LOCUS       XM_002728436            5513 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus Rho guanine nucleotide exchange factor
            10 (Arhgef10), transcript variant X1, mRNA.
ACCESSION   XM_002728436
VERSION     XM_002728436.6
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051351.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Jan 9, 2024 this sequence was replaced by
            NM_001427033.1.
            
            On Jan 21, 2021 this sequence version replaced XM_002728436.5.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5513
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..5513
                     /gene="Arhgef10"
                     /note="Rho guanine nucleotide exchange factor 10; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 24 ESTs, 1 long SRA read, 2 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 93 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:306618"
                     /db_xref="RGD:1565043"
     CDS             223..4344
                     /gene="Arhgef10"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 10
                     isoform X1"
                     /protein_id="XP_002728482.2"
                     /db_xref="GeneID:306618"
                     /db_xref="RGD:1565043"
                     /translation="MDQGEASPPVPAEHEVKCDTSNNEEEGELFDFESGDEVPEADRQ
                     APTADDGTGVAEADGADENTSPDGTGVAEADGADENTSPDGTRVDEADGADENTSPAG
                     NGTGAESVPEAEPEKLVVPIKVNPYSVIDITPFQEDQPPSPDANPEEEGVGLRVPSGY
                     CVPVPCGYAVPSNLPLLLPTYSSQIIIRAQSVEEEVAAEVAGDGQCNSLSSEDLPHSG
                     DQGSQEGSALARWAADPANTAWMENPEEAIYDDVPRENSDSEPDEMIYDDVENGGEGG
                     NSSLEYGWSSSEFESYEEPSDSEGKNGIPRSFLRSNHKKQLSHDLTRFKAHCEEKMRG
                     LVASTVGAMEAQQRQEWKMQRLMKAAKEGTRDGLEKTKAAVKRGRSFIRTKSLVSQDH
                     RYYFEEEQNLFIDVDCKHPEAVLTPMPEGLSQQQVVRRYILGSIVESEKNYVDALRRI
                     LEQYEKPLSEMEPRLLSDRKLRMVFYRIKEILQCHSMFQIALASRVSEWDAVETIGDV
                     FVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKLSQDSSPDRVTLHSL
                     MMRPIQRFPQFILLLQDMLKNTAKGHPDRLPLQMALTELETLAEKLNERKRDADQRCE
                     IKQIAKAINERYLNKLLSSGNRYLVRSDDVIETVYNDRGEIVKTKQRRIFMLNDVLMC
                     ATASSRNSHESHAMMNQRYLLKWSVPLGQVDVIEYSGSSGTGDHSRHHTAHSPESLAV
                     VANVKPHKVYMGPGQLYQDLQNLLHDLNVVGQISQLIGNLRGSYQNLNQSVAHDWTSG
                     LQQLILRKEDAIRAADRCRIQLQLPGKQDKSGRPTFFTAVFNTFTPAIKESWVSSLQM
                     AKLALEEENHMGWFCVDDDGSLAKKETHPLLVGHTSVMVAKQPEFKIECAAYNPEPYP
                     SNDNQPASPSTARGFLWIGSCSNQMGQVAIVSFQSANPKVIECFNVESRILCMIYIPA
                     EESKPQEPADTKDPEATASRAPHVPTICLGTEEGSISIYKSSQGCKKVRLQHFYTPDK
                     STVMSLACSPHGLYAGLVNGSVASYTKAPDGSWNSEPQQVIKLGVLPVRSLLLVEGAL
                     WAASGGQVFMASVETHTVENQLEAHQDEGMVISHMAVAGVGIWIAFTSGSTLRLFHTE
                     TLKHLQDVNIDAPVHSMLPGHQRLSVTSLLVCHGLLMVGTSLGVVVALPVPRLQGIPK
                     VTGRGMVSYHAHNGPVKFIVTATAFQNKDRARDRPRSSSELQDEDPKDLLCGEEGTSC
                     LGQTDTSTAVWLGDSLGLTAQNDLSSSSGSLSHGSSSLEHRSVDSSLCDLLRDPSAFP
                     RSRAQSSRRARASSALVVCGGQGHRRVHRKARQPSQEDLVSSVMVWQIPLLGM"
ORIGIN      
        1 ggcggggtgg gagcgcatcg cgggcggggc gcgcgggggg cgcgggacaa ctggcggacg
       61 cagacggcgg atggcgcccg gcccctcggt tgcctctaga aagccccgac tggcgtctcc
      121 tgggaaggtt tcatatgcca acttgaggga caatgtctgt gcctgcaggg gcccctgtcc
      181 cctgatgctg tccacgtgtg gaggaaggag gcaaggctga gcatggacca gggagaggcc
      241 tcaccacctg tgcctgcaga acacgaggtg aaatgtgaca ccagcaacaa tgaggaggag
      301 ggagagctgt ttgactttga gagtggagat gaagtcccgg aagccgaccg acaggccccg
      361 actgccgatg acgggacggg agttgctgaa gcagacggtg cagatgagaa cacgtcccct
      421 gacgggacgg gagttgctga agcagacggt gcagatgaga acacgtcccc tgatgggacg
      481 agagttgatg aagcagacgg tgcagatgag aacacgtccc ctgcaggaaa cggaactgga
      541 gcggaatctg tccctgaggc agagcctgag aaacttgtgg tcccaataaa agtgaaccca
      601 tattctgtca ttgacatcac gccgttccag gaggaccagc cgccatctcc agatgcaaac
      661 ccagaggagg aaggggtggg cctgcgcgtg cccagtggtt actgtgtgcc tgtgccctgt
      721 ggctacgctg tcccatctaa cctgccgttg ctgctgccca cctactccag ccaaatcatc
      781 atccgagccc agtctgtaga ggaggaagtt gcagcagaag ttgcgggaga cgggcagtgc
      841 aattccctaa gttctgagga cctaccacac agcggtgatc aaggcagcca agaaggcagt
      901 gccctggccc gatgggcagc cgaccctgcc aacacagcct ggatggaaaa tccagaggaa
      961 gcaatttacg atgatgttcc aagggaaaac tcagactctg aaccagatga aatgatttac
     1021 gatgacgtgg agaacggagg cgagggtgga aacagctccc tggagtacgg gtggagctcc
     1081 agcgagtttg aaagctacga ggagccaagc gactcggagg gcaagaacgg gattcccagg
     1141 tccttcctac gcagcaacca taaaaagcaa ctctctcatg acctaacccg ctttaaggcg
     1201 cactgtgagg aaaagatgag aggtttggtg gccagtacgg tgggagccat ggaggcacag
     1261 cagaggcagg agtggaagat gcagagactt atgaaggcag ccaaggaggg caccagagat
     1321 ggtttggaga agaccaaggc tgccgtgaag agaggccgct ccttcatcag gaccaagtcc
     1381 ttggtctctc aagatcacag gtattatttt gaagaagagc agaatttgtt cattgatgtt
     1441 gactgcaagc acccggaggc tgtcctcact ccaatgcccg agggtctgtc tcagcagcag
     1501 gttgtgagga gatacattct gggctccatt gttgagagtg agaagaacta cgtagatgct
     1561 ctccggcgga ttttggagca atatgagaag ccactgtccg agatggagcc ccggctcctg
     1621 agtgacagga agctcaggat ggtattttac cgcatcaaag agatcctgca gtgtcattcc
     1681 atgttccaga tcgcactggc cagccgggtg tctgagtggg atgccgtgga aacaatcgga
     1741 gatgttttcg tggcctcgtt ctccaagtcc atggtgctgg atgcttacag cgagtatgtg
     1801 aacaacttca gcacggccgt ggctgtcctc aagaagacgt gtgccacaaa gcctgccttc
     1861 cttgagttct taaagctgag ccaggattcc agtccagacc gagtcacact ccacagcctt
     1921 atgatgcggc ccatccagcg gttcccacag ttcatcctcc tgctgcagga catgctgaag
     1981 aacacagcca aaggacaccc tgacaggctg ccccttcaga tggcgctgac ggagctcgag
     2041 accctggcgg agaagctaaa cgagagaaag agagatgctg accagcggtg tgaaatcaag
     2101 caaatagcaa aagccataaa cgaaagatac ctgaacaagc tcctcagcag tgggaaccgg
     2161 tacctcgttc gctccgatga cgtcattgag acggtttaca acgaccgggg agaaatcgtc
     2221 aagaccaagc agcgccggat ctttatgctg aatgacgtgc tgatgtgtgc taccgccagc
     2281 tcacggaact cacatgaaag ccatgccatg atgaaccaga ggtacctgct caagtggagc
     2341 gtccctctag gacaggtgga cgtgatcgag tacagcggca gttctggcac gggggatcac
     2401 agccggcacc acactgcaca ctcaccggag agcctggccg tggtggccaa tgtgaagccg
     2461 cacaaagttt acatggggcc agggcagctg taccaggatc tgcagaacct actgcacgac
     2521 ctgaatgttg tcggccagat ctcgcagctg ataggaaacc tccgggggag ctatcagaac
     2581 ttaaaccagt cagtagccca cgactggacg tctggcttac agcagctgat cctgaggaaa
     2641 gaagatgcga tcagagccgc cgaccgctgc aggattcagt tacagctccc gggaaagcag
     2701 gacaagtcag ggcggcccac attcttcacc gctgtgttca atacgtttac ccccgccatc
     2761 aaggagtcct gggtcagcag cctgcagatg gccaagctgg cccttgagga ggaaaaccat
     2821 atgggatggt tctgtgtgga tgacgatggc agcctcgcca agaaagagac acaccctctc
     2881 ctggtgggac acacgtctgt gatggtggcc aagcagccag agttcaagat cgaatgtgca
     2941 gcttataacc ccgagcctta cccaagcaac gataaccaac cagcgtcacc ctccacggcg
     3001 cgtggcttcc tgtggatcgg aagctgcagc aatcagatgg gtcaggtcgc cattgtctcc
     3061 ttccaaagtg ccaaccccaa agtcatcgag tgcttcaatg tggagtcacg catcctgtgt
     3121 atgatttaca tcccggcgga ggagtcaaag ccccaagagc ccgctgacac caaggaccca
     3181 gaggccacag cgtcgagagc accccacgtg cccaccatct gcctgggcac agaggaggga
     3241 agcatttcca tttacaaaag cagtcagggc tgcaagaagg tgaggctcca gcacttctac
     3301 acgcctgaca agtccacagt catgagcttg gcctgctccc cgcacggcct gtatgcaggc
     3361 ctggtcaatg ggtctgtagc cagctacacc aaggctccag atggatcctg gaactcggaa
     3421 ccccagcaag tgatcaagtt gggtgtcctg ccagtcagaa gccttctcct ggtggagggc
     3481 gcgctgtggg cagcctcggg agggcaggtg ttcatggcca gcgtggagac tcacaccgta
     3541 gagaatcagc tggaggccca ccaagacgag gggatggtca tctcccacat ggctgtggct
     3601 ggggtcggca tttggattgc cttcacctcg gggtccacgc ttcgcctctt ccacacagag
     3661 accttgaagc acctgcagga tgtcaacatc gacgcccccg tgcatagcat gttgccaggg
     3721 caccagcgtc tgtctgtgac cagcctgctc gtctgccatg gcctgctcat ggttggtacc
     3781 agcctgggtg ttgtagtggc cctgccagtc cctcggcttc agggtatccc caaagtgaca
     3841 gggcgaggca tggtctccta ccatgcgcat aatgggcccg ttaagttcat tgtcacagcc
     3901 acagcgtttc agaacaagga cagagcccgg gacagaccac gttccagttc tgagcttcag
     3961 gacgaagacc ccaaggactt gctctgcggt gaggagggca cttcttgcct gggccagact
     4021 gacaccagca cagcggtttg gttgggagac tccctaggat tgacagctca gaacgacctg
     4081 tcttcatcgt cggggtcact gtcccatggc tccagctccc tagagcacag atctgtggac
     4141 agcagcctgt gtgacctcct gagggacccc agtgcctttc caaggagcag ggcacagagc
     4201 tctaggagag ccagagccag ttcagcgctg gtggtatgtg ggggccaggg ccaccggcgg
     4261 gtgcacagga aggccaggca gccttctcag gaggacctgg tttcttcggt gatggtgtgg
     4321 cagattccac tgctgggcat gtaggtcaga ggtcagaggc agctgcctgg catcaggtgg
     4381 cgagcaagga caactctcag ctggatgcag accgactgac aggcagcatc catactcact
     4441 gggaccaact ggaaaggaag tgtgcagcgg tcacacagct cccgtgcctc gtgtgctggg
     4501 gacgcagagc agcattctgg ctcttgggtc cctgagcaac gttccaggat aatgttacag
     4561 tccgccccgt cattcacctg agacgccaag tgagccgtct gtgtgagttc cagtcacatc
     4621 tcagagaact gacggggaac tgtagcatct actagcatag gaggccgtta acaattctta
     4681 aaatcattct acttgactca acctcgctac cattatttat attctatata tttttaaaat
     4741 tccagagtac agattgtaac aatttggaaa gccaggtaac acacccaagt ccagtcagct
     4801 tggtattttg tgggggagca actgaggctt tccaaagtag acttttatgt gtactgtccc
     4861 ctctaacaaa tactcttttt atattgcatt tttttctatt aaaaatcaac agctaacatt
     4921 tagtcaatgt cctatctgta gcgtttcacg tgtaatcttt aagccaaaat gttcagtacc
     4981 tatcaagttt tgaggtccag cttccacact gtacttgccc tatctgcgtg ggacaggtgc
     5041 tggcccagtc gtgcagggat ggtgctagtc gagtcttggg tcttctgggc acctgctgtc
     5101 agggagccat cgcagttgga cactccttct gagtggttcg tggtgctgat cagtcagccg
     5161 ctacccccac tgcctgctgt cccagtgcca ccccccttcc caaagaatgc acagggtcat
     5221 gtgggacact tgagaagcag ccgcggatgt caaggggtat gagtagccca tagactccct
     5281 ttgctccacc tgtatttata catcagcgtc tcactggatg gttaaaaaaa aatttttttt
     5341 aaacctaatg cagatattca ccaggaacaa cttctcagca ctttacaaag gactaaaatg
     5401 ctaacttttt accttagcca aatactgtct aaattgcaca tatacccagc ctttcttaaa
     5461 ctgttagctg ctatctcgtt tgataaaaat aaaagacttt attttagaat ata
//
