctc
     3661 atgctggctc ggtttgatgg tcctgcccga gaagaactcc agcaagtagc tgcacaattc
     3721 tgttcctatc agtcagtagc cctagagcta atcaggacta agcaacgtaa ggagagtcgg
     3781 ttccagctct tcatgcagga ggctgagagc caccctcagt gccggcgtct gcagctccga
     3841 gacctcatcg tctctgaaat gcaacggctc accaagtacc cactgctgct agagaacatc
     3901 atcaagcaca cagagggtgg cacctctgag catgagaagc tctgccgtgc ccgggaccag
     3961 tgccgggaga ttctcaagtt tgtgaatgaa gcagtaaagc agacagagaa ccgccaccgg
     4021 ctagaggggt accagaaacg cctggatgcc actgccctag agcgggccag caaccccttg
     4081 gcagcagagt tcaagagcct ggatcttaca acaaggaaga tgatccacga ggggcctctg
     4141 acctggagga tcagcaaaga caagaccctg gacctccagg tgcttctgct tgaggacctg
     4201 gtggtactgc tgcagagaca agaggagcgg ctgctgctaa agtgccacag caagacagcc
     4261 gtgggctcct ccgacagcaa gcagacgttc agccctgtgc tgaagctcaa tgctgtgctc
     4321 atccgctccg tggctacaga caagcgagcc ttcttcatca tctgcacctc cgagctgggc
     4381 cctccccaga tctatgagct ggttgcattg acgtcatcag acaagaatat atggatggag
     4441 ctcttagaag aggccgtgca gaatgccacc aagcaccctg gagctgcccc aatccccatc
     4501 catccctcac caccaggatc ccaggagccg gcctaccagg gctccacctc cagcagggta
     4561 gaaataaatg actcagaagt atatcacact gaaaaagaac ccaagaagct acctgaaggc
     4621 cccgggcctg agcagagagt tcaagacaag cagctgatag cacaagggga gcctgtgcag
     4681 gaagaggatg aagaggaatt gaggaccttg cctcgagctc ccccctccct ggatggagaa
     4741 aacagaggca tcaggacaag ggaccctgtc cttctggccc tcacaggccc tctgctcatg
     4801 gagggacttg ctgatgctgc cctggaagat gtggagaact tgcgtcacct gatcctgtgg
     4861 agcctgctgc ctggtcacac tgtgaagact caggctgctg gcgagcctga ggatgacctc
     4921 acacccaccc cttctgtcgt gagcatcacc tctcacccct gggacccagg gtccccaggg
     4981 caagctccca ccataagtga cagcacccga cttgcgaggc cagagggcag ccagccagag
     5041 ggcgaggatg ttgctgtcag ttctctggca cacctgccgc caaggaccag aagttctggc
     5101 gtctgggact ctcctgagct ggataggaat ccggctgcag aggctgcaag cacagaacca
     5161 gcagcaagtt acaaggttgt gagaaaagtc tctctactcc ctggtggtgg tgtcggtgca
     5221 gccaaggtgg cgggcagcaa tgctatccct gacagtggcc agtcagaatc tgagctatct
     5281 gaagtggaag gcggagcaca ggctacgggg aactgtttct atgtcagcat gccagcagga
     5341 cctctggact ccagcactga gcctactggg acacccccaa gcccctcaca gtgtcacagc
     5401 ctccctgcat ggccaacaga gcctcagccc tacaggggag tccgtggggg tcagtgttcc
     5461 agcctggtcc ggagggatgt ggatgtgatc ttccatacca tcgagcagct caccatcaag
     5521 cttcacagac tgaaggacat ggagctggcc cacagagagc tgctcaagtc ccttggagga
     5581 gagtcatcgg gtggaaccac acctgtgggg agttttcaca cagaggcagc cagatggaca
     5641 gactactccc tctctcctcc agccaaggaa gccctggcct ctgattccca aaatggtcag
     5701 gagcaggggt cctgccctga agaaggctcc gacatcgccc tggaagacag tgccactgac
     5761 acagctgtgt caccaggacc atagcatcca gacaaccaga gtctggcctg cctcagagca
     5821 caaccctggg agacccaagc ctccccttga aagatgccac ggggccaggg aatccctcgt
     5881 gttgcctggt ctgtttccac cagacagtcc agttcagtgt ctcttcctct gttagcccaa
     5941 gtctccatgg cttttgtctc ctgagcatgt tgaccacaac agaaaggcct ccaccctgca
     6001 tagccacata gccagtgtgg ggtgtgctgt gtgcacagtg ccctcaggtg tgcatgtcag
     6061 aggaggaggc ttatgtgtga ttgcactttt ttcctcccct tcttcctagg ccctgagaca
     6121 gctaggtgcc tggctctcct ctttgcccct ttagtttcct ataaatgtct actgtatgtg
     6181 tatctttgca attgtaaata acagcctttt ttttctgtcc ctagcatgtt caaccagtta
     6241 gagagagcca ggcagcagcc cagctcaggg ccatgattgt ttatgtccca ctggcaggga
     6301 ggtctcccag actccagctc tgtcaagctc cagggcccgc ctctgaagcc ttggccactt
     6361 ctcccttctt gttgtcagga gacacccctg cagggttccc cagcccttcc ccacctgccc
     6421 catagaaaca aatacagcag gtacggatct caaaacagac cccgagagag atgtggagtg
     6481 gattgctgga gtccctgagt taagtcaggg ctcttccttc cccaggggcc acagcaccat
     6541 tgcctcatca ccctgtcctc acgccactcc ccacgatgaa catacacact gtgctaggtg
     6601 tatatataca tatatataaa tatatataat atataaaata cagatatgga aatgactgtt
     6661 ttgctgttaa aataatgtat actcttattt tcttcctttc atggttaaga tttttttaaa
     6721 gaaaagttaa atattc
//
