LOCUS       NM_001007005            1963 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus Rho GDP dissociation inhibitor alpha (Arhgdia),
            mRNA.
ACCESSION   NM_001007005 XM_340950
VERSION     NM_001007005.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1963)
  AUTHORS   Zhang,H., Lu,F., Liu,P., Qiu,Z., Li,J., Wang,X., Xu,H., Zhao,Y.,
            Li,X., Wang,H., Lu,D. and Qi,R.
  TITLE     A direct interaction between RhoGDIalpha/Tau alleviates
            hyperphosphorylation of Tau in Alzheimer's disease and vascular
            dementia
  JOURNAL   J Neuroimmune Pharmacol 18 (1-2), 58-71 (2023)
   PUBMED   35080740
  REMARK    GeneRIF: A direct interaction between RhoGDIalpha/Tau alleviates
            hyperphosphorylation of Tau in Alzheimer's disease and vascular
            dementia.
REFERENCE   2  (bases 1 to 1963)
  AUTHORS   Wei,Z., Xu,H., Zhang,Y., Yi,X., Yang,X., Chen,Y., Mao,N., Li,S.,
            Xu,D., Li,S., Zhang,H., Li,D., Zhang,G., Zhang,B., Jin,F., Gao,X.,
            Cai,W., Zhang,L., Wang,R. and Yang,F.
  TITLE     Rho GDP dissociation inhibitor alpha silencing attenuates silicosis
            by inhibiting RhoA/Rho kinase signalling
  JOURNAL   Exp Cell Res 380 (2), 131-140 (2019)
   PUBMED   31029634
  REMARK    GeneRIF: Rho GDP dissociation inhibitor alpha silencing attenuates
            silicosis by inhibiting RhoA/Rho kinase signalling
REFERENCE   3  (bases 1 to 1963)
  AUTHORS   Potokar,M., Jorgacevski,J., Lacovich,V., Kreft,M., Vardjan,N.,
            Bianchi,V., D'Adamo,P. and Zorec,R.
  TITLE     Impaired alphaGDI Function in the X-Linked Intellectual Disability:
            The Impact on Astroglia Vesicle Dynamics
  JOURNAL   Mol Neurobiol 54 (4), 2458-2468 (2017)
   PUBMED   26971292
  REMARK    GeneRIF: The siRNA-mediated suppression of expression of alphaGDI
            especially affected vesicle dynamics.
REFERENCE   4  (bases 1 to 1963)
  AUTHORS   Pasini,S., Liu,J., Corona,C., Peze-Heidsieck,E., Shelanski,M. and
            Greene,L.A.
  TITLE     Activating Transcription Factor 4 (ATF4) modulates Rho GTPase
            levels and function via regulation of RhoGDIalpha
  JOURNAL   Sci Rep 6, 36952 (2016)
   PUBMED   27841340
  REMARK    GeneRIF: Results show that RhoGDIalpha is transcriptionally
            regulated by ATF4 in neurons and that RhoGDIalpha knockown reduces
            Cdc42 expression supporting the view that RhoGDIalpha mediates the
            effects of ATF4 on Cdc42 and therefore on mushroom spines and
            excitatory synapses.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1963)
  AUTHORS   Liu,W., Shang,F.F., Xu,Y., Belegu,V., Xia,L., Zhao,W., Liu,R.,
            Wang,W., Liu,J., Li,C.Y. and Wang,T.H.
  TITLE     eIF5A1/RhoGDIalpha pathway: a novel therapeutic target for
            treatment of spinal cord injury identified by a proteomics approach
  JOURNAL   Sci Rep 5, 16911 (2015)
   PUBMED   26593060
  REMARK    GeneRIF: eIF5A1 upregulates RhoGDIalpha to promote neuroplasticity
            caudal to the spinal cord injury and functional recovery after
            spinal cord injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1963)
  AUTHORS   Allenspach,E.J., Cullinan,P., Tong,J., Tang,Q., Tesciuba,A.G.,
            Cannon,J.L., Takahashi,S.M., Morgan,R., Burkhardt,J.K. and
            Sperling,A.I.
  TITLE     ERM-dependent movement of CD43 defines a novel protein complex
            distal to the immunological synapse
  JOURNAL   Immunity 15 (5), 739-750 (2001)
   PUBMED   11728336
REFERENCE   7  (bases 1 to 1963)
  AUTHORS   Chinni,S.R., Brenz,M. and Shisheva,A.
  TITLE     Modulation of GDP-dissociation inhibitor protein membrane retention
            by the cellular redox state in adipocytes
  JOURNAL   Exp Cell Res 242 (1), 373-380 (1998)
   PUBMED   9665834
REFERENCE   8  (bases 1 to 1963)
  AUTHORS   Tolias,K.F., Couvillon,A.D., Cantley,L.C. and Carpenter,C.L.
  TITLE     Characterization of a Rac1- and RhoGDI-associated lipid kinase
            signaling complex
  JOURNAL   Mol Cell Biol 18 (2), 762-770 (1998)
   PUBMED   9447972
REFERENCE   9  (bases 1 to 1963)
  AUTHORS   Zalcman,G., Closson,V., Camonis,J., Honore,N., Rousseau-Merck,M.F.,
            Tavitian,A. and Olofsson,B.
  TITLE     RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification
            of a non-cytosolic GDI protein interacting with the small
            GTP-binding proteins RhoB and RhoG
  JOURNAL   J Biol Chem 271 (48), 30366-30374 (1996)
   PUBMED   8939998
REFERENCE   10 (bases 1 to 1963)
  AUTHORS   Leffers,H., Nielsen,M.S., Andersen,A.H., Honore,B., Madsen,P.,
            Vandekerckhove,J. and Celis,J.E.
  TITLE     Identification of two human Rho GDP dissociation inhibitor proteins
            whose overexpression leads to disruption of the actin cytoskeleton
  JOURNAL   Exp Cell Res 209 (2), 165-174 (1993)
   PUBMED   8262133
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083817.1.
            
            On Nov 22, 2004 this sequence version replaced XM_340950.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083817.1, EV764406.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132299, SAMEA5756307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1963
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..1963
                     /gene="Arhgdia"
                     /gene_synonym="Bles01; Rho GDI 1"
                     /note="Rho GDP dissociation inhibitor alpha"
                     /db_xref="GeneID:360678"
                     /db_xref="RGD:1359547"
     exon            1..54
                     /gene="Arhgdia"
                     /gene_synonym="Bles01; Rho GDI 1"
                     /inference="alignment:Splign:2.1.0"
     exon            55..266
                     /gene="Arhgdia"
                     /gene_synonym="Bles01; Rho GDI 1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..691
                     /gene="Arhgdia"
                     /gene_synonym="Bles01; Rho GDI 1"
                     /note="rho-GDI alpha; Rho GDP dissociation inhibitor (GDI)
                     alpha"
                     /codon_start=1
                     /product="rho GDP-dissociation inhibitor 1"
                     /protein_id="NP_001007006.1"
                     /db_xref="GeneID:360678"
                     /db_xref="RGD:1359547"
                     /translation="MAEQEPTAEQLAQIAAENEEDEHSVNYKPPAQKSIQEIQELDKD
                     DESLRKYKEALLGRVAVSADPNVPNVIVTRLTLVCSTAPGPLELDLTGDLESFKKQSF
                     VLKEGVEYRIKISFRVNREIVSGMKYIQHTYRKGVKIDKTDYMVGSYGPRAEEYEFLT
                     PMEEAPKGMLARGSYNIKSRFTDDDKTDHLSWEWNLTIKKEWKD"
     exon            267..350
                     /gene="Arhgdia"
                     /gene_synonym="Bles01; Rho GDI 1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..427
                     /gene="Arhgdia"
                     /gene_synonym="Bles01; Rho GDI 1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..491
                     /gene="Arhgdia"
                     /gene_synonym="Bles01; Rho GDI 1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..1823
                     /gene="Arhgdia"
                     /gene_synonym="Bles01; Rho GDI 1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgacgttcgt catttggtgc gggagggagc gcgagagcgg tggtcgagcc tccggtgtcc
       61 caaactagag gtgagcatgg cagaacagga acccactgct gagcagctcg ctcagatagc
      121 tgcagagaat gaggaagacg agcactctgt gaactacaag cctccagccc agaagagcat
      181 ccaggagatc caggaactgg acaaggatga tgaaagcctt cgaaagtaca aggaggccct
      241 gctgggccga gtagctgtct ctgcagaccc caatgtcccc aacgtcattg tgacccgctt
      301 gaccttggtg tgcagcactg ccccaggccc tctggaactg gacctgacag gtgatctgga
      361 gagcttcaag aaacagtcat ttgtgttgaa ggaaggtgtg gagtaccgga taaaaatctc
      421 tttccgggtg aacagagaga tcgtgtcagg catgaagtac atccagcaca catacaggaa
      481 aggggtcaaa attgacaaga ctgactacat ggtcgggagc tatgggccaa gggctgagga
      541 gtatgagttc ctgacaccca tggaagaggc ccccaaaggc atgcttgctc ggggcagtta
      601 caacatcaag tcccgcttca cagatgatga caaaactgac cacctgtcct gggagtggaa
      661 tctcaccatc aaaaaggaat ggaaggactg agctccagct gggaggcggg cagggcgacg
      721 gacagacaga aggaccgaca tgcccctccc taaaccccta cccaccccaa accaaagtgc
      781 tgacaggacc tccctcacca ttcctcccta gtccactcag gcagtcagct cttctgtctg
      841 cccctcctcc acctcctgcc cgcaggcccc tgtggtctct agtgtcacat tgctgcttct
      901 gcctgtgcag tgggggaggg gttctagccc aggcctccaa tctgctgtgt ccctccaggt
      961 tccccctgtc ttcccctcct caggccctgg cttctagaat ggaacaggac gctgtctggg
     1021 ttgcccggcc taccttgtct ctgttccagc tgagcaaccc tcagtgtggg gctgggctgg
     1081 gctgtcgtcc tctagcccca ccactccatg gccaggtcat ccatcactgt cagtcactgt
     1141 ctaaccatga tgccttaaca tgtggaacgt gtactggggg ccgtcgctaa ctcttaactc
     1201 cctgtctgca tgagcatgtg gtctccccgt ccttgccttg tctgccatcc ccatcctggt
     1261 gacccaccca aaggaggcct ggggtgtgct gctgttgctt cctgcgggcc tggccagctc
     1321 ttcccctccc cgtggccagg gttgggggtg gcaccagtag ctaggggagg gtcaattgcc
     1381 aaaactcaat gcctccagcc ccatctagga ggcagggtag ggtgcctcat tcctctgcct
     1441 tctctgtccc ttgtaggcag tactcagagc ccctgtcccc acagacagcc cctgagggac
     1501 aaagccagcc gagccttact tgtctcacct gggccctgtg gcctgaacct cgtgcctggc
     1561 ctgtcagtat ttattgcctc catttgggcc agctggcctg atgcctctgc cctggttctt
     1621 ggtgccacca tccctgggca ggccctccct ggacccaacc aggacaaacg tgggaccaag
     1681 ttcacgcagt tgggagctgt ctcctgtgcc tcccctccct atccccagtc cctgtgtggt
     1741 gtctgccagg cccagcctca acaggcagag gagcctgtcc ctgcttctct tctgactggg
     1801 aaataaacac ccctgaagga gtcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1861 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1921 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
