LOCUS       NM_001009600            1157 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus Rho GDP dissociation inhibitor beta (Arhgdib),
            mRNA.
ACCESSION   NM_001009600 XM_342777
VERSION     NM_001009600.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1157)
  AUTHORS   Liu S, Cui H, Li Q, Zhang L, Na Q and Liu C.
  TITLE     RhoGDI2 is expressed in human trophoblasts and involved in their
            migration by inhibiting the activation of RAC1
  JOURNAL   Biol Reprod 90 (4), 88 (2014)
   PUBMED   24554735
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1157)
  AUTHORS   Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M and
            Stoorvogel W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 1157)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1157)
  AUTHORS   Huang CY, Yang LC, Liu KY, Liao PH, Chou JI, Chou MY, Lin WW and
            Yang JJ.
  TITLE     RhoGDIbeta-induced hypertrophic growth in H9c2 cells is negatively
            regulated by ZAK
  JOURNAL   J Biomed Sci 16 (1), 11 (2009)
   PUBMED   19272173
  REMARK    GeneRIF: Data demonstrate that RhoGDIbeta physically interacts with
            ZAK and is phosphorylated by ZAK in vitro, and this phosphorylation
            negatively regulates RhoGDIbeta functions.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1157)
  AUTHORS   Davis AR, Clements MK, Bunger PL, Siemsen DW and Quinn MT.
  TITLE     Cloning and characterization of bovine low molecular weight GTPases
            (Rac1 and Rac2) and rho GDP-dissociation inhibitor 2 (D4-GDI)
  JOURNAL   Vet Immunol Immunopathol 74 (3-4), 285-301 (2000)
   PUBMED   10802295
REFERENCE   6  (bases 1 to 1157)
  AUTHORS   Chinni SR, Brenz M and Shisheva A.
  TITLE     Modulation of GDP-dissociation inhibitor protein membrane retention
            by the cellular redox state in adipocytes
  JOURNAL   Exp Cell Res 242 (1), 373-380 (1998)
   PUBMED   9665834
REFERENCE   7  (bases 1 to 1157)
  AUTHORS   Leffers H, Nielsen MS, Andersen AH, Honore B, Madsen P,
            Vandekerckhove J and Celis JE.
  TITLE     Identification of two human Rho GDP dissociation inhibitor proteins
            whose overexpression leads to disruption of the actin cytoskeleton
  JOURNAL   Exp Cell Res 209 (2), 165-174 (1993)
   PUBMED   8262133
REFERENCE   8  (bases 1 to 1157)
  AUTHORS   Adra CN, Ko J, Leonard D, Wirth LJ, Cerione RA and Lim B.
  TITLE     Identification of a novel protein with GDP dissociation inhibitor
            activity for the ras-like proteins CDC42Hs and rac I
  JOURNAL   Genes Chromosomes Cancer 8 (4), 253-261 (1993)
   PUBMED   7512369
REFERENCE   9  (bases 1 to 1157)
  AUTHORS   Scherle P, Behrens T and Staudt LM.
  TITLE     Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding
            protein, is expressed preferentially in lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 90 (16), 7568-7572 (1993)
   PUBMED   8356058
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088209.1.
            
            On Jan 13, 2005 this sequence version replaced XM_342777.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088209.1, FQ215399.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1157
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q43"
     gene            1..1157
                     /gene="Arhgdib"
                     /note="Rho GDP dissociation inhibitor beta"
                     /db_xref="GeneID:362456"
                     /db_xref="RGD:1305383"
     exon            1..58
                     /gene="Arhgdib"
                     /inference="alignment:Splign:2.1.0"
     exon            59..251
                     /gene="Arhgdib"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..676
                     /gene="Arhgdib"
                     /note="Rho, GDP dissociation inhibitor (GDI) beta"
                     /codon_start=1
                     /product="rho GDP-dissociation inhibitor 2"
                     /protein_id="NP_001009600.1"
                     /db_xref="GeneID:362456"
                     /db_xref="RGD:1305383"
                     /translation="MTEKDEQPQLEEGEDELDSKLNYKPPPQKSLKELQEMDKDDESL
                     TKYKKTLLGDVPVVADPTVPNVTVTRLSLVCDSAPGPITMDLTGDLKALKKDTFVLKE
                     GIEYRVKINFKVNKDIVSGLKYVQQTYRNGMKVDKATFMVGSYGPRPEEYEFLTPVEE
                     APKGMLARGTYHNKSFFTDDDKQDHLTWEWNLAIKKDWTD"
     exon            252..335
                     /gene="Arhgdib"
                     /inference="alignment:Splign:2.1.0"
     exon            336..412
                     /gene="Arhgdib"
                     /inference="alignment:Splign:2.1.0"
     exon            413..476
                     /gene="Arhgdib"
                     /inference="alignment:Splign:2.1.0"
     exon            477..1130
                     /gene="Arhgdib"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgagagaca ggcagaggta acctacagag acacacaggg cggacaggag cctggaatta
       61 aggaacaatc aagatgacgg agaaggatga gcagccacag ctggaggagg gagaggatga
      121 gctggacagc aagctcaact acaagccgcc ccctcagaag tccctgaagg agctgcagga
      181 gatggacaaa gatgacgaga gtctaaccaa gtacaagaaa acactgctgg gagatgtccc
      241 cgtggtagca gacccaacag ttcccaacgt gactgtgacc cggcttagcc ttgtttgtga
      301 cagtgcacca ggaccaatca ccatggacct tactggtgat ctcaaggcgc tcaaaaagga
      361 tacatttgtg ctaaaggaag gtatcgaata cagggtcaag attaacttca aagtgaataa
      421 ggatattgtg tctggcctga agtatgttca gcagacgtac cggaatggga tgaaagtgga
      481 taaagctacg ttcatggttg gcagctacgg gcctcgacca gaggagtacg agttcctcac
      541 tccagtagag gaggctccca agggcatgtt ggcccgaggc acttaccaca acaagtcctt
      601 cttcaccgat gatgacaagc aggaccacct cacctgggaa tggaacctgg ccattaagaa
      661 ggattggaca gactgagtgc atctgtccat ccctcccgcc cggaccatgt tgatcattgc
      721 gttctccctc ctccctccct gttccctgct gggtccttta tcacacacac acacacacac
      781 acacccctca tcactgatat gttttatctt accccatctc tcagagtgtt cccttaaaac
      841 ccaggcttta acccggcatg ttccctcaga ctgtctcccc agagcagagc aaggccagag
      901 ttctgaagtt ctccatctca tttagtggcc tcctctcttc tcccagtttg agtcctggag
      961 gccaggaaac gggcaagctg ttgctcatgg ctccgtggcc ttctgttcag aaacttattc
     1021 ttccactggt tcaatgaatc tcatcaccct ctctgccaat gggagctctt ctcttgtggg
     1081 agacactgta aacaacacca aaggaaaaaa taaaaccact gtgtgtgtga aaaaaaaaaa
     1141 aaaaaaaaaa aaaaaaa
//
