LOCUS       NM_001108269            1042 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus Rho GDP dissociation inhibitor gamma (Arhgdig),
            mRNA.
ACCESSION   NM_001108269 XM_001061568 XM_340775
VERSION     NM_001108269.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1042)
  AUTHORS   Sun J, Zhu Q, Yu X, Liang X, Guan H, Zhao H and Yao W.
  TITLE     RhoGDI3 at the trans-Golgi network participates in NLRP3
            inflammasome activation, VSMC phenotypic modulation, and neointima
            formation
  JOURNAL   Atherosclerosis 387, 117391 (2023)
   PUBMED   38029612
  REMARK    GeneRIF: RhoGDI3 at the trans-Golgi network participates in NLRP3
            inflammasome activation, VSMC phenotypic modulation, and neointima
            formation.
REFERENCE   2  (bases 1 to 1042)
  AUTHORS   Cui W, Dai X, Marcho C, Han Z, Zhang K, Tremblay KD and Mager J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1042)
  AUTHORS   Liu W, Yuen EY and Yan Z.
  TITLE     The stress hormone corticosterone increases synaptic
            alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
            receptors via serum- and glucocorticoid-inducible kinase (SGK)
            regulation of the GDI-Rab4 complex
  JOURNAL   J Biol Chem 285 (9), 6101-6108 (2010)
   PUBMED   20051515
  REMARK    GeneRIF: corticosterone, via SGK phosphorylation of GDI at Ser-213,
            increases the formation of GDI-Rab4 complex, facilitating the
            functional cycle of Rab4 and Rab4-mediated recycling of AMPARs to
            the synaptic membrane
REFERENCE   4  (bases 1 to 1042)
  AUTHORS   Zalcman G, Closson V, Camonis J, Honore N, Rousseau-Merck MF,
            Tavitian A and Olofsson B.
  TITLE     RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification
            of a non-cytosolic GDI protein interacting with the small
            GTP-binding proteins RhoB and RhoG
  JOURNAL   J Biol Chem 271 (48), 30366-30374 (1996)
   PUBMED   8939998
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_340775.3, XM_001061568.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5756307,
                              SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1042
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1042
                     /gene="Arhgdig"
                     /note="Rho GDP dissociation inhibitor gamma"
                     /db_xref="GeneID:360500"
                     /db_xref="RGD:1310739"
     exon            1..280
                     /gene="Arhgdig"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..885
                     /gene="Arhgdig"
                     /note="Rho GDP dissociation inhibitor (GDI) gamma"
                     /codon_start=1
                     /product="rho GDP-dissociation inhibitor 3"
                     /protein_id="NP_001101739.1"
                     /db_xref="GeneID:360500"
                     /db_xref="RGD:1310739"
                     /translation="MLGLDACELGAQLLELLRLALCARVLLADKDGEPTPSDEVLDEI
                     VPEYRAPGKKSMLEIWQLDPGDVSLVKYKQALLGPLPPIMDPSLPNVQVTRLTLLTEH
                     APGPMVMDLTGDLDALKNQVFVLKEGIEYKVKITFKVNKEIVSGLKCLHHTYRRGLRV
                     DKATFMVGSYGPRAQEYEFVTPVEEAPRGALARGLYVVRSLFTDDDRLNHLSWEWCLH
                     VCQDWKD"
     exon            281..460
                     /gene="Arhgdig"
                     /inference="alignment:Splign:2.1.0"
     exon            461..544
                     /gene="Arhgdig"
                     /inference="alignment:Splign:2.1.0"
     exon            545..621
                     /gene="Arhgdig"
                     /inference="alignment:Splign:2.1.0"
     exon            622..685
                     /gene="Arhgdig"
                     /inference="alignment:Splign:2.1.0"
     exon            686..1042
                     /gene="Arhgdig"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggcgcggc agggacaacc gggttccggc gcggtgcgga cgacacgcgc gtctctgcgg
       61 gctgcgcggg gtccgcggag cggctggggg cgcgcggcgc gggcgcggcg ctgggcgcgg
      121 ggggcgctcc cggccgggat gagctcaccg cagtcgcgcc ggggctgagc cgagcgggcg
      181 gcggctccgc ggcgggccgc ggctaccatg ctgggcctgg acgcgtgcga gctgggggcg
      241 cagctgttgg agctgctccg gctggcgctg tgcgcccgag ttctcttggc tgacaaggat
      301 ggggagccaa ctccatcaga cgaggtgctg gacgaaattg taccagagta ccgggcccct
      361 gggaagaaga gcatgctgga gatttggcag ctggaccctg gggacgtgag cttggtcaag
      421 tacaagcagg cgctccttgg gcccctgcca cccattatgg accccagcct gcccaacgtg
      481 caagtgacta ggctgacact gctgacggag catgctccag ggcctatggt catggacctt
      541 acaggagacc tagatgcact gaaaaaccag gtgtttgtcc tgaaggaggg cattgaatac
      601 aaggtgaaga tcaccttcaa ggtcaacaag gagattgtca gtggcctcaa atgtctacat
      661 cacacctatc gtcggggact gcgtgtggac aaggccacct tcatggtggg aagctatggc
      721 cccagggccc aggagtatga atttgtgact ccagtggagg aagcacccag gggagcattg
      781 gcacgtggtc tgtacgtggt caggtccctc ttcaccgatg atgacaggct gaaccacctg
      841 tcctgggagt ggtgcctcca tgtctgccag gactggaagg actgaacccc acttgggggg
      901 ggggggtctg tattcccaat ctctgtcagt tgcagagacc tgcaagcatt ccctagacct
      961 cccggttggt gaccagatgt cccctactct ctgctgtgtc ctccctgcct ggtgcctatt
     1021 aaatgttacc ttgtcttgct gc
//
